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Volumn 68, Issue 4, 2015, Pages 253-257

Gene of the month: PIK3CA

Author keywords

[No Author keywords available]

Indexed keywords

ALPELISIB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; ANTINEOPLASTIC AGENT; PIK3CA PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; TUMOR MARKER;

EID: 84924974079     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jclinpath-2015-202885     Document Type: Article
Times cited : (42)

References (54)
  • 1
    • 13944284494 scopus 로고    scopus 로고
    • Oncogenic mutations of PIK3CA in human cancers
    • Samuels Y, Velculescu VE. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 2004;3:1221-4.
    • (2004) Cell Cycle , vol.3 , pp. 1221-1224
    • Samuels, Y.1    Velculescu, V.E.2
  • 2
    • 0028601306 scopus 로고
    • Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene
    • Volinia S, Hiles I, Ormondroyd E, et al. Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene. Genomics 1994;24:472-7.
    • (1994) Genomics , vol.24 , pp. 472-477
    • Volinia, S.1    Hiles, I.2    Ormondroyd, E.3
  • 4
    • 0034794639 scopus 로고    scopus 로고
    • Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment
    • Stein RC. Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment. Endocr Relat Cancer 2001;8:237-48.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 237-248
    • Stein, R.C.1
  • 5
    • 0027953284 scopus 로고
    • PI 3-kinase is a dual specificity enzyme: Autoregulation by an intrinsic protein-serine kinase activity
    • Dhand R, Hiles I, Panayotou G, et al. PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO J 1994;13:522-33.
    • (1994) EMBO J , vol.13 , pp. 522-533
    • Dhand, R.1    Hiles, I.2    Panayotou, G.3
  • 6
    • 31944448780 scopus 로고    scopus 로고
    • Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase
    • Kang S, Denley A, Vanhaesebroeck B, et al. Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. Proc Natl Acad Sci USA 2006;103:1289-94.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1289-1294
    • Kang, S.1    Denley, A.2    Vanhaesebroeck, B.3
  • 7
    • 84889636479 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinases as accelerators and brakes of autophagy
    • O'Farrell F, Rusten TE, Stenmark H. Phosphoinositide 3-kinases as accelerators and brakes of autophagy. FEBS J 2013;280:6322-37.
    • (2013) FEBS J , vol.280 , pp. 6322-6337
    • O'Farrell, F.1    Rusten, T.E.2    Stenmark, H.3
  • 8
    • 84881660990 scopus 로고    scopus 로고
    • Genetic deregulation of the PIK3CA oncogene in oral cancer
    • Murugan AK, Munirajan AK, Tsuchida N. Genetic deregulation of the PIK3CA oncogene in oral cancer. Cancer Lett 2013;338:193-203.
    • (2013) Cancer Lett , vol.338 , pp. 193-203
    • Murugan, A.K.1    Munirajan, A.K.2    Tsuchida, N.3
  • 9
    • 84979673540 scopus 로고    scopus 로고
    • Molecular pathways in head and neck cancer: EGFR, PI3K, and more
    • Psyrri A, Seiwert TY, Jimeno A. Molecular pathways in head and neck cancer: EGFR, PI3K, and more. Am Soc Clin Oncol Educ Book 2013:246-55. doi: 10.1200/EdBook-AM.2013.33.246
    • Am Soc Clin Oncol Educ Book , vol.2013 , pp. 246-255
    • Psyrri, A.1    Seiwert, T.Y.2    Jimeno, A.3
  • 10
    • 84860206692 scopus 로고    scopus 로고
    • Regulation and cellular functions of class II phosphoinositide 3-kinases
    • Falasca M, Maffucci T. Regulation and cellular functions of class II phosphoinositide 3-kinases. Biochem J 2012;443:587-601.
    • (2012) Biochem J , vol.443 , pp. 587-601
    • Falasca, M.1    Maffucci, T.2
  • 11
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • Bader AG, Kang S, Zhao L, et al. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 2005;5:921-9.
    • (2005) Nat Rev Cancer , vol.5 , pp. 921-929
    • Bader, A.G.1    Kang, S.2    Zhao, L.3
  • 12
    • 51849128358 scopus 로고    scopus 로고
    • Class I PI3K in oncogenic cellular transformation
    • Zhao L, Vogt PK. Class I PI3K in oncogenic cellular transformation. Oncogene 2008;27:5486-96.
    • (2008) Oncogene , vol.27 , pp. 5486-5496
    • Zhao, L.1    Vogt, P.K.2
  • 13
    • 33645084781 scopus 로고    scopus 로고
    • PIK3CA mutations in head and neck squamous cell carcinoma
    • Qiu W, Schonleben F, Li X, et al. PIK3CA mutations in head and neck squamous cell carcinoma. Clin Cancer Res 2006;12:1441-6.
    • (2006) Clin Cancer Res , vol.12 , pp. 1441-1446
    • Qiu, W.1    Schonleben, F.2    Li, X.3
  • 14
    • 84902150384 scopus 로고    scopus 로고
    • Combined mutational analysis of RAS, BRAF, PIK3CA, and TP53 genes in Taiwanese patients with oral squamous cell carcinoma
    • Chang YS, Hsu HT, Ko YC, et al. Combined mutational analysis of RAS, BRAF, PIK3CA, and TP53 genes in Taiwanese patients with oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol 2014;118:110-6 e1.
    • (2014) Oral Surg Oral Med Oral Pathol Oral Radiol , vol.118 , pp. 110-6e1
    • Chang, Y.S.1    Hsu, H.T.2    Ko, Y.C.3
  • 15
    • 38749089046 scopus 로고    scopus 로고
    • Novel mutant-enriched sequencing identified high frequency of PIK3CA mutations in pharyngeal cancer
    • Qiu W, Tong GX, Manolidis S, et al. Novel mutant-enriched sequencing identified high frequency of PIK3CA mutations in pharyngeal cancer. Int J Cancer 2008;122:1189-94.
    • (2008) Int J Cancer , vol.122 , pp. 1189-1194
    • Qiu, W.1    Tong, G.X.2    Manolidis, S.3
  • 16
    • 84961289657 scopus 로고    scopus 로고
    • Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas
    • Seiwert TY, Zuo Z, Keck MK, et al. Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. Clin Cancer Res 2014. doi:10.1158/1078-0432.CCR-13-3310
    • (2014) Clin Cancer Res
    • Seiwert, T.Y.1    Zuo, Z.2    Keck, M.K.3
  • 17
    • 84919617522 scopus 로고    scopus 로고
    • Sequencing the head and neck cancer genome: Implications for therapy
    • Sun W, Califano JA. Sequencing the head and neck cancer genome: implications for therapy. Ann N Y Acad Sci 2014;1333:33-42.
    • (2014) Ann N y Acad Sci , vol.1333 , pp. 33-42
    • Sun, W.1    Califano, J.A.2
  • 18
    • 77951251423 scopus 로고    scopus 로고
    • Absence of hotspot mutations in exons 9 and 20 of the PIK3CA gene in human oral squamous cell carcinoma in the Greek population
    • Kostakis GC, Papadogeorgakis N, Koumaki V, et al. Absence of hotspot mutations in exons 9 and 20 of the PIK3CA gene in human oral squamous cell carcinoma in the Greek population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;109: e53-8.
    • (2010) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.109 , pp. e53-e58
    • Kostakis, G.C.1    Papadogeorgakis, N.2    Koumaki, V.3
  • 19
    • 38749116169 scopus 로고    scopus 로고
    • Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas
    • Murugan AK, Hong NT, Fukui Y, et al. Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas. Int J Oncol 2008;32:101-11.
    • (2008) Int J Oncol , vol.32 , pp. 101-111
    • Murugan, A.K.1    Hong, N.T.2    Fukui, Y.3
  • 20
    • 34548048411 scopus 로고    scopus 로고
    • Analysis of PIK3CA and Akt/protein kinase B in head and neck squamous cell carcinoma
    • Fenic I, Steger K, Gruber C, et al. Analysis of PIK3CA and Akt/protein kinase B in head and neck squamous cell carcinoma. Oncol Rep 2007;18:253-9.
    • (2007) Oncol Rep , vol.18 , pp. 253-259
    • Fenic, I.1    Steger, K.2    Gruber, C.3
  • 21
    • 84878111732 scopus 로고    scopus 로고
    • Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibition
    • Young NR, Liu J, Pierce C, et al. Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibition. Mol Oncol 2013;7:359-68.
    • (2013) Mol Oncol , vol.7 , pp. 359-368
    • Young, N.R.1    Liu, J.2    Pierce, C.3
  • 22
    • 84899499283 scopus 로고    scopus 로고
    • Biological basis for increased sensitivity to radiation therapy in HPV-positive head and neck cancers
    • Bol V, Gregoire V. Biological basis for increased sensitivity to radiation therapy in HPV-positive head and neck cancers. Biomed Res Int 2014;2014:696028.
    • (2014) Biomed Res Int , vol.2014 , pp. 696028
    • Bol, V.1    Gregoire, V.2
  • 23
    • 42149083899 scopus 로고    scopus 로고
    • Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers
    • Barault L, Veyrie N, Jooste V, et al. Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers. Int J Cancer 2008;122:2255-9.
    • (2008) Int J Cancer , vol.122 , pp. 2255-2259
    • Barault, L.1    Veyrie, N.2    Jooste, V.3
  • 24
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • De Roock W, Claes B, Bernasconi D, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010;11:753-62.
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3
  • 25
    • 84860634396 scopus 로고    scopus 로고
    • PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: A systematic review and meta-analysis
    • Mao C, Yang ZY, Hu XF, et al. PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis. Ann Oncol 2012;23:1518-25.
    • (2012) Ann Oncol , vol.23 , pp. 1518-1525
    • Mao, C.1    Yang, Z.Y.2    Hu, X.F.3
  • 26
    • 77952956887 scopus 로고    scopus 로고
    • Oncogenic mutations as predictive factors in colorectal cancer
    • Lievre A, Blons H, Laurent-Puig P. Oncogenic mutations as predictive factors in colorectal cancer. Oncogene 2010;29:3033-43.
    • (2010) Oncogene , vol.29 , pp. 3033-3043
    • Lievre, A.1    Blons, H.2    Laurent-Puig, P.3
  • 27
    • 84859865072 scopus 로고    scopus 로고
    • Prognostic role of PIK3CA mutation in colorectal cancer: Cohort study and literature review
    • Liao X, Morikawa T, Lochhead P, et al. Prognostic role of PIK3CA mutation in colorectal cancer: cohort study and literature review. Clin Cancer Res 2012;18:2257-68.
    • (2012) Clin Cancer Res , vol.18 , pp. 2257-2268
    • Liao, X.1    Morikawa, T.2    Lochhead, P.3
  • 28
    • 84862550874 scopus 로고    scopus 로고
    • Oncogenic PIK3CA mutations in colorectal cancers and polyps
    • Whitehall VL, Rickman C, Bond CE, et al. Oncogenic PIK3CA mutations in colorectal cancers and polyps. Int J Cancer 2012;131:813-20.
    • (2012) Int J Cancer , vol.131 , pp. 813-820
    • Whitehall, V.L.1    Rickman, C.2    Bond, C.E.3
  • 29
    • 72549116865 scopus 로고    scopus 로고
    • PIK3CA mutations predict local recurrences in rectal cancer patients
    • He Y, Van't Veer LJ, Mikolajewska-Hanclich I, et al. PIK3CA mutations predict local recurrences in rectal cancer patients. Clin Cancer Res 2009;15:6956-62.
    • (2009) Clin Cancer Res , vol.15 , pp. 6956-6962
    • He, Y.1    Van'T Veer, L.J.2    Mikolajewska-Hanclich, I.3
  • 30
    • 84867817838 scopus 로고    scopus 로고
    • Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
    • Liao X, Lochhead P, Nishihara R, et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med 2012;367:1596-606.
    • (2012) N Engl J Med , vol.367 , pp. 1596-1606
    • Liao, X.1    Lochhead, P.2    Nishihara, R.3
  • 31
    • 32244445352 scopus 로고    scopus 로고
    • PIK3CA mutation and histological type in breast carcinoma: High frequency of mutations in lobular carcinoma
    • Buttitta F, Felicioni L, Barassi F, et al. PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma. J Pathol 2006;208:350-5.
    • (2006) J Pathol , vol.208 , pp. 350-355
    • Buttitta, F.1    Felicioni, L.2    Barassi, F.3
  • 32
    • 7444250290 scopus 로고    scopus 로고
    • Mutation of the PIK3CA gene in ovarian and breast cancer
    • Campbell IG, Russell SE, Choong DY, et al. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 2004;64:7678-81.
    • (2004) Cancer Res , vol.64 , pp. 7678-7681
    • Campbell, I.G.1    Russell, S.E.2    Choong, D.Y.3
  • 33
    • 33846854921 scopus 로고    scopus 로고
    • Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women
    • Maruyama N, Miyoshi Y, Taguchi T, et al. Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women. Clin Cancer Res 2007;13(2 Pt 1):408-14.
    • (2007) Clin Cancer Res , vol.13 , Issue.2 , pp. 408-414
    • Maruyama, N.1    Miyoshi, Y.2    Taguchi, T.3
  • 34
    • 20144387695 scopus 로고    scopus 로고
    • PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
    • Saal LH, Holm K, Maurer M, et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 2005;65:2554-9.
    • (2005) Cancer Res , vol.65 , pp. 2554-2559
    • Saal, L.H.1    Holm, K.2    Maurer, M.3
  • 35
    • 69349105634 scopus 로고    scopus 로고
    • PIK3CA mutation associates with improved outcome in breast cancer
    • Kalinsky K, Jacks LM, Heguy A, et al. PIK3CA mutation associates with improved outcome in breast cancer. Clin Cancer Res 2009;15:5049-59.
    • (2009) Clin Cancer Res , vol.15 , pp. 5049-5059
    • Kalinsky, K.1    Jacks, L.M.2    Heguy, A.3
  • 36
    • 84856767715 scopus 로고    scopus 로고
    • PIK3CA mutation impact on survival in breast cancer patients and in ERalpha, PR and ERBB2-based subgroups
    • Cizkova M, Susini A, Vacher S, et al. PIK3CA mutation impact on survival in breast cancer patients and in ERalpha, PR and ERBB2-based subgroups. Breast Cancer Res 2012;14:R28.
    • (2012) Breast Cancer Res , vol.14 , pp. R28
    • Cizkova, M.1    Susini, A.2    Vacher, S.3
  • 37
    • 34250749822 scopus 로고    scopus 로고
    • PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer
    • Perez-Tenorio G, Alkhori L, Olsson B, et al. PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer. Clin Cancer Res 2007;13:3577-84.
    • (2007) Clin Cancer Res , vol.13 , pp. 3577-3584
    • Perez-Tenorio, G.1    Alkhori, L.2    Olsson, B.3
  • 38
    • 84857921336 scopus 로고    scopus 로고
    • Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes
    • Boyault S, Drouet Y, Navarro C, et al. Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes. Breast Cancer Res Treat 2012;132:29-39.
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 29-39
    • Boyault, S.1    Drouet, Y.2    Navarro, C.3
  • 39
    • 84880230412 scopus 로고    scopus 로고
    • Somatic mutation profiling and associations with prognosis and trastuzumab benefit in early breast cancer
    • Loi S, Michiels S, Lambrechts D, et al. Somatic mutation profiling and associations with prognosis and trastuzumab benefit in early breast cancer. J Natl Cancer Inst 2013;105:960-7.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 960-967
    • Loi, S.1    Michiels, S.2    Lambrechts, D.3
  • 40
    • 79959733118 scopus 로고    scopus 로고
    • Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer
    • Razis E, Bobos M, Kotoula V, et al. Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer. Breast Cancer Res Treat 2011;128:447-56.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 447-456
    • Razis, E.1    Bobos, M.2    Kotoula, V.3
  • 41
    • 84871238855 scopus 로고    scopus 로고
    • Frequent mutational activation of the PI3K-AKT pathway in trastuzumab-resistant breast cancer
    • Chandarlapaty S, Sakr RA, Giri D, et al. Frequent mutational activation of the PI3K-AKT pathway in trastuzumab-resistant breast cancer. Clin Cancer Res 2012;18:6784-91.
    • (2012) Clin Cancer Res , vol.18 , pp. 6784-6791
    • Chandarlapaty, S.1    Sakr, R.A.2    Giri, D.3
  • 42
    • 77957352037 scopus 로고    scopus 로고
    • PTEN, PIK3CA, p-AKT, and p-p70S6K status: Association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer
    • Esteva FJ, Guo H, Zhang S, et al . PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer. Am J Pathol 2010;177:1647-56.
    • (2010) Am J Pathol , vol.177 , pp. 1647-1656
    • Esteva, F.J.1    Guo, H.2    Zhang, S.3
  • 43
    • 79958765919 scopus 로고    scopus 로고
    • PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib
    • Wang L, Zhang Q, Zhang J, et al . PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib. BMC Cancer 2011;11:248.
    • (2011) BMC Cancer , vol.11 , pp. 248
    • Wang, L.1    Zhang, Q.2    Zhang, J.3
  • 44
    • 84904392089 scopus 로고    scopus 로고
    • PIK3CA mutations are a predictor of docetaxel plus epirubicin neoadjuvant chemotherapy clinical efficacy in breast cancer
    • Zhang Y, Liu M, Yang H, et al. PIK3CA mutations are a predictor of docetaxel plus epirubicin neoadjuvant chemotherapy clinical efficacy in breast cancer. Neoplasma 2014;61:461-7.
    • (2014) Neoplasma , vol.61 , pp. 461-467
    • Zhang, Y.1    Liu, M.2    Yang, H.3
  • 45
    • 0032125580 scopus 로고    scopus 로고
    • Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors
    • Phillips WA, St Clair F, Munday AD, et al. Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors. Cancer 1998;83:41-7.
    • (1998) Cancer , vol.83 , pp. 41-47
    • Phillips, W.A.1    St Clair, F.2    Munday, A.D.3
  • 46
    • 0032590011 scopus 로고    scopus 로고
    • PIK3CA is implicated as an oncogene in ovarian cancer
    • Shayesteh L, Lu Y, Kuo WL, et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 1999;21:99-102.
    • (1999) Nat Genet , vol.21 , pp. 99-102
    • Shayesteh, L.1    Lu, Y.2    Kuo, W.L.3
  • 47
    • 84878836487 scopus 로고    scopus 로고
    • Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation
    • Furet P, Guagnano V, Fairhurst RA, et al. Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. Bioorg Med Chem Lett 2013;23:3741-8.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 3741-3748
    • Furet, P.1    Guagnano, V.2    Fairhurst, R.A.3
  • 48
    • 84899785427 scopus 로고    scopus 로고
    • Characterization of the novel and specific PI3Kalpha inhibitor NVP-BYL719 and development of the patient stratifi cation strategy for clinical trials
    • Fritsch C, Huang A, Chatenay-Rivauday C, et al . Characterization of the novel and specific PI3Kalpha inhibitor NVP-BYL719 and development of the patient stratifi cation strategy for clinical trials. Mol Cancer Ther 2014;13:1117-29.
    • (2014) Mol Cancer Ther , vol.13 , pp. 1117-1129
    • Fritsch, C.1    Huang, A.2    Chatenay-Rivauday, C.3
  • 52
    • 84907256951 scopus 로고    scopus 로고
    • The significance of autophagy in colorectal cancer pathogenesis and implications for therapy
    • Lai K, Killingsworth MC, Lee CS. The significance of autophagy in colorectal cancer pathogenesis and implications for therapy. J Clin Pathol 2014;67:854-8.
    • (2014) J Clin Pathol , vol.67 , pp. 854-858
    • Lai, K.1    Killingsworth, M.C.2    Lee, C.S.3
  • 53
    • 78149475478 scopus 로고    scopus 로고
    • Akt and autophagy cooperate to promote survival of drug-resistant glioma
    • Fan QW, Cheng C, Hackett C, et al. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal 2010;3:ra81.
    • (2010) Sci Signal , vol.3 , pp. ra81
    • Fan, Q.W.1    Cheng, C.2    Hackett, C.3
  • 54
    • 51049109033 scopus 로고    scopus 로고
    • Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
    • Maira SM, Stauffer F, Brueggen J, et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 2008;7:1851-63.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1851-1863
    • Maira, S.M.1    Stauffer, F.2    Brueggen, J.3


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