Impact of severe sepsis on serum and urinary biomarkers of acute kidney injury in critically ill children: An observational study

Blood Purification

Volumn 35, Issue 1-3, 2013, Pages 172-176

  Di Nardo, Matteo ^a   Ficarella, Alessio ^a   Ricci, Zaccaria ^a   Luciano, Rosa ^a   Stoppa, Francesca ^a   Picardo, Sergio ^a   Picca, Stefano ^a   Muraca, Maurizio ^a   Cogo, Paola ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

Acute kidney injury; Biomarkers; Intensive care unit; Pediatric critical illness; Sepsis

Indexed keywords

CREATININE; CYSTATIN C; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; ACUTE PHASE PROTEIN; BIOLOGICAL MARKER; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN;

ACUTE KIDNEY FAILURE; AMBULATORY SURGERY; ARTICLE; ARTIFICIAL VENTILATION; CHILD; CLINICAL ARTICLE; COHORT ANALYSIS; CONTINUOUS RENAL REPLACEMENT THERAPY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CRITICALLY ILL PATIENT; DIAGNOSTIC PROCEDURE; DISEASE SEVERITY; EXTRACORPOREAL OXYGENATION; FEMALE; HUMAN; INFANT; INTENSIVE CARE UNIT; MALE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; SEPSIS; BLOOD; CASE CONTROL STUDY; CRITICAL ILLNESS; KIDNEY FUNCTION TEST; PRESCHOOL CHILD; URINE;

ACUTE KIDNEY INJURY; ACUTE-PHASE PROTEINS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; CYSTATIN C; FEMALE; HUMANS; INFANT; INTENSIVE CARE UNITS, PEDIATRIC; KIDNEY FUNCTION TESTS; LIPOCALINS; MALE; PROTO-ONCOGENE PROTEINS; SEPSIS;

MLCS; MLOWN;

EID: 84879031207     PISSN: 02535068     EISSN: 14219735     Source Type: Journal    
DOI: 10.1159/000346629     Document Type: Article

References (14)

1. Bagshaw S, Bennett M, Haase M, Haase-Fielitz A, Egi M, Morimatsu H, D'amico G, Goldsmith D, Devarajan P, Bellomo R: Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med 2010; 36: 452-461.
2. Wheeler DS, Devarajan P, Ma Q, Harmon K, Monaco M, Cvijanovich N, Wong HR: Serum neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury in critically ill children with septic shock. Crit Care Med 2008; 36: 1297-1303.
3. Bailey D, Phan V, Litalien C, Ducruet T, Merouani A, Lacroix J, Gauvin F: Risk factors of acute renal failure in critically ill children: a prospective descriptive epidemiological study. Pediatr Crit Care Med 2007; 8: 29-35.
4. Abraham BP, Frazier EA, Morrow WR, Blaszak RT, Devarajan P, Mitsnefes M, Bryant JC, Sachdeva R: Cystatin C and neutrophil gelatinase-associated lipocalin as markers of renal function in pediatric heart transplant recipients. Pediatr Transplant 2011; 15: 564-569.
5. Tomino Y: Serum cystatin C. Contrib Nephrol. Basel, Karger, 2001, vol 134, pp 82-84.
6. Brierley J, Carcillo JA, Choong K, Cornell T, Decaen A, Deymann A, et al: Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit Care Med 2009; 37: 666-688.
7. Akcan-Arikan A, Zappitelli M, Loftis LL, Washburn KK, Jefferson LS, Goldstein SL: Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int 2007; 71: 1028-1035.
8. Wilkinson JD, Pollack MM, Glass NL, Kanter RK, Katz RW, Steinhart CM: Mortality associated with multiple organ system failure and sepsis in pediatric intensive care unit. J Pediatr 1987; 111: 324-328.
9. Hariharan S, Krishnamurthy K, Grannum D: Validation of Pediatric Index of Mortality-2 scoring system in a pediatric intensive care unit, Barbados. J Trop Pediatr 2011; 57: 9-13.
10. Martensson J, Bell M, Oldner A, Xu S, Venge P, Martling CR: Neutrophil gelatinase-associated lipocalin in adult septic with and without acute kidney injury. Intensive Care Med 2010; 36: 1333-1340.
11. Soni SS, Ronco C, Katz N, Cruz DN: Early diagnosis of acute kidney injury: the promise of novel biomarkers. Blood Purif 2009; 28: 165-174.
12. Lisowska-Myjak B: Serum and urinary biomarkers of acute kidney injury. Blood Purif 2010; 29: 357-365.
13. Zappitelli M, Washburn KK, Arikan AA, Loftis L, Ma Q, Devarajan P, Parikh CR, Goldstein SL: Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. Crit Care 2007; 11:R84.
14. Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P: Neutrophil gelatinase-associated lipocalin as a biomarker for acute renal injury after cardiac surgery. Lancet 2005; 365: 1231-1238.