Inhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester

Annals of the New York Academy of Sciences

Volumn 1030, Issue , 2004, Pages 501-507

  Lee, Ki Won ^a   Chun, Kyung Soo ^a   Lee, Jeong Sang ^a   Kang, Kyung Sun ^a   Surh, Young Joon ^a   Lee, Hyong Joo ^a  

^a Seoul National University   (South Korea)

Author keywords

Caffeic acid phenethyl ester; Cyclooxygenase 2; Gap junction intercellular communication; H ras; Nuclear factor B; Rat liver epithelial cells

Indexed keywords

CAFFEIC ACID PHENETHYL ESTER; CONNEXIN 43; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL CELL; ANIMAL TISSUE; CELL COMMUNICATION; CELL TRANSFORMATION; CONFERENCE PAPER; DNA BINDING; ENZYME INHIBITION; GAP JUNCTION; HONEY; NONHUMAN; PHYTOCHEMISTRY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

PROPOLIS;

EID: 15044342684     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1329.062     Document Type: Conference Paper

References (13)

1. SURH, Y.-J., K.-S. CHUN, H.-H. CHA, et al. 2001. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mutat. Res. 480-481: 243-268.
2. ROSENKRANZ, H.S., N. POLLACK & A.R. CUNNINGHAM. 2000. Exploring the relationship between the inhibition of gap junctional intercellular communication and other biological phenomena. Carcinogenesis 21: 1007-1011.
3. TROSKO, J.E. & C.C. CHANG. 2000. Modulation of cell-cell communication in the cause and chemoprevention/chemotherapy of cancer. Biofactors 12: 259-263.
4. NA, H.K. & Y.-J. SURH. 2002. Induction of cyclooxygenase-2 in ras-transformed human mammary epithelial cells undergoing apoptosis. Ann. N.Y. Acad. Sci. 973: 153-160.
5. HAYAHI, T., K. NOMATA, C.C. CHANG, et al. 1998. Cooperative effects of v-myc and c-Ha-ras oncogenes on gap junctional intercellular communication and tumorigenicity in rat liver epithelial cells. Cancer Lett. 128: 145-154.
6. SURH, Y.-J. 2003. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 3: 768-780.
7. Su, Z.Z., J. LIN, M. PREWETT, et al. 1998. Apoptosis mediates the selective toxicity of caffeic acid phenethyl ester (CAPE) toward oncogene-transformed rat embryo fibroblast cells. Anticancer Res. 15: 1841-1848.
8. BORRELLI, F., A.A. IZZO, G. DI CARLO, et al. 2002. Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon. Fitoterapia 73: S38-S43.
9. NATARAJAN, K., S. SINGH, T.R. BURKE, JR., et al. 1996. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB. Proc. Natl. Acad. Sci. USA 93: 9090-9095.
10. KIM, J.Y., K.W. LEE, S.H. KIM, et al. 2002. Inhibitory effect of tumor cell proliferation and induction of G2/M cell cycle arrest by panaxytriol. Planta Med. 68: 119-122.
11. CHO, J.H., S.D. CHO, H. HU, et al. 2002. The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide. Carcinogenesis 23: 1163-1169.
12. CHUN, K.-S., Y.-S. KEUM, S.S. HAN, et al. 2003. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-κB activation. Carcinogenesis 24: 1515-1524.
13. MOON, A., M.S. KIM, T.G. KIM, et al. 2000. H-ras, but not N-ras, induces an invasive phenotype in human breast epithelial cells: a role for MMP-2 in the H-ras-induced invasive phenotype. Int. J. Cancer 85: 176-181.