The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition

Nature Communications

Volumn 6, Issue , 2015, Pages

  Mignogna, Maria Lidia ^a,b,c   Giannandrea, Maila ^a,b   Gurgone, Antonia ^a,c   Fanelli, Francesca ^d   Raimondi, Francesco ^d   Mapelli, Lisa ^e   Bassani, Silvia ^e   Fang, Huaqiang ^f   Van Anken, Eelco ^a   Alessio, Massimo ^a   Passafaro, Maria ^e   Gatti, Silvia ^b   Esteban, José A ^g   Huganir, Richard ^f   D'Adamo, Patrizia ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLE PROPIONIC ACID RECEPTOR; GLUA2 PROTEIN; PROTEIN; PROTEIN INTERACTING WITH PROTEIN KINASE C; RAB39B PROTEIN; RECEPTOR; UNCLASSIFIED DRUG; AMPA RECEPTOR; CARRIER PROTEIN; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEIN; GUANOSINE TRIPHOSPHATE; NUCLEAR PROTEIN; PICK1 PROTEIN, HUMAN; RAB PROTEIN; RAB39B PROTEIN, HUMAN; RAB39B PROTEIN, MOUSE;

CELL ORGANELLE; DISABILITY; ENZYME ACTIVITY; GENE EXPRESSION; MUTATION; NEUROLOGY; PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LYSATE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ELECTROPHYSIOLOGICAL PROCEDURES; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; HIPPOCAMPAL NEURONAL CULTURE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VITRO STUDY; LIPID COMPOSITION; MOUSE; NONHUMAN; PDZ DOMAIN; POINT MUTATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; SYNAPTIC TRANSMISSION; ANIMAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; COGNITIVE DEFECT; COS 1 CELL LINE; ELECTROPHYSIOLOGY; GENE EXPRESSION REGULATION; GENETICS; GLYCOSYLATION; GOLGI COMPLEX; HEK293 CELL LINE; HIPPOCAMPUS; INTELLECTUAL IMPAIRMENT; METABOLISM; MUTATION; NERVE CELL; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; SYNAPSE; TWO HYBRID SYSTEM;

ANIMALS; CARRIER PROTEINS; CERCOPITHECUS AETHIOPS; COGNITION DISORDERS; COS CELLS; ELECTROPHYSIOLOGY; GENE EXPRESSION REGULATION; GLUTATHIONE TRANSFERASE; GLYCOSYLATION; GOLGI APPARATUS; GREEN FLUORESCENT PROTEINS; GUANOSINE TRIPHOSPHATE; HEK293 CELLS; HIPPOCAMPUS; HUMANS; INTELLECTUAL DISABILITY; MICE; MUTATION; NEURONS; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; RECEPTORS, AMPA; SYNAPSES; SYNAPTIC TRANSMISSION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84925059164     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7504     Document Type: Article

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