Intestinal transport of scutellarein and scutellarin and first-pass metabolism by UDP-glucuronosyltransferase-mediated glucuronidation of scutellarein and hydrolysis of scutellarin

Xenobiotica

Volumn 41, Issue 7, 2011, Pages 538-548

  Wang, Yazhi ^a   Ao, Heisio ^a   Qian, Zhengming ^a   Zheng, Ying ^a  

^a University of Macau   (Macao)

Author keywords

Caco 2 cell monolayer; glucuronidation; scutellarein (S); scutellarin (SG); UDP glucuronosyltransferase

Indexed keywords

BETA GLUCURONIDASE; CYTOCHROME P450; DRUG METABOLITE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; SCUTELLAREIN; SCUTELLARIN; VERLUKAST;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DIFFUSION; DRUG GLUCURONIDATION; DRUG HYDROLYSIS; DRUG HYDROXYLATION; DRUG STRUCTURE; ENZYME KINETICS; FIRST PASS EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE MICROSOME; LIVER MICROSOME; MICROSOME; MONOLAYER CULTURE; PROTEIN FUNCTION; TANDEM MASS SPECTROMETRY;

APIGENIN; BIOLOGICAL TRANSPORT; BIOTRANSFORMATION; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; GLUCURONIC ACIDS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; HYDROLYSIS; HYDROXYLATION; INTESTINES; ISOENZYMES; KINETICS; MASS SPECTROMETRY; MICROSOMES, LIVER; NADP; RECOMBINANT PROTEINS; ULTRAVIOLET RAYS;

EID: 79958861829     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.578762     Document Type: Article

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