A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current

Journal of Physiology

Volumn 593, Issue 6, 2015, Pages 1429-1442

  Yang, Pei Chi ^a   Song, Yejia ^c   Giles, Wayne R ^d   Horvath, Balazs ^a   Chen Izu, Ye ^a   Belardinelli, Luiz ^b   Rajamani, Sridharan ^b   Clancy, Colleen E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Gilead Sciences   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; DELAYED RECTIFIER POTASSIUM CHANNEL; GS 458967; ION TRANSPORT AFFECTING AGENT; SODIUM ION; UNCLASSIFIED DRUG; 6-(4-(TRIFLUOROMETHOXY)PHENYL)-3-(TRIFLUOROMETHYL)(1,2,4)TRIAZOLO(4,3-A)PYRIDINE; PROTEIN BINDING; PYRIDINE DERIVATIVE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; TRIAZOLE DERIVATIVE;

ACTION POTENTIAL DURATION; ANIMAL CELL; ARTICLE; COMPUTATIONAL MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; FEMALE; GUINEA PIG; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE; LONG QT SYNDROME; MALE; MATHEMATICAL MODEL; MEMBRANE RESISTANCE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SIMULATION; SODIUM CURRENT; THEORETICAL STUDY; ACTION POTENTIAL; ANIMAL; BIOLOGICAL MODEL; CYTOLOGY; DRUG EFFECTS; HEART VENTRICLE FUNCTION; METABOLISM; PHYSIOLOGY;

ACTION POTENTIALS; ANIMALS; FEMALE; GUINEA PIGS; HEART VENTRICLES; MALE; MODELS, NEUROLOGICAL; MYOCYTES, CARDIAC; PROTEIN BINDING; PYRIDINES; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TRIAZOLES; VENTRICULAR FUNCTION;

EID: 84924546284     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2014.279554     Document Type: Article

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