Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 18, 2013, Pages 5830-5840

  Su, Tao ^a   Xie, Shishun ^a   Wei, Hui ^b   Yan, Jun ^a   Huang, Ling ^a   Li, Xingshu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Amyloid aggregation; Alzheimer's disease berberine thiophenyl hybrids; Antioxidants; Inhibitors of AChE

Indexed keywords

9 2 (2 THIOPHENYL)ETHYL BERBERINE BROMIDE; 9 2 (3 THIOPHENYL)PROPYL BERBERINE BROMIDE; 9 2 (4 THIOPHENYL)BUTYL BERBERINE BROMIDE; 9 2 (5 THIOPHENYL)PENTYL BERBERINE BROMIDE; 9 2 (6 THIOPHENYL)HEXYL BERBERINE BROMIDE; 9 2 [2 (2 CHLORO)THIOPHENYL]ETHYL BERBERINE BROMIDE; 9 2 [2 (2 ETHYL)THIOPHENYL]ETHYL BERBERINE BROMIDE; 9 2 [2 (2 FLURO)THIOPHENYL]ETHYL BERBERINE BROMIDE; 9 2 [2 (2 METHOXYL)THIOPHENYL]ETHYL BERBERINE BROMIDE; 9 2 [2 (2 METHYL)THIOPHENYL]ETHYL BERBERINE BROMIDE; 9 2 [2 (3 CHLORO)THIOPHENYL]ETHYL BERBERINE BROMIDE; 9 2 [2 (3 METHYL)THIOPHENYL]ETHYL BERBERINE BROMIDE; 9 2 [2 (4 CHLORO)THIOPHENYL]ETHYL BERBERINE BROMIDE; 9 2 [2 (4 METHYL)THIOPHENYL]ETHYL BERBERINE BROMIDE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN[1-42]; ANTIOXIDANT; BERBERINE; CHOLINESTERASE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; DRUG BINDING; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MOLECULAR DYNAMICS; MOLECULAR MODEL; PROTEIN AGGREGATION;

ALZHEIMER'S DISEASE; ANTIOXIDANTS; BERBERINE-THIOPHENYL HYBRIDS; INHIBITORS OF ACHE; Β-AMYLOID AGGREGATION;

ACETYLCHOLINESTERASE; AMYLOID BETA-PEPTIDES; ANTIOXIDANTS; BERBERINE; BINDING SITES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HYDROGEN PEROXIDE; KINETICS; MOLECULAR DOCKING SIMULATION; PHENOLS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SULFHYDRYL COMPOUNDS;

EID: 84882920768     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.07.011     Document Type: Article

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