Clinical Approach to the Patient With AKI and Sepsis

Seminars in Nephrology

Volumn 35, Issue 1, 2015, Pages 12-22

  Godin, Mélanie ^a   Murray, Patrick ^b   Mehta, Ravindra L ^c  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE SHERBROOKE   (Canada)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AKI; Management; Renal injury; Sepsis

Indexed keywords

CREATININE; ANTIINFECTIVE AGENT; VASOCONSTRICTOR AGENT;

ACUTE KIDNEY FAILURE; CLINICAL FEATURE; CONSERVATIVE TREATMENT; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; DISEASE COURSE; EARLY DIAGNOSIS; FLUID THERAPY; HIGH RISK PATIENT; HUMAN; KIDNEY BIOPSY; MEDICAL RESEARCH; MORBIDITY; MORTALITY; PATIENT IDENTIFICATION; PREVENTIVE MEDICINE; PRIORITY JOURNAL; REHABILITATION CARE; RENAL REPLACEMENT THERAPY; REVIEW; RISK FACTOR; RISK REDUCTION; TREATMENT RESPONSE; URINALYSIS; UROSEPSIS; ACUTE KIDNEY INJURY; COMPLICATION; DISEASE MANAGEMENT; EARLY INTERVENTION; IMMUNOMODULATION; SEPSIS;

ACUTE KIDNEY INJURY; ANTI-BACTERIAL AGENTS; DISEASE MANAGEMENT; EARLY DIAGNOSIS; EARLY MEDICAL INTERVENTION; FLUID THERAPY; HUMANS; IMMUNOMODULATION; RENAL REPLACEMENT THERAPY; SEPSIS; VASOCONSTRICTOR AGENTS;

EID: 84925247314     PISSN: 02709295     EISSN: 15584488     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2015.01.003     Document Type: Review

References (87)

1. Hoste E.A., Lameire N.H., Vanholder R.C., Benoit D.D., Decruyenaere J.M., Colardyn F.A. Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity, and outcome. J Am Soc Nephrol 2003, 14:1022-1030.
2. Bagshaw S.M., George C., Bellomo R., Committee A.D.M. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care 2008, 12:R47.
3. White L.E., Hassoun H.T., Bihorac A., Moore L.J., Sailors R.M., McKinley B.A., et al. Acute kidney injury is surprisingly common and a powerful predictor of mortality in surgical sepsis. J Trauma Acute Care Surg 2013, 75:432-438.
4. Uchino S., Kellum J.A., Bellomo R., Doig G.S., Morimatsu H., Morgera S., et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005, 294:813-818.
5. Rangel-Frausto M.S., Pittet D., Costigan M., Hwang T., Davis C.S., Wenzel R.P. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA 1995, 273:117-123.
6. Murugan R., Karajala-Subramanyam V., Lee M., Yende S., Kong L., Carter M., et al. Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int 2010, 77:527-535.
7. Ergin B., Kapucu A., Demirci-Tansel C., Ince C. The renal microcirculation in sepsis. Nephrol Dial Transplant 2014, In press.
8. Wan L., Bagshaw S.M., Langenberg C., Saotome T., May C., Bellomo R. Pathophysiology of septic acute kidney injury: what do we really know?. Crit Care Med 2008, 36(Suppl):S198-S203.
9. Murugan R., Weissfeld L., Yende S., Singbartl K., Angus D.C., Kellum J.A., et al. Association of statin use with risk and outcome of acute kidney injury in community-acquired pneumonia. Clin J Am Soc Nephrol 2012, 7:895-905.
10. Mehta R.L., Bouchard J., Soroko S.B., Ikizler T.A., Paganini E.P., Chertow G.M., et al. Sepsis as a cause and consequence of acute kidney injury: Program to Improve Care in Acute Renal Disease. Intensive Care Med 2011, 37:241-248.
11. Scheel P.J., Liu M., Rabb H. Uremic lung: new insights into a forgotten condition. Kidney Int 2008, 74:849-851.
12. Coresh J. CKD prognosis: beyond the traditional outcomes. Am J Kidney Dis 2009, 54:1-3.
13. Himmelfarb J., Le P., Klenzak J., Freedman S., McMenamin M.E., Ikizler T.A., et al. Impaired monocyte cytokine production in critically ill patients with acute renal failure. Kidney Int 2004, 66:2354-2360.
14. Bolignano D., Coppolino G., Donato V., Lacquaniti A., Bono C., Buemi M. Neutrophil gelatinase-associated lipocalin (NGAL): a new piece of the anemia puzzle?. Med Sci Monit 2010, 16:RA131-RA135.
15. Yegenaga I., Hoste E., Van Biesen W., Vanholder R., Benoit D., Kantarci G., et al. Clinical characteristics of patients developing ARF due to sepsis/systemic inflammatory response syndrome: results of a prospective study. Am J Kidney Dis 2004, 43:817-824.
16. Leedahl D.D., Frazee E.N., Schramm G.E., Dierkhising R.A., Bergstralh E.J., Chawla L.S., et al. Derivation of urine output thresholds that identify a very high risk of AKI in patients with septic shock. Clin J Am Soc Nephrol 2014, 9:1168-1174.
17. Suh S.H., Kim C.S., Choi J.S., Bae E.H., Ma S.K., Kim S.W. Acute kidney injury in patients with sepsis and septic shock: risk factors and clinical outcomes. Yonsei Med J 2013, 54:965-972.
18. Sood M., Mandelzweig K., Rigatto C., Tangri N., Komenda P., Martinka G., et al. Non-pulmonary infections but not specific pathogens are associated with increased risk of AKI in septic shock. Intensive Care Med 2014, 40:1080-1088.
19. Bellomo R., Ronco C., Kellum J.A., Mehta R.L., Palevsky P. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 2004, 8:R204-R212.
20. Doi K., Yuen P.S., Eisner C., Hu X., Leelahavanichkul A., Schnermann J., et al. Reduced production of creatinine limits its use as marker of kidney injury in sepsis. J Am Soc Nephrol 2009, 20:1217-1221.
21. Sood M.M., Shafer L.A., Ho J., Reslerova M., Martinka G., Keenan S., et al. Early reversible acute kidney injury is associated with improved survival in septic shock. J Crit Care 2014, 29:711-717.
22. Bagshaw S.M., Bennett M., Devarajan P., Bellomo R. Urine biochemistry in septic and non-septic acute kidney injury: a prospective observational study. J Crit Care 2013, 28:371-378.
23. Vanmassenhove J., Glorieux G., Hoste E., Dhondt A., Vanholder R., Van Biesen W. Urinary output and fractional excretion of sodium and urea as indicators of transient versus intrinsic acute kidney injury during early sepsis. Crit Care 2013, 17:R234.
24. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl 2012, 2:1-138. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group.
25. Bagshaw S.M., Haase M., Haase-Fielitz A., Bennett M., Devarajan P., Bellomo R. A prospective evaluation of urine microscopy in septic and non-septic acute kidney injury. Nephrol Dial Transplant 2012, 27:582-588.
26. Lerolle N., Guerot E., Faisy C., Bornstain C., Diehl J.L., Fagon J.Y. Renal failure in septic shock: predictive value of Doppler-based renal arterial resistive index. Intensive Care Med 2006, 32:1553-1559.
27. Deruddre S., Cheisson G., Mazoit J.X., Vicaut E., Benhamou D., Duranteau J. Renal arterial resistance in septic shock: effects of increasing mean arterial pressure with norepinephrine on the renal resistive index assessed with Doppler ultrasonography. Intensive Care Med 2007, 33:1557-1562.
28. Darmon M., Schortgen F., Vargas F., Liazydi A., Schlemmer B., Brun-Buisson C., et al. Diagnostic accuracy of Doppler renal resistive index for reversibility of acute kidney injury in critically ill patients. Intensive Care Med 2011, 37:68-76.
29. Schnell D., Camous L., Guyomarc'h S., Duranteau J., Canet E., Gery P., et al. Renal perfusion assessment by renal Doppler during fluid challenge in sepsis. Crit Care Med 2013, 41:1214-1220.
30. Bagshaw S.M., Langenberg C., Haase M., Wan L., May C.N., Bellomo R. Urinary biomarkers in septic acute kidney injury. Intensive Care Med 2007, 33:1285-1296.
31. Di Nardo M., Ficarella A., Ricci Z., Luciano R., Stoppa F., Picardo S., et al. Impact of severe sepsis on serum and urinary biomarkers of acute kidney injury in critically ill children: an observational study. Blood Purif 2013, 35:172-176.
32. Aydogdu M., Gursel G., Sancak B., Yeni S., Sari G., Tasyurek S., et al. The use of plasma and urine neutrophil gelatinase associated lipocalin (NGAL) and Cystatin C in early diagnosis of septic acute kidney injury in critically ill patients. Dis Markers 2013, 34:237-246.
33. Doi K., Noiri E., Sugaya T. Urinary L-type fatty acid-binding protein as a new renal biomarker in critical care. Curr Opin Crit Care 2010, 16:545-549.
34. Nakamura T., Sugaya T., Koide H. Urinary liver-type fatty acid-binding protein in septic shock: effect of polymyxin B-immobilized fiber hemoperfusion. Shock 2009, 31:454-459.
35. Bagshaw S.M., Bellomo R. Urine abnormalities in acute kidney injury and sepsis. Contrib Nephrol 2010, 165:274-283.
36. Kumar A., Roberts D., Wood K.E., Light B., Parrillo J.E., Sharma S., et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006, 34:1589-1596.
37. Dellinger R.P., Levy M.M., Rhodes A., Annane D., Gerlach H., Opal S.M., et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013, 41:580-637.
38. Bagshaw S.M., Lapinsky S., Dial S., Arabi Y., Dodek P., Wood G., et al. Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy. Intensive Care Med 2009, 35:871-881.
39. Bradley V.E., Shier M.R., Lucas C.E., Rosenberg I.K. Renal hemodynamic response to furosemide in septic and injured patients. Surgery 1976, 79:549-554.
40. Brenner M., Schaer G.L., Mallory D.L., Suffredini A.F., Parrillo J.E. Detection of renal blood flow abnormalities in septic and critically ill patients using a newly designed indwelling thermodilution renal vein catheter. Chest 1990, 98:170-179.
41. Langenberg C., Wan L., Egi M., May C.N., Bellomo R. Renal blood flow in experimental septic acute renal failure. Kidney Int 2006, 69:1996-2002.
42. Rivers E., Nguyen B., Havstad S., Ressler J., Muzzin A., Knoblich B., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345:1368-1377.
43. Dellinger R.P., Carlet J.M., Masur H., Gerlach H., Calandra T., Cohen J., et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med 2004, 30:536-555.
44. Ahmed W., Memon A.I., Rehmani R., Al Juhaiman A. Outcome of patients with acute kidney injury in severe sepsis and septic shock treated with early goal-directed therapy in an intensive care unit. Saudi J Kidney Dis Transpl 2014, 25:544-551.
45. Pro C.I., Yealy D.M., Kellum J.A., Huang D.T., Barnato A.E., Weissfeld L.A., et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014, 370:1683-1693.
46. Badin J., Boulain T., Ehrmann S., Skarzynski M., Bretagnol A., Buret J., et al. Relation between mean arterial pressure and renal function in the early phase of shock: a prospective, explorative cohort study. Crit Care 2011, 15:R135.
47. Asfar P., Teboul J.L., Radermacher P. High versus low blood-pressure target in septic shock. N Engl J Med 2014, 371:283-284.
48. Godin M., Bouchard J., Mehta R.L. Fluid balance in patients with acute kidney injury: emerging concepts. Nephron Clin Pract 2013, 123:238-245.
49. Van Biesen W., Yegenaga I., Vanholder R., Verbeke F., Hoste E., Colardyn F., et al. Relationship between fluid status and its management on acute renal failure (ARF) in intensive care unit (ICU) patients with sepsis: a prospective analysis. J Nephrol 2005, 18:54-60.
50. Payen D., de Pont A.C., Sakr Y., Spies C., Reinhart K., Vincent J.L., et al. A positive fluid balance is associated with a worse outcome in patients with acute renal failure. Crit Care 2008, 12:R74.
51. Bouchard J., Soroko S.B., Chertow G.M., Himmelfarb J., Ikizler T.A., Paganini E.P., et al. Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury. Kidney Int 2009, 76:422-427.
52. Legrand M., Dupuis C., Simon C., Gayat E., Mateo J., Lukaszewicz A.C., et al. Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study. Crit Care 2013, 17:R278.
53. Rajendram R., Prowle J.R. Venous congestion: are we adding insult to kidney injury in sepsis?. Crit Care 2014, 18:104.
54. Zarychanski R., Turgeon A.F., Abou-Setta A.M. Meta-analyses of hydroxyethyl starch for volume resuscitation--reply. JAMA 2013, 309:2209.
55. Bellomo R., Wan L., May C. Vasoactive drugs and acute kidney injury. Crit Care Med 2008, 36(Suppl):S179-S186.
56. Russell J.A., Walley K.R., Singer J., Gordon A.C., Hebert P.C., Cooper D.J., et al. Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 2008, 358:877-887.
57. Gordon A.C., Russell J.A., Walley K.R., Singer J., Ayers D., Storms M.M., et al. The effects of vasopressin on acute kidney injury in septic shock. Intensive Care Med 2010, 36:83-91.
58. Zahar J.R., Rioux C., Girou E., Hulin A., Sauve C., Bernier-Combes A., et al. Inappropriate prescribing of aminoglycosides: risk factors and impact of an antibiotic control team. J Antimicrob Chemother 2006, 58:651-656.
59. Barrett B.J., Parfrey P.S. Preventing nephropathy induced by contrast medium. N Engl J Med 2006, 354:379-386. Clinical practice.
60. Morelli A., Ricci Z., Bellomo R., Ronco C., Rocco M., Conti G., et al. Prophylactic fenoldopam for renal protection in sepsis: a randomized, double-blind, placebo-controlled pilot trial. Crit Care Med 2005, 33:2451-2456.
61. Patel N.N., Angelini G.D. Pharmacological strategies for the prevention of acute kidney injury following cardiac surgery: an overview of systematic reviews. Curr Pharm Des 2014, 20:5484-5488.
62. Heemskerk S., Masereeuw R., Moesker O., Bouw M.P., van der Hoeven J.G., Peters W.H., et al. Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients. Crit Care Med 2009, 37(417-23):e1.
63. Pickkers P., Heemskerk S., Schouten J., Laterre P.F., Vincent J.L., Beishuizen A., et al. Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial. Crit Care 2012, 16:R14.
64. Pickkers P., Snellen F., Rogiers P., Bakker J., Jorens P., Meulenbelt J., et al. Clinical pharmacology of exogenously administered alkaline phosphatase. Eur J Clin Pharmacol 2009, 65:393-402.
65. Peters E., Heemskerk S., Masereeuw R., Pickkers P. Alkaline phosphatase: a possible treatment for sepsis-associated acute kidney injury in critically ill patients. Am J Kidney Dis 2014, 63:1038-1048.
66. Bellomo R. How to feed patients with renal dysfunction. Blood Purif 2002, 20:296-303.
67. Btaiche I.F., Mohammad R.A., Alaniz C., Mueller B.A. Amino acid requirements in critically ill patients with acute kidney injury treated with continuous renal replacement therapy. Pharmacotherapy 2008, 28:600-613.
68. McCarthy M.S., Phipps S.C. Special nutrition challenges: current approach to acute kidney injury. Nutr Clin Pract 2014, 29:56-62.
69. Liu K.D., Himmelfarb J., Paganini E., Ikizler T.A., Soroko S.H., Mehta R.L., et al. Timing of initiation of dialysis in critically ill patients with acute kidney injury. Clin J Am Soc Nephrol 2006, 1:915-919.
70. Bouman C.S., Oudemans-Van Straaten H.M., Tijssen J.G., Zandstra D.F., Kesecioglu J. Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: a prospective, randomized trial. Crit Care Med 2002, 30:2205-2211.
71. Smith O.M., Wald R., Adhikari N.K., Pope K., Weir M.A., Bagshaw S.M., et al. Standard versus accelerated initiation of renal replacement therapy in acute kidney injury (STARRT-AKI): study protocol for a randomized controlled trial. Trials 2013, 14:320.
72. Barbar S.D., Binquet C., Monchi M., Bruyere R., Quenot J.P. Impact on mortality of the timing of renal replacement therapy in patients with severe acute kidney injury in septic shock: the IDEAL-ICU study (initiation of dialysis early versus delayed in the intensive care unit): study protocol for a randomized controlled trial. Trials 2014, 15:270.
73. Wald R., Shariff S.Z., Adhikari N.K., Bagshaw S.M., Burns K.E., Friedrich J.O., et al. The association between renal replacement therapy modality and long-term outcomes among critically ill adults with acute kidney injury: a retrospective cohort study*. Crit Care Med 2014, 42:868-877.
74. Schneider A.G., Bellomo R., Bagshaw S.M., Glassford N.J., Lo S., Jun M., et al. Choice of renal replacement therapy modality and dialysis dependence after acute kidney injury: a systematic review and meta-analysis. Intensive Care Med 2013, 39:987-997.
75. Sun Z., Ye H., Shen X., Chao H., Wu X., Yang J. Continuous venovenous hemofiltration versus extended daily hemofiltration in patients with septic acute kidney injury: a retrospective cohort study. Crit Care 2014, 18:R70.
76. Renal Replacement Therapy Study Investigators, Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, et al. Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med. 2009;361:1627-1638.
77. VA/NIH Acute Renal Failure Network, Palevsky PM, Zhang JH, O'Connor TZ, Chertow GM, Crowley ST, et al. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med. 2008;359:7-20.
78. Kellum J.A., Ronco C. Dialysis: results of RENAL--what is the optimal CRRT target dose?. Nat Rev Nephrol 2010, 6:191-192.
79. Vesconi S., Cruz D.N., Fumagalli R., Kindgen-Milles D., Monti G., Marinho A., et al. Delivered dose of renal replacement therapy and mortality in critically ill patients with acute kidney injury. Crit Care 2009, 13:R57.
80. Cole L., Bellomo R., Hart G., Journois D., Davenport P., Tipping P., et al. A phase II randomized, controlled trial of continuous hemofiltration in sepsis. Crit Care Med 2002, 30:100-106.
81. Payen D., Mateo J., Cavaillon J.M., Fraisse F., Floriot C., Vicaut E., et al. Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trial. Crit Care Med 2009, 37:803-810.
82. Zhang P., Yang Y., Lv R., Zhang Y., Xie W., Chen J. Effect of the intensity of continuous renal replacement therapy in patients with sepsis and acute kidney injury: a single-center randomized clinical trial. Nephrol Dial Transplant 2012, 27:967-973.
83. Joannes-Boyau O., Honore P.M., Perez P., Bagshaw S.M., Grand H., Canivet J.L., et al. High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial. Intensive Care Med 2013, 39:1535-1546.
84. Clark E., Molnar A.O., Joannes-Boyau O., Honore P.M., Sikora L., Bagshaw S.M. High-volume hemofiltration for septic acute kidney injury: a systematic review and meta-analysis. Crit Care 2014, 18:R7.
85. Bagshaw S.M., Uchino S., Bellomo R., Morimatsu H., Morgera S., Schetz M., et al. Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. Clin J Am Soc Nephrol 2007, 2:431-439.
86. Martin G.S., Mannino D.M., Eaton S., Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348:1546-1554.
87. Jo S.K., Rosner M.H., Okusa M.D. Pharmacologic treatment of acute kidney injury: why drugs haven[U+05F3]t worked and what is on the horizon. Clin J Am Soc Nephrol 2007, 2:356-365.