Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model

Cardiovascular Research

Volumn 92, Issue 1, 2011, Pages 67-74

  Lemoine, Marc D ^a,b   Duverger, James Elber ^a   Naud, Patrice ^a   Chartier, Denis ^a   Qi, Xiao Yan ^a   Comtois, Philippe ^a   Fabritz, Larissa ^b   Kirchhof, Paulus ^b   Nattel, Stanley ^a,c  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Antiarrhythmic drugs; Arrhythmia (mechanisms); Atrial fibrillation; Cellular electrophysiology; Late Na current

Indexed keywords

RANOLAZINE;

ACTION POTENTIAL; ANIMAL CELL; ARRHYTHMOGENESIS; ARTICLE; HEART ATRIUM FIBRILLATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; LONG QT SYNDROME; MALE; MICROELECTRODE; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; SODIUM CURRENT; WHOLE CELL;

ACETANILIDES; ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; DISEASE MODELS, ANIMAL; HEART ATRIA; LONG QT SYNDROME; MALE; MICE; PIPERAZINES; SODIUM CHANNELS;

EID: 80052884048     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvr166     Document Type: Article

References (35)

1. Nattel S. New ideas about atrial fibrillation 50 years on. Nature 2002;415:219-226. (Pubitemid 34059528)
2. Kirchhof P, Eckardt L, Franz MR, Mönnig G, Loh P, Wedekind H et al. Prolonged atrial action potential durations and polymorphic atrial tachyarrhythmias in patients with long QT syndrome. J Cardiovasc Electrophysiol 2003;14:1027-1033. (Pubitemid 37412078)
3. Zellerhoff S, Pistulli R, Monnig G, Hinterseer M, Beckmann BM, Köbe J et al. Atrial arrhythmias in long-qt syndrome under daily life conditions: a nested case control study. J Cardiovasc Electrophysiol 2009;20:401-407.
4. Johnson JN, Tester DJ, Perry J, Salisbury BA, Reed CR, Ackerman MJ. Prevalence of early-onset atrial fibrillation in congenital long QT syndrome. Heart Rhythm 2008;5: 704-709.
5. Nuyens D, Stengl M, Dugarmaa S, Rossenbacker T, Compernolle V, Rudy Y et al. Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome. Nat Med 2001;7:1021-1027. (Pubitemid 32937382)
6. Fabritz L, Kirchhof P, Franz MR, Nuyens D, Rossenbacker T, Ottenhof A et al. Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DKPQ SCN5A (long QT3) mice. Cardiovasc Res 2003;57:1085-1093. (Pubitemid 36324614)
7. Dautova Y, Zhang Y, Sabir I, Grace AA, Huang CL. Atrial arrhythmogenesis in wild-type and SCN5a+/delta murine hearts modelling LQTS3 syndrome. Pflugers Arch 2009;458:443-457.
8. Guzadhur L, Pearcey SM, Duehmke RM, Jeevaratnam K, Hohmann AF, Zhang Y et al. Atrial arrhythmogenicity in aged SCN5a+/△kpq mice modeling long QT type 3 syndrome and its relationship to Na+ channel expression and cardiac conduction. Pflügers Arch-Eur J Physiol 2010;460:593-601.
9. Blana A, Kaese S, Fortmüller L, Laakmann S, Damke D, van Bragt K et al. Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability. Heart Rhythm 2010;7:1862-1869.
10. Yue L, Feng J, Gaspo R, Li GR, Wang Z, Nattel S. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ Res 1997;81:512-525. (Pubitemid 27432738)
11. Fredj S, Sampson KJ, Liu H, Kass RS. Molecular basis of ranolazine block of LQT-3 mutant sodium channels: Evidence for site of action. Br J Pharmacol 2006;148:16-24. (Pubitemid 43675596)
12. Nattel S, Quantz MA. Pharmacological response of quinidine induced early after depolarisations in canine cardiac Purkinje fibres: insights into underlying ionic mechanisms. Cardiovasc Res 1988;22:808-817. (Pubitemid 18268710)
13. Nattel S. Atrial electrophysiology and mechanisms of atrial fibrillation. J Cardiovasc Pharmacol Ther 2003;8(Suppl. 1):S5-S11. (Pubitemid 36903219)
14. Satoh T, Zipes DP. Cesium-induced atrial tachycardia degenerating into atrial fibrillation in dogs: atrial torsades de pointes? J Cardiovasc Electrophysiol 1998;9:970-975. (Pubitemid 28455966)
15. Nayebpour M, Solymoss BC, Nattel S. Cardiovascular and metabolic effects of caesium chloride injection in dogs-limitations as a model for the long QT syndrome. Cardiovasc Res 1989;23:756-766. (Pubitemid 19225856)
16. Ehrlich JR, Zicha S, Coutu P, Hébert TE, Nattel S. Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization. Cardiovasc Res 2005;67:520-528. (Pubitemid 41019559)
17. Olson TM, Alekseev AE, Liu XK, Park S, Zingman LV, Bienengraeber M et al. Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. Hum Mol Genet 2006;15:2185-2191. (Pubitemid 43985509)
18. Wang Z, Fermini B, Nattel S. Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents. Circ Res 1993;73:1061-1076. (Pubitemid 23340202)
19. Song Y, Shryock JC, Belardinelli L. An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes. Am J Physiol Heart Circ Physiol 2008;294:H2031-H2039.
20. Nagatomo T, January CT, Ye B, Abe H, Nakashima Y, Makielski JC. Rate-dependent QT shortening mechanism for the LQTS3 deltaKPQ mutant. Cardiovasc Res 2002; 54:624-629. (Pubitemid 34595421)
21. Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C. Atriumselective sodium channel block as a strategy for suppression of atrial fibrillation: Differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Circulation 2007;116:1449-1457. (Pubitemid 47480635)
22. Wang DW, Yazawa K, Makita N, George AL Jr, Bennett PB. Pharmacological targeting of long QT mutant sodium channels. J Clin Invest 1997;99:1714-1720. (Pubitemid 27163823)
23. Dumaine R, Kirsch GE. Mechanism of lidocaine block of late current in long q-t mutant Na+ channels. Am J Physiol 1998;274:H477-H487.
24. Abriel H,Wehrens XH, Benhorin J, Kerem B, Kass RS. Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome. Circulation 2000; 102:921-925.
25. Nagatomo T, January CT, Makielski JC. Preferential block of late sodium current in the LQTS3 deltaKPQ mutant by the class I(c) antiarrhythmic flecainide. Mol Pharmacol 2000;57:101-107. (Pubitemid 30033265)
26. Schotten U, Verheule S, Kirchhof P, Goette A. Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. Physiol Rev 2011;91:265-325.
27. Undrovinas NA, Maltsev VA, Belardinelli L, Sabbah HN, Undrovinas A. Late sodium current contributes to diastolic cell Ca2+ accumulation in chronic heart failure. J Physiol Sci 2010;60:245-257.
28. Yeh Y-H, Wakili R, Qi XY, Chartier D, Boknik P, Kääb S et al. Calcium handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure. Circ Arrhythm Electrophysiol 2008;1:93-102.
29. Sossalla S, Kallmeyer B, Wagner S, Mazur M, Maurer U, Toischer K et al. Altered Na+ currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium. J Am Coll Cardiol 2010;55:2330-2342.
30. Schotten U, Verheule S, Kerfant BG, Greiser M. Enhanced late Na+ currents in atrial fibrillation new drug target or just an epiphenomenon? J Am Coll Cardiol 2010;55: 2343-2345.
31. Nerbonne JM. Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium. J Physiol 2000;525(Part 2):285-298. (Pubitemid 30398360)
32. Antzelevitch C, Belardinelli L, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM et al. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 2004;110:904-910. (Pubitemid 39136212)
33. Schram G, Zhang L, Derakhchan K, Ehrlich JR, Belardinelli L, Nattel S. Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects. Br J Pharmacol 2004;142:1300-1308. (Pubitemid 39185852)
34. Murdock DK, Kersten M, Kaliebe J, Larrain G. The use of oral ranolazine to convert new or paroxysmal atrial fibrillation: a review of experience with implications for possible 'pill in the pocket' approach to atrial fibrillation. Indian Pacing Electrophysiol J 2009;9:260-267.
35. Comtois P, Sakabe M, Vigmond EJ, Munoz M, Texier A, Shiroshita-Takeshita A et al. Mechanisms of atrial fibrillation termination by rapidly unbinding Na+ channel blockers: insights from mathematical models and experimental correlates. Am J Physiol Heart Circ Physiol 2008;295:H1489-H1504.