Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells

Aging

Volumn 7, Issue 1, 2015, Pages 26-37

  Aliper, Alexander M ^a,b   Csoka, Antonei Benjamin ^c,d   Buzdin, Anton ^a,e   Jetka, Tomasz ^f   Roumiantsev, Sergey ^a,g,h   Moskalev, Alexey ^a,h,j   Zhavoronkov, Alex ^a,b,h,i  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Federal Research and Clinical Center of Pediatric Hematology   (Russian Federation)

^c Vision Genomics LLC   (United States)

^d HOWARD UNIVERSITY   (United States)

^e Personalized Medicine Pathway Pharmaceuticals Ltd   (China)

^f INSTITUTE OF FUNDAMENTAL TECHNOLOGICAL RESEARCH   (Poland)

^g PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

^h MOSCOW INSTITUTE OF PHYSICS AND TECHNOLOGY   (Russian Federation)

ⁱ The Biogerontology Research Foundation   (United Kingdom)

^j GEORGE MASON UNIVERSITY   (United States)

more..

Author keywords

Aging; Aging pathway; Geroprotectors; Geroscope; HGPS; Lamin; LMNA; Pathway activation; Pathway drift; Progeria; Senescence

Indexed keywords

AGE; AGING; CASE CONTROL STUDY; CELL AGING; CELL CULTURE; CELL PROLIFERATION; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC DATABASE; GENETIC PREDISPOSITION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PHENOTYPE; PROCEDURES; PROGERIA; SIGNAL TRANSDUCTION;

AGE FACTORS; AGING; CASE-CONTROL STUDIES; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; DATABASES, GENETIC; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; PHENOTYPE; PROGERIA; SIGNAL TRANSDUCTION;

EID: 84925135107     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100717     Document Type: Article

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