Formation of spatially discordant alternans due to fluctuations and diffusion of calcium

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Sato, Daisuke ^a   Bers, Donald M ^a   Shiferaw, Yohannes ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIALS; CALCIUM; DIFFUSION; GLUCANS; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; SARCOMERES; SPATIO-TEMPORAL ANALYSIS;

EID: 84894090130     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0085365     Document Type: Article

References (44)

1. Clusin WT (2003) Calcium and cardiac arrhythmias: DADs, EADs, and alternans. Crit Rev Clin Lab Sci 40: 337-375. doi:10.1080/713609356. PubMed: 12892319.
2. Walker ML, Rosenbaum DS (2003) Repolarization alternans: implications for the mechanism and prevention of sudden cardiac death. Cardiovasc Res 57: 599-614. doi:10.1016/S0008-6363(02)00737-X. PubMed: 12618222. (Pubitemid 36254855)
3. Nolasco JB, Dahlen RW (1968) A graphic method for the study of alternation in cardiac action potentials. J Appl Physiol 25: 191-196. PubMed: 5666097.
4. Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS (1999) Mechanism linking T-wave alternans to the genesis of cardiac fibrillation. Circulation 99: 1385-1394. doi:10.1161/01.CIR.99.10.1385. PubMed: 10077525. (Pubitemid 29129926)
5. Qian YW, Clusin WT, Lin SF, Han J, Sung RJ (2001) Spatial heterogeneity of calcium transient alternans during the early phase of myocardial ischemia in the blood-perfused rabbit heart. Circulation 104: 2082-2087. doi:10.1161/hc4201.097136. PubMed: 11673350. (Pubitemid 33027050)
6. Rosenbaum DS, Jackson LE, Smith JM, Garan H, Ruskin JN et al. (1994) Electrical alternans and vulnerability to ventricular arrhythmias. N Engl J Med 330: 235-241. doi:10.1056/NEJM199401273300402. PubMed: 8272084. (Pubitemid 24034135)
7. Laurita KR, Rosenbaum DS (2008) Cellular mechanisms of arrhythmogenic cardiac alternans. Prog Biophys Mol Biol 97: 332-347. doi:10.1016/j.pbiomolbio. 2008.02.014. PubMed: 18395246.
8. Shiferaw Y, Sato D, Karma A (2005) Coupled dynamics of voltage and calcium in paced cardiac cells. Phys Rev E Stat Nonlin Soft Matter Phys 71: 021903. doi:10.1103/PhysRevE.71.021903. PubMed: 15783348.
9. Chudin E, Goldhaber J, Garfinkel A, Weiss J, Kogan B (1999) Intracellular Ca(2+) dynamics and the stability of ventricular tachycardia. Biophys J 77: 2930-2941. doi:10.1016/S0006-3495(99)77126-2. PubMed: 10585917.
10. Watanabe MA, Fenton FH, Evans SJ, Hastings HM, Karma A (2001) Mechanisms for discordant alternans. J Cardiovasc Electrophysiol 12: 196-206. doi:10.1046/j.1540-8167.2001.00196.x. PubMed: 11232619. (Pubitemid 32171511)
11. Qu Z, Garfinkel A, Chen PS, Weiss JN (2000) Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue. Circulation 102: 1664-1670. doi:10.1161/01.CIR.102.14.1664. PubMed: 11015345.
12. Echebarria B, Karma A (2007) Amplitude equation approach to spatiotemporal dynamics of cardiac alternans. Phys Rev E Stat Nonlin Soft Matter Phys 76: 051911. doi:10.1103/PhysRevE.76.051911. PubMed: 18233691.
13. Echebarria B, Karma A (2002) Instability and spatiotemporal dynamics of alternans in paced cardiac tissue. Phys Rev Lett 88: 208101. doi:10.1103/PhysRevLett.88.208101. PubMed: 12005608.
14. Sato D, Shiferaw Y, Garfinkel A, Weiss JN, Qu Z et al. (2006) Spatially discordant alternans in cardiac tissue: role of calcium cycling. Circ Res 99: 520-527. doi:10.1161/01.RES.0000240542.03986.e7. PubMed: 16902177. (Pubitemid 44337824)
15. Skardal PS, Karma A, Restrepo JG (2012) Unidirectional pinning and hysteresis of spatially discordant alternans in cardiac tissue. Phys Rev Lett 108: 108103. doi:10.1103/PhysRevLett.108.108103. PubMed: 22463458.
16. ter Keurs HE, Wakayama Y, Sugai Y, Price G, Kagaya Y et al. (2006) Role of sarcomere mechanics and Ca2+ overload in Ca2+ waves and arrhythmias in rat cardiac muscle. Ann N Y Acad Sci 1080: 248-267. doi:10.1196/annals.1380.020. PubMed: 17132788. (Pubitemid 44955426)
17. Pogwizd SM, Bers DM (2002) Calcium cycling in heart failure: the arrhythmia connection. J Cardiovasc Electrophysiol 13: 88-91. doi:10.1046/j.1540-8167.2002.00088.x. PubMed: 11843491. (Pubitemid 34113628)
18. Lou Q, Janardhan A, Efimov IR (2012) Remodeling of calcium handling in human heart failure. Adv Exp Med Biol 740: 1145-1174. doi:10.1007/978-94-007- 2888-2-52. PubMed: 22453987.
19. Györke S (2009) Molecular basis of catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm 6: 123-129. doi:10.1016/j.hrthm.2008.09. 013. PubMed: 19121813.
20. Laurita KR, Rosenbaum DS (2008) Mechanisms and potential therapeutic targets for ventricular arrhythmias associated with impaired cardiac calcium cycling. J Mol Cell Cardiol 44: 31-43. doi:10.1016/j.yjmcc.2007.10.012. PubMed: 18061204.
21. Picht E, DeSantiago J, Blatter LA, Bers DM (2006) Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations. Circ Res 99: 740-748. doi:10.1161/01.RES.0000244002.88813.91. PubMed: 16946134. (Pubitemid 44498307)
22. Cordeiro JM, Malone JE, Di Diego JM, Scornik FS, Aistrup GL et al. (2007) Cellular and subcellular alternans in the canine left ventricle. Am J Physiol Heart Circ Physiol 293: H3506-H3516. doi:10.1152/ajpheart.00757.2007. PubMed: 17906109. (Pubitemid 350230894)
23. Gaeta SA, Christini DJ (2012) Non-linear dynamics of cardiac alternans: subcellular to tissue-level mechanisms of arrhythmia. Front - Physiol (Bethesda, Md.) 3: 157. PubMed: 22783195.
24. Shiferaw Y, Karma A (2006) Turing instability mediated by voltage and calcium diffusion in paced cardiac cells. Proc Natl Acad Sci U S A 103: 5670-5675. doi:10.1073/pnas.0511061103. PubMed: 16574775.
25. Chen W, Aistrup G, Wasserstrom JA, Shiferaw Y (2011) A mathematical model of spontaneous calcium release in cardiac myocytes. Am J Physiol Heart Circ Physiol 300: H1794-H1805. doi:10.1152/ajpheart.01121.2010. PubMed: 21357507.
26. Fox JJ, McHarg JL, Gilmour RF Jr. (2002) Ionic mechanism of electrical alternans. Am J Physiol Heart Circ Physiol 282: H516-H530. PubMed: 11788399. (Pubitemid 34654975)
27. Shiferaw Y, Watanabe MA, Garfinkel A, Weiss JN, Karma A (2003) Model of intracellular calcium cycling in ventricular myocytes. Biophys J 85: 3666-3686. doi:10.1016/S0006-3495(03)74784-5. PubMed: 14645059. (Pubitemid 37490280)
28. Aistrup GL, Kelly JE, Kapur S, Kowalczyk M, Sysman-Wolpin I et al. (2006) Pacing-induced heterogeneities in intracellular Ca2+ signaling, cardiac alternans, and ventricular arrhythmias in intact rat heart. Circ Res 99: e65-e73. Available online at: doi:10.1161/01.RES. 0000244087.36230.bf. PubMed: 16960102.
29. Qu Z, Garfinkel A (1999) An advanced algorithm for solving partial differential equation in cardiac conduction. IEEE Trans Biomed Eng 46: 1166-1168. doi:10.1109/10.784149. PubMed: 10493080. (Pubitemid 29409327)
30. Rubenstein DS, Lipsius SL (1995) Premature beats elicit a phase reversal of mechanoelectrical alternans in cat ventricular myocytes. A possible mechanism for reentrant arrhythmias. Circulation 91: 201-214. doi:10.1161/01.CIR.91.1. 201. PubMed: 7805204.
31. Mahajan A, Shiferaw Y, Sato D, Baher A, Olcese R et al. (2008) A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophys J 94: 392-410. doi:10.1529/biophysj. 106.98160. PubMed: 18160660.
32. Gaeta SA, Bub G, Abbott GW, Christini DJ (2009) Dynamical mechanism for subcellular alternans in cardiac myocytes. Circ Res 105: 335-342. doi:10.1161/CIRCRESAHA.109.197590. PubMed: 19628792.
33. Hayashi H, Shiferaw Y, Sato D, Nihei M, Lin SF et al. (2007) Dynamic origin of spatially discordant alternans in cardiac tissue. Biophys J 92: 448-460. doi:10.1529/biophysj.106.091009. PubMed: 17071663. (Pubitemid 46145778)
34. Langer GA, Peskoff A (1997) Role of the diadic cleft in myocardial contractile control. Circulation 96: 3761-3765. doi:10.1161/01.CIR. 96.10.3761. PubMed: 9396480.
35. Restrepo JG, Weiss JN, Karma A (2008) Calsequestrin-mediated mechanism for cellular calcium transient alternans. Biophys J 95: 3767-3789. doi:10.1529/biophysj.108.130419. PubMed: 18676655.
36. Díaz ME, O'Neill SC, Eisner DA (2004) Sarcoplasmic reticulum calcium content fluctuation is the key to cardiac alternans. Circ Res 94: 650-656. doi:10.1161/01.RES.0000119923.64774.72. PubMed: 14752033. (Pubitemid 38387748)
37. Kang G, Giovannone SF, Liu N, Liu FY, Zhang J et al. (2010) Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy. Circ Res 107: 512-519. doi:10.1161/CIRCRESAHA.110.221481. PubMed: 20595652.
38. Aizawa Y, Komura S, Okada S, Chinushi M, Aizawa Y et al. (2006) Distinct U wave changes in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT). Int Heart J 47: 381-389. doi:10.1536/ihj.47.381. PubMed: 16823244. (Pubitemid 44082833)
39. Euler DE (1999) Cardiac alternans: mechanisms and pathophysiological significance. Cardiovasc Res 42: 583-590. doi:10.1016/S0008-6363(99)00011-5. PubMed: 10533597. (Pubitemid 29298126)
40. Murphy CF, Horner SM, Dick DJ, Coen B, Lab MJ (1996) Electrical alternans and the onset of rate-induced pulsus alternans during acute regional ischaemia in the anaesthetised pig heart. Cardiovasc Res 32: 138-147. doi:10.1016/S0008- 6363(96)00033-8. PubMed: 8776411. (Pubitemid 26232661)
41. Gizzi A, Cherry EM, Gilmour RF Jr., Luther S, Filippi S et al. (2013) Effects of pacing site and stimulation history on alternans dynamics and the development of complex spatiotemporal patterns in cardiac tissue. Front - Physiol (Bethesda, Md.) 4: 71. PubMed: 23637684.
42. Lehnart SE, Terrenoire C, Reiken S, Wehrens XH, Song LS et al. (2006) Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A 103: 7906-7910. doi:10.1073/pnas. 0602133103. PubMed: 16672364.
43. Sabir IN, Ma N, Jones VJ, Goddard CA, Zhang Y et al. (2010) Alternans in genetically modified langendorff-perfused murine hearts modeling catecholaminergic polymorphic ventricular tachycardia. Front - Physiol (Bethesda, Md.) 1: 126. PubMed: 21423368.
44. Coote JH (2010) Recovery of heart rate following intense dynamic exercise. Exp Physiol 95: 431-440. doi:10.1113/expphysiol.2009.047548. PubMed: 19837772.