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Volumn 42, Issue 12, 2012, Pages 1128-1137

Cytoplasmic Trop-1/Ep-CAM overexpression is associated with a favorable outcome in node-positive breast cancer

Author keywords

Breast cancer; Cytoplasmic Trop 1 Ep CAM; Node positive; Prognosis

Indexed keywords

ANTINEOPLASTIC AGENT; EPITHELIAL CELL ADHESION MOLECULE; TAMOXIFEN;

EID: 84870445093     PISSN: 03682811     EISSN: 14653621     Source Type: Journal    
DOI: 10.1093/jjco/hys159     Document Type: Article
Times cited : (9)

References (38)
  • 1
    • 0035045052 scopus 로고    scopus 로고
    • Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2 M1S1) to human chromosome 1p32 by in situ hybridization
    • Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S. Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization. Cytogenet Cell Genet 2001;92:164-5.
    • (2001) Cytogenet Cell Genet , vol.92 , pp. 164-165
    • Calabrese, G.1    Crescenzi, C.2    Morizio, E.3    Palka, G.4    Guerra, E.5    Alberti, S.6
  • 2
    • 0031800858 scopus 로고    scopus 로고
    • The human Trop-2 is a tumor-associated calcium signal transducer
    • Ripani E, Sacchetti A, Corda D, Alberti S. The human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer 1998;76: 671-6.
    • (1998) Int J Cancer , vol.76 , pp. 671-676
    • Ripani, E.1    Sacchetti, A.2    Corda, D.3    Alberti, S.4
  • 3
    • 0025358969 scopus 로고
    • Expression of 38-kD cell-surface glycoprotein in transformed human keratinocyte cell lines, basal cell carcinomas, and epithelial germs
    • Klein CE, Hartmann B, Schön MP, Weber L, Alberti S. Expression of 38-kD cell-surface glycoprotein in transformed human keratinocyte cell lines, basal cell carcinomas, and epithelial germs. J Invest Dermatol 1990;95:74-82.
    • (1990) J Invest Dermatol , vol.95 , pp. 74-82
    • Klein, C.E.1    Hartmann, B.2    Schön, M.P.3    Weber, L.4    Alberti, S.5
  • 4
    • 0027139886 scopus 로고
    • Biochemical and immunological characterization of the human carcinoma-associated antigen MH 99/KS 1/4
    • Schön MP, Schön M, Mattes MJ, et al. Biochemical and immunological characterization of the human carcinoma-associated antigen MH 99/KS 1/4. Int J Cancer 1993;55:988-95.
    • (1993) Int J Cancer , vol.55 , pp. 988-995
    • Schön, M.P.1    Schön, M.2    Mattes, M.J.3
  • 5
    • 34547143357 scopus 로고    scopus 로고
    • Trop-1 is a novel cell growth stimulatory molecule that marks early stages of tumor progression
    • Zanna P, Trerotola M, Vacca G, et al. Trop-1 is a novel cell growth stimulatory molecule that marks early stages of tumor progression. Cancer 2007;110:452-64.
    • (2007) Cancer , vol.110 , pp. 452-464
    • Zanna, P.1    Trerotola, M.2    Vacca, G.3
  • 6
    • 0033998141 scopus 로고    scopus 로고
    • Targets of extinction: identification of genes whose expression is repressed as a consequence of somatic fusion between cells representing basal and luminal mammary epithelial phenotypes
    • MacDougall JR, Matrisian LM. Targets of extinction: identification of genes whose expression is repressed as a consequence of somatic fusion between cells representing basal and luminal mammary epithelial phenotypes. J Cell Sci 2000;113:409-23.
    • (2000) J Cell Sci , vol.113 , pp. 409-423
    • MacDougall, J.R.1    Matrisian, L.M.2
  • 8
    • 34548462222 scopus 로고    scopus 로고
    • Clinicopathologic significance of EpCAM expression in squamous cell carcinoma of the tongue and its possibility as a potential target for tongue cancer gene therapy
    • Yanamoto S, Kawasaki G, Yoshitomi I, Iwamoto T, Hirata K, Mizuno A. Clinicopathologic significance of EpCAM expression in squamous cell carcinoma of the tongue and its possibility as a potential target for tongue cancer gene therapy. Oral Oncol 2007;43:869-77.
    • (2007) Oral Oncol , vol.43 , pp. 869-877
    • Yanamoto, S.1    Kawasaki, G.2    Yoshitomi, I.3    Iwamoto, T.4    Hirata, K.5    Mizuno, A.6
  • 9
    • 1642580506 scopus 로고    scopus 로고
    • Frequent EpCAM protein expression in human carcinomas
    • Went PT, Lugli A, Meier S, et al. Frequent EpCAM protein expression in human carcinomas. Hum Pathol 2004;35:122-8.
    • (2004) Hum Pathol , vol.35 , pp. 122-128
    • Went, P.T.1    Lugli, A.2    Meier, S.3
  • 11
    • 0034627152 scopus 로고    scopus 로고
    • Ep-CAM over-expression in breast cancer as a predictor of survival
    • Gastl G, Spizzo G, Obrist P, Dünser M, Mikuz G. Ep-CAM over-expression in breast cancer as a predictor of survival. Lancet 2000;356:1981-2.
    • (2000) Lancet , vol.356 , pp. 1981-1982
    • Gastl, G.1    Spizzo, G.2    Obrist, P.3    Dünser, M.4    Mikuz, G.5
  • 12
    • 53249097862 scopus 로고    scopus 로고
    • Prognostic effect of epithelial cell adhesion molecule over-expression in untreated node-negative breast cancer
    • Schmidt M, Hasenclever D, Schaeffer M, et al. Prognostic effect of epithelial cell adhesion molecule over-expression in untreated node-negative breast cancer. Clin Cancer Res 2008;14:5849-55.
    • (2008) Clin Cancer Res , vol.14 , pp. 5849-5855
    • Schmidt, M.1    Hasenclever, D.2    Schaeffer, M.3
  • 14
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008;8:755-68.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 15
    • 0343839113 scopus 로고
    • Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies
    • Herlyn M, Steplewski Z, Herlyn D, Koprowski H. Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies. Proc Natl Acad Sci USA 1979;76:1438-42.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 1438-1442
    • Herlyn, M.1    Steplewski, Z.2    Herlyn, D.3    Koprowski, H.4
  • 16
    • 0343965762 scopus 로고    scopus 로고
    • Monoclonal antibody therapy for resected Dukes' C colorectal cancer: seven-year outcome of a multicenter randomized trial
    • Riethmuller G, Holz E, Schlimok G, et al. Monoclonal antibody therapy for resected Dukes' C colorectal cancer: seven-year outcome of a multicenter randomized trial. J Clin Oncol 1998;16:1788-94.
    • (1998) J Clin Oncol , vol.16 , pp. 1788-1794
    • Riethmuller, G.1    Holz, E.2    Schlimok, G.3
  • 17
    • 0032858151 scopus 로고    scopus 로고
    • Tumor-specific gene transfer via an adenoviral vector targeted to the pan-carcinoma antigen EpCAM
    • Haisma HJ, Pinedo HM, Rijswijk A, et al. Tumor-specific gene transfer via an adenoviral vector targeted to the pan-carcinoma antigen EpCAM. Gene Ther 1999;6:1469-74.
    • (1999) Gene Ther , vol.6 , pp. 1469-1474
    • Haisma, H.J.1    Pinedo, H.M.2    Rijswijk, A.3
  • 18
    • 4143074922 scopus 로고    scopus 로고
    • EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy
    • Osta WA, Chen Y, Mikhitarian K, et al. EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res 2004;64:5818-24.
    • (2004) Cancer Res , vol.64 , pp. 5818-5824
    • Osta, W.A.1    Chen, Y.2    Mikhitarian, K.3
  • 19
    • 77951881160 scopus 로고    scopus 로고
    • An open-label, randomized phase II study of adecatumumab, a fully human anti-EpCAM antibody, as monotherapy in patients with metastatic breast cancer
    • Schmidt M, Scheulen ME, Dittrich C, et al. An open-label, randomized phase II study of adecatumumab, a fully human anti-EpCAM antibody, as monotherapy in patients with metastatic breast cancer. Ann Oncol 2010;21:275-82.
    • (2010) Ann Oncol , vol.21 , pp. 275-282
    • Schmidt, M.1    Scheulen, M.E.2    Dittrich, C.3
  • 20
    • 0035105519 scopus 로고    scopus 로고
    • Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep-CAM molecules in homophilic adhesions
    • Balzar M, Briaire-De Bruijn IH, Rees-Bakker H, et al. Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep-CAM molecules in homophilic adhesions. Mol Cell Biol 2001;21:2570-80.
    • (2001) Mol Cell Biol , vol.21 , pp. 2570-2580
    • Balzar, M.1    Briaire-De Bruijn, I.H.2    Rees-Bakker, H.3
  • 21
    • 23844534811 scopus 로고    scopus 로고
    • Statistics subcommitee of the NCI-EORTC working group on cancer diagnostics Reporting recommendations for tumour marker prognostic studies (REMARK)
    • McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM. Statistics subcommitee of the NCI-EORTC working group on cancer diagnostics. Reporting recommendations for tumour marker prognostic studies (REMARK). J Natl Cancer Inst 2005;97:1180-4.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1180-1184
    • McShane, L.M.1    Altman, D.G.2    Sauerbrei, W.3    Taube, S.E.4    Gion, M.5    Clark, G.M.6
  • 22
    • 0037140119 scopus 로고    scopus 로고
    • Prognostic significance of Ep-CAM and Her-2/neu over-expression in invasive breast cancer
    • Spizzo G, Obrist P, Ensinger C, et al. Prognostic significance of Ep-CAM and Her-2/neu over-expression in invasive breast cancer. Int J Cancer 2002;98:883-8.
    • (2002) Int J Cancer , vol.98 , pp. 883-888
    • Spizzo, G.1    Obrist, P.2    Ensinger, C.3
  • 23
    • 4043147142 scopus 로고    scopus 로고
    • High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer
    • Spizzo G, Went P, Dirnhofer S, et al. High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer. Breast Cancer Res Treat 2004;86:207-13.
    • (2004) Breast Cancer Res Treat , vol.86 , pp. 207-213
    • Spizzo, G.1    Went, P.2    Dirnhofer, S.3
  • 24
    • 84870424437 scopus 로고    scopus 로고
    • R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing ISBN 3-900051-07-0
    • R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing, 2011, ISBN 3-900051-07-0, URL. http://www.R-project.org/.
    • (2011)
  • 26
    • 77956888457 scopus 로고
    • Partial residuals for the proportional hazard regression model
    • Schoenfeld D. Partial residuals for the proportional hazard regression model. Biometrica 1982;69:239-41.
    • (1982) Biometrica , vol.69 , pp. 239-241
    • Schoenfeld, D.1
  • 27
    • 0029851283 scopus 로고    scopus 로고
    • A note on quantifying follow-up in studies of failure time
    • Schemper M, Smith TL. A note on quantifying follow-up in studies of failure time. Clin Trials 1996;17:343-6.
    • (1996) Clin Trials , vol.17 , pp. 343-346
    • Schemper, M.1    Smith, T.L.2
  • 28
    • 0030731464 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule (Ep-CAM) modulated cell-cell interactions mediated by classic cadherins
    • Litvinov SV, Balzar M, Winter MJ, et al. Epithelial cell adhesion molecule (Ep-CAM) modulated cell-cell interactions mediated by classic cadherins. J Cell Biol 1997;139:1337-48.
    • (1997) J Cell Biol , vol.139 , pp. 1337-1348
    • Litvinov, S.V.1    Balzar, M.2    Winter, M.J.3
  • 29
    • 4143065769 scopus 로고    scopus 로고
    • The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation
    • Munz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O. The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation. Oncogene 2004;23:5748-58.
    • (2004) Oncogene , vol.23 , pp. 5748-5758
    • Munz, M.1    Kieu, C.2    Mack, B.3    Schmitt, B.4    Zeidler, R.5    Gires, O.6
  • 30
    • 0025362976 scopus 로고
    • Association of the 323/A3 surface glycoprotein with tumour characteristics and behaviour in human breast cancer
    • Tandon AK, Clark GM, Chamness GC, McGuire WL. Association of the 323/A3 surface glycoprotein with tumour characteristics and behaviour in human breast cancer. Cancer Res 1990;50:3317-21.
    • (1990) Cancer Res , vol.50 , pp. 3317-3321
    • Tandon, A.K.1    Clark, G.M.2    Chamness, G.C.3    McGuire, W.L.4
  • 33
    • 0034628471 scopus 로고    scopus 로고
    • Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
    • Bilder D, Perrimon N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 2000;403:676-80.
    • (2000) Nature , vol.403 , pp. 676-680
    • Bilder, D.1    Perrimon, N.2
  • 34
    • 12344293943 scopus 로고    scopus 로고
    • Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity
    • Albertson R, Chabu C, Sheehan A, Doe CQ. Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity. J Cell Sci 2005;117:6061-70.
    • (2005) J Cell Sci , vol.117 , pp. 6061-6070
    • Albertson, R.1    Chabu, C.2    Sheehan, A.3    Doe, C.Q.4
  • 35
    • 35148819132 scopus 로고    scopus 로고
    • aPKC cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia
    • Grifoni D, Garoia F, Bellosta P, et al. aPKC cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia. Oncogene 2007;26:5960-5.
    • (2007) Oncogene , vol.26 , pp. 5960-5965
    • Grifoni, D.1    Garoia, F.2    Bellosta, P.3
  • 36
    • 33747465415 scopus 로고    scopus 로고
    • Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression
    • Gardiol D, Zacchi A, Petrera F, Stanta G, Banks L. Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression. Int J Cancer 2006;119:1285-90.
    • (2006) Int J Cancer , vol.119 , pp. 1285-1290
    • Gardiol, D.1    Zacchi, A.2    Petrera, F.3    Stanta, G.4    Banks, L.5
  • 37
    • 56349098933 scopus 로고    scopus 로고
    • Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma
    • Zhan L, Rosenberg A, Bergami KC, et al. Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell 2008;135:865-78.
    • (2008) Cell , vol.135 , pp. 865-878
    • Zhan, L.1    Rosenberg, A.2    Bergami, K.C.3
  • 38
    • 67650661180 scopus 로고    scopus 로고
    • Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study
    • Lisovsky M, Dresser K, Baker S, et al. Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study. Mod Pathol 2009;22: 977-84.
    • (2009) Mod Pathol , vol.22 , pp. 977-984
    • Lisovsky, M.1    Dresser, K.2    Baker, S.3


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