Border between natural product and drug: Comparison of the related benzoquinones idebenone and coenzyme Q10

Redox Biology

Volumn 4, Issue , 2015, Pages 289-295

  Gueven, Nuri ^a   Woolley, Krystel ^a   Smith, Jason ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Antioxidant; Benzoquinone; Coenzyme Q10; Idebenone; Mitochondria

Indexed keywords

BENZOQUINONE DERIVATIVE; IDEBENONE; UBIDECARENONE; ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; BIOLOGICAL PRODUCT; NQO1 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UBIQUINONE;

ANTIOXIDANT ACTIVITY; CELL ENERGY; CELL FUNCTION; COMPARATIVE STUDY; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; ELECTRON TRANSPORT; ENZYME ACTIVATION; HUMAN; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TIME TO MAXIMUM PLASMA CONCENTRATION; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOLECULAR WEIGHT; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; ANTIOXIDANTS; BIOLOGICAL PRODUCTS; ELECTRON TRANSPORT; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MOLECULAR WEIGHT; NAD(P)H DEHYDROGENASE (QUINONE); STRUCTURE-ACTIVITY RELATIONSHIP; UBIQUINONE;

EID: 84925267993     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2015.01.009     Document Type: Review

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