Cell-specific RNA aptamer against human CCR5 specifically targets HIV-1 susceptible cells and inhibits HIV-1 infectivity

Chemistry and Biology

Volumn 22, Issue 3, 2015, Pages 379-390

  Zhou, Jiehua ^a   Satheesan, Sangeetha ^a   Li, Haitang ^a   Weinberg, Marc S ^b,c   Morris, Kevin V ^c,d   Burnett, John C ^a   Rossi, John J ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; APTAMER; CHEMOKINE RECEPTOR CCR5; RNA; SMALL INTERFERING RNA; KARYOPHERIN BETA; TNPO3 PROTEIN, HUMAN;

ANTIVIRAL THERAPY; ARTICLE; CD4+ T LYMPHOCYTE; CELL SPECIFICITY; CLINICAL ASSESSMENT; CLINICAL EVALUATION; GENE SILENCING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VIVO STUDY; INFECTION RESISTANCE; INHIBITORY CONCENTRATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN TARGETING; TISSUE SPECIFICITY; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE; CELL CULTURE TECHNIQUE; DRUG EFFECTS; GENETICS; HIV INFECTIONS; IMMUNOLOGY; MACROPHAGE; METABOLISM; MONONUCLEAR CELL; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PROCEDURES; RNA INTERFERENCE; SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT APTAMER TECHNIQUE; VIROLOGY;

APTAMERS, NUCLEOTIDE; BASE SEQUENCE; BETA KARYOPHERINS; CD4-POSITIVE T-LYMPHOCYTES; CELL CULTURE TECHNIQUES; CELLS, CULTURED; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; RECEPTORS, CCR5; RNA INTERFERENCE; RNA, SMALL INTERFERING; SELEX APTAMER TECHNIQUE;

EID: 84925037469     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2015.01.005     Document Type: Article

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