First report on an inotropic peptide activating tetrodotoxin-sensitive, neuronal sodium currents in the heart

Circulation: Heart Failure

Volumn 8, Issue 1, 2015, Pages 79-88

  Kirchhof, Paulus ^a,b   Tal, Tzachy ^c,d   Fabritz, Larissa ^a   Klimas, Jan ^a,e   Nesher, Nir ^d   Schulte, Jan S ^a   Ehling, Petra ^f   Kanyshkova, Tatayana ^g   Budde, Thomas ^h   Nikol, Sigrid ^a,h   Fortmueller, Lisa ^a,c   Stallmeyer, Birgit ^a   Mller, Frank U ^a   Schulze Bahr, Eric ^a   Schmitz, Wilhelm ^a   Zlotkin, Eliahu ^d   Kirchhefer, Uwe ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^e Physics and Informatics   (Slovakia)

^f Department of Neurology Division of Neuropathophysiology Institute of Physiology I   (United States)

^g UNIVERSITY OF MÜNSTER   (Germany)

^h Department of Clinical and Interventional Angiology Asklepios Clinic St Georg   (United States)

Author keywords

Acute heart failure; Arrhythmias, cardiac; Drug therapy; Inotropic agents, positive cardiac; Sodium channels

Indexed keywords

BLACK JUDEAN INOTROPIC PEPTIDE; INOTROPIC AGENT; MESSENGER RNA; PEPTIDE; PROTEIN SCN7A; SCORPION VENOM; SODIUM CHANNEL NAV1.1; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.3; SODIUM CHANNEL NAV1.6; SODIUM CHANNEL NAV1.9; SODIUM CHANNEL STIMULATING AGENT; TETRODOTOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; SODIUM; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT;

ACTION POTENTIAL DURATION; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; HEART ELECTROPHYSIOLOGY; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CONTRACTILITY; HEART REPOLARIZATION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE CONTRACTILITY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INOTROPISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCORPION; SODIUM CURRENT; ANIMAL; DISEASE MODEL; DRUG EFFECTS; HEART; HEART CONTRACTION; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PILOT STUDY;

ANIMALS; DISEASE MODELS, ANIMAL; HEART; HEART FAILURE; HEART VENTRICLES; MICE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PILOT PROJECTS; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN;

EID: 84925020428     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.113.001066     Document Type: Article

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