메뉴 건너뛰기




Volumn 27, Issue 3, 2013, Pages 263-277

EpCAM Controls Actomyosin Contractility and Cell Adhesion by Direct Inhibition of PKC

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; EPITHELIAL CELL ADHESION MOLECULE; MYOSIN ADENOSINE TRIPHOSPHATASE; PROTEIN KINASE C;

EID: 84887615793     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2013.10.003     Document Type: Article
Times cited : (48)

References (42)
  • 1
    • 0037348332 scopus 로고    scopus 로고
    • Invitro and invivo pharmacology and pharmacokinetics of a human engineered monoclonal antibody to epithelial cell adhesion molecule
    • Ammons W.S., Bauer R.J., Horwitz A.H., Chen Z.J., Bautista E., Ruan H.H., Abramova M., Scott K.R., Dedrick R.L. Invitro and invivo pharmacology and pharmacokinetics of a human engineered monoclonal antibody to epithelial cell adhesion molecule. Neoplasia 2003, 5:146-154.
    • (2003) Neoplasia , vol.5 , pp. 146-154
    • Ammons, W.S.1    Bauer, R.J.2    Horwitz, A.H.3    Chen, Z.J.4    Bautista, E.5    Ruan, H.H.6    Abramova, M.7    Scott, K.R.8    Dedrick, R.L.9
  • 2
    • 64849097958 scopus 로고    scopus 로고
    • Functional suppression of E-cadherin by protein kinase Cdelta
    • Chen C.L., Chen H.C. Functional suppression of E-cadherin by protein kinase Cdelta. J.Cell Sci. 2009, 122:513-523.
    • (2009) J.Cell Sci. , vol.122 , pp. 513-523
    • Chen, C.L.1    Chen, H.C.2
  • 3
    • 70349175559 scopus 로고    scopus 로고
    • Trop2: a possible therapeutic target for late stage epithelial carcinomas
    • Cubas R., Li M., Chen C., Yao Q. Trop2: a possible therapeutic target for late stage epithelial carcinomas. Biochim. Biophys. Acta 2009, 1796:309-314.
    • (2009) Biochim. Biophys. Acta , vol.1796 , pp. 309-314
    • Cubas, R.1    Li, M.2    Chen, C.3    Yao, Q.4
  • 7
    • 33748302057 scopus 로고    scopus 로고
    • Repulsion or adhesion: receptors make the call
    • Halloran M.C., Wolman M.A. Repulsion or adhesion: receptors make the call. Curr. Opin. Cell Biol. 2006, 18:533-540.
    • (2006) Curr. Opin. Cell Biol. , vol.18 , pp. 533-540
    • Halloran, M.C.1    Wolman, M.A.2
  • 9
    • 2442426180 scopus 로고    scopus 로고
    • Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway
    • Iwabu A., Smith K., Allen F.D., Lauffenburger D.A., Wells A. Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway. J.Biol. Chem. 2004, 279:14551-14560.
    • (2004) J.Biol. Chem. , vol.279 , pp. 14551-14560
    • Iwabu, A.1    Smith, K.2    Allen, F.D.3    Lauffenburger, D.A.4    Wells, A.5
  • 10
    • 12544257169 scopus 로고    scopus 로고
    • E-cadherin phosphorylation by protein kinase D1/protein kinase Cmu is associated with altered cellular aggregation and motility in prostate cancer
    • Jaggi M., Rao P.S., Smith D.J., Wheelock M.J., Johnson K.R., Hemstreet G.P., Balaji K.C. E-cadherin phosphorylation by protein kinase D1/protein kinase Cmu is associated with altered cellular aggregation and motility in prostate cancer. Cancer Res. 2005, 65:483-492.
    • (2005) Cancer Res. , vol.65 , pp. 483-492
    • Jaggi, M.1    Rao, P.S.2    Smith, D.J.3    Wheelock, M.J.4    Johnson, K.R.5    Hemstreet, G.P.6    Balaji, K.C.7
  • 11
    • 0026040191 scopus 로고
    • Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases
    • Kennelly P.J., Krebs E.G. Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J.Biol. Chem. 1991, 266:15555-15558.
    • (1991) J.Biol. Chem. , vol.266 , pp. 15555-15558
    • Kennelly, P.J.1    Krebs, E.G.2
  • 12
    • 0038001141 scopus 로고    scopus 로고
    • PKC delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements
    • Kinoshita N., Iioka H., Miyakoshi A., Ueno N. PKC delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements. Genes Dev. 2003, 17:1663-1676.
    • (2003) Genes Dev. , vol.17 , pp. 1663-1676
    • Kinoshita, N.1    Iioka, H.2    Miyakoshi, A.3    Ueno, N.4
  • 13
    • 0022348840 scopus 로고
    • Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase
    • Kishimoto A., Nishiyama K., Nakanishi H., Uratsuji Y., Nomura H., Takeyama Y., Nishizuka Y. Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase. J.Biol. Chem. 1985, 260:12492-12499.
    • (1985) J.Biol. Chem. , vol.260 , pp. 12492-12499
    • Kishimoto, A.1    Nishiyama, K.2    Nakanishi, H.3    Uratsuji, Y.4    Nomura, H.5    Takeyama, Y.6    Nishizuka, Y.7
  • 15
    • 72149120318 scopus 로고    scopus 로고
    • "Developmental mechanics": cellular patterns controlled by adhesion, cortical tension and cell division
    • Lecuit T. "Developmental mechanics": cellular patterns controlled by adhesion, cortical tension and cell division. HFSP J 2008, 2:72-78.
    • (2008) HFSP J , vol.2 , pp. 72-78
    • Lecuit, T.1
  • 16
    • 84867142054 scopus 로고    scopus 로고
    • EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins
    • Lei Z., Maeda T., Tamura A., Nakamura T., Yamazaki Y., Shiratori H., Yashiro K., Tsukita S., Hamada H. EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev. Biol. 2012, 371:136-145.
    • (2012) Dev. Biol. , vol.371 , pp. 136-145
    • Lei, Z.1    Maeda, T.2    Tamura, A.3    Nakamura, T.4    Yamazaki, Y.5    Shiratori, H.6    Yashiro, K.7    Tsukita, S.8    Hamada, H.9
  • 18
    • 55949111134 scopus 로고    scopus 로고
    • A genome-wide expression analysis identifies a network of EpCAM-induced cell cycle regulators
    • Maaser K., Borlak J. A genome-wide expression analysis identifies a network of EpCAM-induced cell cycle regulators. Br. J. Cancer 2008, 99:1635-1643.
    • (2008) Br. J. Cancer , vol.99 , pp. 1635-1643
    • Maaser, K.1    Borlak, J.2
  • 20
    • 78049514693 scopus 로고    scopus 로고
    • The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling
    • Maghzal N., Vogt E., Reintsch W., Fraser J.S., Fagotto F. The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling. J.Cell Biol. 2010, 191:645-659.
    • (2010) J.Cell Biol. , vol.191 , pp. 645-659
    • Maghzal, N.1    Vogt, E.2    Reintsch, W.3    Fraser, J.S.4    Fagotto, F.5
  • 21
    • 0025678899 scopus 로고
    • Studies on the primary sequence requirements for PKC-alpha, -beta 1 and -gamma peptide substrates
    • Marais R.M., Nguyen O., Woodgett J.R., Parker P.J. Studies on the primary sequence requirements for PKC-alpha, -beta 1 and -gamma peptide substrates. FEBS Lett. 1990, 277:151-155.
    • (1990) FEBS Lett. , vol.277 , pp. 151-155
    • Marais, R.M.1    Nguyen, O.2    Woodgett, J.R.3    Parker, P.J.4
  • 22
    • 4143065769 scopus 로고    scopus 로고
    • The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation
    • Münz M., Kieu C., Mack B., Schmitt B., Zeidler R., Gires O. The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation. Oncogene 2004, 23:5748-5758.
    • (2004) Oncogene , vol.23 , pp. 5748-5758
    • Münz, M.1    Kieu, C.2    Mack, B.3    Schmitt, B.4    Zeidler, R.5    Gires, O.6
  • 23
    • 67651003100 scopus 로고    scopus 로고
    • The emerging role of EpCAM in cancer and stem cell signaling
    • Munz M., Baeuerle P.A., Gires O. The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 2009, 69:5627-5629.
    • (2009) Cancer Res. , vol.69 , pp. 5627-5629
    • Munz, M.1    Baeuerle, P.A.2    Gires, O.3
  • 25
    • 0035413601 scopus 로고    scopus 로고
    • Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions
    • Newton A.C. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem. Rev. 2001, 101:2353-2364.
    • (2001) Chem. Rev. , vol.101 , pp. 2353-2364
    • Newton, A.C.1
  • 26
    • 0033549558 scopus 로고    scopus 로고
    • Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner
    • Nguyen D.H., Catling A.D., Webb D.J., Sankovic M., Walker L.A., Somlyo A.V., Weber M.J., Gonias S.L. Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner. J.Cell Biol. 1999, 146:149-164.
    • (1999) J.Cell Biol. , vol.146 , pp. 149-164
    • Nguyen, D.H.1    Catling, A.D.2    Webb, D.J.3    Sankovic, M.4    Walker, L.A.5    Somlyo, A.V.6    Weber, M.J.7    Gonias, S.L.8
  • 27
    • 0031012892 scopus 로고    scopus 로고
    • Determination of the specific substrate sequence motifs of protein kinase C isozymes
    • Nishikawa K., Toker A., Johannes F.J., Songyang Z., Cantley L.C. Determination of the specific substrate sequence motifs of protein kinase C isozymes. J.Biol. Chem. 1997, 272:952-960.
    • (1997) J.Biol. Chem. , vol.272 , pp. 952-960
    • Nishikawa, K.1    Toker, A.2    Johannes, F.J.3    Songyang, Z.4    Cantley, L.C.5
  • 28
    • 1842828975 scopus 로고    scopus 로고
    • Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins
    • Noren N.K., Pasquale E.B. Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins. Cell. Signal. 2004, 16:655-666.
    • (2004) Cell. Signal. , vol.16 , pp. 655-666
    • Noren, N.K.1    Pasquale, E.B.2
  • 30
    • 84855952224 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule expression (CD326) in cancer: a short review
    • Patriarca C., Macchi R.M., Marschner A.K., Mellstedt H. Epithelial cell adhesion molecule expression (CD326) in cancer: a short review. Cancer Treat. Rev. 2012, 38:68-75.
    • (2012) Cancer Treat. Rev. , vol.38 , pp. 68-75
    • Patriarca, C.1    Macchi, R.M.2    Marschner, A.K.3    Mellstedt, H.4
  • 33
    • 0036305635 scopus 로고    scopus 로고
    • ROCK and Dia have opposing effects on adherens junctions downstream of Rho
    • Sahai E., Marshall C.J. ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat. Cell Biol. 2002, 4:408-415.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 408-415
    • Sahai, E.1    Marshall, C.J.2
  • 34
    • 77956344338 scopus 로고    scopus 로고
    • Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy
    • Seimetz D., Lindhofer H., Bokemeyer C. Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy. Cancer Treat. Rev. 2010, 36:458-467.
    • (2010) Cancer Treat. Rev. , vol.36 , pp. 458-467
    • Seimetz, D.1    Lindhofer, H.2    Bokemeyer, C.3
  • 35
    • 70349448435 scopus 로고    scopus 로고
    • PKC-delta binds to E-cadherin and mediates EGF-induced cell scattering
    • Singh R., Lei P., Andreadis S.T. PKC-delta binds to E-cadherin and mediates EGF-induced cell scattering. Exp. Cell Res. 2009, 315:2899-2913.
    • (2009) Exp. Cell Res. , vol.315 , pp. 2899-2913
    • Singh, R.1    Lei, P.2    Andreadis, S.T.3
  • 36
    • 68249099141 scopus 로고    scopus 로고
    • The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development
    • Slanchev K., Carney T.J., Stemmler M.P., Koschorz B., Amsterdam A., Schwarz H., Hammerschmidt M. The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development. PLoS Genet. 2009, 5:e1000563.
    • (2009) PLoS Genet. , vol.5
    • Slanchev, K.1    Carney, T.J.2    Stemmler, M.P.3    Koschorz, B.4    Amsterdam, A.5    Schwarz, H.6    Hammerschmidt, M.7
  • 37
    • 10944238407 scopus 로고    scopus 로고
    • Distinctive activation mechanisms and functions for protein kinase Cdelta
    • Steinberg S.F. Distinctive activation mechanisms and functions for protein kinase Cdelta. Biochem. J. 2004, 384:449-459.
    • (2004) Biochem. J. , vol.384 , pp. 449-459
    • Steinberg, S.F.1
  • 38
    • 0035910502 scopus 로고    scopus 로고
    • Oligomeric state of the colon carcinoma-associated glycoprotein GA733-2 (Ep-CAM/EGP40) and its role in GA733-mediated homotypic cell-cell adhesion
    • Trebak M., Begg G.E., Chong J.M., Kanazireva E.V., Herlyn D., Speicher D.W. Oligomeric state of the colon carcinoma-associated glycoprotein GA733-2 (Ep-CAM/EGP40) and its role in GA733-mediated homotypic cell-cell adhesion. J.Biol. Chem. 2001, 276:2299-2309.
    • (2001) J.Biol. Chem. , vol.276 , pp. 2299-2309
    • Trebak, M.1    Begg, G.E.2    Chong, J.M.3    Kanazireva, E.V.4    Herlyn, D.5    Speicher, D.W.6
  • 39
    • 83355176606 scopus 로고    scopus 로고
    • TROP2 expressed in the trunk of the ureteric duct regulates branching morphogenesis during kidney development
    • Tsukahara Y., Tanaka M., Miyajima A. TROP2 expressed in the trunk of the ureteric duct regulates branching morphogenesis during kidney development. PLoS ONE 2011, 6:e28607.
    • (2011) PLoS ONE , vol.6
    • Tsukahara, Y.1    Tanaka, M.2    Miyajima, A.3
  • 41
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    • Visvader J.E., Lindeman G.J. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat. Rev. Cancer 2008, 8:755-768.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 42
    • 25844484590 scopus 로고    scopus 로고
    • Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factor
    • Wong C., Jin Z.G. Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factor. J.Biol. Chem. 2005, 280:33262-33269.
    • (2005) J.Biol. Chem. , vol.280 , pp. 33262-33269
    • Wong, C.1    Jin, Z.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.