Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  Fan, Xiaodi ^a,b   Wang, Jun ^b   Hou, Jincai ^b   Lin, Chengren ^b   Bensoussan, Alan ^c   Chang, Dennis ^c   Liu, Jianxun ^b   Wang, Bing ^d  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^c UNIVERSITY OF WESTERN SYDNEY   (Australia)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMPK mTOR; Autophagy; Berberine; Inflammation; Macrophage

Indexed keywords

BERBERINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 10; LC3I PROTEIN; LC3II PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MARKER; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN P62; RANTES; SQSTM1 PROTEIN; UNCLASSIFIED DRUG; AUTACOID; CCL5 PROTEIN, MOUSE; LOW DENSITY LIPOPROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; MACROPHAGE; NONHUMAN; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; IMMUNOBLOTTING; METABOLISM; MOUSE; TIME FACTOR; ULTRASTRUCTURE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; BERBERINE; CELL LINE; CHEMOKINE CCL3; CHEMOKINE CCL5; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOBLOTTING; INFLAMMATION MEDIATORS; INTERLEUKIN-10; LIPOPROTEINS, LDL; MACROPHAGES; MICE; SIGNAL TRANSDUCTION; TIME FACTORS; TOR SERINE-THREONINE KINASES; UP-REGULATION;

EID: 84925046323     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0450-z     Document Type: Article

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