Defective lamin A-Rb signaling in Hutchinson-Gilford progeria syndrome and reversal by farnesyltransferase inhibition

PLoS ONE

Volumn 5, Issue 6, 2010, Pages

  Marji, Jackleen ^a   O'Donoghue, Seán I ^b   McClintock, Dayle ^a   Satagopam, Venkata P ^b   Schneider, Reinhard ^b   Ratner, Desiree ^a   Worman, Howard J ^a   Gordon, Leslie B ^c   Djabali, Karima ^a,d  

^a Columbia University ^*  (United States)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c BROWN UNIVERSITY   (United States)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIN; LAMIN A; LAMIN C; LONAFARNIB; PRELAMIN A; PROGERIN; PROTEIN FARNESYLTRANSFERASE; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE;

ADULT; AGED; ARTICLE; CHILD; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE MUTATION; GENOMICS; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROARRAY ANALYSIS; PATHOGENESIS; PROGERIA; SCHOOL CHILD; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; UPREGULATION; ANIMAL; DISEASE MODEL; DNA MICROARRAY; DRUG ANTAGONISM; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC ASSOCIATION; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALIA;

ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LAMIN TYPE A; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGERIA; RETINOBLASTOMA PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 77956222384     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011132     Document Type: Article

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