Clinical pharmacology of exogenously administered alkaline phosphatase

European Journal of Clinical Pharmacology

Volumn 65, Issue 4, 2009, Pages 393-402

  Pickkers, P ^a   Snellen, F ^b   Rogiers, P ^c   Bakker, J ^d   Jorens, P ^e   Meulenbelt, J ^f   Spapen, H ^g   Tulleken, J E ^h   Lins, R ⁱ   Ramael, S ⁱ   Bulitta, M ^j   Van Der Hoeven, J G ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Isala Klinieken ^*  (Netherlands)

^c Hospital Network Antwerp   (Belgium)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^g UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^h UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

ⁱ SGS Life Science Services   (Belgium)

^j CRM Biometrics GmbH   (Germany)

more..

Author keywords

Alkaline phosphatase; Clinical trial; Inflammation; Renal failure; Sepsis; Volunteer

Indexed keywords

ALKALINE PHOSPHATASE; ANTIBODY; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PLACEBO;

ADULT; ANTIGENICITY; AREA UNDER THE CURVE; ARTICLE; BACKACHE; BODY TEMPERATURE DISORDER; CLINICAL PHARMACOLOGY; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIALYSIS; DISEASE EXACERBATION; DIZZINESS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG CLEARANCE; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG ELIMINATION; DRUG FATALITY; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; ENDOTOXEMIA; ENZYME ACTIVITY; FATIGUE; FEMALE; FLU LIKE SYNDROME; HEADACHE; HEART ATRIUM FIBRILLATION; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; INFLAMMATION; INJECTION SITE REACTION; INNATE IMMUNITY; INTENSIVE CARE UNIT; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MYALGIA; NAUSEA; NOSE CONGESTION; PHARMACODYNAMICS; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RIGOR; SEPSIS; SIDE EFFECT; VOMITING;

ADULT; AGED; ALKALINE PHOSPHATASE; DOUBLE-BLIND METHOD; ENDOTOXEMIA; FEMALE; HALF-LIFE; HUMANS; INFUSIONS, INTRAVENOUS; INTERLEUKINS; MALE; MIDDLE AGED; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 62549086972     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-008-0591-6     Document Type: Article

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