Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: Associations with clinicopathological and dietary factors

BMC Cancer

Volumn 11, Issue , 2011, Pages

  Naguib, Adam ^a   Cooke, James C ^a   Happerfield, Lisa ^b   Kerr, Lucy ^b   Gay, Laura J ^a   Luben, Robert N ^b   Ball, Richard Y ^c   Mitrou, Panagiota N ^b   McTaggart, Alison ^b   Arends, Mark J ^b  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PIK3CA; UNCLASSIFIED DRUG; PIK3CA PROTEIN, HUMAN; PTEN PROTEIN, HUMAN;

ADENOCARCINOMA; AGED; ARTICLE; CANCER STAGING; CLINICAL FEATURE; COLORECTAL ADENOMA; COLORECTAL CARCINOMA; CONTROLLED STUDY; DIET; DIETARY INTAKE; DISEASE ASSOCIATION; DNA SEQUENCE; EXON; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MUTATION RATE; PROTEIN EXPRESSION; PROTO ONCOGENE; QUESTIONNAIRE; SIGNAL TRANSDUCTION; TUMOR DIFFERENTIATION; TUMOR SUPPRESSOR GENE; COLON TUMOR; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENETICS; METABOLISM; MIDDLE AGED; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PATHOPHYSIOLOGY; SEX DIFFERENCE;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; COLONIC NEOPLASMS; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC ASSOCIATION STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PTEN PHOSPHOHYDROLASE; QUESTIONNAIRES; SEX FACTORS;

EID: 79953683140     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-11-123     Document Type: Article

References (29)

1. Samuels Y, Velculescu VE. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 2004, 3(10):1221-1224. 10.4161/cc.3.10.1164, 15467468.
2. Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004, 304(5670):554. 10.1126/science.1096502, 15016963.
3. Abubaker J, Bavi P, Al-Harbi S, Ibrahim M, Siraj AK, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, et al. Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population. Oncogene 2008, 27(25):3539-3545. 10.1038/sj.onc.1211013, 18193083.
4. Benvenuti S, Frattini M, Arena S, Zanon C, Cappelletti V, Coradini D, Daidone MG, Pilotti S, Pierotti MA, Bardelli A. PIK3CA cancer mutations display gender and tissue specificity patterns. Hum Mutat 2008, 29(2):284-288. 10.1002/humu.20648, 18022911.
5. Campbell IG, Russell SE, Choong DY, Montgomery KG, Ciavarella ML, Hooi CS, Cristiano BE, Pearson RB, Phillips WA. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 2004, 64(21):7678-7681. 10.1158/0008-5472.CAN-04-2933, 15520168.
6. Velho S, Oliveira C, Ferreira A, Ferreira AC, Suriano G, Schwartz S, Duval A, Carneiro F, Machado JC, Hamelin R, et al. The prevalence of PIK3CA mutations in gastric and colon cancer. Eur J Cancer 2005, 41(11):1649-1654. 10.1016/j.ejca.2005.04.022, 15994075.
7. Zhao L, Vogt PK. Class I PI3K in oncogenic cellular transformation. Oncogene 2008, 27(41):5486-5496. 10.1038/onc.2008.244, 2757120, 18794883.
8. Chang JG, Chen YJ, Perng LI, Wang NM, Kao MC, Yang TY, Chang CP, Tsai CH. Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract. Eur J Cancer 1999, 35(4):647-651. 10.1016/S0959-8049(98)00411-0, 10492641.
9. Danielsen SA, Lind GE, Bjornslett M, Meling GI, Rognum TO, Heim S, Lothe RA. Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation-status. Hum Mutat 2008,
10. Dicuonzo G, Angeletti S, Garcia-Foncillas J, Brugarolas A, Okrouzhnov Y, Santini D, Tonini G, Lorino G, De Cesaris M, Baldi A. Colorectal carcinomas and PTEN/MMAC1 gene mutations. Clin Cancer Res 2001, 7(12):4049-4053.
11. Goel A, Arnold CN, Niedzwiecki D, Carethers JM, Dowell JM, Wasserman L, Compton C, Mayer RJ, Bertagnolli MM, Boland CR. Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. Cancer Res 2004, 64(9):3014-3021. 10.1158/0008-5472.CAN-2401-2, 15126336.
12. Nassif NT, Lobo GP, Wu X, Henderson CJ, Morrison CD, Eng C, Jalaludin B, Segelov E. PTEN mutations are common in sporadic microsatellite stable colorectal cancer. Oncogene 2004, 23(2):617-628. 10.1038/sj.onc.1207059, 14724591.
13. Wang ZJ, Taylor F, Churchman M, Norbury G, Tomlinson I. Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes. Am J Pathol 1998, 153(2):363-366. 10.1016/S0002-9440(10)65579-4, 1852980, 9708796.
14. Guanti G, Resta N, Simone C, Cariola F, Demma I, Fiorente P, Gentile M. Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis. Hum Mol Genet 2000, 9(2):283-287. 10.1093/hmg/9.2.283, 10607839.
15. Zhou XP, Loukola A, Salovaara R, Nystrom-Lahti M, Peltomaki P, de la Chapelle A, Aaltonen LA, Eng C. PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers. Am J Pathol 2002, 161(2):439-447. 10.1016/S0002-9440(10)64200-9, 1850747, 12163369.
16. Frattini M, Saletti P, Romagnani E, Martin V, Molinari F, Ghisletta M, Camponovo A, Etienne LL, Cavalli F, Mazzucchelli L. PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer 2007, 97(8):1139-1145. 10.1038/sj.bjc.6604009, 2360431, 17940504.
17. Molinari F, Martin V, Saletti P, De Dosso S, Spitale A, Camponovo A, Bordoni A, Crippa S, Mazzucchelli L, Frattini M. Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant. Br J Cancer 2009, 100(7):1087-1094. 10.1038/sj.bjc.6604848, 2669991, 19293803.
18. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005, 55(2):74-108. 10.3322/canjclin.55.2.74, 15761078.
19. Cummings JH, Bingham SA. Diet and the prevention of cancer. BMJ 1998, 317(7173):1636-1640. 1114436, 9848907.
20. Naguib A, Mitrou PN, Gay LJ, Cooke JC, Luben RN, Ball RY, McTaggart A, Arends MJ, Rodwell SA. Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study. BMC Cancer 2010, 10:99. 10.1186/1471-2407-10-99, 2847960, 20233436.
21. Li VS, Wong CW, Chan TL, Chan AS, Zhao W, Chu KM, So S, Chen X, Yuen ST, Leung SY. Mutations of PIK3CA in gastric adenocarcinoma. BMC Cancer 2005, 5:29. 10.1186/1471-2407-5-29, 1079799, 15784156.
22. Soreide K, Janssen EA, Soiland H, Korner H, Baak JP. Microsatellite instability in colorectal cancer. Br J Surg 2006, 93(4):395-406. 10.1002/bjs.5328, 16555243.
23. Dahia PL, FitzGerald MG, Zhang X, Marsh DJ, Zheng Z, Pietsch T, von Deimling A, Haluska FG, Haber DA, Eng C. A highly conserved processed PTEN pseudogene is located on chromosome band 9p21. Oncogene 1998, 16(18):2403-2406. 10.1038/sj.onc.1201762, 9620558.
24. Klose RJ, Bird AP. Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 2006, 31(2):89-97. 10.1016/j.tibs.2005.12.008, 16403636.
25. Garcia JM, Rodriguez R, Silva J, Munoz C, Dominguez G, Silva JM, Carcereny E, Provencio M, Espana P, Bonilla F. Intratumoral heterogeneity in microsatellite alterations in BRCA1 and PTEN regions in sporadic colorectal cancer. Ann Surg Oncol 2003, 10(8):876-881. 10.1245/ASO.2003.02.004, 14527905.
26. Naguib A, Wilson CH, Adams DJ, Arends MJ. Activation of K-RAS by co-mutation of codons 19 and 20 is transforming. J Mol Signal 2011, 6:2. 10.1186/1750-2187-6-2, 3056876, 21371307.
27. Day N, McKeown N, Wong M, Welch A, Bingham S. Epidemiological assessment of diet: a comparison of a 7-day diary with a food frequency questionnaire using urinary markers of nitrogen, potassium and sodium. Int J Epidemiol 2001, 30(2):309-317. 10.1093/ije/30.2.309, 11369735.
28. Nemes S, Jonasson JM, Genell A, Steineck G. Bias in odds ratios by logistic regression modelling and sample size. BMC Med Res Methodol 2009, 9:56. 10.1186/1471-2288-9-56, 2724427, 19635144.
29. Velho S, Moutinho C, Cirnes L, Albuquerque C, Hamelin R, Schmitt F, Carneiro F, Oliveira C, Seruca R. BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?. BMC Cancer 2008, 8:255. 10.1186/1471-2407-8-255, 2553419, 18782444.