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Volumn 71, Issue 22, 2014, Pages 4393-4402

Dynamic EpCAM expression on circulating and disseminating tumor cells: Causes and consequences

Author keywords

CTCs; DTCs; EMT; EpCAM; MET; Metastases

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPITHELIAL CELL ADHESION MOLECULE; SCATTER FACTOR RECEPTOR; CELL ADHESION MOLECULE; TUMOR ANTIGEN; TUMOR-ASSOCIATED ANTIGEN GA733;

EID: 84925285931     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-014-1693-1     Document Type: Review
Times cited : (98)

References (99)
  • 1
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • 10.1038/nrc2627 19308069 1:CAS:528:DC%2BD1MXjsFSrsr8%3D
    • Klein CA (2009) Parallel progression of primary tumours and metastases. Nat Rev Cancer 9(4):302-312. doi: 10.1038/nrc2627
    • (2009) Nat Rev Cancer , vol.9 , Issue.4 , pp. 302-312
    • Klein, C.A.1
  • 2
    • 67650434696 scopus 로고    scopus 로고
    • Lessons from an aggressive cancer: Evolutionary dynamics in esophageal carcinoma
    • 10.1158/0008-5472.CAN-08-4586 19549904 1:CAS:528:DC%2BD1MXnvFWquro%3D
    • Klein CA, Stoecklein NH (2009) Lessons from an aggressive cancer: evolutionary dynamics in esophageal carcinoma. Cancer Res 69(13):5285-5288. doi: 10.1158/0008-5472.CAN-08-4586
    • (2009) Cancer Res , vol.69 , Issue.13 , pp. 5285-5288
    • Klein, C.A.1    Stoecklein, N.H.2
  • 3
    • 73449133770 scopus 로고    scopus 로고
    • Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis
    • 10.1002/ijc.24916 19795462 1:CAS:528:DC%2BD1MXhsFGjs7nE
    • Stoecklein NH, Klein CA (2010) Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis. Int J Cancer 126(3):589-598. doi: 10.1002/ijc.24916
    • (2010) Int J Cancer , vol.126 , Issue.3 , pp. 589-598
    • Stoecklein, N.H.1    Klein, C.A.2
  • 4
    • 84878814203 scopus 로고    scopus 로고
    • Detection of cancer before distant metastasis
    • 10.1186/1471-2407-13-283 23763955 3684526
    • Coumans FA, Siesling S, Terstappen LW (2013) Detection of cancer before distant metastasis. BMC Cancer 13(1):283. doi: 10.1186/1471-2407-13-283
    • (2013) BMC Cancer , vol.13 , Issue.1 , pp. 283
    • Coumans, F.A.1    Siesling, S.2    Terstappen, L.W.3
  • 6
    • 84890283025 scopus 로고    scopus 로고
    • Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes
    • 10.1002/path.4280 24114677 4090031
    • Lehmann BD, Pietenpol JA (2014) Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes. J Pathol 232(2):142-150. doi: 10.1002/path.4280
    • (2014) J Pathol , vol.232 , Issue.2 , pp. 142-150
    • Lehmann, B.D.1    Pietenpol, J.A.2
  • 7
    • 84901008741 scopus 로고    scopus 로고
    • Circulating tumor cells: A multifunctional biomarker
    • 10.1158/1078-0432.CCR-13-2664 24831278 1:CAS:528:DC%2BC2cXnvF2gt7o%3D
    • Yap TA, Lorente D, Omlin A, Olmos D, de Bono JS (2014) Circulating tumor cells: a multifunctional biomarker. Clin Cancer Res 20(10):2553-2568. doi: 10.1158/1078-0432.CCR-13-2664
    • (2014) Clin Cancer Res , vol.20 , Issue.10 , pp. 2553-2568
    • Yap, T.A.1    Lorente, D.2    Omlin, A.3    Olmos, D.4    De Bono, J.S.5
  • 8
    • 77956268304 scopus 로고    scopus 로고
    • Circulating tumour cells in cancer patients: Challenges and perspectives
    • 10.1016/j.molmed.2010.07.001 20667783
    • Pantel K, Alix-Panabieres C (2010) Circulating tumour cells in cancer patients: challenges and perspectives. Trends Mol Med 16(9):398-406. doi: 10.1016/j.molmed.2010.07.001
    • (2010) Trends Mol Med , vol.16 , Issue.9 , pp. 398-406
    • Pantel, K.1    Alix-Panabieres, C.2
  • 9
    • 68549137924 scopus 로고    scopus 로고
    • Cancer micrometastases
    • 10.1038/nrclinonc.2009.44 19399023 1:CAS:528:DC%2BD1MXms12gtbw%3D
    • Pantel K, Alix-Panabieres C, Riethdorf S (2009) Cancer micrometastases. Nat Rev Clin Oncol 6(6):339-351. doi: 10.1038/nrclinonc.2009.44
    • (2009) Nat Rev Clin Oncol , vol.6 , Issue.6 , pp. 339-351
    • Pantel, K.1    Alix-Panabieres, C.2    Riethdorf, S.3
  • 10
    • 84896395959 scopus 로고    scopus 로고
    • New frontiers in circulating tumor cell analysis: A reference guide for biomolecular profiling toward translational clinical use
    • 10.1002/ijc.28516 24122526 1:CAS:528:DC%2BC3sXhs1yksbzN
    • Becker TM, Caixeiro NJ, Lim SH, Tognela A, Kienzle N, Scott KF, Spring KJ, de Souza P (2014) New frontiers in circulating tumor cell analysis: a reference guide for biomolecular profiling toward translational clinical use. Int J Cancer 134(11):2523-2533. doi: 10.1002/ijc.28516
    • (2014) Int J Cancer , vol.134 , Issue.11 , pp. 2523-2533
    • Becker, T.M.1    Caixeiro, N.J.2    Lim, S.H.3    Tognela, A.4    Kienzle, N.5    Scott, K.F.6    Spring, K.J.7    De Souza, P.8
  • 12
    • 84867535653 scopus 로고    scopus 로고
    • Challenges in the enumeration and phenotyping of CTC
    • 10.1158/1078-0432.CCR-12-1585 23014524
    • Coumans FA, Ligthart ST, Uhr JW, Terstappen LW (2012) Challenges in the enumeration and phenotyping of CTC. Clin Cancer Res 18(20):5711-5718. doi: 10.1158/1078-0432.CCR-12-1585
    • (2012) Clin Cancer Res , vol.18 , Issue.20 , pp. 5711-5718
    • Coumans, F.A.1    Ligthart, S.T.2    Uhr, J.W.3    Terstappen, L.W.4
  • 14
    • 0022496512 scopus 로고
    • In vivo and in vitro labelling of epithelial tumor cells with anti 17-1A monoclonal antibodies in bone marrow of cancer patients
    • 3744380
    • Schlimok G, Gottlinger H, Funke I, Swierkot S, Hauser H, Riethmuller G (1986) In vivo and in vitro labelling of epithelial tumor cells with anti 17-1A monoclonal antibodies in bone marrow of cancer patients. Hybridoma 5(Suppl 1):S163-S170
    • (1986) Hybridoma , vol.5 , pp. S163-S170
    • Schlimok, G.1    Gottlinger, H.2    Funke, I.3    Swierkot, S.4    Hauser, H.5    Riethmuller, G.6
  • 15
    • 84889781527 scopus 로고    scopus 로고
    • Towards the biological understanding of CTC: Capture technologies, definitions and potential to create metastasis
    • 10.3390/cancers5041619 24305653 3875957
    • Barradas AM, Terstappen LW (2013) Towards the biological understanding of CTC: capture technologies, definitions and potential to create metastasis. Cancers 5(4):1619-1642. doi: 10.3390/cancers5041619
    • (2013) Cancers , vol.5 , Issue.4 , pp. 1619-1642
    • Barradas, A.M.1    Terstappen, L.W.2
  • 18
    • 0032749197 scopus 로고    scopus 로고
    • The biology of the 17-1A antigen (Ep-CAM)
    • 10606205 1:CAS:528:DC%2BD3cXltlCmsQ%3D%3D
    • Balzar M, Winter MJ, de Boer CJ, Litvinov SV (1999) The biology of the 17-1A antigen (Ep-CAM). J Mol Med 77(10):699-712
    • (1999) J Mol Med , vol.77 , Issue.10 , pp. 699-712
    • Balzar, M.1    Winter, M.J.2    De Boer, C.J.3    Litvinov, S.V.4
  • 19
    • 33846804010 scopus 로고    scopus 로고
    • EpCAM (CD326) finding its role in cancer
    • 17211480 1:CAS:528:DC%2BD2sXhtlKjtrg%3D 2360029
    • Baeuerle PA, Gires O (2007) EpCAM (CD326) finding its role in cancer. Br J Cancer 96(3):417-423
    • (2007) Br J Cancer , vol.96 , Issue.3 , pp. 417-423
    • Baeuerle, P.A.1    Gires, O.2
  • 20
    • 84860367617 scopus 로고    scopus 로고
    • EpCAM and its potential role in tumor-initiating cells
    • 10.4161/cam.18953 22647938 3364135
    • Imrich S, Hachmeister M, Gires O (2012) EpCAM and its potential role in tumor-initiating cells. Cell Adh Migr 6(1):30-38. doi: 10.4161/cam.18953
    • (2012) Cell Adh Migr , vol.6 , Issue.1 , pp. 30-38
    • Imrich, S.1    Hachmeister, M.2    Gires, O.3
  • 21
    • 69249092641 scopus 로고    scopus 로고
    • EpCAM is involved in maintenance of the murine embryonic stem cell phenotype
    • 10.1002/stem.97 19544432 1:CAS:528:DC%2BD1MXht1ajsr7P
    • Gonzalez B, Denzel S, Mack B, Conrad M, Gires O (2009) EpCAM is involved in maintenance of the murine embryonic stem cell phenotype. Stem Cells 27(8):1782-1791. doi: 10.1002/stem.97
    • (2009) Stem Cells , vol.27 , Issue.8 , pp. 1782-1791
    • Gonzalez, B.1    Denzel, S.2    Mack, B.3    Conrad, M.4    Gires, O.5
  • 22
    • 75349094231 scopus 로고    scopus 로고
    • Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells
    • 10.1002/stem.221
    • Ng VY, Ang SN, Chan JX, Choo AB (2009) Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells. Stem Cells. doi: 10.1002/stem.221
    • (2009) Stem Cells
    • Ng, V.Y.1    Ang, S.N.2    Chan, J.X.3    Choo, A.B.4
  • 23
    • 0031872418 scopus 로고    scopus 로고
    • Flow cytometry-principles and feasibility in transfusion medicine. Enumeration of epithelial derived tumor cells in peripheral blood
    • 9704456 1:CAS:528:DyaK1cXkvFCis7w%3D
    • Terstappen LW, Rao C, Gross S, Kotelnikov V, Racilla E, Uhr J, Weiss A (1998) Flow cytometry-principles and feasibility in transfusion medicine. Enumeration of epithelial derived tumor cells in peripheral blood. Vox Sang 74(Suppl 2):269-274
    • (1998) Vox Sang , vol.74 , pp. 269-274
    • Terstappen, L.W.1    Rao, C.2    Gross, S.3    Kotelnikov, V.4    Racilla, E.5    Uhr, J.6    Weiss, A.7
  • 26
    • 84867556074 scopus 로고    scopus 로고
    • Meta-analysis of the prognostic value of circulating tumor cells in breast cancer
    • 10.1158/1078-0432.CCR-12-1587 22908097
    • Zhang L, Riethdorf S, Wu G, Wang T, Yang K, Peng G, Liu J, Pantel K (2012) Meta-analysis of the prognostic value of circulating tumor cells in breast cancer. Clin Cancer Res 18(20):5701-5710. doi: 10.1158/1078-0432.CCR-12-1587
    • (2012) Clin Cancer Res , vol.18 , Issue.20 , pp. 5701-5710
    • Zhang, L.1    Riethdorf, S.2    Wu, G.3    Wang, T.4    Yang, K.5    Peng, G.6    Liu, J.7    Pantel, K.8
  • 32
    • 0028144072 scopus 로고
    • Evidence for a role of the epithelial glycoprotein 40 (Ep-CAM) in epithelial cell-cell adhesion
    • 7842256 1:CAS:528:DyaK2MXitlGktrc%3D
    • Litvinov SV, Bakker HA, Gourevitch MM, Velders MP, Warnaar SO (1994) Evidence for a role of the epithelial glycoprotein 40 (Ep-CAM) in epithelial cell-cell adhesion. Cell Adhes Commun 2(5):417-428
    • (1994) Cell Adhes Commun , vol.2 , Issue.5 , pp. 417-428
    • Litvinov, S.V.1    Bakker, H.A.2    Gourevitch, M.M.3    Velders, M.P.4    Warnaar, S.O.5
  • 35
    • 24644451986 scopus 로고    scopus 로고
    • Expression of epithelial cell adhesion molecule in carcinoma cells present in blood and primary and metastatic tumors
    • 15942643 1:CAS:528:DC%2BD2MXmtlKisLc%3D
    • Rao CG, Chianese D, Doyle GV, Miller MC, Russell T, Sanders RA Jr, Terstappen LW (2005) Expression of epithelial cell adhesion molecule in carcinoma cells present in blood and primary and metastatic tumors. Int J Oncol 27(1):49-57
    • (2005) Int J Oncol , vol.27 , Issue.1 , pp. 49-57
    • Rao, C.G.1    Chianese, D.2    Doyle, G.V.3    Miller, M.C.4    Russell, T.5    Sanders, Jr.R.A.6    Terstappen, L.W.7
  • 38
    • 84877726784 scopus 로고    scopus 로고
    • The identification and characterization of breast cancer CTCs competent for brain metastasis
    • 10.1126/scitranslmed.3005109
    • Zhang L, Ridgway LD, Wetzel MD, Ngo J, Yin W, Kumar D, Goodman JC, Groves MD, Marchetti D (2013) The identification and characterization of breast cancer CTCs competent for brain metastasis. Sci Transl Med 5((180)):180ra148. doi: 10.1126/scitranslmed.3005109
    • (2013) Sci Transl Med , vol.5 , Issue.180 , pp. 180ra148
    • Zhang, L.1    Ridgway, L.D.2    Wetzel, M.D.3    Ngo, J.4    Yin, W.5    Kumar, D.6    Goodman, J.C.7    Groves, M.D.8    Marchetti, D.9
  • 39
    • 84860999602 scopus 로고    scopus 로고
    • Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition
    • 10.1186/1471-2407-12-178 22591372 1:CAS:528:DC%2BC3sXitVSqug%3D%3D 3502112
    • Gorges TM, Tinhofer I, Drosch M, Rose L, Zollner TM, Krahn T, von Ahsen O (2012) Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition. BMC Cancer 12:178. doi: 10.1186/1471-2407-12-178
    • (2012) BMC Cancer , vol.12 , pp. 178
    • Gorges, T.M.1    Tinhofer, I.2    Drosch, M.3    Rose, L.4    Zollner, T.M.5    Krahn, T.6    Von Ahsen, O.7
  • 40
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • 10.1016/j.cell.2009.11.007 19945376 1:CAS:528:DC%2BC3cXksFWltA%3D%3D
    • Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139(5):871-890. doi: 10.1016/j.cell.2009.11.007
    • (2009) Cell , vol.139 , Issue.5 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 41
    • 84876451247 scopus 로고    scopus 로고
    • Tumor dissemination: An EMT affair
    • 10.1016/j.ccr.2013.03.004 23518345 1:CAS:528:DC%2BC3sXktlOiu74%3D
    • Thiery JP, Lim CT (2013) Tumor dissemination: an EMT affair. Cancer Cell 23(3):272-273. doi: 10.1016/j.ccr.2013.03.004
    • (2013) Cancer Cell , vol.23 , Issue.3 , pp. 272-273
    • Thiery, J.P.1    Lim, C.T.2
  • 42
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: Migrating cancer stem cells - An integrated concept of malignant tumour progression
    • 10.1038/nrc1694 16148886 1:CAS:528:DC%2BD2MXpsleksLw%3D
    • Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T (2005) Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 5(9):744-749. doi: 10.1038/nrc1694
    • (2005) Nat Rev Cancer , vol.5 , Issue.9 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3    Hlubek, F.4    Kirchner, T.5
  • 43
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • 10.1016/j.devcel.2008.05.009 18539112 1:CAS:528:DC%2BD1cXnsVCrs7g%3D
    • Yang J, Weinberg RA (2008) Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14(6):818-829. doi: 10.1016/j.devcel.2008.05.009
    • (2008) Dev Cell , vol.14 , Issue.6 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 44
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • 10.1016/j.ccr.2012.09.022 23201165 1:CAS:528:DC%2BC38XhslKqsLjL 3522773
    • Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J (2012) Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22(6):725-736. doi: 10.1016/j.ccr.2012.09.022
    • (2012) Cancer Cell , vol.22 , Issue.6 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 45
    • 79958265710 scopus 로고    scopus 로고
    • Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    • 10.1016/j.cell.2011.04.029 21663795 1:CAS:528:DC%2BC3MXnsVOkt7s%3D 3930331
    • Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, Kah KJ, Bell G, Guo W, Rubin J, Richardson AL, Weinberg RA (2011) Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 145(6):926-940. doi: 10.1016/j.cell.2011.04.029
    • (2011) Cell , vol.145 , Issue.6 , pp. 926-940
    • Scheel, C.1    Eaton, E.N.2    Li, S.H.3    Chaffer, C.L.4    Reinhardt, F.5    Kah, K.J.6    Bell, G.7    Guo, W.8    Rubin, J.9    Richardson, A.L.10    Weinberg, R.A.11
  • 46
    • 63749105896 scopus 로고    scopus 로고
    • Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition
    • 10.1016/j.ceb.2009.01.021 19237272 1:CAS:528:DC%2BD1MXksVClurY%3D
    • Heldin CH, Landstrom M, Moustakas A (2009) Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition. Curr Opin Cell Biol 21(2):166-176. doi: 10.1016/j.ceb.2009.01.021
    • (2009) Curr Opin Cell Biol , vol.21 , Issue.2 , pp. 166-176
    • Heldin, C.H.1    Landstrom, M.2    Moustakas, A.3
  • 47
    • 34548175512 scopus 로고    scopus 로고
    • Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression
    • 10.1111/j.1349-7006.2007.00550.x 17645776 1:CAS:528:DC%2BD2sXhtF2qtb7J
    • Moustakas A, Heldin CH (2007) Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci 98(10):1512-1520. doi: 10.1111/j.1349-7006.2007.00550.x
    • (2007) Cancer Sci , vol.98 , Issue.10 , pp. 1512-1520
    • Moustakas, A.1    Heldin, C.H.2
  • 48
    • 0035991607 scopus 로고    scopus 로고
    • Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT
    • 12095232 1:CAS:528:DC%2BD38XltVShur8%3D
    • Kim K, Lu Z, Hay ED (2002) Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT. Cell Biol Int 26(5):463-476
    • (2002) Cell Biol Int , vol.26 , Issue.5 , pp. 463-476
    • Kim, K.1    Lu, Z.2    Hay, E.D.3
  • 49
    • 84887456252 scopus 로고    scopus 로고
    • The epigenetics of epithelial-mesenchymal plasticity in cancer
    • 10.1038/nm.3336 24202396 1:CAS:528:DC%2BC3sXhslCnur%2FI 4190672
    • Tam WL, Weinberg RA (2013) The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med 19(11):1438-1449. doi: 10.1038/nm.3336
    • (2013) Nat Med , vol.19 , Issue.11 , pp. 1438-1449
    • Tam, W.L.1    Weinberg, R.A.2
  • 50
    • 4544297471 scopus 로고    scopus 로고
    • Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1
    • 10.1016/j.devcel.2004.08.003 15363416 1:CAS:528:DC%2BD2cXotV2ltbs%3D
    • Nakaya Y, Kuroda S, Katagiri YT, Kaibuchi K, Takahashi Y (2004) Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1. Dev Cell 7(3):425-438. doi: 10.1016/j.devcel.2004.08.003
    • (2004) Dev Cell , vol.7 , Issue.3 , pp. 425-438
    • Nakaya, Y.1    Kuroda, S.2    Katagiri, Y.T.3    Kaibuchi, K.4    Takahashi, Y.5
  • 51
  • 52
    • 84906937781 scopus 로고    scopus 로고
    • EpCAM is overexpressed in local and metastatic prostate cancer, suppressed by chemotherapy and modulated by MET-associated miRNA-200c/205
    • 10.1038/bjc.2014.366 24992580
    • Massoner P, Thomm T, Mack B, Untergasser G, Martowicz A, Bobowski K, Klocker H, Gires O, Puhr M (2014) EpCAM is overexpressed in local and metastatic prostate cancer, suppressed by chemotherapy and modulated by MET-associated miRNA-200c/205. Br J Cancer. doi: 10.1038/bjc.2014.366
    • (2014) Br J Cancer
    • Massoner, P.1    Thomm, T.2    Mack, B.3    Untergasser, G.4    Martowicz, A.5    Bobowski, K.6    Klocker, H.7    Gires, O.8    Puhr, M.9
  • 53
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • 10.1016/j.cell.2011.07.026 21854987 1:CAS:528:DC%2BC3MXhtVKjsbrM
    • Gupta PB, Fillmore CM, Jiang G, Shapira SD, Tao K, Kuperwasser C, Lander ES (2011) Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146(4):633-644. doi: 10.1016/j.cell.2011.07.026
    • (2011) Cell , vol.146 , Issue.4 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5    Kuperwasser, C.6    Lander, E.S.7
  • 55
    • 75449106680 scopus 로고    scopus 로고
    • Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
    • 10.1186/bcr2333 19589136 2750105
    • Aktas B, Tewes M, Fehm T, Hauch S, Kimmig R, Kasimir-Bauer S (2009) Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Res 11(4):R46. doi: 10.1186/bcr2333
    • (2009) Breast Cancer Res , vol.11 , Issue.4 , pp. R46
    • Aktas, B.1    Tewes, M.2    Fehm, T.3    Hauch, S.4    Kimmig, R.5    Kasimir-Bauer, S.6
  • 57
    • 70349512496 scopus 로고    scopus 로고
    • EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins
    • 10.1158/1535-7163.MCT-09-0402 19723880 1:CAS:528:DC%2BD1MXhtFCis7jM 2948527
    • Winkler J, Martin-Killias P, Pluckthun A, Zangemeister-Wittke U (2009) EpCAM-targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins. Mol Cancer Ther 8(9):2674-2683. doi: 10.1158/1535-7163.MCT-09-0402
    • (2009) Mol Cancer Ther , vol.8 , Issue.9 , pp. 2674-2683
    • Winkler, J.1    Martin-Killias, P.2    Pluckthun, A.3    Zangemeister-Wittke, U.4
  • 58
    • 33947283773 scopus 로고    scopus 로고
    • Loss of membranous Ep-CAM in budding colorectal carcinoma cells
    • 10.1038/modpathol.3800733 17361206 1:CAS:528:DC%2BD2sXivVSlsbk%3D
    • Gosens MJ, van Kempen LC, van de Velde CJ, van Krieken JH, Nagtegaal ID (2007) Loss of membranous Ep-CAM in budding colorectal carcinoma cells. Mod Pathol 20(2):221-232. doi: 10.1038/modpathol.3800733
    • (2007) Mod Pathol , vol.20 , Issue.2 , pp. 221-232
    • Gosens, M.J.1    Van Kempen, L.C.2    Van De Velde, C.J.3    Van Krieken, J.H.4    Nagtegaal, I.D.5
  • 60
    • 67651003100 scopus 로고    scopus 로고
    • The emerging role of EpCAM in cancer and stem cell signaling
    • 10.1158/0008-5472.CAN-09-0654 19584271 1:CAS:528:DC%2BD1MXosV2msrs%3D
    • Munz M, Baeuerle PA, Gires O (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res 69(14):5627-5629. doi: 10.1158/0008-5472.CAN-09-0654
    • (2009) Cancer Res , vol.69 , Issue.14 , pp. 5627-5629
    • Munz, M.1    Baeuerle, P.A.2    Gires, O.3
  • 61
    • 60649111501 scopus 로고    scopus 로고
    • EpCAM: Another surface-to-nucleus missile
    • 10.1016/j.ccr.2009.02.005 19249674 1:CAS:528:DC%2BD1MXltFSmtbw%3D
    • Carpenter G, Red Brewer M (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell 15(3):165-166. doi: 10.1016/j.ccr.2009.02.005
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 165-166
    • Carpenter, G.1    Red Brewer, M.2
  • 65
    • 77950571597 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells
    • 10.1074/jbc.M109.077081 20064925 1:CAS:528:DC%2BC3cXjtFShs7Y%3D 2838295
    • Lu TY, Lu RM, Liao MY, Yu J, Chung CH, Kao CF, Wu HC (2010) Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. J Biol Chem 285(12):8719-8732. doi: 10.1074/jbc.M109.077081
    • (2010) J Biol Chem , vol.285 , Issue.12 , pp. 8719-8732
    • Lu, T.Y.1    Lu, R.M.2    Liao, M.Y.3    Yu, J.4    Chung, C.H.5    Kao, C.F.6    Wu, H.C.7
  • 66
    • 34249989097 scopus 로고    scopus 로고
    • DNA methylation and histone modification regulate silencing of epithelial cell adhesion molecule for tumor invasion and progression
    • 17213811 1:CAS:528:DC%2BD2sXmtFeqs78%3D
    • Tai KY, Shiah SG, Shieh YS, Kao YR, Chi CY, Huang E, Lee HS, Chang LC, Yang PC, Wu CW (2007) DNA methylation and histone modification regulate silencing of epithelial cell adhesion molecule for tumor invasion and progression. Oncogene 26(27):3989-3997
    • (2007) Oncogene , vol.26 , Issue.27 , pp. 3989-3997
    • Tai, K.Y.1    Shiah, S.G.2    Shieh, Y.S.3    Kao, Y.R.4    Chi, C.Y.5    Huang, E.6    Lee, H.S.7    Chang, L.C.8    Yang, P.C.9    Wu, C.W.10
  • 67
    • 84879564968 scopus 로고    scopus 로고
    • Zeb1 regulates E-cadherin and Epcam expression to control cell behavior in early zebrafish development
    • 10.1074/jbc.M113.467787
    • Vannier C, Mock K, Brabletz T, Driever W (2013) Zeb1 regulates E-cadherin and Epcam expression to control cell behavior in early zebrafish development. J Biol Chem. doi: 10.1074/jbc.M113.467787
    • (2013) J Biol Chem
    • Vannier, C.1    Mock, K.2    Brabletz, T.3    Driever, W.4
  • 68
    • 78650713193 scopus 로고    scopus 로고
    • EPCAM deletions, lynch syndrome, and cancer risk
    • 10.1016/S1470-2045(10)70291-6 21195320
    • Lynch HT, Lynch JF, Snyder CL, Riegert-Johnson D (2011) EPCAM deletions, lynch syndrome, and cancer risk. Lancet Oncol 12(1):5-6. doi: 10.1016/S1470-2045(10)70291-6
    • (2011) Lancet Oncol , vol.12 , Issue.1 , pp. 5-6
    • Lynch, H.T.1    Lynch, J.F.2    Snyder, C.L.3    Riegert-Johnson, D.4
  • 69
    • 84898774680 scopus 로고    scopus 로고
    • History, genetics, and strategies for cancer prevention in lynch syndrome
    • 10.1016/j.cgh.2013.06.031 23891921 1:CAS:528:DC%2BC3sXitVShtbzK
    • Kastrinos F, Stoffel EM (2014) History, genetics, and strategies for cancer prevention in lynch syndrome. Clin Gastroenterol Hepatol 12(5):715-727. doi: 10.1016/j.cgh.2013.06.031
    • (2014) Clin Gastroenterol Hepatol , vol.12 , Issue.5 , pp. 715-727
    • Kastrinos, F.1    Stoffel, E.M.2
  • 70
    • 68249099141 scopus 로고    scopus 로고
    • The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development
    • 10.1371/journal.pgen.1000563 19609345 2700972
    • Slanchev K, Carney TJ, Stemmler MP, Koschorz B, Amsterdam A, Schwarz H, Hammerschmidt M (2009) The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development. PLoS Genet 5(7):e1000563. doi: 10.1371/journal.pgen.1000563
    • (2009) PLoS Genet , vol.5 , Issue.7 , pp. e1000563
    • Slanchev, K.1    Carney, T.J.2    Stemmler, M.P.3    Koschorz, B.4    Amsterdam, A.5    Schwarz, H.6    Hammerschmidt, M.7
  • 71
    • 78049514693 scopus 로고    scopus 로고
    • The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling
    • 10.1083/jcb.201004074 20974811 1:CAS:528:DC%2BC3cXhsVamsr%2FE 3003323
    • Maghzal N, Vogt E, Reintsch W, Fraser JS, Fagotto F (2010) The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling. J Cell Biol 191(3):645-659. doi: 10.1083/jcb.201004074
    • (2010) J Cell Biol , vol.191 , Issue.3 , pp. 645-659
    • Maghzal, N.1    Vogt, E.2    Reintsch, W.3    Fraser, J.S.4    Fagotto, F.5
  • 72
    • 84887615793 scopus 로고    scopus 로고
    • EpCAM controls actomyosin contractility and cell adhesion by direct inhibition of PKC
    • 10.1016/j.devcel.2013.10.003 24183651 1:CAS:528:DC%2BC3sXhslWmsLnF
    • Maghzal N, Kayali HA, Rohani N, Kajava AV, Fagotto F (2013) EpCAM controls actomyosin contractility and cell adhesion by direct inhibition of PKC. Dev Cell 27(3):263-277. doi: 10.1016/j.devcel.2013.10.003
    • (2013) Dev Cell , vol.27 , Issue.3 , pp. 263-277
    • Maghzal, N.1    Kayali, H.A.2    Rohani, N.3    Kajava, A.V.4    Fagotto, F.5
  • 75
    • 84867142054 scopus 로고    scopus 로고
    • EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins
    • 10.1016/j.ydbio.2012.07.005 22819673 1:CAS:528:DC%2BC38XhtlGqtb7L
    • Lei Z, Maeda T, Tamura A, Nakamura T, Yamazaki Y, Shiratori H, Yashiro K, Tsukita S, Hamada H (2012) EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev Biol 371(2):136-145. doi: 10.1016/j.ydbio.2012.07.005
    • (2012) Dev Biol , vol.371 , Issue.2 , pp. 136-145
    • Lei, Z.1    Maeda, T.2    Tamura, A.3    Nakamura, T.4    Yamazaki, Y.5    Shiratori, H.6    Yashiro, K.7    Tsukita, S.8    Hamada, H.9
  • 76
    • 84870323717 scopus 로고    scopus 로고
    • MTrop1/Epcam knockout mice develop congenital tufting enteropathy THROUGH dysregulation of intestinal E-cadherin/beta-catenin
    • 10.1371/journal.pone.0049302 23209569 1:CAS:528:DC%2BC38XhvVGjsbfP 3509129
    • Guerra E, Lattanzio R, La Sorda R, Dini F, Tiboni GM, Piantelli M, Alberti S (2012) mTrop1/Epcam knockout mice develop congenital tufting enteropathy THROUGH dysregulation of intestinal E-cadherin/beta-catenin. PLoS ONE 7(11):e49302. doi: 10.1371/journal.pone.0049302
    • (2012) PLoS ONE , vol.7 , Issue.11 , pp. e49302
    • Guerra, E.1    Lattanzio, R.2    La Sorda, R.3    Dini, F.4    Tiboni, G.M.5    Piantelli, M.6    Alberti, S.7
  • 77
    • 4143074922 scopus 로고    scopus 로고
    • EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy
    • 15313925 1:CAS:528:DC%2BD2cXmslaks74%3D
    • Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, Cole DJ, Gillanders WE (2004) EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res 64(16):5818-5824
    • (2004) Cancer Res , vol.64 , Issue.16 , pp. 5818-5824
    • Osta, W.A.1    Chen, Y.2    Mikhitarian, K.3    Mitas, M.4    Salem, M.5    Hannun, Y.A.6    Cole, D.J.7    Gillanders, W.E.8
  • 78
    • 59149084182 scopus 로고    scopus 로고
    • Transcriptional repression of epithelial cell adhesion molecule contributes to p53 control of breast cancer invasion
    • 19141643 1:CAS:528:DC%2BD1MXhtFOksLg%3D 3907266
    • Sankpal NV, Willman MW, Fleming TP, Mayfield JD, Gillanders WE (2009) Transcriptional repression of epithelial cell adhesion molecule contributes to p53 control of breast cancer invasion. Cancer Res 69(3):753-757
    • (2009) Cancer Res , vol.69 , Issue.3 , pp. 753-757
    • Sankpal, N.V.1    Willman, M.W.2    Fleming, T.P.3    Mayfield, J.D.4    Gillanders, W.E.5
  • 79
    • 79960936439 scopus 로고    scopus 로고
    • Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative
    • 10.1158/0008-5472.CAN-11-1059 21685475 1:CAS:528:DC%2BC3MXpsVOgs7s%3D
    • Biddle A, Liang X, Gammon L, Fazil B, Harper LJ, Emich H, Costea DE, Mackenzie IC (2011) Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative. Cancer Res 71(15):5317-5326. doi: 10.1158/0008-5472.CAN-11-1059
    • (2011) Cancer Res , vol.71 , Issue.15 , pp. 5317-5326
    • Biddle, A.1    Liang, X.2    Gammon, L.3    Fazil, B.4    Harper, L.J.5    Emich, H.6    Costea, D.E.7    Mackenzie, I.C.8
  • 80
    • 84867902041 scopus 로고    scopus 로고
    • Phenotype-dependent effects of EpCAM expression on growth and invasion of human breast cancer cell lines
    • 10.1186/1471-2407-12-501 23110550 1:CAS:528:DC%2BC3sXjsFShtw%3D%3D 3519683
    • Martowicz A, Spizzo G, Gastl G, Untergasser G (2012) Phenotype-dependent effects of EpCAM expression on growth and invasion of human breast cancer cell lines. BMC Cancer 12:501. doi: 10.1186/1471-2407-12-501
    • (2012) BMC Cancer , vol.12 , pp. 501
    • Martowicz, A.1    Spizzo, G.2    Gastl, G.3    Untergasser, G.4
  • 81
    • 84876462198 scopus 로고    scopus 로고
    • EpCAM expression varies significantly and is differentially associated with prognosis in the luminal B HER2(+), basal-like, and HER2 intrinsic subtypes of breast cancer
    • 10.1038/bjc.2013.80 23519058 1:CAS:528:DC%2BC3sXmt1Ojs7g%3D 3629430
    • Soysal SD, Muenst S, Barbie T, Fleming T, Gao F, Spizzo G, Oertli D, Viehl CT, Obermann EC, Gillanders WE (2013) EpCAM expression varies significantly and is differentially associated with prognosis in the luminal B HER2(+), basal-like, and HER2 intrinsic subtypes of breast cancer. Br J Cancer 108(7):1480-1487. doi: 10.1038/bjc.2013.80
    • (2013) Br J Cancer , vol.108 , Issue.7 , pp. 1480-1487
    • Soysal, S.D.1    Muenst, S.2    Barbie, T.3    Fleming, T.4    Gao, F.5    Spizzo, G.6    Oertli, D.7    Viehl, C.T.8    Obermann, E.C.9    Gillanders, W.E.10
  • 83
    • 4143065769 scopus 로고    scopus 로고
    • The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation
    • 15195135
    • Munz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O (2004) The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation. Oncogene 23(34):5748-5758
    • (2004) Oncogene , vol.23 , Issue.34 , pp. 5748-5758
    • Munz, M.1    Kieu, C.2    Mack, B.3    Schmitt, B.4    Zeidler, R.5    Gires, O.6
  • 84
    • 19544383212 scopus 로고    scopus 로고
    • The tumor-associated antigen EpCAM up-regulates the fatty acid binding protein E-FABP
    • 15922867
    • Munz M, Zeidler R, Gires O (2005) The tumor-associated antigen EpCAM up-regulates the fatty acid binding protein E-FABP. Cancer Lett 225(1):151-157
    • (2005) Cancer Lett , vol.225 , Issue.1 , pp. 151-157
    • Munz, M.1    Zeidler, R.2    Gires, O.3
  • 85
    • 84873409026 scopus 로고    scopus 로고
    • EpCAM regulates cell cycle progression via control of cyclin D1 expression
    • 10.1038/onc.2012.75 22391566 1:CAS:528:DC%2BC38XjtlOrur4%3D
    • Chaves-Perez A, Mack B, Maetzel D, Kremling H, Eggert C, Harreus U, Gires O (2013) EpCAM regulates cell cycle progression via control of cyclin D1 expression. Oncogene 32(5):641-650. doi: 10.1038/onc.2012.75
    • (2013) Oncogene , vol.32 , Issue.5 , pp. 641-650
    • Chaves-Perez, A.1    Mack, B.2    Maetzel, D.3    Kremling, H.4    Eggert, C.5    Harreus, U.6    Gires, O.7
  • 86
    • 84875241987 scopus 로고    scopus 로고
    • EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development
    • 10.1016/j.devcel.2013.01.021 23484855 1:CAS:528:DC%2BC3sXktFaqtro%3D
    • Lu H, Ma J, Yang Y, Shi W, Luo L (2013) EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development. Dev Cell 24(5):543-553. doi: 10.1016/j.devcel.2013.01.021
    • (2013) Dev Cell , vol.24 , Issue.5 , pp. 543-553
    • Lu, H.1    Ma, J.2    Yang, Y.3    Shi, W.4    Luo, L.5
  • 87
    • 84896138209 scopus 로고    scopus 로고
    • Loss of membranous expression of the intracellular domain of EpCAM is a frequent event and predicts poor survival in patients with pancreatic cancer
    • 10.1111/his.12307 24117877
    • Fong D, Moser P, Kasal A, Seeber A, Gastl G, Martowicz A, Wurm M, Mian C, Obrist P, Mazzoleni G, Spizzo G (2014) Loss of membranous expression of the intracellular domain of EpCAM is a frequent event and predicts poor survival in patients with pancreatic cancer. Histopathology 64(5):683-692. doi: 10.1111/his.12307
    • (2014) Histopathology , vol.64 , Issue.5 , pp. 683-692
    • Fong, D.1    Moser, P.2    Kasal, A.3    Seeber, A.4    Gastl, G.5    Martowicz, A.6    Wurm, M.7    Mian, C.8    Obrist, P.9    Mazzoleni, G.10    Spizzo, G.11
  • 88
    • 77955378388 scopus 로고    scopus 로고
    • EpCAM nuclear localization identifies aggressive thyroid cancer and is a marker for poor prognosis
    • 10.1186/1471-2407-10-331 20579375 2912862
    • Ralhan R, Cao J, Lim T, Macmillan C, Freeman JL, Walfish PG (2010) EpCAM nuclear localization identifies aggressive thyroid cancer and is a marker for poor prognosis. BMC Cancer 10(1):331. doi: 10.1186/1471-2407-10-331
    • (2010) BMC Cancer , vol.10 , Issue.1 , pp. 331
    • Ralhan, R.1    Cao, J.2    Lim, T.3    MacMillan, C.4    Freeman, J.L.5    Walfish, P.G.6
  • 91
    • 55949111134 scopus 로고    scopus 로고
    • A genome-wide expression analysis identifies a network of EpCAM-induced cell cycle regulators
    • 19002182 1:CAS:528:DC%2BD1cXhtlGrurzF 2584962
    • Maaser K, Borlak J (2008) A genome-wide expression analysis identifies a network of EpCAM-induced cell cycle regulators. Br J Cancer 99(10):1635-1643
    • (2008) Br J Cancer , vol.99 , Issue.10 , pp. 1635-1643
    • Maaser, K.1    Borlak, J.2
  • 92
    • 84890860977 scopus 로고    scopus 로고
    • EpCAM expression in the prostate cancer makes the difference in the response to growth factors
    • 10.1016/j.bbrc.2013.11.093 24309103 1:CAS:528:DC%2BC3sXhvFOhu7%2FO
    • Yoshida GJ, Saya H (2014) EpCAM expression in the prostate cancer makes the difference in the response to growth factors. Biochem Biophys Res Commun 443(1):239-245. doi: 10.1016/j.bbrc.2013.11.093
    • (2014) Biochem Biophys Res Commun , vol.443 , Issue.1 , pp. 239-245
    • Yoshida, G.J.1    Saya, H.2
  • 93
    • 84876870029 scopus 로고    scopus 로고
    • Filtration parameters influencing circulating tumor cell enrichment from whole blood
    • 10.1371/journal.pone.0061774 23658615 1:CAS:528:DC%2BC3sXntlCltbk%3D 3637225
    • Coumans FA, van Dalum G, Beck M, Terstappen LW (2013) Filtration parameters influencing circulating tumor cell enrichment from whole blood. PLoS ONE 8(4):e61774. doi: 10.1371/journal.pone.0061774
    • (2013) PLoS ONE , vol.8 , Issue.4 , pp. e61774
    • Coumans, F.A.1    Van Dalum, G.2    Beck, M.3    Terstappen, L.W.4
  • 95
    • 84882655536 scopus 로고    scopus 로고
    • Presence of EpCAM-positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma
    • 10.1002/ijc.28230 23616258 1:CAS:528:DC%2BC3sXptV2rsL8%3D
    • Schulze K, Gasch C, Staufer K, Nashan B, Lohse AW, Pantel K, Riethdorf S, Wege H (2013) Presence of EpCAM-positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma. Int J Cancer 133(9):2165-2171. doi: 10.1002/ijc.28230
    • (2013) Int J Cancer , vol.133 , Issue.9 , pp. 2165-2171
    • Schulze, K.1    Gasch, C.2    Staufer, K.3    Nashan, B.4    Lohse, A.W.5    Pantel, K.6    Riethdorf, S.7    Wege, H.8
  • 98
    • 84875129950 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy
    • 10.1517/17425247.2013.759938 23316711 1:CAS:528:DC%2BC3sXktFSqsLk%3D
    • Simon M, Stefan N, Pluckthun A, Zangemeister-Wittke U (2013) Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy. Expert Opin Drug Deliv 10(4):451-468. doi: 10.1517/17425247.2013.759938
    • (2013) Expert Opin Drug Deliv , vol.10 , Issue.4 , pp. 451-468
    • Simon, M.1    Stefan, N.2    Pluckthun, A.3    Zangemeister-Wittke, U.4
  • 99
    • 12344289903 scopus 로고    scopus 로고
    • EpCAM: A new therapeutic target for an old cancer antigen
    • 14508099 1:CAS:528:DC%2BD3sXps1Kgsbg%3D
    • Armstrong A, Eck SL (2003) EpCAM: a new therapeutic target for an old cancer antigen. Cancer Biol Ther 2(4):320-326
    • (2003) Cancer Biol Ther , vol.2 , Issue.4 , pp. 320-326
    • Armstrong, A.1    Eck, S.L.2


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