Minocycline Attenuates Cognitive Impairment Induced by Isoflurane Anesthesia in Aged Rats

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Kong, Feijuan ^a   Chen, Shuping ^a   Cheng, Yuan ^a   Ma, Leilei ^b   Lu, Huishun ^b   Zhang, Honghai ^a   Hu, Wenwen ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; INTERLEUKIN 1BETA; ISOFLURANE; MINOCYCLINE;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; COGNITIVE DEFECT; CONTROLLED STUDY; HIPPOCAMPAL CA1 REGION; MAZE TEST; NEUROPROTECTION; NONHUMAN; PROTEIN SECRETION; RAT; SPATIAL LEARNING; SPATIAL MEMORY;

AGING; ANESTHESIA; ANIMALS; APOPTOSIS; ARTERIAL PRESSURE; CA1 REGION, HIPPOCAMPAL; CASPASE 3; COGNITION DISORDERS; HEART RATE; INTERLEUKIN-1BETA; ISOFLURANE; MALE; MAZE LEARNING; MINOCYCLINE; RATS; RATS, SPRAGUE-DAWLEY; SYNAPSES; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; RATTUS;

EID: 84876249306     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061385     Document Type: Article

References (47)

1. Moller JT, Cluitmans P, Rasmussen LS, Houx P, Rasmussen H, et al. (1998) Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet 351: 857-861.
2. Newman MF, Kirchner JL, Phillips-Bute B, Gaver V, Grocott H, et al. (2001) Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N Engl J Med 344: 395-402.
3. Abildstrom H, Rasmussen LS, Rentowl P, Hanning CD, Rasmussen H, et al. (2000) Cognitive dysfunction 1-2 years after non-cardiac surgery in the elderly. ISPOCD group. International Study of Post-Operative Cognitive Dysfunction. Acta Anaesthesiologica Scand 44: 1246-1251.
4. Williams-Russo P, Sharrock NE, Mattis S, Szatrowski TP, Charlson ME, (1995) Cognitive effects after epidural vs general anesthesia in older adults. A randomized trial. JAMA 274: 44-50.
5. Rasmussen LS, Johnson T, Kuipers HM, Kristensen D, Siersma VD, et al. (2003) Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiol Scand 47: 260-266.
6. Bekker AY, Weeks EJ, (2003) Cognitive function after anesthesia in the elderly. Best Pract Res Clin Anaesthesiol 17: 259-272.
7. Monk TG, Weldon BC, Garvan CW, Dede DE, van der Aa MT, et al. (2008) Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology 108: 18-30.
8. Steinmetz J, Christensen KB, Lund T, Lohse N, Rasmussen LS, (2009) Long term consequences of postoperative cognitive dysfunction. Anesthesiology 110: 548-555.
9. Clergue F, Auroy Y, Pequignot F, Jougla E, Lienhart A, et al. (1999) French survey of anesthesia in 1996. Anesthesiology 91: 1509-1520.
10. Ramaiah R, Lam AM, (2009) Postoperative cognitive dysfunction in the elderly. Anesthesiol Clin 27: 485-496.
11. Culley DJ, Baxter MG, Yukhananov R, Crosby G, (2004) Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats. Anesthesiology 100: 309-314.
12. Culley DJ, Baxter M, Yukhananov R, Crosby G, (2003) The memory effects of general anesthesia persist for weeks in young and aged rats. Anesth Analg 96: 1004-1009.
13. Mawhinney LJ, de Rivero VJ, Alonso OF, Jimenez CA, Furones C, et al. (2012) Isoflurane/nitrous oxide anesthesia induces increases in NMDA receptor subunit NR2B protein expression in the aged rat brain. Brain Res 1431: 23-34.
14. Lin D, Zuo Z, (2011) Isoflurane induces hippocampal cell injury and cognitive impairments in adult rats. Neuropharmacology 61: 1354-1359.
15. Sanderson DJ, Cunningham C, Deacon RM, Bannerman DM, Perry VH, et al. (2009) A double dissociation between the effects of sub-pyrogenic systemic inflammation and hippocampal lesions on learning. Behav Brain Res 201: 103-111.
16. Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, et al. (2012) The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-alpha, IL-6, and IL-1beta. Neurobiol Aging 33: 1364-1378.
17. Zhang Y, Xu Z, Wang H, Dong Y, Shi HN, et al. (2012) Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning and memory. Ann Neurol 71: 687-698.
18. Kong FJ, Xu LH, He DQ, Zhang XM, Lu HS, (2011) Effects of gestational isoflurane exposure on postnatal memory and learning in rats. Eur J Pharmacol 670: 168-174.
19. Kong FJ, Ma LL, Hu WW, Wang WN, Lu HS, et al. (2012) Fetal exposure to high isoflurane concentration induces postnatal memory and learning deficits in rats. Biochem Pharmacol 84: 558-563.
20. Choi Y, Kim HS, Shin KY, Kim EM, Kim M, et al. (2007) Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models. Neuropsychopharmacology 32: 2393-2404.
21. Palazuelos J, Aguado T, Pazos MR, Julien B, Carrasco C, et al. (2009) Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity. Brain 132: 3152-3164.
22. Stirling DP, Khodarahmi K, Liu J, McPhail LT, McBride CB, et al. (2004) Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. J Neurosci 24: 2182-2190.
23. Jevtovic-Todorovic V, Hartman RE, Izumi Y, Benshoff ND, Dikranian K, et al. (2003) Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 23: 876-882.
24. Grasshoff C, Drexler B, Antkowiak B, (2007) Effects of cholinergic overstimulation on isoflurane potency and efficacy in cortical and spinal networks. Toxicology 229: 206-213.
25. Izquierdo I, Medina JH, Vianna MR, Izquierdo LA, Barros DM, (1999) Separate mechanisms for short- and long-term memory. Behav Brain Res 103: 1-11.
26. Li Y, Liang G, Wang S, Meng Q, Wang Q, et al. (2007) Effects of fetal exposure to isoflurane on postnatal memory and learning in rats. Neuropharmacology 53: 942-950.
27. Valentim AM, Di Giminiani P, Ribeiro PO, Rodrigues P, Olsson IA, et al. (2010) Lower isoflurane concentration affects spatial learning and neurodegeneration in adult mice compared with higher concentrations. Anesthesiology 113: 1099-1108.
28. Aronson AL, (1980) Pharmacotherapeutics of the newer tetracyclines. J Am Vet Med Assoc 176: 1061-1068.
29. Yrjanheikki J, Tikka T, Keinanen R, Goldsteins G, Chan PH, et al. (1999) Atetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci USA 96: 13496-13500.
30. Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, et al. (2002) Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 22: 1763-1771.
31. Szymanska A, Biernaskie J, Laidley DM, Granter-Button S, Corbett D, (2006) Minocycline treatment and intracerebral hemorrhage: Influence of injury severity and delay to treatment. Exp Neurol 197: 189-196.
32. Diguet E, Gross CE, Tison F, Bezard E, (2004) Rise and fall of minocycline in neuroprotection: need to promote publication of negative results. Exp Neurol 189: 1-4.
33. Blum D, Chtarto A, Tenenbaum L, Brotchi J, Levivier M, (2004) Clinical potential of minocycline for neurodegenerative disorders. Neurobiol Disease 17: 359-366.
34. Smith DL, Woodman B, Mahal A, Sathasivam K, Ghazi-Noori S, et al. (2003) Minocycline and doxycycline are not beneficial in a model of Huntington's disease. Ann Neurol 54: 186-196.
35. Bonelli RM, Heuberger C, Reisecker F, (2003) Minocycline for Huntington's disease: an open label study. Neurology 60: 883-884.
36. Terrando N, Monaco C, Ma D, Foxwell BM, Feldmann M, et al. (2010) Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proc Natl Acad Sci U S A 107: 20518-20522.
37. Terrando N, Rei Fidalgo A, Vizcaychipi M, Cibelli M, Ma D, et al. (2010) The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Crit Care 14: R88.
38. Baranov D, Bickler PE, Crosby GJ, Culley DJ, Eckenhoff MF, et al. (2009) Consensus statement: first international workshop on anesthetics and Alzheimer's disease. Anesth Analg 108: 1627-1630.
39. Sametsky EA, Disterhoft JF, Geinisman Y, Nicholson DA, (2010) Synaptic strength and postsynaptically silent synapses through advanced aging in rat hippocampal CA1 pyramidal neurons. Neurobiol Aging 3: 813-825.
40. Thompson JV, Sullivan RM, Wilson DA, (2008) Developmental emergence of fear learning corresponds with changes in amygdale synaptic plasticity. Brain Res 1200: 58-65.
41. Gruart A, Munoz MD, Delgado-Garcia JM, (2006) Involvement of the CA3-CA1 synapse in the acquisition of associative learning in behaving mice. J Neurosci 26: 1077-1087.
42. Ziff EB, (1997) Enlightening the postsynaptic density. Neuron 19: 1163-1174.
43. Lunardi N, Ori C, Erisir A, Jevtovic-Todorovic V, (2010) General anesthesia causes long-lasting disturbances in the ultrastructural properties of developing synapses in young rats. Neurotox Res 17: 179-188.
44. Tao YX, Johns RA, (2004) Neuronal PDZ domains: a promising new molecular target for inhaled anesthetics? Mol Interv 4: 215-221.
45. Fang M, Tao YX, He F, Zhang M, Levine CF, et al. (2003) Synaptic PDZ domain-mediated protein interactions are disrupted by inhalational anesthetics. J Biol Chem 278: 36669-36675.
46. Nicholson DA, Yoshida R, Berry RW, Gallagher M, Geinisman Y, (2004) Reduction in size of perforated postsynaptic densities in hippocampal axospinous synapses and agerelated spatial learning impairments. J Neurosci 24: 7648-7653.
47. Planel E, Richter KE, Nolan CE, Finley JE, Liu L, et al. (2007) Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. J Neurosci 27: 3090-3097.