EpCAM is involved in maintenance of the murine embryonic stem cell phenotype

Stem Cells

Volumn 27, Issue 8, 2009, Pages 1782-1791

  González, Bárbara ^a,b   Denzel, Sabine ^c   Mack, Brigitte ^c   Conrad, Marcus ^a   Gires, Olivier ^a,b,c  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Cell adhesion molecules; Cell surface markers; Embryonic stem cells; Self renewal

Indexed keywords

ALKALINE PHOSPHATASE; EPITHELIAL CELL ADHESION MOLECULE; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; SEX DETERMINING REGION Y BOX 2; STAGE SPECIFIC EMBRYO ANTIGEN 1; STAT3 PROTEIN; TESTIS DETERMINING FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CELL STRUCTURE; CONTROLLED STUDY; CULTURE MEDIUM; DOWN REGULATION; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE C MYC; PHENOTYPE; PROTEIN EXPRESSION; RNA INTERFERENCE;

ANIMALS; ANTIGENS, NEOPLASM; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CELL LINE, TUMOR; DOWN-REGULATION; EMBRYONIC STEM CELLS; EPITHELIAL CELLS; HUMANS; LEUKEMIA INHIBITORY FACTOR; MICE; MICROSCOPY, CONFOCAL; PHENOTYPE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

MURINAE;

EID: 69249092641     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.97     Document Type: Article

References (52)

1. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981;292:154-156.
2. Boyer LA, Lee TI, Cole MF et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005;122:947-956.
3. Cartwright P, McLean C, Sheppard A et al. LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development 2005;132:885-896.
4. Liu N, Lu M, Tian X et al. Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells. J Cell Physiol 2007;211:279-286.
5. Matsuda T, Nakamura T, Nakao K et al. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J 1999;18:4261-4269.
6. Okita K, Yamanaka S. Intracellular signaling pathways regulating pluripotency of embryonic stem cells. Curr Stem Cell Res Ther 2006;1:103-111.
7. Pan G, Thomson JA. Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res 2007;17:42-49.
8. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676.
9. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005;434:843-850.
10. Reya T, Duncan AW, Ailles L et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 2003;423:409-414.
11. Tada T. Toti-/pluripotential stem cells and epigenetic modifications. Neurodegener Dis 2006;3:32-37.
12. Wernig M, Meissner A, Foreman R et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 2007;448:318-324.
13. Gires O. TACSTD1 (tumor-associated calcium signal transducer 1). Atlas of Genetics and Cytogenetics in Oncology and Haematology. Available at http://atlasgeneticsoncology.org/Genes/TACSTD1ID42459ch2p21.html. Accessed.
14. Schmelzer E, Reid LM. EpCAM expression in normal, non-pathological tissues. Front Biosci 2008;13:3096-3100.
15. Schmelzer E, Zhang L, Bruce A et al. Human hepatic stem cells from fetal and postnatal donors. J Exp Med 2007;204:1973-1987.
16. Cairo S, Armengol C, De Reynies A et al. Hepatic stem-like phenotype and interplay of Wnt/β-catenin and Myc signaling in aggressive childhood liver cancer. Cancer Cell 2008;14:471-484.
17. Trzpis M, McLaughlin P, van Goor H et al. Expression of EpCAM is up-regulated during regeneration of renal epithelia. J Pathol 2008;216:201-208.
18. Baeuerle PA, Gires O. EpCAM (CD326) finding its role in cancer. Br J Cancer 2007;96:417-423.
19. Balzar M, Winter MJ, de Boer CJ et al. The biology of the 17-1A antigen (Ep-CAM). J Mol Med 1999;77:699-712.
20. Armstrong A, Eck SL. EpCAM: A new therapeutic target for an old cancer antigen. Cancer Biol Ther 2003;2:320-326.
21. Trzpis M, McLaughlin PM, de Leij LM et al. Epithelial cell adhesion molecule. more than a carcinoma marker and adhesion molecule. Am J Pathol 2007;171:386-395.
22. Münz M, Kieu C, Mack B et al. The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation. Oncogene 2004;23:5748-5758.
23. Osta WA, Chen Y, Mikhitarian K et al. EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res 2004;64:5818-5824.
24. Münz M, Hofmann T, Scheibe B et al. The carcinoma-associated antigen EpCAM induces glyoxalase 1 resulting in enhanced methylglyoxal turnover. Cancer Genomics Proteomics 2004;1:241-247.
25. Münz M, Zeidler R, Gires O. The tumor-associated antigen EpCAM up-regulates the fatty acid binding protein E-FABP. Cancer Lett 2005;225:151-157.
26. Maetzel D, Denzel S, Mack B et al. Nuclear signalling by tumour-associated antigen EpCAM. Nat Cell Biol 2009;11:162-171.
27. Yamashita T, Budhu A, Forgues M et al. Activation of hepatic stem cell marker EpCAM by Wnt-β-catenin signaling in hepatocellular carcinoma. Cancer Res 2007;67:10831-10839.
28. Brock R, Hamelers IH, Jovin TM. Comparison of fixation protocols for adherent cultured cells applied to a GFP fusion protein of the epidermal growth factor receptor. Cytometry 1999;35:353-362.
29. Berrill A, Tan HL, Wuang SC et al. Assessment of stem cell markers during long-term culture of mouse embryonic stem cells. Cytotechnology 2004;44:77-91.
30. Munz M, Fellinger K, Hofmann T et al. Glycosylation is crucial for stability of tumour and cancer stem cell antigen EpCAM. Front Biosci 2008;13:5195-5201.
31. Solter D, Knowles BB. Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1). Proc Natl Acad Sci U|S|A 1978;75:5565-5569.
32. Solter D. From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research. Nat Rev Genet 2006;7:319-327.
33. Jones DL, Wagers AJ. No place like home: anatomy and function of the stem cell niche. Nat Rev Mol Cell Biol 2008;9:11-21.
34. Gordon MY. Stem cells for regenerative medicine - biological attributes and clinical application. Exp Hematol 2008;36:726-732.
35. Corsten MF, Shah K. Therapeutic stem-cells for cancer treatment: hopes and hurdles in tactical warfare. Lancet Oncol 2008;9:376-384.
36. Murry CE, Keller G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 2008;132:661-680.
37. Keller G. Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev 2005;19:1129-1155.
38. Pera MF, Trounson AO. Human embryonic stem cells: prospects for development. Development 2004;131:5515-5525.
39. Cerletti M, Jurga S, Witczak CA et al. Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles. Cell 2008;134:37-47.
40. Anderson R, Schaible K, Heasman J et al. Expression of the homophilic adhesion molecule, Ep-CAM, in the mammalian germ line. J Reprod Fertil 1999;116:379-384.
41. Maaser K, Borlak J. A genome-wide expression analysis identifies a network of EpCAM-induced cell cycle regulators. Br J Cancer 2008;99:1635-1643.
42. Carpenter G, Red Brewer M. EpCAM: another surface-to-nucleus missile. Cancer Cell 2009;15:165-166.
43. Schmelzer E, Wauthier E, Reid LM. The phenotypes of pluripotent human hepatic progenitors. Stem Cells 2006;24:1852-1858.
44. de Boer CJ, van Krieken JH, Janssen-van Rhijn CM et al. Expression of Ep-CAM in normal, regenerating, metaplastic, and neoplastic liver. J Pathol 1999;188:201-206.
45. Ricci-Vitiani L, Lombardi DG, Pilozzi E et al. Identification and expansion of human colon-cancer-initiating cells. Nature 2007;445:111-115.
46. Dalerba P, Dylla SJ, Park IK et al. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA 2007;104:10158-10163.
47. Al-Hajj M, Wicha MS, Benito-Hernandez A et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003;100:3983-3988.
48. Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008;8:755-768.
49. Gires O, Klein CA, Baeuerle PA. On the abundance of EpCAM on cancer stem cells. Nat Rev Cancer 9:143, 2009; author reply 143.
50. Litvinov SV, van Driel W, van Rhijn CM et al. Expression of EpCAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation. Am J Pathol 1996;148:865-875.
51. Schön MP, Schon M, Klein CE et al. Carcinoma-associated 38-kD membrane glycoprotein MH 99/KS 1/4 is related to proliferation and age of transformed epithelial cell lines. J Invest Dermatol 1994;102:987-991.
52. Nagrath S, Sequist LV, Maheswaran S et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 2007;450:1235-1239.