The insulin and IGF1 receptor kinase domains are functional dimers in the activated state

Nature Communications

Volumn 6, Issue , 2015, Pages

  Cabail, M Zulema ^a   Li, Shiqing ^b,c   Lemmon, Eric ^a   Bowen, Mark E ^a   Hubbard, Stevan R ^b   Miller, W Todd ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Novak Druce Connolly Bove + Quigg LLP   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; INSULIN; SOMATOMEDIN C RECEPTOR; IGF1R PROTEIN, HUMAN; INSR PROTEIN, HUMAN; INSULIN RECEPTOR; LEUKOCYTE ANTIGEN; LIPOSOME; PROTEIN BINDING; RECOMBINANT PROTEIN; SOMATOMEDIN RECEPTOR;

BIOCHEMISTRY; BIOPHYSICS; CHEMICAL BINDING; CRYSTALLOGRAPHY; DIABETES; DRUG DEVELOPMENT; HORMONE; LIGAND; PROTEIN;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; X RAY CRYSTALLOGRAPHY; ANIMAL; BACULOVIRIDAE; BINDING SITE; CHEMISTRY; GENE EXPRESSION; GENETICS; HEK293 CELL LINE; HUMAN; MOLECULAR CLONING; MOLECULAR MODEL; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; SF9 CELL LINE; SPODOPTERA;

ANIMALS; ANTIGENS, CD; BACULOVIRIDAE; BINDING SITES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; GENE EXPRESSION; HEK293 CELLS; HUMANS; INSULIN; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, INSULIN; RECEPTORS, SOMATOMEDIN; RECOMBINANT PROTEINS; SF9 CELLS; SPODOPTERA; UNILAMELLAR LIPOSOMES;

EID: 84924710415     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7406     Document Type: Article

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