A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses

European Journal of Immunology

Volumn 36, Issue 11, 2006, Pages 2951-2959

  La Gruta, Nicole L ^a   Doherty, Peter C ^a,b   Turner, Stephen J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Avidity; CD8+ T cells; Cytokines; Influenza virus

Indexed keywords

CD8 ANTIGEN; CYTOKINE; EPITOPE; T LYMPHOCYTE RECEPTOR; TETRAMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; INFLUENZA; INFLUENZA VIRUS; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FUNCTION; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; EPITOPES, T-LYMPHOCYTE; FEMALE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; ORTHOMYXOVIRIDAE; OVALBUMIN; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL;

EID: 33751224154     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636390     Document Type: Article

References (41)

1. Jameson, S. C., Hogquist, K. A. and Bevan, M. J., Positive selection of thymocytes. Annu. Rev. Immunol. 1995. 13: 93-126.
2. Saito, T. and Watanabe, N., Positive and negative thymocyte selection. Crit. Rev. Immunol. 1998. 18: 359-370.
3. Konig, R., Interactions between MHC molecules and co-receptors of the TCR Curr. Opin. Immunol. 2002. 14: 75-83.
4. Valitutti, S., Muller, S., Cella, M., Padovan, E. and Lanzavecchia, A., Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 1995. 375: 148-151.
5. Kersh, G. J. and Allen, P. M., Essential flexibility in the T-cell recognition of antigen. Nature 1996. 380: 495-498.
6. Patke, D. S. and Farber, D. L., Modulation of memory CD4 T cell function and survival potential by altering the strength of the recall stimulus. J. Immunol. 2005. 174: 5433-5443.
7. + T cells in response to antagonist ligands. J. Exp. Med. 1996. 184: 149-157.
8. Slifka, M. K. and Whitton, J. L., Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR. Nat. Immunol. 2001. 2: 711-717.
9. + T cell immunodominance hierarchies when antigen is limiting. J. Immunol. 2006. 177: 2917-2925.
10. + T cell response to influenza A viruses. J. Immunol. 2000. 165: 2404-2409.
11. + T cells in primary and secondary influenza pneumonia. Immunity 1998. 8: 683-691.
12. + T cell responses. J. Immunol. 2001. 166: 4627-4633.
13. + T cell responses: Correlation of cytokine profile and TCR avidity. J. Immunol. 2004. 172: 5553-5560.
14. + T cells initiate IFN-gamma synthesis increases markedly over the course of infection and correlates with immunodominance. J. Immunol. 2004. 173: 456-462.
15. Crawford, F., Kozono, H., White, J., Marrack, P. and Kappler, J., Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity 1998. 8: 675-682.
16. Daniels, M. A. and Jameson, S. C., Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility, complex multimers. J. Exp. Med. 2000. 191: 335-346.
17. Yee, C., Savage, P. A., Lee, P. P., Davis, M. M. and Greenberg, P. D., Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. J. Immunol. 1999. 162: 2227-2234.
18. Kersh, G. J., Kersh, E. N., Fremont, D. H. and Allen, P. M., High- and low-potency ligands with similar affinities for the TCR: The importance of kinetics in TCR signaling. Immunity 1998. 9: 817-826.
19. Lyons, D. S., Lieberman, S. A., Hampl, J., Boniface, J. J., Chien, Y., Berg, L. J. and Davis, M. M., A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 1996. 5: 53-61.
20. k complexes: Correlation of the dissociation rate with T-cell responsiveness. Proc. Natl. Acad. Sci. USA 1994. 91: 12862-12866.
21. + effector T cells. Proc. Natl. Acad. Sci. USA 2004. 101: 3545-3550.
22. Choi E. M., Chen, J. L., Wooldridge, L., Salio, M., Lissina, A., Lissin, N., Hermans, I. F. et al., High avidity antigen-specific CTL identified by CD8-independent tetramer staining. J. Immunol. 2003. 171: 5116-5123.
23. Kerry, S. E., Buslepp, J., Cramer, L. A., Maile, R., Hensley, L L, Nielsen, A. I., Kavathas, P. et al., Interplay between TCR affinity and necessity of coreceptor ligation: High-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement. J. Immunol. 2003. 171: 4493-4503.
24. Hofmann, M., Radsak, M, Rechtsteiner, G., Wiemann K., Gunder, M., Bien-Grater, U., Offringa, R. et al., T cell avidity determines the level of CTL activation. Eur. J. Immunol. 2004. 34: 1798-1806.
25. Cawthon, A. G. and Alexander-Miller, M. A., Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity. J. Immunol. 2002.169: 3492-3498.
26. Cawthon, A. G., Lu, H. and Alexander-Miller, M. A., Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: Correlation with CD8alphabeta versus CD8alphaalpha expression. J. Immunol. 2001. 167: 2577-2584.
27. Hodge, J. W., Chakraborty, M., Rudo-Saito, C., Garnett C. T. and Schlom, J., Multiple costimulatory modalities enhance CTL avidity. J. Immunol. 2005. 174: 5994-6004.
28. Oh, S., Hodge, J. W., Ahlers, J. D., Burke, D. S., Schlom, J. and Berzofsky, J. A., Selective induction of high avidity CTL by altering the balance of signals from APC. J. Immunol. 2003. 170: 2523-2530.
29. Fahmy, T. M., Bieler, J. G., Edidin, M. and Schneck, J. P., Increased TCR avidity after T cell activation: A mechanism for sensing low-density antigen. Immunity 2001. 14: 135-143.
30. Savage, P. A., Boniface, J. J. and Davis, M. M., A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity 1999. 10: 485-492.
31. Wooldridge, L., Scriba, T. J., Milicic, A., Laugel, B., Gostick E., Price, D. A., Phillips, R. E. and Sewell, A. K., Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers. Eur. J. Immunol. 2006. 36: 1847-1855.
32. + T cell populations specific for persistent DNA viruses. J. Exp. Med. 2005. 202: 1349-1361.
33. Faroudi M., Utzny, C., Salio, M., Cerundolo, V., Guiraud, M., Muller, S. and Valitutti, S., Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold. Proc. Natl. Acad. Sci. USA 2003. 100: 14145-14150.
34. Valitutti S., Muller, S., Dessing, M. and Lanzavecchia, A., Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J. Exp. Med. 1996. 183: 1917-1921.
35. Wiedemann, A., Depoil, D., Faroudi M. and Valitutti S., Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapses. Proc. Natl. Acad. Sci. USA 2006. 103: 10985-10990.
36. + T cell immunodominance in primary and secondary influenza virus infections. J. Exp. Med. 2003. 198: 399-410.
37. Kilbourne, E. D., Future influenza vaccines and the use of genetic recombinants. Bull. World Health Organ. 1969. 41: 643-645.
38. Hoffinann E., Neumann, G., Kawaoka, Y., Hobom, G. and Webster, R. G., A DNA transfection system for generation of influenza A virus from eight plasmids. Proc. Natl. Acad. Sci. USA 2000. 97: 6108-6113.
39. b complex to T cells. J. Immunol. 1993. 150: 2724-2736.
40. Chen, W., Norbury, C. C., Cho, Y., Yewdell, J. W. and Bennink, J. R., Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens. J. Exp. Med. 2001. 193: 1319-1326.
41. Kalergis, A. M., Boucheron, N., Doucey, M. A., Palmieri, E., Goyarts, E. C., Vegh, Z., Luescher, I. F. and Nathenson, S. G., Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nat. Immunol. 2001. 2: 229-234.