The long pentraxin PTX3 promotes fibrocyte differentiation

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Pilling, Darrell ^a   Cox, Nehemiah ^a   Vakil, Varsha ^b   Verbeek, J Sjef ^c   Gomer, Richard H ^a,b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b RICE UNIVERSITY   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; FC RECEPTOR; FC RECEPTOR I; PENTRAXIN 3; SERUM AMYLOID P; UNCLASSIFIED DRUG; C REACTIVE PROTEIN; FCGR1 PROTEIN, MOUSE; FCGR1A PROTEIN, HUMAN; NERVE PROTEIN; NEURONAL PENTRAXIN;

ARTICLE; BINDING COMPETITION; BINDING SITE; CELL DIFFERENTIATION; CELLS BY BODY ANATOMY; CONTROLLED STUDY; FIBROCYTE; HUMAN; HUMAN CELL; LUNG FIBROSIS; LUNG PARENCHYMA; MONOCYTE; MURINE MODEL; PROTEIN BINDING; PROTEIN LOCALIZATION; ANIMAL; FEMALE; FIBROBLAST; LUNG; MALE; METABOLISM; MOUSE; PATHOLOGY;

MURINAE;

ANIMALS; C-REACTIVE PROTEIN; CELL DIFFERENTIATION; FEMALE; FIBROBLASTS; HUMANS; LUNG; MALE; MICE; MONOCYTES; NERVE TISSUE PROTEINS; PULMONARY FIBROSIS; RECEPTORS, IGG; SERUM AMYLOID P-COMPONENT;

EID: 84925061777     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0119709     Document Type: Article

References (112)

1. Auffray C, Sieweke MH, Geissmann F (2009) Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells. Annual Review of Immunology 27: 669-692. doi: 10.1146/annurev. immunol.021908.132557 PMID: 19132917
2. Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A (1994) Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Molecular Medicine 1: 71-81. PMID: 8790603
3. Reilkoff RA, Bucala R, Herzog EL (2011) Fibrocytes: emerging effector cells in chronic inflammation. Nat Rev Immunol 11: 427-435. doi: 10.1038/nri2990 PMID: 21597472
4. Abe R, Donnelly SC, Peng T, Bucala R, Metz CN (2001) Peripheral blood fibrocytes: Differentiation pathway and migration to wound sites. Journal of Immunology 166: 7556-7562. PMID: 11390511
5. Pilling D, Buckley CD, Salmon M, Gomer RH (2003) Inhibition of fibrocyte differentiation by serum amyloid P. Journal Of Immunology 17: 5537-5546.
6. Pilling D, Fan T, Huang D, Kaul B, Gomer RH (2009) Identification of markers that distinguish monocyte- derived fibrocytes from monocytes, macrophages, and fibroblasts. PLOS ONE 4: e7475. doi: 10.1371/journal.pone.0007475 PMID: 19834619
7. Phillips RJ, Burdick MD, Hong K, Lutz MA, Murray LA, et al. (2004) Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J ClinInvest 114: 438-446.
8. Haudek SB, Xia Y, Huebener P, Lee JM, Carlson S, et al. (2006) Bone Marrow-derived Fibroblast Precursors Mediate Ischemic Cardiomyopathy in Mice. Proceedings of the National Academy of Sciences 103: 18284-18289. PMID: 17114286
9. Kisseleva T, Uchinami H, Feirt N, Quintana-Bustamante O, Segovia JC, et al. (2006) Bone marrowderived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol 45: 429-438. PMID: 16846660
10. Mehrad B, Burdick MD, Zisman DA, Keane MP, Belperio JA, et al. (2007) Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease. Biochem Biophys Res Commun 353: 104-108. PMID: 17174272
11. Sakai N, Furuichi K, Shinozaki Y, Yamauchi H, Toyama T, et al. (2010) Fibrocytes are involved in the pathogenesis of human chronic kidney disease. Human pathology 41: 672-678. doi: 10.1016/j. humpath.2009.10.008 PMID: 20040395
12. Shao DD, Suresh R, Vakil V, Gomer RH, Pilling D (2008) Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation. Journal of Leukocyte Biology 83: 1323-1333. doi: 10.1189/jlb.1107782 PMID: 18332234
13. Maharjan AS, Pilling D, Gomer RH (2011) High and Low Molecular Weight Hyaluronic Acid Differentially Regulate Human Fibrocyte Differentiation. PLOS One 6: e26078. doi: 10.1371/journal.pone. 0026078 PMID: 22022512
14. Lu J, Marjon KD, Mold C, Du Clos TW, Sun PD (2012) Pentraxins and Fc receptors. Immunological Reviews 250: 230-238. doi: 10.1111/j.1600-065X.2012.01162.x PMID: 23046133
15. Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M (2013) Macrophage plasticity and polarization in tissue repair and remodelling. The Journal of Pathology 229: 176-185. doi: 10.1002/path.4133 PMID: 23096265
16. Deban L, Jaillon S, Garlanda C, Bottazzi B, Mantovani A (2011) Pentraxins in innate immunity: Lessons from PTX3. Cell Tissue Res 343: 237-249. doi: 10.1007/s00441-010-1018-0 PMID: 20683616
17. Bottazzi B, Doni A, Garlanda C, Mantovani A (2010) An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm. Annual Review of Immunology 28: 157-183. doi: 10.1146/annurevimmunol- 030409-101305 PMID: 19968561
18. Wagenaar JF, Goris MG, Gasem MH, Isbandrio B, Moalli F, et al. (2009) Long pentraxin PTX3 is associated with mortality and disease severity in severe Leptospirosis. J Infect 58: 425-432. doi: 10.1016/ j.jinf.2009.04.004 PMID: 19443038
19. Sprong T, Peri G, Neeleman C, Mantovani A, Signorini S, et al. (2009) Pentraxin 3 and C-reactive protein in severe meningococcal disease. Shock 31: 28-32. doi: 10.1097/SHK.0b013e31817fd543 PMID: 18650775
20. Hawkins PN, Tennent GA, Woo P, Pepys MB (1991) Studies in vivo and in vitro of serum amyloid P component in normals and in a patient with AA amyloidosis. ClinExpImmunol 84: 308-316.
21. Pilling D, Roife D, Wang M, Ronkainen SD, Crawford JR, et al. (2007) Reduction of bleomycin-induced pulmonary fibrosis by serum amyloid P. The Journal of Immunology 179: 4035-4044. PMID: 17785842
22. Castano AP, Lin SL, Surowy T, Nowlin BT, Turlapati SA, et al. (2009) Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo. Science translational medicine 1: 5ra13. doi: 10.1126/scitranslmed.3000111 PMID: 20368175
23. Maharjan AS, Roife D, Brazill D, Gomer RH (2013) Serum amyloid P inhibits granulocyte adhesion. Fibrogenesis Tissue Repair 6: doi: 10.1186/1755-1536-6-2 PMID: 23324174
24. Murray LA, Rosada R, Moreira AP, Joshi A, Kramer MS, et al. (2010) Serum Amyloid P Therapeutically Attenuates Murine Bleomycin-Induced Pulmonary Fibrosis via Its Effects on Macrophages. PLOS ONE 5: e9683. doi: 10.1371/journal.pone.0009683 PMID: 20300636
25. Dillingh MR, van den Blink B, Moerland M, van Dongen MGJ, Levi M, et al. (2013) Recombinant human serum amyloid P in healthy volunteers and patients with pulmonary fibrosis. Pulmonary Pharmacology & Therapeutics 26: 672-676
26. Li ZI, Chung AC, Zhou L, Huang XR, Liu F, et al. (2011) C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice. Lab Invest 91: 837-851. doi: 10.1038/labinvest.2011.42 PMID: 21383672
27. Teoh H, Quan A, Lovren F, Wang G, Tirgari S, et al. (2008) Impaired endothelial function in C-reactive protein overexpressing mice. Atherosclerosis 201: 318-325. doi: 10.1016/j.atherosclerosis.2008.02. 034 PMID: 18433756
28. Liu F, Chen HY, Huang XR, Chung AC, Zhou L, et al. (2011) C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes. Diabetologia 54: 2713-2723. doi: 10.1007/s00125- 011-2237-y PMID: 21744073
29. Pegues MA, McCrory MA, Zarjou A, Szalai AJ (2013) C-reactive protein exacerbates renal ischemiareperfusion injury. American Journal of Physiology-Renal Physiology 304: F1358-F1365.
30. Mantovani A, Valentino S, Gentile S, Inforzato A, Bottazzi B, et al. (2013) The long pentraxin PTX3: A paradigm for humoral pattern recognition molecules. Annals of the New York Academy of Sciences 1285: 1-14. doi: 10.1111/nyas.12043 PMID: 23527487
31. Bonacina F, Baragetti A, Catapano AL, Norata GD (2013) Long Pentraxin 3: Experimental and Clinical Relevance in Cardiovascular Diseases. Mediators of Inflammation 2013:10
32. Crawford JR, Pilling D, Gomer RH (2012) FcγRI mediates serum amyloid P inhibition of fibrocyte differentiation. Journal of Leukocyte Biology 92: 699-711. doi: 10.1189/jlb.0112033 PMID: 22493081
33. Haudek SB, Trial J, Xia Y, Gupta D, Pilling D, et al. (2008) Fc Receptor Engagement Mediates Differentiation of Cardiac Fibroblast Precursor Cells. Proceedings of the National Academy of Sciences 105: 10179-10184 doi: 10.1073/pnas.0804910105 PMID: 18632582
34. Lu J, Marnell LL, Marjon KD, Mold C, Du Clos TW, et al. (2008) Structural recognition and functional activation of FcgR by innate pentraxins. Nature 456: 989-992. doi: 10.1038/nature07468 PMID: 19011614
35. Bharadwaj D, Mold C, Markham E, Du Clos TW (2001) Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis. JImmunol 166: 6735-6741. PMID: 11359830
36. Nimmerjahn F, Ravetch JV (2008) Fcgamma receptors as regulators of immune responses. Nat Rev Immunol 8: 34-47. PMID: 18064051
37. Bruhns P, Iannascoli B, England P, Mancardi DA, Fernandez N, et al. (2009) Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Blood 113: 3716-3725. doi: 10.1182/blood-2008-09-179754 PMID: 19018092
38. Bruhns P (2012) Properties of mouse and human IgG receptors and their contribution to disease models. Blood 119: 5640-5649. doi: 10.1182/blood-2012-01-380121 PMID: 22535666
39. Nimmerjahn F, Ravetch JV (2006) Fcgamma receptors: Old friends and new family members. Immunity 24: 19-28. PMID: 16413920
40. Ravetch JV, Lanier LL (2000) Immune inhibitory receptors. Science 290: 84-89. PMID: 11021804
41. Pilling D, Tucker NM, Gomer RH (2006) Aggregated IgG inhibits the differentiation of human fibrocytes. Journal Of Leukocyte Biology 79: 1242-1251. PMID: 16543402
42. Pilling D, Vakil V, Gomer RH (2009) Improved serum-free culture conditions for the differentiation of human and murine fibrocytes. Journal of Immunological Methods 351: 62-70. doi: 10.1016/j.jim. 2009.09.011 PMID: 19818792
43. Maharjan AS, Pilling D, Gomer RH (2010) Toll-like receptor 2 agonists inhibit human fibrocyte differentiation. Fibrogenesis Tissue Repair 3: 23 doi: 10.1186/1755-1536-3-23 PMID: 21106092
44. White MJV, Glenn M, Gomer RH (2013) Trypsin Potentiates Human Fibrocyte Differentiation. PLOS ONE 8: e70795. doi: 10.1371/journal.pone.0070795 PMID: 23951012
45. Cox N, Pilling D, Gomer RH (2014) Distinct Fcγ Receptors Mediate the Effect of Serum Amyloid P on Neutrophil Adhesion and Fibrocyte Differentiation. The Journal of Immunology 193: 1701-1708. doi: 10.4049/jimmunol.1400281 PMID: 25024390
46. Ioan-Facsinay A, de Kimpe SJ, Hellwig SM, van Lent PL, Hofhuis FM, et al. (2002) FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity 16: 391-402. PMID: 11911824
47. Hazenbos WL, Gessner JE, Hofhuis FM, Kuipers H, Meyer D, et al. (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity 5: 181-188. PMID: 8769481
48. Boross P, Arandhara VL, Martin-Ramirez J, Santiago-Raber M-L, Carlucci F, et al. (2011) The Inhibiting Fc Receptor for IgG, FcγRIIB, Is a Modifier of Autoimmune Susceptibility. The Journal of Immunology 187: 1304-1313. doi: 10.4049/jimmunol.1101194 PMID: 21724994
49. Crawford JR, Pilling D, Gomer RH (2010) Improved serum-free culture conditions for spleen-derived murine fibrocytes. Journal Of Immunological Methods 363: 9-20. doi: 10.1016/j.jim.2010.09.025 PMID: 20888336
50. Pilling D, Gomer RH (2014) Persistent Lung Inflammation and Fibrosis in Serum Amyloid P Component (Apcs-/-) Knockout Mice. PLOS ONE 9: e93730. doi: 10.1371/journal.pone.0093730 PMID: 24695531
51. Pilling D, Crawford JR, Verbeek JS, Gomer RH (2014) Inhibition of murine fibrocyte differentiation by cross-linked IgG is dependent on FcγRI. Journal of Leukocyte Biology
52. Herlihy SE, Pilling D, Maharjan AS, Gomer RH (2013) Dipeptidyl Peptidase IV Is a Human and Murine Neutrophil Chemorepellent. The Journal of Immunology 190: 6468-6477. doi: 10.4049/jimmunol. 1202583 PMID: 23677473
53. Seiler CY, Park JG, Sharma A, Hunter P, Surapaneni P, et al. (2014) DNASU plasmid and PSI:Biology- Materials repositories: resources to accelerate biological research. Nucleic Acids Res 42: D1253- 1260. doi: 10.1093/nar/gkt1060 PMID: 24225319
54. Boonnak K, Slike BM, Donofrio GC, Marovich MA (2013) Human FcγRII Cytoplasmic Domains Differentially Influence Antibody-Mediated Dengue Virus Infection. The Journal of Immunology 190: 5659-5665. doi: 10.4049/jimmunol.1203052 PMID: 23616574
55. Moalli F, Doni A, Deban L, Zelante T, Zagarella S, et al. (2010) Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus. Blood 116: 5170-5180. doi: 10.1182/blood-2009-12-258376 PMID: 20829368
56. Cox N, Pilling D, Gomer RH (2012) NaCl Potentiates Human Fibrocyte Differentiation. PLOS One 7: e45674. doi: 10.1371/journal.pone.0045674 PMID: 23029177
57. Bianchetti L, Barczyk M, Cardoso J, Schmidt M, Bellini A, et al. (2012) Extracellular matrix remodelling properties of human fibrocytes. Journal of Cellular and Molecular Medicine 16: 483-495. doi: 1111/j.1582-4934.2011.01344.x PMID: 21595824
58. Nebuloni M, Pasqualini F, Zerbi P, Lauri E, Mantovani A, et al. (2011) PTX3 expression in the heart tissues of patients with myocardial infarction and infectious myocarditis. Cardiovasc Pathol 20: e27-35. doi: 10.1016/j.carpath.2010.02.005 PMID: 20356766
59. Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, et al. (2012) Pentraxin 3 (PTX3) Expression in Allergic Asthmatic Airways: Role in Airway Smooth Muscle Migration and Chemokine Production. PLOS ONE 7: e34965. doi: 10.1371/journal.pone.0034965 PMID: 22529962
60. Balhara J, Koussih L, Zhang J, Gounni AS (2013) Pentraxin 3: An Immuno-regulator in the Lungs. Frontiers in Immunology 4.
61. Nauta AJ, de Haij S, Bottazzi B, Mantovani A, Borrias MC, et al. (2005) Human renal epithelial cells produce the long pentraxin PTX3. Kidney Int 67: 543-553. PMID: 15673302
62. Introna M, Alles VV, Castellano M, Picardi G, De Gioia L, et al. (1996) Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites. Blood 87: 1862-1872. PMID: 8634434
63. Lee GW, Lee TH, Vilcek J (1993) TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. The Journal of Immunology 150: 1804-1812. PMID: 7679696
64. Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S (2003) Identification of Circulating Fibrocytes as Precursors of Bronchial Myofibroblasts in Asthma. The Journal of Immunology 171: 380-389. PMID: 12817021
65. Quan TE, Cowper S, Wu SP, Bockenstedt LK, Bucala R (2004) Circulating fibrocytes: collagen-secreting cells of the peripheral blood. The International Journal of Biochemistry & Cell Biology 36: 598-606.
66. Yang L, Scott PG, Dodd C, Medina A, Jiao H, et al. (2005) Identification of fibrocytes in postburn hypertrophic scar. Wound Repair and Regeneration 13: 398-404. PMID: 16008729
67. Mori L, Bellini A, Stacey MA, Schmidt M, Mattoli S (2005) Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone marrow. Experimental Cell Research 304: 81-90. PMID: 15707576
68. Andersson-Sjöland A, de Alba CG, Nihlberg K, Becerril C, Ramírez R, et al. (2008) Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis. The International Journal of Biochemistry & Cell Biology 40: 2129-2140.
69. Aiba S, Tagami H (1997) Inverse correlation between CD34 expression and proline-4-hydroxylase immunoreactivity on spindle cells noted in hypertrophic scars and keloids. J Cutan Pathol 24: 65-69. PMID: 9162737
70. Cowper SE (2003) Nephrogenic fibrosing dermopathy: The first 6 years. CurrOpinRheumatol 15: 785-790.
71. Hashimoto N, Jin H, Liu T, Chensue SW, Phan SH (2004) Bone marrow-derived progenitor cells in pulmonary fibrosis. Journal Of Clinical Investigation 113: 243-252. PMID: 14722616
72. Moore BB, Murray L, Das A, Wilke CA, Herrygers AB, et al. (2006) The Role of CCL12 in the Recruitment of Fibrocytes and Lung Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 35: 175-181. PMID: 16543609
73. Direkze NC, Forbes SJ, Brittan M, Hunt T, Jeffery R, et al. (2003) Multiple Organ Engraftment by Bone-Marrow-Derived Myofibroblasts and Fibroblasts in Bone-Marrow-Transplanted Mice. Stem Cells 21: 514-520. PMID: 12968105
74. Epperly MW, Guo H, Gretton JE, Greenberger JS (2003) Bone Marrow Origin of Myofibroblasts in Irradiation Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 29: 213-224. PMID: 12649121
75. Varcoe RL, Mikhail M, Guiffre AK, Pennings G, Vicaretti M, et al. (2006) The role of the fibrocyte in intimal hyperplasia. J ThrombHaemost 4: 1125-1133. PMID: 16689767
76. Sakai N, Wada T, Yokoyama H, Lipp M, Ueha S, et al. (2006) Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis. Proceedings of the National Academy of Sciences 103: 14098-14103. PMID: 16966615
77. Santhiago MR, Singh V, Barbosa FL, Agrawal V, Wilson SE (2011) Monocyte development inhibitor PRM-151 decreases corneal myofibroblast generation in rabbits. Experimental Eye Research 93: 810-817. doi: 10.1016/j.exer.2011.09.012 PMID: 21978952
78. Sakai N, Wada T, Matsushima K, Bucala R, Iwai M, et al. (2008) The renin-angiotensin system contributes to renal fibrosis through regulation of fibrocytes. Journal of Hypertension 26: 780-790 710.1097/HJH.1090b1013e3282f1093e1099e1096. doi: 10.1097/HJH.0b013e3282f3e9e6 PMID: 18327089
79. Hartlapp I, Abe R, Saeed RW, Peng T, Voelter W, et al. (2001) Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo. The FASEB Journal 15: 2215-2224. PMID: 11641248
80. Smadja DM, Dorfmüller P, Guerin CL, Bieche I, Badoual C, et al. (2014) Cooperation between human fibrocytes and endothelial colony-forming cells increases angiogenesis via the CXCR4 pathway. Thrombosis and Haemostasis 112: 1002-1013. doi: 10.1160/TH13-08-0711 PMID: 25103869
81. Wang JF, Jiao H, Stewart TL, Shankowsky HA, Scott PG, et al. (2007) Fibrocytes from burn patients regulate the activities of fibroblasts. Wound Repair Regen 15: 113-121. PMID: 17244327
82. Kleaveland KR, Moore BB, Kim KK (2014) Paracrine functions of fibrocytes to promote lung fibrosis. Expert Review of Respiratory Medicine 8: 163-172. doi: 10.1586/17476348.2014.862154 PMID: 24451025
83. Han B, Mura M, Andrade CF, Okutani D, Lodyga M, et al. (2005) TNFa-Induced Long Pentraxin PTX3 Expression in Human Lung Epithelial Cells via JNK. The Journal of Immunology 175: 8303-8311. PMID: 16339571
84. Okutani D, Han B, Mura M, Waddell TK, Keshavjee S, et al. (2007) High-volume ventilation induces pentraxin 3 expression in multiple acute lung injury models in rats. American Journal of Physiology- Lung Cellular and Molecular Physiology 292: L144-L153.
85. Pauwels NS, Bracke KR, Maes T, Van Pottelberge GR, Garlanda C, et al. (2010) Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner. Respir Res 11: 134. doi: 10.1186/1465-9921-11-134 PMID: 20920344
86. Jaillon S, Mancuso G, Hamon Y, Beauvillain C, Cotici V, et al. (2013) Prototypic Long Pentraxin PTX3 Is Present in Breast Milk, Spreads in Tissues, and Protects Neonate Mice from Pseudomonas aeruginosa Lung Infection. The Journal of Immunology 191: 1873-1882. doi: 10.4049/jimmunol.1201642 PMID: 23863905
87. Garlanda C, Hirsch E, Bozza S, Salustri A, De Acetis M, et al. (2002) Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature 420: 182-186. PMID: 12432394
88. He X, Han B, Liu M (2007) Long pentraxin 3 in pulmonary infection and acute lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology 292: L1039-L1049.
89. van Rossum AP, Fazzini F, Limburg PC, Manfredi AA, Rovere-Querini P, et al. (2004) The prototypic tissue pentraxin PTX3, in contrast to the short pentraxin serum amyloid P, inhibits phagocytosis of late apoptotic neutrophils by macrophages. Arthritis Rheum 50: 2667-2674. PMID: 15334483
90. Job ER, Bottazzi B, Gilbertson B, Edenborough KM, Brown LE, et al. (2013) Serum Amyloid P Is a Sialylated Glycoprotein Inhibitor of Influenza A Viruses. PLOS ONE 8: e59623. doi: 10.1371/journal. pone.0059623 PMID: 23544079
91. Ma YJ, Doni A, Skjoedt MO, Honore C, Arendrup M, et al. (2011) Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system. J Biol Chem 286: 3405-3417. doi: 10.1074/jbc.M110.190637 PMID: 21106539
92. Daigo K, Nakakido M, Ohashi R, Fukuda R, Matsubara K, et al. (2014) Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis. ra88-ra88 p.
93. Jaillon S, Peri G, Delneste Y, Fremaux I, Doni A, et al. (2007) The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med 204: 793-804. PMID: 17389238
94. Doni A, Mantovani G, Porta C, Tuckermann J, Reichardt HM, et al. (2008) Cell-specific Regulation of PTX3 by Glucocorticoid Hormones in Hematopoietic and Nonhematopoietic Cells. Journal of Biological Chemistry 283: 29983-29992. doi: 10.1074/jbc.M805631200 PMID: 18703503
95. Doni A, Michela M, Bottazzi B, Peri G, Valentino S, et al. (2006) Regulation of PTX3, a key component of humoral innate immunity in human dendritic cells: stimulation by IL-10 and inhibition by IFNgamma. J Leukoc Biol 79: 797-802. PMID: 16461742
96. Banerjee E, HendersonW(2012) Characterization of lung stem cell niches in a mouse model of bleomycin- induced fibrosis. Stem Cell Research & Therapy 3: 21
97. Misharin AV, Morales-Nebreda L, Mutlu GM, Budinger GRS, Perlman H (2013) Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung. American Journal of Respiratory Cell and Molecular Biology 49: 503-510. doi: 10.1165/rcmb.2013-0086MA PMID: 23672262
98. Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, et al. (2010) Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis. L442-L452 p.
99. Moore BB, Lawson WE, Oury TD, Sisson TH, Raghavendran K, et al. (2013) Animal Models of Fibrotic Lung Disease. American Journal of Respiratory Cell and Molecular Biology 49: 167-179. doi: 1165/rcmb.2013-0094TR PMID: 23526222
100. van Vugt MJ, Heijnen AF, Capel PJ, Park SY, Ra C, et al. (1996) FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo. Blood 87: 3593-3599. PMID: 8611682
101. Boross P, Verbeek JS (2006) The complex role of Fcgamma receptors in the pathology of arthritis. Springer Semin Immunopathol 28: 339-350. PMID: 1704386
102. Hughes AL (1996) Gene duplication and recombination in the evolution of mammalian Fc receptors. Journal of molecular evolution 43: 4-10. PMID: 8660423
103. Daeron M (1997) Fc Receptor Biology. Annual Review Of Immunology 15: 203-234. PMID: 9143687
104. Kitaura J, Xiao W, Maeda-Yamamoto M, Kawakami Y, Lowell CA, et al. (2004) Early Divergence of Fce Receptor I Signals for Receptor Up-Regulation and Internalization from Degranulation, Cytokine Production, and Survival. The Journal of Immunology 173: 4317-4323. PMID: 15383560
105. Hutchinson WL, Hohenester E, Pepys MB (2000) Human serum amyloid P component is a single uncomplexed pentamer in whole serum. MolMed 6: 482-493. PMID: 10972085
106. Bottazzi B, Vouret-Craviari V, Bastone A, De Gioia L, Matteucci C, et al. (1997) Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component. Journal of Biological Chemistry 272: 32817-32823. PMID: 9407058
107. Kenakin T (2011) Functional Selectivity and Biased Receptor Signaling. Journal of Pharmacology and Experimental Therapeutics 336: 296-302. doi: 10.1124/jpet.110.173948 PMID: 21030484
108. Verzijl D, Ijzerman A (2011) Functional selectivity of adenosine receptor ligands. Purinergic Signalling 7: 171-192. doi: 10.1007/s11302-011-9232-0 PMID: 21544511
109. Rajagopal S, Rajagopal K, Lefkowitz RJ (2010) Teaching old receptors new tricks: biasing seventransmembrane receptors. Nat Rev Drug Discov 9: 373-386. doi: 10.1038/nrd3024 PMID: 20431569
110. Lu J, Marjon KD, Marnell LL, Wang R, Mold C, et al. (2011) Recognition and functional activation of the human IgA receptor (FcalphaRI) by C-reactive protein. Proc Natl Acad Sci U S A 108: 4974-4979. doi: 10.1073/pnas.1018369108 PMID: 21383176
111. van Egmond M, van Vuuren AJ, Morton HC, van Spriel AB, Shen L, et al. (1999) Human immunoglobulin A receptor (FcalphaRI, CD89) function in transgenic mice requires both FcR gamma chain and CR3 (CD11b/CD18). Blood 93: 4387-4394. PMID: 10361137
112. Monteiro RC, van de Winkel JGJ (2003) IgA Fc Receptors. Annual Review Of Immunology 21: 177-204. PMID: 12524384