메뉴 건너뛰기




Volumn 21, Issue 21, 2014, Pages 12583-12604

Post-acquisition data processing for the screening of transformation products of different organic contaminants. Two-year monitoring of river water using LC-ESI-QTOF-MS and GCxGC-EI-TOF-MS

Author keywords

Automated search; LC ESI QTOF MS; Monitoring; Post acquisition data processing; Targeted and non targeted screening; Transformation products (TPs)

Indexed keywords

OMEPRAZOLE; PESTICIDE; POLYCYCLIC AROMATIC HYDROCARBON; WATER POLLUTANT;

EID: 84924936057     PISSN: 09441344     EISSN: 16147499     Source Type: Journal    
DOI: 10.1007/s11356-014-3187-y     Document Type: Article
Times cited : (34)

References (52)
  • 1
    • 84878105594 scopus 로고    scopus 로고
    • New trends in the analytical determination of emerging contaminants and their transformation products in environmental waters
    • Agüera A, Martínez Bueno MJ, Fernández-Alba AR (2013) New trends in the analytical determination of emerging contaminants and their transformation products in environmental waters. Environ Sci Pollut Res 20:3496–3515
    • (2013) Environ Sci Pollut Res , vol.20 , pp. 3496-3515
    • Agüera, A.1    Martínez Bueno, M.J.2    Fernández-Alba, A.R.3
  • 4
    • 0035416421 scopus 로고    scopus 로고
    • Systematic LC/MS metabolite identification in drug discovery. A four-step strategy to characterize metabolites by LC/MS techniques early in the pharmaceutical discovery process
    • Clarke NJ, Rindgen D, Korfmacher WA, Cox KA (2001) Systematic LC/MS metabolite identification in drug discovery. A four-step strategy to characterize metabolites by LC/MS techniques early in the pharmaceutical discovery process. Anal Chem 73:431A
    • (2001) Anal Chem , vol.73 , pp. 431A
    • Clarke, N.J.1    Rindgen, D.2    Korfmacher, W.A.3    Cox, K.A.4
  • 5
    • 0011224447 scopus 로고
    • Fragmentation characteristic of glutathione conjugates activated by high-energy collisions
    • Constance MM, Fenselau C (1992) Fragmentation characteristic of glutathione conjugates activated by high-energy collisions. J Am See Mass Spectrom 3:815–822
    • (1992) J Am See Mass Spectrom , vol.3 , pp. 815-822
    • Constance, M.M.1    Fenselau, C.2
  • 6
    • 0034532968 scopus 로고    scopus 로고
    • Directly coupled liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the identification of drug metabolites in urine: Application to diclofenac using chlorine and sulfur detection
    • COI: 1:CAS:528:DC%2BD3MXhsFSquw%3D%3D
    • Corcoran O, Nicholson JK, Lenz EM, Abou-Shakra F, Castro-Perez J, Sage AB, Wilson ID (2000) Directly coupled liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the identification of drug metabolites in urine: application to diclofenac using chlorine and sulfur detection. Rapid Commun Mass Spectrom 14:2377–2384
    • (2000) Rapid Commun Mass Spectrom , vol.14 , pp. 2377-2384
    • Corcoran, O.1    Nicholson, J.K.2    Lenz, E.M.3    Abou-Shakra, F.4    Castro-Perez, J.5    Sage, A.B.6    Wilson, I.D.7
  • 8
    • 85003208473 scopus 로고    scopus 로고
    • Directive 2000/60/EC of the European Parliament and of the Council of 23 October 2000 establishing a framework for Community action in the field of water policy. Official Journal L 327, 22/12/2000 P. 0001 - 0073. http://eurlex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32000L0060
  • 9
    • 43049180321 scopus 로고    scopus 로고
    • Photodegradation study of three dipyrone metabolites in various water systems: Identification and toxicity of their photodegradation products
    • Gómez MJ, Sirtori C, Mezcua M, Fernández-Alba AR, Agüera A (2008) Photodegradation study of three dipyrone metabolites in various water systems: Identification and toxicity of their photodegradation products. Water Res 42:2698–2706
    • (2008) Water Res , vol.42 , pp. 2698-2706
    • Gómez, M.J.1    Sirtori, C.2    Mezcua, M.3    Fernández-Alba, A.R.4    Agüera, A.5
  • 10
    • 77957876192 scopus 로고    scopus 로고
    • Rapid automated screening, identification and quantification of organic micro-contaminants and their main transformation products in wastewater and river waters using liquid chromatography–quadrupole-time-of-flight mass spectrometry with an accurate-mass database
    • Gómez MJ, Gómez-Ramos MM, Malato O, Mezcua M, Férnandez-Alba AR (2010) Rapid automated screening, identification and quantification of organic micro-contaminants and their main transformation products in wastewater and river waters using liquid chromatography–quadrupole-time-of-flight mass spectrometry with an accurate-mass database. J Chromatogr A 1217:7038–7054
    • (2010) J Chromatogr A , vol.1217 , pp. 7038-7054
    • Gómez, M.J.1    Gómez-Ramos, M.M.2    Malato, O.3    Mezcua, M.4    Férnandez-Alba, A.R.5
  • 11
    • 79953282723 scopus 로고    scopus 로고
    • Automatic searching and evaluation of priority and emerging contaminants in wastewater and river water by stir bar sorptive extraction followed by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry
    • Gómez MJ, Herrera S, Sole D, García-Calvo E, Fernández-Alba AR (2011) Automatic searching and evaluation of priority and emerging contaminants in wastewater and river water by stir bar sorptive extraction followed by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry. Anal Chem 83:2638–2647
    • (2011) Anal Chem , vol.83 , pp. 2638-2647
    • Gómez, M.J.1    Herrera, S.2    Sole, D.3    García-Calvo, E.4    Fernández-Alba, A.R.5
  • 12
    • 84857649180 scopus 로고    scopus 로고
    • Spatio-temporal evaluation of organic contaminants and their transformation products along a river basin affected by urban, agricultural and industrial pollution
    • Gómez MJ, Herrera S, Solé D, García-Calvo E, Fernández-Alba AR (2012) Spatio-temporal evaluation of organic contaminants and their transformation products along a river basin affected by urban, agricultural and industrial pollution. Sci Total Environ 420:134–145
    • (2012) Sci Total Environ , vol.420 , pp. 134-145
    • Gómez, M.J.1    Herrera, S.2    Solé, D.3    García-Calvo, E.4    Fernández-Alba, A.R.5
  • 13
    • 80053964813 scopus 로고    scopus 로고
    • Use of an accurate-mass database for the systematic identification of transformation products of organic contaminants in wastewater effluents
    • Gómez-Ramos MM, Pérez-Parada A, García-Reyes JF, Fernández-Alba AR, Agüera A (2011) Use of an accurate-mass database for the systematic identification of transformation products of organic contaminants in wastewater effluents. J Chromatogr A 1218:8002–8012
    • (2011) J Chromatogr A , vol.1218 , pp. 8002-8012
    • Gómez-Ramos, M.M.1    Pérez-Parada, A.2    García-Reyes, J.F.3    Fernández-Alba, A.R.4    Agüera, A.5
  • 14
    • 54849418890 scopus 로고    scopus 로고
    • Analysis of emerging contaminants of municipal and industrial origin
    • Gros M, Petrovic M, Barceló D (2008) Analysis of emerging contaminants of municipal and industrial origin. Hdb Env Chem 5:37–104
    • (2008) Hdb Env Chem , vol.5 , pp. 37-104
    • Gros, M.1    Petrovic, M.2    Barceló, D.3
  • 15
    • 84877248837 scopus 로고    scopus 로고
    • Investigation of galaxolide degradation products generated under oxidative and irradiation processes by liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry and comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry
    • Herrera López S, Hernando MD, Gómez MJ, Santiago-Morales J, Rosal R, Fernández-Alba AR (2013) Investigation of galaxolide degradation products generated under oxidative and irradiation processes by liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry and comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 27:1237–1250
    • (2013) Rapid Commun Mass Spectrom , vol.27 , pp. 1237-1250
    • Herrera López, S.1    Hernando, M.D.2    Gómez, M.J.3    Santiago-Morales, J.4    Rosal, R.5    Fernández-Alba, A.R.6
  • 17
    • 84881471716 scopus 로고    scopus 로고
    • Comparative toxicokinetics of organic micropollutants in freshwater crustaceans
    • COI: 1:CAS:528:DC%2BC3sXptFehsLc%3D
    • Jeon J, Kurth D, Ashauer R, Hollender J (2013) Comparative toxicokinetics of organic micropollutants in freshwater crustaceans. Environ Sci Technol 47:8809–8817
    • (2013) Environ Sci Technol , vol.47 , pp. 8809-8817
    • Jeon, J.1    Kurth, D.2    Ashauer, R.3    Hollender, J.4
  • 18
    • 84868699229 scopus 로고    scopus 로고
    • Emerging organic contaminants in groundwater in Spain: A review of sources, recent occurrence and fate in a European context
    • COI: 1:CAS:528:DC%2BC38Xhs1elsrzL
    • Jurado A, Vàzquez-Suñé E, Carrera J, López de Alda M, Pujades E, Barceló D (2012) Emerging organic contaminants in groundwater in Spain: a review of sources, recent occurrence and fate in a European context. Sci Total Environ 440:82–94
    • (2012) Sci Total Environ , vol.440 , pp. 82-94
    • Jurado, A.1    Vàzquez-Suñé, E.2    Carrera, J.3    López de Alda, M.4    Pujades, E.5    Barceló, D.6
  • 19
    • 77954861741 scopus 로고    scopus 로고
    • Stereoselective determination of venlafaxine and its three demethylated metabolites in human plasma and whole blood by liquid chromatography with electrospray tandem mass spectrometric detection and solid phase extraction
    • Kingbäck M, Josefsson M, Karlsson L, Ahlnera J, Bengtsson F, Fredrik C, Kugelberga FC, Carlsson B (2010) Stereoselective determination of venlafaxine and its three demethylated metabolites in human plasma and whole blood by liquid chromatography with electrospray tandem mass spectrometric detection and solid phase extraction. J Pharmaceut Biomed 53:583–590
    • (2010) J Pharmaceut Biomed , vol.53 , pp. 583-590
    • Kingbäck, M.1    Josefsson, M.2    Karlsson, L.3    Ahlnera, J.4    Bengtsson, F.5    Fredrik, C.6    Kugelberga, F.C.7    Carlsson, B.8
  • 20
    • 0037649064 scopus 로고    scopus 로고
    • Liquid chromatography/atmospheric pressure ionization–mass spectrometry in drug metabolism studies
    • COI: 1:CAS:528:DC%2BD3sXjvVyqs7c%3D
    • Kostiainen R, Kotiaho T, Kuuranne T, Auriola S (2003) Liquid chromatography/atmospheric pressure ionization–mass spectrometry in drug metabolism studies. J Mass Spectrom 38:357–372
    • (2003) J Mass Spectrom , vol.38 , pp. 357-372
    • Kostiainen, R.1    Kotiaho, T.2    Kuuranne, T.3    Auriola, S.4
  • 21
    • 85003404944 scopus 로고    scopus 로고
    • Simultaneous determination of losartan, losartan acid and amlodipine in human plasma by LC-MS/MS and its application to a human pharmacokinetic study
    • Kumari Karra V, Rao Pilli N, Inamadugu JK, Seshagiri Rao JV (2012) Simultaneous determination of losartan, losartan acid and amlodipine in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. Pharm Methods 3
    • (2012) Pharm Methods , pp. 3
    • Kumari Karra, V.1    Rao Pilli, N.2    Inamadugu, J.K.3    Seshagiri Rao, J.V.4
  • 22
    • 3042855893 scopus 로고    scopus 로고
    • Profiling of sulfoconjugates in urine using precursor ion and neutral loss scans in tandem mass spectrometry. Application to the investigation of heavy metal toxicity in rats
    • COI: 1:CAS:528:DC%2BD2cXls1art7Y%3D
    • Lafaye A, Junot C, Gall BR, Fritsch P, Ezan E, Tabet J-C (2004) Profiling of sulfoconjugates in urine using precursor ion and neutral loss scans in tandem mass spectrometry. Application to the investigation of heavy metal toxicity in rats. J Mass Spectrom 39:655–664
    • (2004) J Mass Spectrom , vol.39 , pp. 655-664
    • Lafaye, A.1    Junot, C.2    Gall, B.R.3    Fritsch, P.4    Ezan, E.5    Tabet, J.-C.6
  • 23
    • 12344263826 scopus 로고    scopus 로고
    • Strategies for characterization of drug metabolites using liquid chromatography-tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange approaches
    • Liu DQ, Hop CE (2005) Strategies for characterization of drug metabolites using liquid chromatography-tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange approaches. J Pharm Biomed 37:1
    • (2005) J Pharm Biomed , vol.37 , pp. 1
    • Liu, D.Q.1    Hop, C.E.2
  • 26
    • 79958086473 scopus 로고    scopus 로고
    • Development of a solvent-free method for the simultaneous identification/quantification of drugs of abuse and their metabolites in environmental water by LC–MS/MS
    • Martínez Bueno MJ, Uclés S, Hernando MD, Fernández-Alba AR (2011a) Development of a solvent-free method for the simultaneous identification/quantification of drugs of abuse and their metabolites in environmental water by LC–MS/MS. Talanta 85:157–166
    • (2011) Talanta , vol.85 , pp. 157-166
    • Martínez Bueno, M.J.1    Uclés, S.2    Hernando, M.D.3    Fernández-Alba, A.R.4
  • 27
    • 79951951105 scopus 로고    scopus 로고
    • Evaluation of selected ubiquitous contaminants in the aquatic environment and their transformation products. A pilot study of their removal from a sewage treatment plant
    • Martínez Bueno MJ, Uclés S, Hernando MD, Dávoli E, Fernández-Alba AR (2011b) Evaluation of selected ubiquitous contaminants in the aquatic environment and their transformation products. A pilot study of their removal from a sewage treatment plant. Water Res 45:2331–2341
    • (2011) Water Res , vol.45 , pp. 2331-2341
    • Martínez Bueno, M.J.1    Uclés, S.2    Hernando, M.D.3    Dávoli, E.4    Fernández-Alba, A.R.5
  • 28
    • 84857516203 scopus 로고    scopus 로고
    • Occurrence and persistence of organic emerging contaminants and priority pollutants in five sewage treatment plants of Spain: Two-year pilot monitoring survey
    • Martínez Bueno MJ, Gómez MJ, Herrera S, Hernando MD, Agüera A, Fernández-Alba AR (2012) Occurrence and persistence of organic emerging contaminants and priority pollutants in five sewage treatment plants of Spain: two-year pilot monitoring survey. Environ Pollut 164:267–273
    • (2012) Environ Pollut , vol.164 , pp. 267-273
    • Martínez Bueno, M.J.1    Gómez, M.J.2    Herrera, S.3    Hernando, M.D.4    Agüera, A.5    Fernández-Alba, A.R.6
  • 29
    • 25144438177 scopus 로고    scopus 로고
    • Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis
    • COI: 1:CAS:528:DC%2BD2MXhtVKntr%2FK
    • Mortishire-Smith RJ, O’Connor D, Castro-Perez JM, Kirby J (2005) Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis. Rapid Commun Mass Spectrom 19:2659–2670
    • (2005) Rapid Commun Mass Spectrom , vol.19 , pp. 2659-2670
    • Mortishire-Smith, R.J.1    O’Connor, D.2    Castro-Perez, J.M.3    Kirby, J.4
  • 30
    • 85003294542 scopus 로고    scopus 로고
    • Regulation (EC) No 1907/2006 2004 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency. http://eurlex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2006:396:0001:0001:EN:PDF
  • 31
    • 65649117746 scopus 로고    scopus 로고
    • On the inter-instrument and inter-laboratory transferability of a tandem mass spectral reference library: 1. Results of an Austrian multicenter study
    • COI: 1:CAS:528:DC%2BD1MXls1Squ7w%3D
    • Oberacher H, Pavlic M, Libiseller K, Schubert B, Sulyok M, Schuhmacher R, Csaszar E, Köfeler HC (2009) On the inter-instrument and inter-laboratory transferability of a tandem mass spectral reference library: 1. Results of an Austrian multicenter study. J Mass Spectrom 44:485–493
    • (2009) J Mass Spectrom , vol.44 , pp. 485-493
    • Oberacher, H.1    Pavlic, M.2    Libiseller, K.3    Schubert, B.4    Sulyok, M.5    Schuhmacher, R.6    Csaszar, E.7    Köfeler, H.C.8
  • 33
    • 0142092612 scopus 로고    scopus 로고
    • Simultaneous determination of losartan and EXP3174 in human plasma and urine utilizing liquid chromatography/ tandem mass spectrometry
    • COI: 1:CAS:528:DC%2BD3sXms12iurk%3D
    • Polinko M, Riffel K, Song H, Lo MW (2003) Simultaneous determination of losartan and EXP3174 in human plasma and urine utilizing liquid chromatography/ tandem mass spectrometry. J Pharmaceut Biomed 33:73–84
    • (2003) J Pharmaceut Biomed , vol.33 , pp. 73-84
    • Polinko, M.1    Riffel, K.2    Song, H.3    Lo, M.W.4
  • 34
    • 84881369390 scopus 로고    scopus 로고
    • Identification of urinary metabolites of imperatorin with a single run on an LC/Triple TOF system based on multiple mass defect filter data acquisition and multiple data mining techniques
    • COI: 1:CAS:528:DC%2BC3sXhtFGmurzP
    • Qiao S, Shi X, Shi R, Liu M, Liu T, Zhang K, Wang Q, Yao M, Zhang L (2013) Identification of urinary metabolites of imperatorin with a single run on an LC/Triple TOF system based on multiple mass defect filter data acquisition and multiple data mining techniques. Anal Bioanal Chem 405:6721–6738
    • (2013) Anal Bioanal Chem , vol.405 , pp. 6721-6738
    • Qiao, S.1    Shi, X.2    Shi, R.3    Liu, M.4    Liu, T.5    Zhang, K.6    Wang, Q.7    Yao, M.8    Zhang, L.9
  • 35
    • 85003288693 scopus 로고    scopus 로고
    • Regulation (EC) No 726/2004 of the European Parliament and of the Council of 31 March 2004 laying down Community procedures for the authorisation and supervision of medicinal products for human and veterinary use and establishing a European Medicines Agency. http://www.biosafety.be/EMEA/726_2004_EN.pdf
  • 36
    • 39749201504 scopus 로고    scopus 로고
    • An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: Application to indinavir metabolite detection
    • COI: 1:CAS:528:DC%2BD1cXivFeitrk%3D
    • Ruan Q, Peterman S, Szewc MA, Ma L, Cui D, Griffith Humphreys W, Zhu M (2008) An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection. J Mass Spectrom 43:251–261
    • (2008) J Mass Spectrom , vol.43 , pp. 251-261
    • Ruan, Q.1    Peterman, S.2    Szewc, M.A.3    Ma, L.4    Cui, D.5    Griffith Humphreys, W.6    Zhu, M.7
  • 37
    • 13444311842 scopus 로고    scopus 로고
    • Assigning product ions from complex MS/MS spectra: The importance of mass uncertainty and resolving power
    • COI: 1:CAS:528:DC%2BD2MXht1CqtL8%3D
    • Sleno L, Volmer DA, Marshall AG (2005) Assigning product ions from complex MS/MS spectra: the importance of mass uncertainty and resolving power. J Am Soc Mass Spectrom 16:183–198
    • (2005) J Am Soc Mass Spectrom , vol.16 , pp. 183-198
    • Sleno, L.1    Volmer, D.A.2    Marshall, A.G.3
  • 38
    • 0036232049 scopus 로고    scopus 로고
    • Identification of glucuronide conjugates of ketobemidone and its phase I metabolites in human urine utilizing accurate mass and tandem time-of-flight mass spectrometry
    • COI: 1:CAS:528:DC%2BD38XjtFKqsrw%3D
    • Sundstrom I, Hedeland M, Bondesson U, Andren PE (2002) Identification of glucuronide conjugates of ketobemidone and its phase I metabolites in human urine utilizing accurate mass and tandem time-of-flight mass spectrometry. J Mass Spectrom 37:414–420
    • (2002) J Mass Spectrom , vol.37 , pp. 414-420
    • Sundstrom, I.1    Hedeland, M.2    Bondesson, U.3    Andren, P.E.4
  • 39
    • 84866123900 scopus 로고    scopus 로고
    • An accelerated workflow for untargeted metabolomics using the METLIN database, Nat
    • COI: 1:CAS:528:DC%2BC38XhtlamtbnJ
    • Tautenhahn R, Cho K, Uritboonthai W, Zhu Z, Patti GJ, Siuzdak G (2012) An accelerated workflow for untargeted metabolomics using the METLIN database, Nat. Biotechnol 30:826–828
    • (2012) Biotechnol , vol.30 , pp. 826-828
    • Tautenhahn, R.1    Cho, K.2    Uritboonthai, W.3    Zhu, Z.4    Patti, G.J.5    Siuzdak, G.6
  • 40
    • 78650859174 scopus 로고    scopus 로고
    • A multi-target screening analysis in human plasma using fast liquid chromatography–hybrid tandem mass spectrometry (Part I)
    • COI: 1:CAS:528:DC%2BC3MXjsVOmtA%3D%3D
    • Viette V, Guillarme D, Mylonas R, Mauron Y, Fathi M, Rudaz S, Hochstrasser D, Veuthey JL (2011) A multi-target screening analysis in human plasma using fast liquid chromatography–hybrid tandem mass spectrometry (Part I). Clin Biochem 44:32–44
    • (2011) Clin Biochem , vol.44 , pp. 32-44
    • Viette, V.1    Guillarme, D.2    Mylonas, R.3    Mauron, Y.4    Fathi, M.5    Rudaz, S.6    Hochstrasser, D.7    Veuthey, J.L.8
  • 41
    • 84892469880 scopus 로고    scopus 로고
    • Assessing antibiotic sorption in soil: A literature review and new case studies on sulfonamides and macrolides
    • Wegst-Uhrich SR, Navarro DAG, Zimmerman L, Aga DS (2014) Assessing antibiotic sorption in soil: a literature review and new case studies on sulfonamides and macrolides. Chem Cent J 8:5. doi:10.1186/1752-153X-8-5
    • (2014) Chem Cent J , vol.8 , pp. 5
    • Wegst-Uhrich, S.R.1    Navarro, D.A.G.2    Zimmerman, L.3    Aga, D.S.4
  • 44
    • 25144468977 scopus 로고    scopus 로고
    • ‘All-in-One’ analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching
    • COI: 1:CAS:528:DC%2BD2MXhtVKntr7F
    • Wrona M, Mauriala T, Bateman KP, Mortishire-Smith RJ, O’Connor D (2005) ‘All-in-One’ analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching. Rapid Commun Mass Spectrom 19:2597–2602
    • (2005) Rapid Commun Mass Spectrom , vol.19 , pp. 2597-2602
    • Wrona, M.1    Mauriala, T.2    Bateman, K.P.3    Mortishire-Smith, R.J.4    O’Connor, D.5
  • 45
    • 0034059568 scopus 로고    scopus 로고
    • Atmospheric pressure ionization time-of-flight mass spectrometry coupled with fast liquid chromatography for quantitation and accurate mass measurement of five pharmaceutical drugs in human plasma
    • COI: 1:CAS:528:DC%2BD3cXitFOrsbw%3D
    • Zhang HW, Heinig K, Henion J (2000) Atmospheric pressure ionization time-of-flight mass spectrometry coupled with fast liquid chromatography for quantitation and accurate mass measurement of five pharmaceutical drugs in human plasma. J Mass Spectrom 35:423–431
    • (2000) J Mass Spectrom , vol.35 , pp. 423-431
    • Zhang, H.W.1    Heinig, K.2    Henion, J.3
  • 46
    • 0242521617 scopus 로고    scopus 로고
    • A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analyses
    • COI: 1:CAS:528:DC%2BD3sXovFCltb0%3D
    • Zhang H, Zhang D, Ray K (2003) A software filter to remove interference ions from drug metabolites in accurate mass liquid chromatography/mass spectrometric analyses. J Mass Spectrom 38:1110–1112
    • (2003) J Mass Spectrom , vol.38 , pp. 1110-1112
    • Zhang, H.1    Zhang, D.2    Ray, K.3
  • 47
    • 67650494794 scopus 로고    scopus 로고
    • Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry
    • COI: 1:CAS:528:DC%2BD1MXpsV2mtro%3D
    • Zhang H, Zhang D, Ray K, Zhu M (2009) Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry. J Mass Spectrom 44:999–1016
    • (2009) J Mass Spectrom , vol.44 , pp. 999-1016
    • Zhang, H.1    Zhang, D.2    Ray, K.3    Zhu, M.4
  • 48
    • 0032968276 scopus 로고    scopus 로고
    • Identification of losartan degradates in stressed tablets by LC-MS and LC-MS/MS
    • COI: 1:CAS:528:DyaK1MXjtVSqtr8%3D
    • Zhao ZZ, Wang Q, Tsai EW, Qin X, Ip D (1999) Identification of losartan degradates in stressed tablets by LC-MS and LC-MS/MS. J Pharm Biomed Anal 20:129–136
    • (1999) J Pharm Biomed Anal , vol.20 , pp. 129-136
    • Zhao, Z.Z.1    Wang, Q.2    Tsai, E.W.3    Qin, X.4    Ip, D.5
  • 49
    • 33748902567 scopus 로고    scopus 로고
    • Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data
    • COI: 1:CAS:528:DC%2BD28XhtVCltbvP
    • Zhu M, Ma L, Zhang D, Ray K, Zhao W, Humphreys WG, Skiles G, Sanders M, Zhang H (2006) Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data. DMD 34:1722–1733
    • (2006) DMD , vol.34 , pp. 1722-1733
    • Zhu, M.1    Ma, L.2    Zhang, D.3    Ray, K.4    Zhao, W.5    Humphreys, W.G.6    Skiles, G.7    Sanders, M.8    Zhang, H.9
  • 50
    • 35848937158 scopus 로고    scopus 로고
    • Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering
    • COI: 1:CAS:528:DC%2BD2sXhtFalurrP
    • Zhu M, Ma L, Zhang H, Humphreys WG (2007) Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering. Anal Chem 79:8333
    • (2007) Anal Chem , vol.79 , pp. 8333
    • Zhu, M.1    Ma, L.2    Zhang, H.3    Humphreys, W.G.4
  • 51
    • 67650757742 scopus 로고    scopus 로고
    • An accurate-mass-based spectral-averaging isotope-pattern-filtering algorithm for extraction of drug metabolites possessing a distinct isotope pattern from LC-MS Data
    • COI: 1:CAS:528:DC%2BD1MXnt1Wktbg%3D
    • Zhu P, Tong W, Alton K, Chowdhury S (2009) An accurate-mass-based spectral-averaging isotope-pattern-filtering algorithm for extraction of drug metabolites possessing a distinct isotope pattern from LC-MS Data. Anal Chem 81:5910–5917
    • (2009) Anal Chem , vol.81 , pp. 5910-5917
    • Zhu, P.1    Tong, W.2    Alton, K.3    Chowdhury, S.4
  • 52
    • 79960431407 scopus 로고    scopus 로고
    • Drugs metabolite profiling and identification by high-resolution mass spectrometry
    • COI: 1:CAS:528:DC%2BC3MXovFCksbg%3D
    • Zhu M, Zhang H, Griffith Humphreys W (2011) Drugs metabolite profiling and identification by high-resolution mass spectrometry. J Biol Chem 286:25419–25425
    • (2011) J Biol Chem , vol.286 , pp. 25419-25425
    • Zhu, M.1    Zhang, H.2    Griffith Humphreys, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.