Smart Polypeptide Nanocarriers for Malignancy Therapeutics

Advanced Biomaterials and Biodevices

Volumn 9781118773635, Issue , 2014, Pages 523-546

  Ding, Jianxun ^a   Li, Di ^a   Zhuang, Xiuli ^a   Chen, Xuesi ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

Author keywords

Malignancy therapies; Nanocarriers; Polypeptides; Stimuli responsive

Indexed keywords

BIOCOMPATIBILITY; BIODEGRADABLE POLYMERS; DISEASES; DRUG PRODUCTS; PROTEINS; SYNTHETIC POLYMERS; TARGETED DRUG DELIVERY;

AMINO-ACIDS; IN-VIVO; MALIGNANCY THERAPY; MATRIX; NANOCARRIERS; NATURAL PROTEINS; POLYMERIC NANOCARRIERS; SMART DRUG DELIVERY SYSTEMS; STIMULI-RESPONSIVE; SYNTHETIC POLYMERS;

CONTROLLED DRUG DELIVERY;

EID: 84924993997     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118774052.ch15     Document Type: Chapter

References (80)

1. Z. Y. Xiao, C. W. Ji, J. J. Shi, E. M. Pridgen, J. Frieder, J. Wu, and O. C. Farokhzad, DNA Self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy, Angewandte Chemie, International Edition, Vol. 51, Iss. 47, pp. 11853-11857, 2012.
2. J. X. Ding, J. J. Chen, D. Li, C. S. Xiao, J. C. Zhang, C. L. He, X. L. Zhuang, and X. S. Chen, Biocompatible reduction-responsive polypeptide micelles as nanocarriers for enhanced chemotherapy efficacy in vitro, Journal of Materials Chemistry B, Vol. 1, Iss. 1, pp. 69-81, 2013.
3. F. H. Shi, J. X. Ding, C. S. Xiao, X. L. Zhuang, C. L. He, L. Chen, and X. S. Chen, Intracellular microenvironment responsive PEGylated polypeptide nanogels with ionizable cores for efficient doxorubicin loading and triggered release, Journal of Materials Chemistry, Vol. 22, Iss. 28, pp. 14168-14179, 2012.
4. A. Bhaw-Luximon, L. M. Meeram, Y. Jugdawa, W. Helbert, and D. Jhurry, Oligoagarose-g-polycaprolactone loaded nanoparticles for drug delivery applications, Polymer Chemistry, Vol. 2, Iss. 1, pp. 77-79, 2011.
5. J. Y. Liu, Y. Pang, W. Huang, X. Y. Zhu, Y. F. Zhou, and D. Y. Yan, Self-assembly of phospholipid-analogous hyperbranched polymers nanomicelles for drug delivery, Biomaterials, Vol. 31, Iss. 6, pp. 1334-1341, 2010.
6. A. Okamatsu, K. Motoyama, R. Onodera, T. Higashi, T. Koshigoe, Y. Shimada, K. Hattori, T. Takeuchi, and H. Arima, Folate-appended β-cyclodextrin as a promising tumor targeting carrier for antitumor drugs in vitro and in vivo, Bioconjugate Chemistry, Vol. 24, Iss. 4, pp. 724-733, 2013.
7. W. Scarano, H. T. T. Duong, H. X. Lu, P. L. De Souza, and M. H. Stenzel, Folate conjugation to polymeric micelles via boronic acid ester to deliver platinum drugs to ovarian cancer cell lines, Biomacromolecules, Vol. 14, Iss. 4, pp. 962-975, 2013.
8. F. Perche, N. R. Patel, and V. P. Torchilin, Accumulation and toxicity of anti-body-targeted doxorubicin-loaded PEG-PE micelles in ovarian cancer cell spheroid model, Journal of Controlled Release, Vol. 164, Iss. 1, pp. 95-102, 2012.
9. A. B. E. Attia, C. Yang, J. P. K. Tan, S. J. Gao, D. F. Williams, J. L. Hedrick, and Y. Y. Yang, The effect of kinetic stability on biodistribution and anti-tumor efficacy of drug-loaded biodegradable polymeric micelles, Biomaterials, Vol. 34, Iss. 12, pp. 3132-3140, 2013.
10. A. Gabizon, Y. Amitay, D. Tzemach, J. Gorin, H. Shmeeda, and S. Zalipsky, Therapeutic efficacy of a lipid-based prodrug of mitomycin C in pegylated liposomes: Studies with human gastro-entero-pancreatic ectopic tumor models, Journal of Controlled Release, Vol. 160, Iss. 2, pp. 245-253, 2012.
11. J. H. Shin, P. Shum, J. Grey, S. Fujiwara, G. S. Malhotra, A. Gonzalez-Bonet, S. H. Hyun, E. Moase, T. M. Allen, and D. H. Thompson, Acid-labile mPEG-vinyl ether-1, 2-dioleylglycerol lipids with tunable pH sensitivity: Synthesis and structural effects on hydrolysis rates, DOPE liposome release performance, and pharmacokinetics, Molecular Pharmaceutics, Vol. 9, Iss. 11, pp. 3266-3276, 2012.
12. E. A. Murphy, B. K. Majeti, R. Mukthavaram, L. M. Acevedo, L. A. Barnes, and D. A. Cheresh, Targeted nanogels: A versatile platform for drug delivery to tumors, Molecular Cancer Therapeutics, Vol. 10, Iss. 6, pp. 972-982, 2011.
13. E. S. Gil, and S. M. Hudson, Stimuli-reponsive polymers and their bioconjugates, Progress in Polymer Science, Vol. 29, Iss. 12, pp. 1173-1222, 2004.
14. Y. Kim, M. H. Pourgholami, D. L. Morris, and M. H. Stenzel, Triggering the fast release of drugs from crosslinked micelles in an acidic environment, Journal of Materials Chemistry, Vol. 21, Iss. 34, pp. 12777-12783, 2011.
15. S. V. Ghugare, P. Mozetic, and G. Paradossi, Temperature-sensitive poly(vinyl alcohol)/poly(methacrylate-co-N-isopropyl acrylamide) microgels for doxorubicin delivery, Biomacromolecules, Vol. 10, Iss. 6, pp. 1589-1596, 2009.
16. P. D. Thornton, R. J. Mart, and R. V. Ulijn, Enzyme-responsive polymer hydrogel particles for controlled release, Advanced Materials, Vol. 19, Iss. 9, pp. 1252-1256, 2007.
17. F. Danhier, O. Feron, and V. Preat, To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery, Journal of Controlled Release, Vol. 148, Iss. 2, pp. 135-146, 2010.
18. L. Y. Tang, Y. C. Wang, Y. Li, J. Z. Du, and J. Wang, Shell-detachable micelles based on disulfide-linked block copolymer as potential carrier for intracellular drug delivery, Bioconjugate Chemistry, Vol. 20, Iss. 6, pp. 1095-1099, 2009.
19. P. Bawa, V. Pillay, Y. E. Choonara, and L. C. du Toit, Stimuli-responsive polymers and their applications in drug delivery, Biomedical Materials, Vol. 4, No. 2, 022001, 2009.
20. E. S. Lee, Z. G. Gao, and Y. H. Bae, Recent progress in tumor pH targeting nanotechnology, Journal of Controlled Release, Vol. 132, Iss. 3, pp. 164-170, 2008.
21. J. X. Ding, C. S. Xiao, Y. C. Li, Y. L. Cheng, N. N. Wang, C. L. He, X. L. Zhuang, X. J. Zhu, and X. S. Chen, Efficacious hepatoma-targeted nanomedicine selfassembled from galactopeptide and doxorubicin driven by two-stage physical interactions, Journal of Controlled Release, Vol. 169, Iss. 3, pp. 193-203, 2013.
22. Y. Huang, Z. H. Tang, X. F. Zhang, H. Y. Yu, H. Sun, X. Pang, and X. S. Chen, pH-triggered charge-reversal polypeptide nanoparticles for cisplatin delivery: Preparation and in vitro evaluation, Biomacromolecules, Vol. 14, Iss. 6, pp. 2023-2032, 2013.
23. J. X. Ding, C. S. Xiao, L. S. Yan, Z. H. Tang, X. L. Zhuang, X. S. Chen, and X. B. Jing, pH and dual redox responsive nanogel based on poly(L-glutamic acid) as potential intracellular drug carrier, Journal of Controlled Release, Vol. 152, Suppl. 1, pp. E11-E13, 2011.
24. C. L. He, X. L. Zhuang, Z. H. Tang, H. Y. Tian, and X. S. Chen, Stimuli-sensitive synthetic polypeptide-based materials for drug and gene delivery, Advanced Healthcare Materials, Vol. 1, Iss. 1, pp. 48-78, 2012.
25. K. M. Galler, L. Aulisa, K. R. Regan, R. N. D'Souza, and J. D. Hartgerink, Selfassembling multidomain peptide hydrogels: Designed susceptibility to enzymatic cleavage allows enhanced cell migration and spreading, Journal of the American Chemical Society, Vol. 132, Iss. 9, pp. 3217-3223, 2010.
26. R. Weissleder, C. H. Tung, U. Mahmood, and A. Bogdanov, In vivo imaging of tumors with protease-activated near-infrared fluorescent probes, Nature Biotechnology, Vol. 17, Iss. 4, pp. 375-378, 1999.
27. A. Carlsen, and S. Lecommandoux, Self-assembly of polypeptide-based block copolymer amphiphiles, Current Opinion in Colloid & Interface Science, Vol. 14, Iss. 5, pp. 329-339, 2009.
28. D. Schmaljohann. Thermo- and pH-responsive polymers in drug delivery, Advanced Drug Delivery Reviews, Vol. 58, Iss. 15, pp. 1655-1670, 2006.
29. L. F. Zhang, H. W. Shen, and A. Eisenberg, Phase separation behavior and crew-cut micelle formation of polystyrene-b-poly(acrylic acid) copolymers in solutions, Macromolecules, Vol. 30, Iss. 4, pp. 1001-1011, 1997.
30. W. Wang, J. X. Ding, C. S. Xiao, Z. H. Tang, D. Li, J. Chen, X. L. Zhuang, and X. S. Chen, Synthesis of amphiphilic alternating polyesters with oligo(ethylene glycol) side chains and potential use for sustained release drug delivery, Biomacromolecules, Vol. 12, Iss. 7, pp. 2466-2474, 2011.
31. J. X. Ding, C. S. Xiao, Z. H. Tang, X. L. Zhuang, and X. S. Chen, Highly efficient "grafting from" an α-helical polypeptide backbone by atom transfer radical polymerization, Macromolecular Bioscience, Vol. 11, Iss. 2, pp. 192-198, 2011.
32. J. X. Ding, C. S. Xiao, L. Zhao, Y. L. Cheng, L. L. Ma, Z. H. Tang, X. L. Zhuang, and X. S. Chen, Poly(L-glutamic acid) grafted with oligo(2-(2-(2-methoxyethoxy)ethoxy) ethyl methacrylate): Thermal phase transition, secondary structure, and self-assembly, Journal of Polymer Science, Part A: Polymer Chemistry, Vol. 49, Iss. 12, pp. 2665-2676, 2011.
33. J. Cheng, J. X. Ding, Y. C. Wang, and J. Wang, Synthesis and characterization of star-shaped block copolymer of poly(ε-caprolactone) and poly(ethyl ethylene phosphate) as drug carrier, Polymer, Vol. 49, Iss. 22, pp. 4784-4790, 2008.
34. D. Li, J. X. Ding, Z. H. Tang, H. Sun, X. L. Zhuang, J. Z. Xu, and X. S. Chen, In vitro evaluation of anticancer nanomedicines based on doxorubicin and amphiphilic Y-shaped copolymers, International Journal of Nanomedicine, Vol. 7, pp. 2687-2697, 2012.
35. H. Otsuka, Y. Nagasaki, and K. Kataoka, PEGylated nanoparticles for biological and pharmaceutical applications, Advanced Drug Delivery Reviews, Vol. 55, Iss. 3, pp. 403-419, 2003.
36. K. Kataoka, A. Harada, and Y. Nagasaki, Block copolymer micelles for drug delivery: Design, characterization and biological significance, Advanced Drug Delivery Reviews, Vol. 64, Supplement, pp. 37-48, 2012.
37. S. Kim, Y. Z. Shi, J. Y. Kim, K. Park, and J. X. Cheng, Overcoming the barriers in micellar drug delivery: Loading efficiency, in vivo stability, and micellecell interaction, Expert Opinion on Drug Delivery, Vol. 7, No. 1, pp. 49-62, 2010.
38. J. Nicolas, S. Mura, D. Brambilla, N. Mackiewicz, and P. Couvreur, Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery, Chemical Society Reviews, Vol. 42, Iss. 3, pp. 1147-1235, 2013.
39. J. X. Ding, L. Zhao, D. Li, C. S. Xiao, X. L. Zhuang, and X. S. Chen, Thermoresponsive "hairy-rod" polypeptides for smart antitumor drug delivery, Polymer Chemistry, Vol. 4, Iss. 11, pp. 3345-3356, 2013.
40. R. P. Johnson, Y. I. Jeong, E. Choi, C. W. Chung, D. H. Kang, S. O. Oh, H. Suh, and I. Kim, Biocompatible poly(2-hydroxyethyl methacrylate)-b-poly(L-histidine) hybrid materials for pH-sensitive intracellular anticancer drug delivery, Advanced Functional Materials, Vol. 22, Iss. 5, pp. 1058-1068, 2012.
41. M. Q. Li, W. T. Song, Z. H. Tang, S. X. Lv, L. Lin, H. Sun, Q. S. Li, Y. Yang, H. Hong, and X. S. Chen, Nanoscaled poly(L-glutamic acid)/doxorubicin-amphiphile complex as pH-responsive drug delivery system for effective treatment of nonsmall cell lung cancer, ACS Applied Materials & Interfaces, Vol. 5, Iss. 5, pp. 1781-1792, 2013.
42. W. T. Song, M. Q. Li, Z. H. Tang, Q. S. Li, Y. Yang, H. Y. Liu, T. C. Duan, H. Hong, and X. S. Chen, Methoxypoly(ethylene glycol)-block-poly(L-glutamic acid)-loaded cisplatin and a combination with iRGD for the treatment of non-small-cell lung cancers, Macromolecular Bioscience, Vol. 12, Iss. 11, pp. 1514-1523, 2012.
43. J. X. Ding, C. L. He, C. S. Xiao, J. Chen, X. L. Zhuang, and X. S. Chen, pH-responsive drug delivery systems based on clickable poly(L-glutamic acid)- grafted comb copolymers, Macromolecular Research, Vol. 20, Iss. 3, pp. 292-301, 2012.
44. E. S. Lee, H. J. Shin, K. Na, and Y. H. Bae, Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization, Journal of Controlled Release, Vol. 90, Iss. 3, pp. 363-374, 2003.
45. Z. G. Gao, D. H. Lee, D. I. Kim, and Y. H. Bae, Doxorubicin loaded pH-sensitive micelle targeting acidic extracellular pH of human ovarian A2780 tumor in mice, Journal of Drug Targeting, Vol. 13, No. 7, pp. 391-397, 2005.
46. Y. Bae, S. Fukushima, A. Harada, and K. Kataoka, Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change, Angewandte Chemie, International Edition, Vol. 42, Iss. 38, pp. 4640-4643, 2003.
47. Y. Bae, N. Nishiyama, S. Fukushima, H. Koyama, M. Yasuhiro, and K. Kataoka, Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: Tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy, Bioconjugate Chemistry, Vol. 16, Iss. 1, pp. 122-130, 2005.
48. H. Yuan, K. Luo, Y. S. Lai, Y. J. Pu, B. He, G. Wang, Y. Wu, and Z. W. Gu, A novel poly(L-glutamic acid) dendrimer based drug delivery system with both pH-sensitive and targeting functions, Molecular Pharmaceutics, Vol. 7, Iss. 4, pp. 953-962, 2010.
49. J. C. Zhang, J. X. Ding, C. S. Xiao, C. L. He, X. L. Zhuang, Y. N. Yang, and X. S. Chen, Synthesis and characterization of tumor-acidity-sensitive poly(L-lysine)-doxorubicin conjugates, Chemical Journal of Chinese Universities, Chinese, Vol. 33, Iss. 12, pp. 2809-2815, 2012.
50. H. Y. Wen, H. Q. Dong, W. J. Xie, Y. Y. Li, K. Wang, G. M. Pauletti, and D. L. Shi, Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery, Chemical Communications, Vol. 47, Iss. 12, pp. 3550-3552, 2011.
51. T. B. Ren, W. J. Xia, H. Q. Dong, and Y. Y. Li, Sheddable micelles based on disulfide-linked hybrid PEG-polypeptide copolymer for intracellular drug delivery, Polymer, Vol. 52, Iss. 16, pp. 3580-3586, 2011.
52. C. Sanson, C. Schatz, J. F. Le Meins, A. Brulet, A. Soum, and S. Lecommandoux, Biocompatible and biodegradable poly(trimethylene carbonate)-b-poly(L-glutamic acid) polymersomes: Size control and stability, Langmuir, Vol. 26, Iss. 4, pp. 2751-2760, 2010.
53. K. K. Upadhyay, J. F. Le Meins, A. Misra, P. Voisin, V. Bouchaud, E. Ibarboure, C. Schatz, and S. Lecommandoux, Biomimetic doxorubicin loaded poly-mersomes from hyaluronan-block-poly(γ-benzyl glutamate) copolymers, Biomacromolecules, Vol. 10, Iss. 10, pp. 2802-2808, 2009.
54. C. Sanson, C. Schatz, J. F. Le Meins, A. Soum, J. Thevenot, E. Garanger, and S. Lecommandoux, A simple method to achieve high doxorubicin loading in biodegradable polymersomes, Journal of Controlled Release, Vol. 147, Iss. 3, pp. 428-435, 2010.
55. D. E. Discher, and A. Eisenberg, Polymer vesicles, Science, Vol. 297, Iss. 5583, pp. 967-973, 2002.
56. B. M. Discher, Y. Y. Won, D. S. Ege, J. C. M. Lee, F. S. Bates, D. E. Discher, and D. A. Hammer, Polymersomes: Tough vesicles made from diblock copolymers, Science, Vol. 284, Iss. 5417, pp. 1143-1146, 1999.
57. A. E. Felber, M. H. Dufresne, and J. C. Leroux, pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates, Advanced Drug Delivery Reviews, Vol. 64, Iss. 11, pp. 979-992, 2012.
58. J. X. Ding, C. S. Xiao, C. L. He, M. Q. Li, D. Li, X. L. Zhuang, and X. S. Chen, Facile preparation of a cationic poly(amino acid) vesicle for potential drug and gene co-delivery, Nanotechnology, Vol. 22, No. 49, p. 494012, 2011.
59. J. X. Ding, C. S. Xiao, X. L. Zhuang, C. L. He, and X. S. Chen, Direct formation of cationic polypeptide vesicle as potential carrier for drug and gene, Materials Letters, Vol. 73, pp. 17-20, 2012.
60. L. D. Mayer, M. B. Bally, and P. R. Cullis, Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient, Biochimica et Biophysica Acta, Vol. 857, Iss. 1, pp. 123-126, 1986.
61. C. Sanson, O. Diou, J. Thevenot, E. Ibarboure, A. Soum, A. Brulet, S. Miraux, E. Thiaudiere, S. Tan, A. Brisson, V. Dupuis, O. Sandre, and S. Lecommandoux, Doxorubicin loaded magnetic polymersomes: Theranostic nanocarriers for MR imaging and magneto-chemotherapy, ACS Nano, Vol. 5, Iss. 2, pp. 1122-1140, 2011.
62. H. Oliveira, E. Perez-Andres, J. Thevenot, O. Sandre, E. Berra, and S. Lecommandoux, Magnetic field triggered drug release from polymersomes for cancer therapeutics, Journal of Controlled Release, Vol. 169, Iss. 3, pp. 165-170, 2013.
63. A. V. Kabanov, and S. V. Vinogradov, Nanogels as pharmaceutical carriers: Finite networks of infinite capabilities, Angewandte Chemie, International Edition, Vol. 48, Iss. 30, pp. 5418-5429, 2009.
64. J. X. Ding, X. L. Zhuang, C. S. Xiao, Y. L. Cheng, L. Zhao, C. L. He, Z. H. Tang, and X. S. Chen, Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery, Journal of Materials Chemistry, Vol. 21, Iss. 30, pp. 11383-11391, 2011.
65. J. K. Oh, R. Drumright, D. J. Siegwart, and K. Matyjaszewski, The development of microgels/nanogels for drug delivery applications, Progress in Polymer Science, Vol. 33, Iss. 4, pp. 448-477, 2008.
66. G. R. Hendrickson, M. H. Smith, A. B. South, and L. A. Lyon, Design of multi-responsive hydrogel particles and assemblies, Advanced Functional Materials, Vol. 20, Iss. 11, pp. 1697-1712, 2010.
67. J. X. Ding, F. H. Shi, D. Li, L. Chen, X. L. Zhuang, and X. S. Chen, Enhanced endocytosis of acid-sensitive doxorubicin derivatives with intelligent nanogel for improved security and efficacy, Biomaterials Science, Vol. 1, Iss. 6, pp. 633-646, 2013.
68. T. Zhou, C. F. Xiao, J. Fan, S. M. Chen, J. Shen, W. T. Wu, and S. Q. Zhou, A nanogel of on-site tunable pH-response for efficient anticancer drug delivery, Acta Biomaterialia, Vol. 9, Iss. 1, pp. 4546-4557, 2013.
69. S. J. Lee, K. H. Min, H. J. Lee, A. N. Koo, H. P. Rim, B. J. Jeon, S. Y. Jeong, J. S. Heo, and S. C. Lee, Ketal cross-linked poly(ethylene glycol)-poly(amino acid)s copolymer micelles for efficient intracellular delivery of doxorubicin, Biomacromolecules, Vol. 12, Iss. 4, pp. 1224-1233, 2011.
70. H. J. Lee, and Y. Bae, Cross-linked nanoassemblies from poly(ethylene glycol)-poly(aspartate) block copolymers as stable supramolecular templates for particulate drug delivery, Biomacromolecules, Vol. 12, No. 7, pp. 2686-2696, 2011.
71. H. J. Lee, and Y. Bae, Pharmaceutical differences between block copolymer self-assembled and cross-linked nanoassemblies as carriers for tunable drug release, Pharmaceutical Research, Vol. 30, Iss. 2, pp. 478-488, 2013.
72. J. Sun, X. S. Chen, J. Z. Wei, L. S. Yan, and X. B. Jing, Application of the bio-degradable diblock copolymer poly(L-lactide)-block-poly(L-cysteine): Drug delivery and protein conjugation, Journal of Applied Polymer Science, Vol. 118, Iss. 3, pp. 1738-1742, 2010.
73. J. X. Ding, F. H. Shi, C. S. Xiao, L. Lin, L. Chen, C. L. He, X. L. Zhuang, and X. S. Chen, One-step preparation of reduction-responsive poly(ethylene glycol)- poly (amino acid)s nanogels as efficient intracellular drug delivery platforms, Polymer Chemistry, Vol. 2, Iss. 12, pp. 2857-2864, 2011.
74. T. Xing, B. Lai, X. D. Ye, and L. F. Yan, Disulfide core cross-linked PEGylated polypeptide nanogel prepared by a one-step ring opening copolymerization of N-carboxyanhydrides for drug delivery, Macromolecular Bioscience, Vol. 11, Iss. 7, pp. 962-969, 2011.
75. T. Xing, B. Lai, and L. F. Yan, Disulfide cross-linked polypeptide nanogel conjugated with a fluorescent probe as a potential image-guided drug-delivery agent, Macromolecular Chemistry and Physics, Vol. 214, Iss. 5, pp. 578-588, 2013.
76. T. Xing, C. Q. Mao, B. Lai, and L. F. Yan, Synthesis of disulfide-cross-linked polypeptide nanogel conjugated with a near-infrared fluorescence probe for direct imaging of reduction-induced drug release, ACS Applied Materials & Interfaces, Vol. 4, Iss. 10, pp. 5662-5672, 2012.
77. Y. L. Cheng, C. L. He, C. S. Xiao, J. X. Ding, K. X. Ren, S. J. Yu, X. L. Zhuang, and X. S. Chen, Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry, Polymer Chemistry, Vol. 4, Iss. 13, pp. 3851-3858, 2013.
78. J. Dai, S. D. Lin, D. Cheng, S. Y. Zou, and X. T. Shuai, Interlayer-crosslinked micelle with partially hydrated core showing reduction and pH dual sensitivity for pinpointed intracellular drug release, Angewandte Chemie, International Edition, Vol. 50, Iss. 40, pp. 9404-9408, 2011.
79. L. L. Wu, Y. Zou, C. Deng, R. Cheng, F. H. Meng, and Z. Y. Zhong, Intracellular release of doxorubicin from core-crosslinked polypeptide micelles triggered by both pH and reduction conditions, Biomaterials, Vol. 34, Iss. 21, pp. 5262-5272, 2013.
80. D. F. Zhou, H. H. Xiao, F. B. Meng, S. Y. Zhou, J. S. Guo, X. Y. Li, X. B. Jing, and Y. B. Huang, Layer-by-layer assembled polypeptide capsules for platinum-based pro-drug delivery, Bioconjugate Chemistry, Vol. 23, Iss. 12, pp. 2335-2343, 2012.