Assessment of Oxidative Stress in Hippocampus, Cerebellum and Frontal Cortex in Rat Pups Exposed to Lead (Pb) During Specific Periods of Initial Brain Development

Biological Trace Element Research

Volumn 164, Issue 2, 2015, Pages 212-218

  Barkur, Rajashekar Rao ^a   Bairy, Laxminarayana Kurady ^b  

^a MELAKA MANIPAL MEDICAL COLLEGE   (India)

^b KASTURBA MEDICAL COLLEGE   (India)

Author keywords

Cerebellum; Hippocampus; Lead acetate; Oxidative stress; Postnatal period

Indexed keywords

GLUTATHIONE; GLUTATHIONE PEROXIDASE; LEAD; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANODIC STRIPPING POTENTIOMETRY; ARTICLE; BRAIN DAMAGE; BRAIN DEVELOPMENT; BRAIN WEIGHT; CEREBELLUM; COGNITION; CONTROLLED STUDY; EMOTIONALITY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; EPISODIC MEMORY; FEMALE; FRONTAL CORTEX; GESTATIONAL AGE; HIPPOCAMPUS; LACTATION; LIPID PEROXIDATION; LOCOMOTION; MALE; NONHUMAN; OXIDATIVE STRESS; PERINATAL PERIOD; RAT; ADVERSE EFFECTS; ANIMAL; BLOOD; BRAIN; CHEMICALLY INDUCED; DRUG EFFECTS; EMBRYOLOGY; FRONTAL LOBE; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NEWBORN; ORGAN SIZE; PREGNANCY; PRENATAL EXPOSURE; TIME; WISTAR RAT;

RATTUS;

ANIMALS; ANIMALS, NEWBORN; BRAIN; CEREBELLUM; FEMALE; FRONTAL LOBE; GESTATIONAL AGE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HIPPOCAMPUS; LACTATION; LEAD; MALE; MATERNAL EXPOSURE; ORGAN SIZE; OXIDATIVE STRESS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS, WISTAR; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TIME FACTORS;

EID: 84924955681     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-014-0221-3     Document Type: Article

References (50)

1. Yiin SJ, Lin TH (1995) Lead-catalyzed peroxidation of essential unsaturated fatty acid. Biol Trace Elem Res 50:167–172
2. Adegbesan BO, Adenuga GA (2007) Effect of lead exposure on liver lipid peroxidative and antioxidant defense systems of protein-undernourished rats. Biol Trace Elem Res 116:219–225
3. Bokara KK, Brown E, McCormick R et al (2008) Lead-induced increase in antioxidant enzymes and lipid peroxidation products in developing rat brain. Biometals 21:9–16
4. Adonaylo VN, Oteiza PI (1999) Lead intoxication: antioxidant defenses and oxidative damage in rat brain. Toxicology 135:77–85
5. Weisbrot-Lefkowitz M, Reuhl K, Perry B, Chan PH, Inouye M, Mirochnitchenko O (1998) Overexpression of human glutathione peroxidase protects transgenic mice against focal cerebral ischemia/reperfusion damage. Mol Brain Res 53:333–338
6. Steullet P, Cabungcal JH, Kulak A et al (2010) Redox dysregulation affects the ventral but not dorsal hippocampus: impairment of parvalbumin neurons, gamma oscillations, and related behaviors. J Neurosci 30:2547–2558
7. Lidsky TI, Schneider JS (2003) Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 126:5–19
8. Goyer RA (1990) Transplacental transport of lead. Environ Health Perspect 89:101–105
9. Lataillade GP, Thoreux-Manlay A, Coffigny H, Masse R, Soufir JC (1995) Reproductive toxicity of chronic lead exposure in male and female mice. Hum Exp Toxicol 14:872–878
10. Namihira D, Saldivar N, Pustilnik N, Carreon GJ, Salinas ME (1993) Lead in human blood and milk from nursing women living near a smelter in Mexico city. J Toxicol Environ Health 388:225–232
11. Hallen PI, Jorhem L, Oskarsson A (1995) Placental and lactational transfer of lead in rats: a study of the lactational process and effects on offspring. Arch Toxicol 69:596–602
12. Needleman HL (1993) The current status of childhood low-level lead toxicity. Neurotoxicology 14:161–166
13. Markowitz M (2000) Lead poisoning: a disease for the next millennium. Curr Probl Pediatr 30:62–70
14. Gurer H, Ozgunes H, Neal R et al (1998) Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats. Toxicology 128:181–189
15. Lu X, Jin C, Yang J et al (2013) Prenatal and lactational lead exposure enhanced oxidative stress and altered apoptosis status in offspring rats' hippocampus. Biol Trace Elem Res 151(1):75–84
16. Muller RU, Bostock E, Taube JS, Kubie JL (1994) On the directional firing properties of hippocampal place cells. J Neurosci 14(12):7235–7251
17. Hayman R, Verriotis MA, Jovalekic A, Fenton AA, Jeffery KJ (2011) Anisotropic encoding of three-dimensional space by place cells and grid cells. Nat Neurosci 14(9):1182–1188
18. Holdstock JS, Mayes AR, Roberts N et al (2002) Under what conditions is recognition spared relative to recall after selective hippocampal damage in humans? Hippocampus 12:341–351
19. Griffiths D, Dickinson A, Clayton N (1999) Episodic memory: what can animals remember about their past? Trends Cogn Sci 3:74–80
20. Tulving E, Markowitsch HJ (1998) Episodic and declarative memory: a role of the hippocampus. Hippocampus 8:198–204
21. Raymond JL, Lisberger SG, Mauk MD (1996) The cerebellum: a neural learning machine? Science 272:1126–1131
22. Andreasen NC, Nopoulos P, O’Leary DS, Miller DD, Wassink T, Flaum M (1999) Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms. Biol Psychiat 46(7):908–920
23. Schmahmann JD (2004) Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. J Neuropsychiatry Clin Neurosci 16(3):367–378
24. Kolb B (1990) Animal models for human PFC-related disorders. Prog Brain Res 85:501–519
25. Stuss DT, Alexander MP (2000) Executive functions and the frontal lobes: a conceptual view. Psychol Res 63:289–298
26. Winocur G, Moscovitch M (1999) Anterograde and retrograde amnesia after lesions to frontal cortex in rats. J Neurosci 19(21):9611–9617
27. Moreira EG, Rosa GJ, Barros SB, Vassilieff VS, Vassillieff I (2001) Antioxidant defense in rat brain regions after developmental lead exposure. Toxicology 169(2):145–151
28. Verma SK, Dua R, Gill KD (2006) Impaired energy metabolism after co-exposure to lead and ethanol. Basic Clin Pharmacol Toxicol 96(6):475–479
29. Barkur RR, Bairy LK (2014) Histological study on hippocampus, amygdala and cerebellum following low lead exposure during prenatal and postnatal brain development in rats. Toxicol Ind Health. doi:10.1177/0748233714545624
30. Jaako-Movits K, Zharkovsky T, Romantchik O et al (2005) Developmental lead exposure impairs contextual fear conditioning and reduces adult hippocampal neurogenesis in the rat brain. Int J Dev Neurosci 23:627–635
31. Heidmets LT, Zharkovsky T, Jurgenson M, Jaako-Movits K, Zharkovsky A (2006) Early postnatal, low-level lead exposure increases the number of PSA-NCAM expressing cells in the dentate gyrus of adult rat hippocampus. Neurotoxicology 27:39–43
32. Chen HH, Ma T, Paul IA, Spencer JL, Ho IK (1997) Developmental lead exposure and two-way active avoidance training alter the distribution of protein kinase C activity in the rat hippocampus. Neurochem Res 22:1119–1125
33. Glowinski J, Iverson LL (1966) Regional studies of catecholamines in the rat brain. The deposition of [3H]norepinephrine, [3H]dopamine, and [3H]dopa in various regions of the brain. J Neurochem 13(8):655–669
34. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358
35. Wendel A (1981) Glutathione peroxidase. In: Jakoly WB (ed) Methods in enzymology, vol 7. Academic, New York, pp 325–333
36. Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882–888
37. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275
38. Kuruvilla A, Pillay VV, Venkatesh T et al (2004) Portable lead analyzer to locate source of lead. Indian J Pediat 71:495–499
39. Quinlan GJ, Halliwell B, Moorhouse CP, Gutteridge JMC (1988) Action of lead(II) and aluminium(III) ions on iron-stimulated lipid peroxidation in liposomes, erythrocytes and rat liver microsomal fractions. Biochim Biophys Acta 962:196–200
40. Zhao Y, Wang L, Shen HB, Wang ZX, Wei QY, Chen F (2007) Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis. J Toxicol Environ Health A 70:1986–1994
41. Flora SJS, Flora G, Saxena G, Mishra M (2007) Arsenic and lead induced free radical generation and their reversibility following chelation. Cell Mol Biol 53:24–46
42. Gleichmann M, Mattson MP (2011) Neuronal calcium homeostasis and dysregulation. Antioxid Redox Signal 14(7):1261–1273
43. Hermes-Lima M, Pereira B, Bechara EJH (1991) Are free radicals involved in lead poisoning? Xenobiotica 21:1085–1090
44. Sandhir R, Julka D, Gill KD (1994) Lipoperoxidative damage on lead exposure in rat brain and its implications on membrane bound enzymes. Pharmacol Toxicol 74:66–71
45. Schwartz BS, Lee BK, Lee GS (2000) Associations of blood lead, dimercaptosuccinic acid-chelatable lead and tibia lead with polymorphisms in the vitamin D receptor and 5-aminolevulinic acid dehydratase genes. Environ Health Perspect 108:949–954
46. Shukla PK, Khanna VK, Khan MY, Srimal RC (2003) Protective effect of curcumin against lead neurotoxicity in rat. Hum Exp Toxicol 22(12):653–658
47. Bolin CM, Basha R, Cox D, Zawia NH, Maloney B, Lahiri DK et al (2006) Exposure to lead and the developmental origin of oxidative DNA damage in the aging brain. FASEB J 20(6):788–790
48. Blaschke AJ, Weiner JA, Chun J (1998) Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the central nervous system. J Comp Neurol 396:39–50
49. Antonsson B, Montessuit S, Lauper S, Eskes R, Martinou JC (2000) Bax oligomerization is required for channel-forming activity in liposomes and trigger cytochrome c release from mitochondria. Biochem J 345:271–278
50. Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770–776