Ambient particulate matter induces interleukin-8 expression through an alternative NF-κB (nuclear factor-kappa B) mechanism in human airway epithelial cells

Environmental Health Perspectives

Volumn 119, Issue 10, 2011, Pages 1379-1383

  Silbajoris, Robert ^a   Osornio Vargas, Alvaro R ^b,d   Simmons, Steven O ^a   Reed, William ^c   Bromberg, Philip A ^c   Dailey, Lisa A ^a   Samet, James M ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b INSTITUTO NACIONAL DE CANCEROLOGÍA   (Mexico)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Human airway epithelium; Interleukin 8; NF B; Particulate matter; Signal transduction

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; TRANSCRIPTION FACTOR RELA;

ADULT; AMBIENT AIR; ARTICLE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENVIRONMENTAL EXPOSURE; EPITHELIUM CELL; GENE; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; HUMAN; HUMAN AIRWAY EPITHELIAL CELL; HUMAN CELL; IL8 GENE; MUTANT; PARTICULATE MATTER; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION;

BLOTTING, WESTERN; CELL LINE; EPITHELIAL CELLS; HUMANS; IMMUNOPRECIPITATION; INTERLEUKIN-8; NF-KAPPA B; PARTICULATE MATTER; SIGNAL TRANSDUCTION;

LENTIVIRUS;

EID: 80053443017     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1103594     Document Type: Article

References (45)

1. Atarod EB, Kehrer JP. 2004. Dissociation of oxidant production by peroxisome proliferator-activated receptor ligands from cell death in human cell lines. Free Radic Biol Med 37:36-47.
2. Bai N, Khazaei M, van Eeden SF, Laher I. 2007. The pharmacology of particulate matter air pollution-induced cardiovascular dysfunction. Pharmacol Ther 113(1):16-29.
3. Becker MN, Diamond G, Verghese MW, Randell SH. 2000. CD14-dependent lipopolysaccharide-induced β-defensin-2 expression in human tracheobronchial epithelium. J Biol Chem 275(38):29731-29736.
4. Beck-Speier I, Dayal N, Karg E, Maier KL, Schumann G, Schulz H, et al. 2005. Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles. Free Radic Biol Med 38:1080-1092.
5. Bijli KM, Fazal F, Minhajuddin M, Rahman A. 2008. Activation of Syk by protein kinase C-δ regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65. J Biol Chem 283(21):14674-14684.
6. Bohuslav J, Chen LF, Kwon H, Mu Y, Greene WC. 2004. p53 induces NF-κB activation by an IκB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1. J Biol Chem 279(25):26115-26125.
7. Bonfield TL, Panuska JR, Konstan MW, Hilliard KA, Hilliard JB, Ghnaim H, et al. 1995. Inflammatory cytokines in cystic fibrosis lungs. Am J Respir Crit Care Med 152(6 pt 1):2111-2118.
8. Chantôme A, Pance A, Gauthier N, Vandroux D, Chenu J, Solary E, et al. 2004. Casein kinase II-mediated phosphorylation of NF-κB p65 subunit enhances inducible nitric-oxide synthase gene transcription in vivo. J Biol Chem 279(23):23953-23960.
9. Chen F, Harrison LE. 2005. Ciglitazone induces early cellular proliferation and NF-κB transcriptional activity in colon cancer cells through p65 phosphorylation. Int J Biochem Cell Biol 37(3):645-654.
10. Dockery DW, Pope CA III, Xu X, Spengler JD, Ware JH, Fay ME, et al. 1993. An association between air pollution and mortality in six U.S. cities. N Engl J Med 329(24):1753-1759.
11. Doyle SL, Jefferies CA, O'Neill LA. 2005. Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFκB activation by lipopolysaccharide. J Biol Chem 280(25):23496-23501.
12. Ghio AJ, Devlin RB. 2001. Inflammatory lung injury after bronchial instillation of air pollution particles. Am J Respir Crit Care Med 164(4):704-708.
13. Ghio AJ, Kennedy TP, Whorton AR, Crumbliss AL, Hatch GE, Hoidal JR. 1992. Role of surface complexed iron in oxidant generation and lung inflammation induced by silicates. Am J Physiol 263:L511-L518.
14. Gibson PG, Simpson JL, Saltos N. 2001. Heterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest 119(5):1329-1336.
15. Harada A, Sekido N, Akahoshi T, Wada T, Mukaida N, Matsushima K. 1994. Essential involvement of interleukin-8 (IL-8) in acute inflammation. J Leukoc Biol 56(5):559-564.
16. Hu J, Nakano H, Sakurai H, Colburn NH. 2004. Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-κB activation and transformation in resistant JB6 cells. Carcinogenesis 25(10):1991-2003.
17. Jung YD, Fan F, McConkey DJ, Jean ME, Liu W, Reinmuth N, et al. 2002. Role of P38 MAPK, AP-1, and NF-κB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells. Cytokine 18(4):206-213.
18. Kai M, Yasuda S, Imai S, Toyota M, Kanoh H, Sakane F. 2009. Diacylglycerol kinase α enhances protein kinase Cζ-dependent phosphorylation at Ser311 of p65/RelA subunit of nuclear factor-κB. FEBS Lett 583(19):3265-3268.
19. Kang JL, Jung HJ, Lee K, Kim HR. 2006. Src tyrosine kinases mediate crystalline silica-induced NF-κB activation through tyrosine phosphorylation of IκB-α and p65 NF-κB in RAW 264.7 macrophages. Toxicol Sci 90(2):470-477.
20. Karin M, Ben-Neriah Y. 2000. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 18:621-663.
21. 2+-induced NF-κB-dependent transcriptional activity involves site-specific p65/RelA phosphorylation. Cell Signal 19(3):538-546.
22. Kim YM, Reed W, Lenz AG, Jaspers I, Silbajoris R, Nick HS, et al. 2005. Ultrafine carbon particles induce interleukin-8 gene transcription and p38 MAPK activation in normal human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 288(3):L432-L441.
23. 2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 290(5):L1028-L1035.
24. Krishna MT, Chauhan AJ, Frew AJ, Holgate ST. 1998. Toxicological mechanisms underlying oxidant pollutant-induced airway injury. Rev Environ Health 13(1-2):59-71.
25. Liu J, Yoshida Y, Yamashita U. 2008. DNA-binding activity of NF-κB and phosphorylation of p65 are induced by N-acetylcysteine through phosphatidylinositol (PI) 3-kinase. Mol Immunol 45(15):3984-3989.
26. Mendoza A, Pardo EI, Gutierrez AA. 2010. Chemical characterization and preliminary source contribution of fine particulate matter in the Mexicali/Imperial Valley border area. J Air Waste Manag Assoc 60(3):258-270.
27. Mukaida N, Morita M, Ishikawa Y, Rice N, Okamoto S, Kasahara T, et al. 1994. Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-κB is target for glucocorticoid-mediated interleukin 8 gene repression. J Biol Chem 269(18):13289-13295.
28. Neumann M, Naumann M. 2007. Beyond IκBs: alternative regulation of NF-κB activity. FASEB J 21(11):2642-2654.
29. 10 from a semi-desert city on the Mexico-US border. Chemosphere:618-626.
30. Peters A, Dockery DW, Muller JE, Mittleman MA. 2001. Increased particulate air pollution and the triggering of myocardial infarction. Circulation 103(23):2810-2815.
31. Pope III. C.A. 2000. Epidemiology of fine particulate air pollution and human health: biologic mechanisms and who's at risk? Environ Health Perspect 108(suppl 4):713-723.
32. Reber L, Vermeulen L, Haegeman G, Frossard N. 2009. Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation. PLoS One 4(2):e4393; doi:10.1371/journal.pone.0004393 [Online 6 February 2009].
33. Samet JM, Tal TL. 2010. Toxicological disruption of signaling homeostasis: tyrosine phosphatases as targets. Annu Rev Pharmacol Toxicol 50:5-79.
34. Samet JM, Zeger SL, Dominici F, Curriero F, Coursac I, Dockery DW, et al. 2000. The National Morbidity, Mortality, and Air Pollution Study. Part II: morbidity and mortality from air pollution in the United States. Res Rep Health Eff Inst 94(pt 2):5-70.
35. Schwarze PE, Ovrevik J, Lag M, Refsnes M, Nafstad P, Hetland RB, et al. 2006. Particulate matter properties and health effects: consistency of epidemiological and toxicological studies. Hum Exp Toxicol 25(10):559-579.
36. Silbajoris R, Huang JM, Cheng WY, Dailey L, Tal TL, Jaspers I, et al. 2009. Nanodiamond particles induce IL-8 expression through a transcript stabilization mechanism in human airway epithelial cells. Nanotoxicology 3(2):152-160.
37. Sparkman L, Boggaram V. 2004. Nitric oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 287(4):L764-L773.
38. Stenfors N, Nordenhall C, Salvi SS, Mudway I, Soderberg M, Blomberg A, et al. 2004. Different airway inflammatory responses in asthmatic and healthy humans exposed to diesel. Eur Respir J 23(1):82-86.
39. Strieter RM. 2002. Interleukin-8: a very important chemokine of the human airway epithelium. Am J Physiol Lung Cell Mol Physiol 283(4):L688-L689.
40. Tal TL, Simmons SO, Silbajoris R, Dailey L, Cho SH, Ramabhadran R, et al. 2010. Differential transcriptional regulation of IL-8 expression by human airway epithelial cells exposed to diesel exhaust particles. Toxicol Appl Pharmacol 243(1):46-54.
41. Wellenius GA, Bateson TF, Mittleman MA, Schwartz J. 2005. Particulate air pollution and the rate of hospitalization for congestive heart failure among Medicare beneficiaries in Pittsburgh, Pennsylvania. Am J Epidemiol 161(11):1030-1036.
42. Wu W, Samet JM, Peden DB, Bromberg PA. 2010. Phosphorylation of p65 is required for zinc oxide nanoparticle-induced interleukin 8 expression in human bronchial epithelial cells. Environ Health Perspect 118:982-987.
43. Yamamoto C, Yoneda T, Yoshikawa M, Fu A, Tokuyama T, Tsukaguchi K, et al. 1997. Airway inflammation in COPD assessed by sputum levels of interleukin-8. Chest 112(2):505-510.
44. Zhang L, Ma Y, Zhang J, Cheng J, Du J. 2005. A new cellular signaling mechanism for angiotensin II activation of NF-κB: an IκB-independent, RSK-mediated phosphorylation of p65. Arterioscler Thromb Vasc Biol 25(6):1148-1153.
45. Zwahlen R, Walz A, Rot A. 1993. In vitro and in vivo activity and pathophysiology of human interleukin-8 and related peptides. Int Rev Exp Pathol 34(pt B):27-42.