-
1
-
-
19544393523
-
Function of RNA-binding protein Musashi-1 in stem cells
-
Okano, H. et al. Function of RNA-binding protein Musashi-1 in stem cells. Exp. Cell Res. 306, 349-356 (2005).
-
(2005)
Exp. Cell Res.
, vol.306
, pp. 349-356
-
-
Okano, H.1
-
2
-
-
20244365304
-
Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell
-
Sakakibara, S. et al. Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell. Dev. Biol. 176, 230-242 (1996).
-
(1996)
Dev. Biol.
, vol.176
, pp. 230-242
-
-
Sakakibara, S.1
-
3
-
-
0035887898
-
Rna-binding protein Musashi2: Developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS
-
Sakakibara, S., Nakamura, Y., Satoh, H. & Okano, H. Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. J. Neurosci. 21, 8091-8107 (2001).
-
(2001)
J. Neurosci.
, vol.21
, pp. 8091-8107
-
-
Sakakibara, S.1
Nakamura, Y.2
Satoh, H.3
Okano, H.4
-
4
-
-
77955431522
-
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
-
Kharas, M. G. et al. Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat. Med. 16, 903-908 (2010).
-
(2010)
Nat. Med.
, vol.16
, pp. 903-908
-
-
Kharas, M.G.1
-
5
-
-
77955512823
-
Regulation of myeloid leukaemia by the cell-fate determinant Musashi
-
Ito, T. et al. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature 466, 765-768 (2010).
-
(2010)
Nature
, vol.466
, pp. 765-768
-
-
Ito, T.1
-
6
-
-
84892533375
-
Musashi-2 controls cell fate, lineage bias, and TGF-beta signaling in HSCs
-
Park, S. M. et al. Musashi-2 controls cell fate, lineage bias, and TGF-beta signaling in HSCs. J. Exp. Med. 211, 71-87 (2014).
-
(2014)
J. Exp. Med.
, vol.211
, pp. 71-87
-
-
Park, S.M.1
-
7
-
-
84891371359
-
Musashi2 predicts poor prognosis and invasion in hepatocellular carcinoma by driving epithelial-mesenchymal transition
-
He, L. et al. Musashi2 predicts poor prognosis and invasion in hepatocellular carcinoma by driving epithelial-mesenchymal transition. J. Cell Mol. Med. 18, 49-58 (2014).
-
(2014)
J. Cell Mol. Med.
, vol.18
, pp. 49-58
-
-
He, L.1
-
8
-
-
84877829476
-
Expression of seven stem-cell-associated markers in human airway biopsy specimens obtained via fiberoptic bronchoscopy
-
Li, L. et al. Expression of seven stem-cell-associated markers in human airway biopsy specimens obtained via fiberoptic bronchoscopy. J. Exp. Clin. Cancer Res. 32, 28 (2013).
-
(2013)
J. Exp. Clin. Cancer Res.
, vol.32
, pp. 28
-
-
Li, L.1
-
9
-
-
77956449328
-
An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity
-
Hope, K. J. et al. An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity. Cell Stem Cell 7, 101-113 (2010).
-
(2010)
Cell Stem Cell
, vol.7
, pp. 101-113
-
-
Hope, K.J.1
-
10
-
-
0012872309
-
Identification of a putative intestinal stem cell and early lineage marker; musashi-1
-
Potten, C. S. et al. Identification of a putative intestinal stem cell and early lineage marker; musashi-1. Differentiation 71, 28-41 (2003).
-
(2003)
Differentiation
, vol.71
, pp. 28-41
-
-
Potten, C.S.1
-
11
-
-
80051552659
-
Msi-1 is a predictor of survival and a novel therapeutic target in colon cancer
-
Li, D. et al. Msi-1 is a predictor of survival and a novel therapeutic target in colon cancer. Ann. Surg. Oncol. 18, 2074-2083 (2011).
-
(2011)
Ann. Surg. Oncol.
, vol.18
, pp. 2074-2083
-
-
Li, D.1
-
12
-
-
72349088959
-
Expression of putative stem cell genes Musashi-1 and beta1- integrin in human colorectal adenomas and adenocarcinomas
-
Fan, L. F. et al. Expression of putative stem cell genes Musashi-1 and beta1- integrin in human colorectal adenomas and adenocarcinomas. Int. J. Colorectal Dis. 25, 17-23 (2010).
-
(2010)
Int. J. Colorectal Dis.
, vol.25
, pp. 17-23
-
-
Fan, L.F.1
-
13
-
-
59049106578
-
Crypt stem cells as the cells-of-origin of intestinal cancer
-
Barker, N. et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457, 608-611 (2009).
-
(2009)
Nature
, vol.457
, pp. 608-611
-
-
Barker, N.1
-
14
-
-
0026894053
-
Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
-
Miyoshi, Y. et al. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum. Mol. Genet. 1, 229-233 (1992).
-
(1992)
Hum. Mol. Genet.
, vol.1
, pp. 229-233
-
-
Miyoshi, Y.1
-
15
-
-
12244308400
-
Screening for germ-line mutations in familial adenomatous polyposis patients: 61 New patients and a summary of 150 unrelated patients
-
Nagase, H. et al. Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients. Hum. Mutat. 1, 467-473 (1992).
-
(1992)
Hum. Mutat.
, vol.1
, pp. 467-473
-
-
Nagase, H.1
-
16
-
-
0025817880
-
Identification of FAP locus genes from chromosome 5q21
-
Kinzler, K. W. et al. Identification of FAP locus genes from chromosome 5q21. Science 253, 661-665 (1991).
-
(1991)
Science
, vol.253
, pp. 661-665
-
-
Kinzler, K.W.1
-
17
-
-
4043059169
-
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
-
el Marjou, F. et al. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39, 186-193 (2004).
-
(2004)
Genesis
, vol.39
, pp. 186-193
-
-
El Marjou, F.1
-
18
-
-
2942668475
-
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
-
Sansom, O. J. et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev. 18, 1385-1390 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 1385-1390
-
-
Sansom, O.J.1
-
19
-
-
18644373146
-
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
-
van de Wetering, M. et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111, 241-250 (2002).
-
(2002)
Cell
, vol.111
, pp. 241-250
-
-
Van De Wetering, M.1
-
20
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
Barker, N. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449, 1003-1007 (2007).
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
-
21
-
-
0031877446
-
APC in the regulation of intestinal crypt fission
-
Wasan, H. S. et al. APC in the regulation of intestinal crypt fission. J. Pathol. 185, 246-255 (1998).
-
(1998)
J. Pathol.
, vol.185
, pp. 246-255
-
-
Wasan, H.S.1
-
22
-
-
29344434237
-
Correlation between Musashi-1 and c-hairy-1 expression and cell proliferation activity in the developing intestine and stomach of both chicken and mouse
-
Asai, R., Okano, H. & Yasugi, S. Correlation between Musashi-1 and c-hairy-1 expression and cell proliferation activity in the developing intestine and stomach of both chicken and mouse. Dev. Growth Differ. 47, 501-510 (2005).
-
(2005)
Dev. Growth Differ.
, vol.47
, pp. 501-510
-
-
Asai, R.1
Okano, H.2
Yasugi, S.3
-
23
-
-
42949142611
-
Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo
-
Sureban, S. M. et al. Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo. Gastroenterology 134, 1448-1458 (2008).
-
(2008)
Gastroenterology
, vol.134
, pp. 1448-1458
-
-
Sureban, S.M.1
-
24
-
-
77956934167
-
The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation
-
Rezza, A. et al. The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation. J. Cell Sci. 123, 3256-3265 (2010).
-
(2010)
J. Cell Sci.
, vol.123
, pp. 3256-3265
-
-
Rezza, A.1
-
25
-
-
84925278849
-
Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state
-
Katz, Y. et al. Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state. eLife 3, e03915 (2014).
-
(2014)
eLife
, vol.3
, pp. e03915
-
-
Katz, Y.1
-
26
-
-
0037069471
-
RNA-binding protein Musashi family: Roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation
-
Sakakibara, S. et al. RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Proc. Natl Acad. Sci. USA 99, 15194-15199 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 15194-15199
-
-
Sakakibara, S.1
-
27
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
-
28
-
-
84870724894
-
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium
-
Hirata, A. et al. Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development 140, 66-75 (2013).
-
(2013)
Development
, vol.140
, pp. 66-75
-
-
Hirata, A.1
-
29
-
-
0035016795
-
The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA
-
Imai, T. et al. The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. Mol. Cell Biol. 21, 3888-3900 (2001).
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 3888-3900
-
-
Imai, T.1
-
30
-
-
30044442091
-
The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1
-
Battelli, C., Nikopoulos, G. N., Mitchell, J. G. & Verdi, J. M. The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1. Mol. Cell Neurosci. 31, 85-96 (2006).
-
(2006)
Mol. Cell Neurosci.
, vol.31
, pp. 85-96
-
-
Battelli, C.1
Nikopoulos, G.N.2
Mitchell, J.G.3
Verdi, J.M.4
-
31
-
-
84859196824
-
The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor
-
Powell, A. E. et al. The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell 149, 146-158 (2012).
-
(2012)
Cell
, vol.149
, pp. 146-158
-
-
Powell, A.E.1
-
32
-
-
0034972978
-
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
-
Howe, J. R. et al. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat. Genet. 28, 184-187 (2001).
-
(2001)
Nat. Genet.
, vol.28
, pp. 184-187
-
-
Howe, J.R.1
-
33
-
-
33846600427
-
PTEN-deficient intestinal stem cells initiate intestinal polyposis
-
He, X. C. et al. PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat. Genet. 39, 189-198 (2007).
-
(2007)
Nat. Genet.
, vol.39
, pp. 189-198
-
-
He, X.C.1
-
34
-
-
2342504508
-
Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers
-
Goel, A. et al. Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. Cancer Res. 64, 3014-3021 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 3014-3021
-
-
Goel, A.1
-
35
-
-
79953683140
-
Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: Associations with clinicopathological and dietary factors
-
Naguib, A. et al. Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors. BMC Cancer 11, 123 (2011).
-
(2011)
BMC Cancer
, vol.11
, pp. 123
-
-
Naguib, A.1
-
36
-
-
56749183466
-
Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation
-
Marsh, V. et al. Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nat. Genet. 40, 1436-1444 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 1436-1444
-
-
Marsh, V.1
-
37
-
-
0037086001
-
Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
-
Stocker, H. et al. Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science 295, 2088-2091 (2002).
-
(2002)
Science
, vol.295
, pp. 2088-2091
-
-
Stocker, H.1
-
38
-
-
77955587900
-
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling
-
Ashton, G. H. et al. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev. Cell 19, 259-269 (2010).
-
(2010)
Dev. Cell
, vol.19
, pp. 259-269
-
-
Ashton, G.H.1
-
39
-
-
51649126752
-
Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice
-
Fujishita, T., Aoki, K., Lane, H. A., Aoki, M. & Taketo, M. M. Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. Proc. Natl Acad. Sci. USA 105, 13544-13549 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 13544-13549
-
-
Fujishita, T.1
Aoki, K.2
Lane, H.A.3
Aoki, M.4
Taketo, M.M.5
-
40
-
-
79951784529
-
CKIalpha ablation highlights a critical role for p53 in invasiveness control
-
Elyada, E. et al. CKIalpha ablation highlights a critical role for p53 in invasiveness control. Nature 470, 409-413 (2011).
-
(2011)
Nature
, vol.470
, pp. 409-413
-
-
Elyada, E.1
-
41
-
-
79953143585
-
Novel double-negative feedback loop between adenomatous polyposis coli and Musashi1 in colon epithelia
-
Spears, E. & Neufeld, K. L. Novel double-negative feedback loop between adenomatous polyposis coli and Musashi1 in colon epithelia. J. Biol. Chem. 286, 4946-4950 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 4946-4950
-
-
Spears, E.1
Neufeld, K.L.2
-
42
-
-
44349125782
-
Musashi1 modulates mammary progenitor cell expansion through proliferin-mediated activation of the Wnt and Notch pathways
-
Wang, X. Y. et al. Musashi1 modulates mammary progenitor cell expansion through proliferin-mediated activation of the Wnt and Notch pathways. Mol. Cell Biol. 28, 3589-3599 (2008).
-
(2008)
Mol. Cell Biol.
, vol.28
, pp. 3589-3599
-
-
Wang, X.Y.1
-
43
-
-
32344453096
-
Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells
-
Beard, C., Hochedlinger, K., Plath, K., Wutz, A. & Jaenisch, R. Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis 44, 23-28 (2006).
-
(2006)
Genesis
, vol.44
, pp. 23-28
-
-
Beard, C.1
Hochedlinger, K.2
Plath, K.3
Wutz, A.4
Jaenisch, R.5
-
44
-
-
0030843461
-
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene
-
Shibata, H. et al. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science 278, 120-123 (1997).
-
(1997)
Science
, vol.278
, pp. 120-123
-
-
Shibata, H.1
-
45
-
-
67349123408
-
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
-
Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262-265 (2009).
-
(2009)
Nature
, vol.459
, pp. 262-265
-
-
Sato, T.1
-
46
-
-
84861837990
-
Identification, isolation, and culture of intestinal epithelial stem cells from murine intestine
-
Gracz, A. D., Puthoff, B. J. & Magness, S. T. Identification, isolation, and culture of intestinal epithelial stem cells from murine intestine. Methods Mol. Biol. 879, 89-107 (2012).
-
(2012)
Methods Mol. Biol.
, vol.879
, pp. 89-107
-
-
Gracz, A.D.1
Puthoff, B.J.2
Magness, S.T.3
-
47
-
-
67749132423
-
Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
-
Chi, S. W., Zang, J. B., Mele, A. & Darnell, R. B. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature 460, 479-486 (2009).
-
(2009)
Nature
, vol.460
, pp. 479-486
-
-
Chi, S.W.1
Zang, J.B.2
Mele, A.3
Darnell, R.B.4
-
48
-
-
65449136284
-
TopHat: Discovering splice junctions with RNA-Seq
-
Trapnell, C., Pachter, L. & Salzberg, S. L. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25, 1105-1111 (2009).
-
(2009)
Bioinformatics
, vol.25
, pp. 1105-1111
-
-
Trapnell, C.1
Pachter, L.2
Salzberg, S.L.3
-
49
-
-
84870471564
-
Site identification in high-throughput RNA-protein interaction data
-
Uren, P. J. et al. Site identification in high-throughput RNA-protein interaction data. Bioinformatics 28, 3013-3020 (2012).
-
(2012)
Bioinformatics
, vol.28
, pp. 3013-3020
-
-
Uren, P.J.1
-
50
-
-
67849122320
-
MEME SUITE: Tools for motif discovery and searching
-
Bailey, T. L. et al. MEME SUITE: tools for motif discovery and searching. Nucleic Acids Res. 37, W202-W208 (2009).
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. W202-W208
-
-
Bailey, T.L.1
-
51
-
-
33847246805
-
Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles
-
Rhodes, D. R. et al. Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia 9, 166-180 (2007).
-
(2007)
Neoplasia
, vol.9
, pp. 166-180
-
-
Rhodes, D.R.1
|