Therapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects (Review)

Experimental and Therapeutic Medicine

Volumn 9, Issue 5, 2015, Pages 1582-1588

  Armutcu, Ferah ^a   Akyol, Sumeyya ^b   Ustunsoy, Seyfettin ^c   Turan, Fatime Filiz ^c  

^a ISTANBUL UNIVERSITY   (Turkey)

^b TURGUT OZAL UNIVERSITY   (Turkey)

^c FATIH UNIVERSITY   (Turkey)

Author keywords

Anti inflammatory activity; Caffeic acid phenethyl ester; Immunomodulatory effect

Indexed keywords

CAFFEIC ACID PHENETHYL ESTER; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; LIPOPOLYSACCHARIDE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; NITRIC OXIDE; PHOSPHOLIPASE D1; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; XANTHINE OXIDASE;

ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ENZYME ACTIVITY; HUMAN; IMMUNOMODULATION; INFLAMMATION; SIGNAL TRANSDUCTION;

EID: 84925070736     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2015.2346     Document Type: Article

References (59)

1. Sud'ina GF, Mirzoeva OK, Pushkareva MA, Korshunova GA, Sumbatyan NV and Varfolomeev SD: Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett 329: 21-24, 1993.
2. Natarajan K, Singh S, Burke TR Jr, Grunberger D and Aggarwal BB: Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci USA 93: 9090-9095, 1996.
3. Koltuksuz U, Mutus HM, Kutlu R, Ozyurt H, Cetin S, Karaman A, Gürbüz N, Akyol O and Aydin NE: Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats. J Pediatr Surg 36: 1504-1509, 2001.
4. Akyol S, Ozturk G, Ginis Z, Armutcu F, Yigitoglu MR and Akyol O: In vivo and in vitro antineoplastic actions of caffeic acid phenethyl ester (CAPE): Therapeutic perspectives. Nutr Cancer 65: 515-526, 2013.
5. Czermak BJ, Friedl HP and Ward PA: Complement, cytokines, and adhesion molecule expression in inflammatory reactions. Proc Assoc Am Physicians 110: 306-312, 1998.
6. Ley K, Laudanna C, Cybulsky MI and Nourshargh S: Getting to the site of inflammation: The leukocyte adhesion cascade updated. Nat Rev Immunol 7: 678-689, 2007.
7. Wang X, Pang J, Maffucci JA, Pade DS, Newman RA, Kerwin SM, Bowman PD and Stavchansky S: Pharmacokinetics of caffeic acid phenethyl ester and its catechol-ring fluorinated derivative following intravenous administration to rats. Biopharm Drug Dispos 30: 221-228, 2009.
8. Eming SA, Krieg T and Davidson JM: Inflammation in wound repair: Molecular and cellular mechanisms. J Invest Dermatol 127: 514-525, 2007.
9. Coussens LM and Werb Z: Inflammation and cancer. Nature 420: 860-867, 2002.
10. Leder C, Ziegler M and Gawaz M: Modulating immune responses and inflammation. Semin Thromb Hemost 36: 219-222, 2010.
11. Stow JL and Murray RZ: Intracellular trafficking and secretion of inflammatory cytokines. Cytokine Growth Factor Rev 24: 227-239, 2013.
12. Dinarello CA: Proinflammatory cytokines. Chest 118: 503-508, 2000.
13. Sabio G and Davis RJ: TNF and MAP kinase signalling pathways. Semin Immunol 26: 237-245, 2014.
14. Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA and Sorger PK: The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell 124: 1225-1239, 2006.
15. Ghosh S, May MJ and Kopp EB: NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16: 225-260, 1998.
16. Chen F, Castranova V, Shi X and Demers LM: New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 45: 7-17, 1999.
17. Tak PP and Firestein GS: NF-kappaB: A key role in inflammatory diseases. J Clin Invest 107: 7-11, 2001.
18. Muller DN, Dechend R, Mervaala EM, Park JK, Schmidt F, Fiebeler A, Theuer J, Breu V, Ganten D, Haller H and Luft FC: NF-kappaB inhibition ameliorates angiotensin II-induced inflammatory damage in rats. Hypertension 35: 193-201, 2000.
19. Jura J, Wegrzyn P, Korostynski M, Guzik K, Oczko-Wojciechowska M, Jarzab M, Kowalska M, Piechota M, Przewlocki R and Koj A: Identification of interleukin-1 and interleukin-6-responsive genes in human monocyte-derived macrophages using microarrays. Biochim Biophys Acta 1779: 383-389, 2008.
20. Bonizzi G and Karin M: The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25: 280-288, 2004.
21. Song YS, Park EH, Hur GM, Ryu YS, Lee YS, Lee JY, Kim YM and Jin C: Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity. Cancer Lett 175: 53-61, 2002.
22. Ilhan A, Akyol O, Gurel A, Armutcu F, Iraz M and Oztas E: Protective effects of caffeic acid phenethyl ester against experimental allergic encephalomyelitis-induced oxidative stress in rats. Free Radic Biol Med 37: 386-394, 2004.
23. Toyoda T, Tsukamoto T, Takasu S, Shi L, Hirano N, Ban H, Kumagai T and Tatematsu M: Anti-inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor-kappaB inhibitor, on Helicobacter pylori-induced gastritis in Mongolian gerbils. Int J Cancer 125: 1786-1795, 2009.
24. Naito Y and Yoshikawa T: Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress. Free Radic Biol Med 33: 323-336, 2002.
25. Keates S, Hitti YS, Upton M and Kelly CP: Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells. Gastroenterology 113: 1099-1109, 1997.
26. Aihara M, Tsuchimoto D, Takizawa H, Azuma A, Wakebe H, Ohmoto Y, Imagawa K, Kikuchi M, Mukaida N and Matsushima K: Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45. Infect Immun 65: 3218-3224, 1997.
27. Orban Z, Mitsiades N, Burke TR Jr, Tsokos M and Chrousos GP: Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation. Neuroimmunomodulation 7: 99-105, 2000.
28. Hosnuter M, Gürel A, Babucçu O, Armutcu F, Kargi E and Isikdemir A: The effect of CAPE on lipid peroxidation and nitric oxide levels in the plasma of rats following thermal injury. Burns 30: 121-125, 2004.
29. Armutcu F, Gürel A, Hosnuter M, Pabuçcu O and Altnyazar C: Caffeic acid phenethyl ester improves oxidative erythrocyte damage in a rat model of thermal injury. J Burn Care Rehabil 25: 171-178, 2004.
30. dos Santos JS and Monte-Alto-Costa A: Caffeic acid phenethyl ester improves burn healing in rats through anti-inflammatory and antioxidant effects. J Burn Care Res 34: 682-688, 2013.
31. Khan M, Elango C, Ansari MA, Singh I and Singh AK: Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. J Neurochem 102: 365-377, 2007.
32. Jung WK, Choi I, Lee DY, et al: Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38/ERK and NF-kappaB pathways. Int J Biochem Cell Biol 40: 2572-2582, 2008.
33. Lee KW, Chun KS, Lee JS, Kang KS, Surh YJ and Lee HJ: Inhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester. Ann NY Acad Sci 1030: 501-507, 2004.
34. Shen YC, Yen JC and Liou KT: Ameliorative effects of caffeic acid phenethyl ester on an eccentric exercise-induced skeletal muscle injury by down-regulating NF-?b mediated inflammation. Pharmacology 91: 219-228, 2013.
35. Juman S, Yasui N, Ikeda K, Ueda A, Sakanaka M, Negishi H and Miki T: Caffeic acid phenethyl ester suppresses the production of pro-inflammatory cytokines in hypertrophic adipocytes through lipopolysaccharide-stimulated macrophages. Biol Pharm Bull 35: 1941-1946, 2012.
36. Kassim M, Mansor M, Kamalden TA, Shariffuddin II, Hasan MS, Ong G, Sekaran SD, Suhaimi A, Al-Abd N and Yusoff KM: Caffeic acid phenethyl ester (CAPE): Scavenger of peroxynitrite in vitro and in sepsis models. Shock 42: 154-160, 2014.
37. Balkwill F and Mantovani A: Inflammation and cancer: Back to Virchow? Lancet 357: 539-545, 2001.
38. Carrasco-Legleu CE, Márquez-Rosado L, Fattel-Fazenda S, Arce-Popoca E, Pérez-Carreón JI and Villa-Treviño S: Chemoprotective effect of caffeic acid phenethyl ester on promotion in a medium-term rat hepatocarcinogenesis assay. Int J Cancer 108: 488-492, 2004.
39. Cao Q, Kaur C, Wu CY, Lu J and Ling EA: Nuclear factor-kappa B regulates Notch signaling in production of proinflammatory cytokines and nitric oxide in murine BV-2 microglial cells. Neuroscience 192: 140-154, 2011.
40. Omene CO, Wu J and Frenkel K: Caffeic Acid Phenethyl Ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells. Invest New Drugs 30: 1279-1288, 2012.
41. Coimbra M, Crielaard BJ, Storm G and Schiffelers RM: Critical factors in the development of tumor-targeted anti-inflammatory nanomedicines. J Control Release 160: 232-238, 2012.
42. Chen YJ, Shiao MS and Wang SY: The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells. Anticancer Drugs 12: 143-149, 2001.
43. Watabe M, Hishikawa K, Takayanagi A, Shimizu N and Nakaki T: Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells. J Biol Chem 279: 6017-6026, 2004.
44. Lee YT, Don MJ, Hung PS, Shen YC, Lo YS, Chang KW, Chen CF and Ho LK: Cytotoxicity of phenolic acid phenethyl esters on oral cancer cells. Cancer Lett 223: 19-25, 2005.
45. Park MH, Kang DW, Jung Y, Choi KY and Min S: Caffeic acid phenethyl ester downregulates phospholipase D1 via direct binding and inhibition of NF?B transactivation. Biochem Biophys Res Commun 442: 1-7, 2013.
46. Yilmaz A, Yildirim O, Tamer L, et al: Effects of caffeic acid phenethyl ester on endotoxin-induced uveitis in rats. Curr Eye Res 30: 755-762, 2005.
47. Shvarzbeyn J and Huleihel M: Effect of propolis and caffeic acid phenethyl ester (CAPE) on NF?B activation by HTLV-1 Tax. Antiviral Res 90: 108-115, 2011.
48. Lee Y, Shin DH, Kim JH, et al: Caffeic acid phenethyl ester-mediated Nrf2 activation and IkappaB kinase inhibition are involved in NFkappaB inhibitory effect: Structural analysis for NFkappaB inhibition. Eur J Pharmacol 643: 21-28, 2010.
49. Bezerra RM, Veiga LF, Caetano AC, Rosalen PL, Amaral ME, Palanch AC and de Alencar SM: Caffeic acid phenethyl ester reduces the activation of the nuclear factor ?B pathway by high-fat diet-induced obesity in mice. Metabolism 61: 1606-1614, 2012.
50. Wang LC, Lin YL, Liang YC, et al: The effect of caffeic acid phenethyl ester on the functions of human monocyte-derived dendritic cells. BMC Immunol 10: 39, 2009.
51. Márquez N, Sancho R, Macho A, Calzado MA, Fiebich BL and Muñoz E: Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors. J Pharmacol Exp Ther 308: 993-1001, 2004.
52. Mirzoeva OK and Calder PC: The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot Essent Fatty Acids 55: 441-449, 1996.
53. Hart LA, Krishnan VL, Adcock IM, Barnes PJ and Chung KF: Activation and localization of transcription factor, nuclear factor-kappaB, in asthma. Am J Respir Crit Care Med 158: 1585-1592, 1998.
54. Jung WK, Lee DY, Choi YH, Yea SS, Choi I, Park SG, Seo SK, Lee SW, Lee CM, Kim SK, et al: Caffeic acid phenethyl ester attenuates allergic airway inflammation and hyperresponsiveness in murine model of ovalbumin-induced asthma. Life Sci 82: 797-805, 2008.
55. Choi IW, Kim DK, Ko HM and Lee HK: Administration of antisense phosphorothioate oligonucleotide to the p65 subunit of NF-kappaB inhibits established asthmatic reaction in mice. Int Immunopharmacol 4: 1817-1828, 2004.
56. Park JH, Lee JK, Kim HS, Chung ST, Eom JH, Kim KA, Chung SJ, Paik SY and Oh HY: Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice. Int Immunopharmacol 4: 429-436, 2004.
57. Park SG, Lee DY, Seo SK, Lee SW, Kim SK, Jung WK, Kang MS, Choi YH, Yea SS, Choi I and Choi IW: Evaluation of anti-allergic properties of caffeic acid phenethyl ester in a murine model of systemic anaphylaxis. Toxicol Appl Pharmacol 226: 22-29, 2008.
58. Nader MA: Caffeic acid phenethyl ester attenuates IgE-induced immediate allergic reaction. Inflammopharmacology 21: 169-176, 2013.
59. Yamamoto Y and Gaynor RB: Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J Clin Invest 107: 135-142, 2001.