A nanogel of on-site tunable pH-response for efficient anticancer drug delivery

Acta Biomaterialia

Volumn 9, Issue 1, 2013, Pages 4546-4557

  Zhou, Ting ^a,b   Xiao, Chuanfu ^a   Fan, Jiao ^a   Chen, Shoumin ^a   Shen, Jing ^b   Wu, Weitai ^a   Zhou, Shuiqin ^b  

^a XIAMEN UNIVERSITY   (China)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Chitosan; Drug delivery; pH responsive nanogels; Poly(ethylene glycol); Remotely modulate

Indexed keywords

CARRIER CONCENTRATION; CHAINS; CHITOSAN; CONTROLLED DRUG DELIVERY; DISEASES; ENZYME ACTIVITY; ETHYLENE GLYCOL; NANOSTRUCTURED MATERIALS; ONCOLOGY; PH; PH SENSORS; PHYSIOLOGICAL MODELS; POLYOLS; TARGETED DRUG DELIVERY; TUMORS;

5-FLUOROURACIL; ANTI-CANCER DRUG DELIVERY; CANCER THERAPY; DRUG CARRIER; NANO PARTICULATES; NANOGELS; PH RESPONSE; PH-RESPONSIVE NANOGEL; REMOTELY MODULATE; TUNABLES;

POLYETHYLENE GLYCOLS;

ANTINEOPLASTIC AGENT; CHITOSAN BASED NANOGEL; FLUOROURACIL; MACROGOL; NANOCARRIER; UNCLASSIFIED DRUG;

ACIDITY; ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL PH; CELL VIABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG RELEASE; DRUG STABILITY; DRUG UPTAKE; ENDOCYTOSIS; HYDROGEN BOND; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; THERMODYNAMICS;

EID: 84870236565     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.08.017     Document Type: Article

References (56)

1. J. Shi, A.R. Votruba, O.C. Farokhzad, and R. Langer Nanotechnology in drug delivery and tissue engineering: from discovery to applications Nano Lett 10 2010 3223 3230
2. B.P. Timko, K. Whitehead, W. Gao, D.S. Kohane, O. Farokhzad, and D. Anderson Advances in drug delivery Annu Rev Mater Res 41 2011 1 20
3. B.H. Tan, and K.C. Tam Review on the dynamics and micro-structure of pH-responsive nano-colloidal systems Adv Colloid Interf Sci 136 2008 25 44
4. A. Nelson Stimuli-responsive polymers: engineering interactions Nat Mater 7 2008 523 525
5. M.A.C. Stuart, W.T.S. Huck, J. Genzer, M. Müller, C. Ober, and M. Stamm Emerging applications of stimuli-responsive polymer materials Nat Mater 9 2010 101 113
6. I.F. Tannock, and D. Rotin Acid pH in tumors and its potential for therapeutic exploitation Cancer Res 49 1989 4373 4384
7. R.D. Coakley, B.R. Grubb, A.M. Paradiso, J.T. Gatzy, L.G. Johnson, and S.M. Kreda Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium Proc Natl Acad Sci USA 100 2003 16083 16088
8. V.P. Torchilin Micellar nanocarriers: pharmaceutical perspectives Pharm Res 24 2007 1 16
9. E.S. Lee, D. Kim, Y.S. Youn, K.T. Oh, and Y.H. Bae A virus-mimetic nanogels vehicle Angew Chem Int Ed 47 2008 2418 2421
10. A.V. Kabanov, and S.V. Vinogradov Nanogels as pharmaceutical carriers: finite networks of infinite capabilities Angew Chem Int Ed 48 2009 5418 5429
11. E. Yan, Y. Ding, C. Chen, R. Li, Y. Hu, and X. Jiang Polymer/silica hybrid hollow nanoshperes with pH-sensitive drug release in physiological and intracellular environments Chem Commun 45 2009 2718 2720
12. N. Bhattarai, J. Gunn, and M. Zhang Chitosan-based hydrogels for controlled, localized drug delivery Adv Drug Delivery Rev 62 2010 83 99
13. W. Wu, T. Zhou, A. Berliner, P. Banerjee, and S.Q. Zhou Smart core-shell hybrid nanogels with Ag nanoparticle core for cancer cell imaging and gel shell for pH-regulated drug delivery Chem Mater 22 2010 1966 1976
14. W. Wu, J. Shen, P. Banerjee, and S.Q. Zhou Chitosan-based responsive hybrid nanogels for integration of optical pH-sensing, tumor cell imaging and controlled drug delivery Biomaterials 31 2010 8371 8381
15. W. Wu, J. Shen, Z. Gai, K. Hong, P. Banerjee, and S.Q. Zhou Multi-functional core-shell hybrid nanogels for pH-dependent magnetic manipulation, fluorescent pH-sensing, and drug delivery Biomaterials 32 2011 9876 9887
16. J.Z. Du, X.J. Du, C.Q. Mao, and J. Wang Tailor-made dual pH-sensitive polymer-docorubicin nanoparticles for efficient anticancer drug delivery J Am Chem Soc 133 2011 17560 17563
17. B.V. Slaughter, S.S. Khurshid, O.Z. Fisher, A. Khademhosseini, and N.A. Peppas Hydrogels in regenerative medicine Adv Mater 21 2009 3307 3329
18. T. Kean, and M. Thanou Biodegradation, biodistribution and toxicity of chitosan Adv Drug Delivery Rev 62 2010 3 11
19. P. Xu, G. Bajaj, T. Shugg, W.G. Van Alstine, and Y. Yeo Zwitterionic chitosan derivatives for pH-sensitive stealth coating Biomacromolecules 11 2010 2352 2358
20. T.A. Sonia, and C.P. Sharma Chitosan and its derivatives for drug delivery perspective Adv Polym Sci 243 2011 23 54
21. Mitsuhiro Shibayama, and T. Tanaka Volume phase transition and related phenomena of polymer gels Adv Polym Sci 109 1993 1 62
22. A.S. Carreira, F.A.M.M. Goncalves, P.V. Mendonca, M.H. Gil, and J.F.J. Coelho Temperature and pH responsive polymers based on chitosan: applications and new graft copolymerization strategies based on living radical polymerization Carbohydr Polym 80 2010 618 630
23. H. Bao, L. Li, L.H. Gan, Y. Ping, J. Li, and P. Ravi Thermo- and pH-responsive association behavior of dual hydrophilic graft chitosan terpolymer synthesized via ATRP and click chemistry Macromolecules 43 2010 5679 5687
24. M. Bodnar, J.F. Hartmann, and J. Borbely Synthesis and study of cross-linked chitosan-N-poly(ethylene glycol) nanoparticles Biomacromolecules 7 2006 3030 3036
25. J. Wu, W. Wei, L.Y. Wang, Z.G. Su, and G.H. Ma A thermosensitive hydrogel based on quaternized chitosan and poly(ethylene glycol) for nasal drug delivery system Biomaterials 28 2007 2220 2232
26. F.M. Goycoolea, M.E. Fernandez-Valle, I. Aranaz, and A. Heras PH- and temperature-sensitive chitosan hydrogels: swelling and MRI studies Macromol Chem Phys 212 2011 887 895
27. J.H. Jang, Y.M. Choi, Y.Y. Choi, M.K. Joo, M.H. Park, and B.G. Choi PH/temperature sensitive chitosan-g-(PA-PEG) aqueous solutions as new thermogelling systems J Mater Chem 21 2011 5484 5491
28. J.F. Lutz, O. Akdemir, and A. Hoth Point by point comparison of two thermosensitive polymers exhibiting a similar LCST: is the age of poly(NIPAM) over? J Am Chem Soc 128 2006 13046 13047
29. J.F. Lutz Thermo-switchable materials prepared using the OEGMA-platform Adv Mater 23 2011 2237 2243
30. Z.B. Hu, T. Cai, and C.L. Chi Thermoresponsive oligo(ethylene glycol)-methacrylate-based polymers and microgels Soft Matter 6 2010 2115 2123
31. W. Wu, J. Shen, P. Banerjee, and S.Q. Zhou A multifunctional nano-platform based on responsive fluorescent plasmonic ZnO-Au@PEG hybrid nanogels Adv Funct Mater 21 2011 2830 2839
32. J.S. Walker, and C.A. Vanse Theory of closed-loop phase diagrams in binary fluid mixtures Phys Lett A 79 1980 421 424
33. M. Annaka, and T. Tanaka Multiple phases of polymer gels Nature 355 1992 430 432
34. M. Annaka, M. Tokita, T. Tanaka, S. Tanaka, and T. Nakahira The gel that memorizes phases J Chem Phys 112 2000 471 477
35. J.D. Debord, and L.A. Lyon Synthesis and characterization of pH-responsive copolymer microgels with tunable volume phase transition temperatures Langmuir 19 2003 7662 7664
36. Y. Hoshino, T. Kodama, Y. Okahata, and K.J. Shea Peptide imprinted polymer nanoparticles: a plastic antibody J Am Chem Soc 130 2008 15242 15243
37. W. Wu, T. Zhou, J. Shen, and S.Q. Zhou Optical detection of glucose by CdS quantum dots immobilized in smart microgels Chem Commun 45 2009 4390 4392
38. R.J. Hunter Zeta potential in colloid science 1981 Academic Press London
39. B. Chu Laser light scattering 2nd ed. 1991 Academic Press New York
40. W. Wu, M. Aiello, T. Zhou, A. Berliner, P. Banerjee, and S.Q. Zhou In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery Biomaterials 31 2010 3023 3031
41. M. Zeng, and Z.P. Fang Preparation of sub-micrometer porous membrane from chitosan/polyethylene glycol semi-IPN J Membr Sci 245 2004 95 102
42. L. Zhang, F.X. Gu, J.M. Chan, A.Z. Wang, R.S. Langer, and O.C. Farokhzad Nanoparticles in medicine: therapeutic applications and developments Clin Pharmacol Ther 83 2008 761 769
43. A.N. Lukyanov, Z. Gao, L. Mazzola, and V.P. Torchilin Polyethylene glycol-diacyllipid micelles demonstrate increased acculumation in subcutaneous tumors in mice Pharm Res 19 2002 1424 1429
44. S.X. Tian, and J.L. Yang Effects of intramolecular hydrogen bonding on the ionization energies of proline Angew Chem Int Ed 45 2006 2069 2072
45. C. Wu, and S.Q. Zhou Volume phase transition of swollen gels: discontinuous or continuous? Macromolecules 30 1997 574 576
46. C. Chi, T. Cai, and Z.B. Hu Oligo(ethylene glycol)-based thermoresponsive core-shell microgels Langmuir 25 2009 3814 3819
47. M. Malet-Martino, and R. Martino Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): a review Oncologist 7 2002 288 323
48. C.A. Burtis, and E.R. Ashwood Tietz textbook of clinical chemistry 3rd ed. 1999 Saunders Philadelphia, PA
49. Y. Matsumura, and H. Maeda A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res 46 1986 6387 6392
50. J. Satija, U. Gupta, and N.K. Jain Pharmaceutical and biomedical potential of surface engineered dendrimers Crit Rev Ther Drug Carrier Syst 24 2007 257 306
51. D.E. Owens III, and N.A. Peppas Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles Int J Pharm 307 2006 93 102
52. A.M. Lowman, T.D. Dziubla, P. Bures, and N.A. Peppas Structural and dynamic response of neutral and intelligent networks in biomedical environments Adv Chem Eng 29 2004 75 130
53. R.B. Diasio, T.L. Beavers, and J.T. Carpenter Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity J Clin Invest 81 1988 47 51
54. S.F. Nadler, K. Weingand, and R.J. Kruse The physiologic basis and clinical applications of cryotherapy and thermotherapy for the pain practitioner Pain Physician 7 2004 395 399
55. R. Savic, L. Luo, A. Eisenberg, and D. Maysinger Micellar nanocontainers distribute to defined cytoplasmic organelles Science 300 2003 615 618
56. G.M. Hahn, J. Braun, and I. Har-kedar Thermochemotherapy: synergism between hyperthermia (42-43 degrees) and adriamycin (of belomycin) in mammalian cell inactivation Proc Natl Acad Sci USA 72 1975 937 940