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Volumn 23, Issue 7, 2015, Pages 1629-1637
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Isoindoline-1,3-dione derivatives targeting cholinesterases: Design, synthesis and biological evaluation of potential anti-Alzheimer's agents
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Author keywords
Alzheimer's disease; Cholinesterase inhibitors; Multi target directed ligands; PAMPA BBB assay; Amyloid aggregation
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Indexed keywords
2 [4 [(2 FLUOROBENZYL)(METHYL)AMINO]BUTYL]ISOINDOLINE 1,3 DIONE;
2 [4 [(3 CHLOROBENZYL)(METHYL)AMINO]BUTYL]ISOINDOLINE 1,3 DIONE;
2 [4 [(BENZYLAMINO)METHYL]BENZYL]ISOINDOLINE 1,3 DIONE;
2 [4 [BENZYL(METHYL)AMINO]BUTYL]ISOINDOLINE 1,3 DIONE;
2 [4 [[(2 FLUOROBENZYL)AMINO]METHYL]BENZYL]ISOINDOLINE 1,3 DIONE;
2 [4 [[(3 CHLOROBENZYL)AMINO]METHYL]BENZYL]ISOINDOLINE 1,3 DIONE;
2 [5 [(2 FLUOROBENZYL)(METHYL)AMINO]PENTYL]ISOINDOLINE 1,3 DIONE;
2 [5 [(3 CHLOROBENZYL)(METHYL)AMINO]PENTYL]ISOINDOLINE 1,3 DIONE;
2 [5 [BENZYL(METHYL)AMINO]PENTYL]ISOINDOLINE 1,3 DIONE;
2 [6 [(2 FLUOROBENZYL)(METHYL)AMINO]HEXYL]ISOINDOLINE 1,3 DIONE;
2 [6 [(3 CHLOROBENZYL)(METHYL)AMINO]HEXYL]ISOINDOLINE 1,3 DIONE;
2 [6 [BENZYL(METHYL)AMINO]HEXYL]ISOINDOLINE 1,3 DIONE;
2 [7 [(2 FLUOROBENZYL)(METHYL)AMINO]HEPTYL]ISOINDOLINE 1,3 DIONE;
2 [7 [(3 CHLOROBENZYL)(METHYL)AMINO]HEPTYL]ISOINDOLINE 1,3 DIONE;
2 [7 [BENZYL(METHYL)AMINO]HEPTYL]ISOINDOLINE 1,3 DIONE;
2 [8 [(2 FLUOROBENZYL)(METHYL)AMINO]OCTYL]ISOINDOLINE 1,3 DIONE;
2 [8 [(3 CHLOROBENZYL)(METHYL)AMINO]OCTYL]ISOINDOLINE 1,3 DIONE;
2 [8 [BENZYL(METHYL)AMINO]OCTYL]ISOINDOLINE 1,3 DIONE;
ACETYLCHOLINESTERASE;
AMYLOID BETA PROTEIN[1-42];
DONEPEZIL;
ISOINDOLINE 1,3 DIONE DERIVATIVE;
NOOTROPIC AGENT;
TACRINE;
UNCLASSIFIED DRUG;
CHOLINESTERASE;
CHOLINESTERASE INHIBITOR;
INDOLE DERIVATIVE;
INDOLINE;
ARTICLE;
BINDING SITE;
BLOOD BRAIN BARRIER;
CONTROLLED STUDY;
DRUG ISOLATION;
DRUG MECHANISM;
DRUG POTENCY;
DRUG SELECTIVITY;
DRUG SYNTHESIS;
DRUG TARGETING;
ELECTROPHORUS;
ENZYME ACTIVE SITE;
HYDROGEN BOND;
IC50;
IN VITRO STUDY;
MEMBRANE PERMEABILITY;
NONHUMAN;
PROTEIN AGGREGATION;
STRUCTURE ACTIVITY RELATION;
ALZHEIMER DISEASE;
ANIMAL;
CHEMISTRY;
DRUG DELIVERY SYSTEM;
DRUG DESIGN;
DRUG SCREENING;
ENZYMOLOGY;
HORSE;
HUMAN;
METABOLISM;
PROCEDURES;
PROTEIN SECONDARY STRUCTURE;
SYNTHESIS;
ALZHEIMER DISEASE;
ANIMALS;
CHOLINESTERASE INHIBITORS;
CHOLINESTERASES;
DRUG DELIVERY SYSTEMS;
DRUG DESIGN;
DRUG EVALUATION, PRECLINICAL;
HORSES;
HUMANS;
INDOLES;
PROTEIN STRUCTURE, SECONDARY;
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EID: 84924678310
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2015.01.045 Document Type: Article |
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Times cited : (53)
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References (48)
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