Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity

Cancer Letters

Volumn 175, Issue 1, 2002, Pages 53-61

  Song, Yun Seon ^a   Park, Eun Hee ^b   Hur, Gang Min ^c   Ryu, Young Sue ^c   Lee, Yong Sup ^a   Lee, Jae Yeol ^a   Kim, Yong Man ^d   Jin, Changbae ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Sookmyung Women's University   (South Korea)

^c Chungnam National University   (South Korea)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Caffeic acid phenethyl ester; Inducible nitric oxide synthase; iNOS activity; NF B; Promoter activity

Indexed keywords

CAFFEIC ACID PHENETHYL ESTER; CHLORAMPHENICOL ACETYLTRANSFERASE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE SYNTHASE; RECOMBINANT ENZYME;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE;

ANIMALS; CAFFEIC ACIDS; CELL LINE; CYTOTOXINS; DNA PRIMERS; GENE EXPRESSION REGULATION; INTERFERON-GAMMA, RECOMBINANT; KINETICS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PHENYLETHYL ALCOHOL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

APIS MELLIFERA; MURINAE; PROPOLIS;

EID: 0037049887     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00787-X     Document Type: Article

References (39)

1. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation
2. NO at work
3. Nitric oxide synthases: Roles, tolls, and controls
4. Nitric oxide synthase: Aspects concerning structure and catalysis
5. Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon gamma and lipopolysaccharide
6. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide
7. NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules
8. Inhibition of neutrophils' chemiluminescence by ethanol extract of propolis (EEP) and its phenolic components
9. Hydroxylated aromatic inhibitors of HIV-1 integrase
10. Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis
11. Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties
12. Lipophilic derivatives of caffeic acid as lipoxygenase inhibitors with antioxidant properties
13. Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon
14. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B
15. Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation
16. Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation
17. The effect of propolis and its components on eicosanoid production during the inflammatory response
18. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
19. Upstream NF-kappaB site is required for the maximal expression of mouse inducible nitric oxide synthase gene in interferon-gamma plus lipopolysaccharide-induced RAW 264.7 macrophages
20. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
21. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro
22. The mode of action of aspirin-like drugs: Effect on inducible nitric oxide synthase
23. Inhibition of oxidative stress in HeLa cells by chemopreventive agents
24. Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester
25. The role of nitric oxide in inflammation and immunity
26. Inducible nitric oxide synthase in human diseases
27. Function and activation of NF-kappa B in the immune system
28. IKK-1 and IKK-2: Cytokine-activated IkappaB kinases essential for NF- kappaB activation
29. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
30. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
31. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation
32. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176
33. Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
34. MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta
35. Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
36. Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cells: The potential role of transcription factor NF-kappaB
37. Expression of v-src in T cells correlates with nuclear expression of NF-kappa B
38. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells