Enhanced AMPK phosphorylation contributes to the beneficial effects of Lactobacillus rhamnosus GG supernatant on chronic-alcohol-induced fatty liver disease

Journal of Nutritional Biochemistry

Volumn 26, Issue 4, 2015, Pages 337-344

  Zhang, Min ^a,b,g   Wang, Cuiling ^b,c,g   Wang, Chunhong ^b,d,g   Zhao, Haiyang ^a,b,e   Zhao, Cuiqing ^a,b,f,g   Chen, Yongping ^b   Wang, Yuhua ^a,b,g   McClain, Craig ^b,e,g   Feng, Wenke ^b,g  

^a JILIN AGRICULTURAL UNIVERSITY   (China)

^b University of Louisville School of Medicine   (United States)

^c WENZHOU MEDICAL UNIVERSITY   (China)

^d NORTHWEST UNIVERSITY   (China)

^e JILIN UNIVERSITY   (China)

^f NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^g VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Alcohol; AMPK; Lipid; Liver; Probiotics

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACYL COENZYME A DESATURASE; ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; ALCOHOL; CARNITINE PALMITOYLTRANSFERASE I; DEXTRIN; LIVER ENZYME; MALTOSE; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR PROTEIN 1 ALPHA; PROBIOTIC AGENT; PROTEIN BAX; PROTEIN BCL 2; STEAROYL COA DESATURASE 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BAX PROTEIN, MOUSE; CARNITINE PALMITOYLTRANSFERASE; CONDITIONED MEDIUM; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SREBF1 PROTEIN, MOUSE;

ALCOHOLIC FATTY LIVER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHRONIC ALCOHOL INDUCED FATTY LIVER DISEASE; COLONY FORMING UNIT; DIET; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FATTY ACID OXIDATION; FATTY LIVER; LACTOBACILLUS RHAMNOSUS; LACTOBACILLUS RHAMNOSUS GG SUPERNATANT; LIPID LIVER LEVEL; LIPID METABOLISM; LIPID STORAGE; LIQUID DIET; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SUPERNATANT; ADVERSE EFFECTS; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; CONDITIONED MEDIUM; DOWN REGULATION; DRINKING BEHAVIOR; DRUG EFFECTS; FATTY LIVER, ALCOHOLIC; GENETICS; METABOLISM; MICROBIOLOGY; PHARMACOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; UPREGULATION;

LACTOBACILLUS RHAMNOSUS; MUS;

ALANINE TRANSAMINASE; ALCOHOL DRINKING; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ASPARTATE AMINOTRANSFERASES; BCL-2-ASSOCIATED X PROTEIN; CARNITINE O-PALMITOYLTRANSFERASE; CELL LINE, TUMOR; CULTURE MEDIA, CONDITIONED; DOWN-REGULATION; FATTY LIVER, ALCOHOLIC; LACTOBACILLUS RHAMNOSUS; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PPAR ALPHA; PPAR GAMMA; PROBIOTICS; STEAROYL-COA DESATURASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UP-REGULATION;

EID: 84924544462     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2014.10.016     Document Type: Article

References (40)

1. Adachi M., Brenner D.A. Clinical syndromes of alcoholic liver disease. Dig Dis 2005, 23:255-263.
2. Gao B., Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 2011, 141:1572-1585.
3. Mann R.E., Smart R.G., Govoni R. The epidemiology of alcoholic liver disease. Alcohol Res Health 2003, 27:209-219.
4. Kirpich I.A., Solovieva N.V., Leikhter S.N., Shidakova N.A., Lebedeva O.V., Sidorov P.I., Bazhukova T.A., Soloviev A.G., Barve S.S., McClain C.J., Cave M. Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study. Alcohol 2008, 42:675-682.
5. Wang Y., Kirpich I., Liu Y., Ma Z., Barve S., McClain C.J., Feng W. Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury. Am J Pathol 2011, 179:2866-2875.
6. Wang Y., Liu Y., Sidhu A., Ma Z., McClain C., Feng W. Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury. Am J Physiol Gastrointest Liver Physiol 2012, 303:G32-G41.
7. Beier J.I., McClain C.J. Mechanisms and cell signaling in alcoholic liver disease. Biol Chem 2010, 391:1249-1264.
8. Crabb D.W., Galli A., Fischer M., You M. Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha. Alcohol 2004, 34:35-38.
9. You M., Crabb D.W. Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins. Alcohol 2004, 34:39-43.
10. Viollet B., Foretz M., Guigas B., Horman S., Dentin R., Bertrand L., Hue L., Andreelli F. Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol 2006, 574:41-53.
11. You M., Matsumoto M., Pacold C.M., Cho W.K., Crabb D.W. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 2004, 127:1798-1808.
12. Wakil S.J., Abu-Elheiga L.A. Fatty acid metabolism: target for metabolic syndrome. J Lipid Res 2009, 50:S138-143. [Suppl.].
13. Lee W.J., Kim M., Park H.S., Kim H.S., Jeon M.J., Oh K.S., Koh E.H., Won J.C., Kim M.S., Oh G.T., Yoon M., Lee K.U., Park J.Y. AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1. Biochem Biophys Res Commun 2006, 340:291-295.
14. Yoon M.J., Lee G.Y., Chung J.J., Ahn Y.H., Hong S.H., Kim J.B. Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes 2006, 55:2562-2570.
15. Hawley S.A., Davison M., Woods A., Davies S.P., Beri R.K., Carling D., Hardie D.G. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem 1996, 271:27879-27887.
16. Munday M.R., Hemingway C.J. The regulation of acetyl-CoA carboxylase - a potential target for the action of hypolipidemic agents. Adv Enzym Regul 1999, 39:205-234.
17. Bull-Otterson L., Feng W., Kirpich I., Wang Y., Qin X., Liu Y., Gobejishvili L., Joshi-Barve S., Ayvaz T., Petrosino J., Kong M., Barker D., McClain C., Barve S. Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment. PLoS One 2013, 8:e53028.
18. Wang Y., Liu Y., Kirpich I., Ma Z., Wang C., Zhang M., Suttles J., McClain C., Feng W. Lactobacillus rhamnosus GG reduces hepatic TNFalpha production and inflammation in chronic alcohol-induced liver injury. J Nutr Biochem 2013, 24:1609-1615.
19. Frazier T.H., Stocker A.M., Kershner N.A., Marsano L.S., McClain C.J. Treatment of alcoholic liver disease. Ther Adv Gastroenterol 2011, 4:63-81.
20. Lieber C.S. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol 2004, 34:9-19.
21. Hardie D.G., Pan D.A. Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase. Biochem Soc Trans 2002, 30:1064-1070.
22. Ajmo J.M., Liang X., Rogers C.Q., Pennock B., You M. Resveratrol alleviates alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol 2008, 295:G833-G842.
23. Shearn C.T., Smathers R.L., Jiang H., Orlicky D.J., Maclean K.N., Petersen D.R. Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis. J Nutr Biochem 2013, 24:1436-1445.
24. Kim S.-W., Park K.-Y., Kim B., Kim E., Hyun C.-K. Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhancement of adiponectin production. Biochem Biophys Res Commun 2013, 431:258-263.
25. Hu M., Wang F., Li X., Rogers C.Q., Liang X., Finck B.N., Mitra M.S., Zhang R., Mitchell D.A., You M. Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice. Hepatology 2012, 55:437-446.
26. Ji C., Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 2003, 124:1488-1499.
27. Lieber C.S., Leo M.A., Wang X., Decarli L.M. Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1alpha in rats. Biochem Biophys Res Commun 2008, 370:44-48.
28. You M., Cao Q., Liang X., Ajmo J.M., Ness G.C. Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice. J Nutr 2008, 138:497-501.
29. Crabb D.W., Liangpunsakul S. Alcohol and lipid metabolism. J Gastroenterol Hepatol 2006, 21(Suppl. 3):S56-60.
30. Guo R., Zhong L., Ren J. Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver. Clin Exp Pharmacol Physiol 2009, 36:463-468.
31. Deaciuc I.V., D'Souza N.B., Burikhanov R., Nasser M.S., Voskresensky I.V., De Villiers W.J.S., McClain C.J. Alcohol, but not lipopolysaccharide-induced liver apoptosis involves changes in intracellular compartmentalization of apoptotic regulators. Alcohol Clin Exp Res 2004, 28:160-172.
32. Deaciuc I.V., Fortunato F., D'Souza N.B., Hill D.B., McClain C.J. Chronic alcohol exposure of rats exacerbates apoptosis in hepatocytes and sinusoidal endothelial cells. Hepatol Res 2001, 19:306-324.
33. Guo R., Zhong L., Ren J. Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver. Clin Exp Pharmacol Physiol 2009, 36:463-468.
34. Yan F., Cao H., Cover T.L., Whitehead R., Washington M.K., Polk D.B. Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology 2007, 132:562-575.
35. Zhang W., Wang H., Liu J., Zhao Y., Gao K., Zhang J. Adhesive ability means inhibition activities for Lactobacillus against pathogens and S-layer protein plays an important role in adhesion. Anaerobe 2013, 22:97-103.
36. Thomas C.M., Hong T., van Pijkeren J.P., Hemarajata P., Trinh D.V., Hu W., Britton R.A., Kalkum M., Versalovic J. Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. PLoS One 2012, 7:e31951.
37. Segawa S., Fujiya M., Konishi H., Ueno N., Kobayashi N., Shigyo T., Kohgo Y. Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway. PLoS One 2011, 6:e23278.
38. Nowak B., Ciszek-Lenda M., Srottek M., Gamian A., Kontny E., Gorska-Fraczek S., Marcinkiewicz J. Lactobacillus rhamnosus exopolysaccharide ameliorates arthritis induced by the systemic injection of collagen and lipopolysaccharide in DBA/1 mice. Arch Immunol Ther Exp 2012, 60:211-220.
39. Ewaschuk J.B., Walker J.W., Diaz H., Madsen K.L. Bioproduction of conjugated linoleic acid by probiotic bacteria occurs in vitro and in vivo in mice. J Nutr 2006, 136:1483-1487.
40. Matsumoto M., Kurihara S., Kibe R., Ashida H., Benno Y. Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production. PLoS One 2011, 6:e23652.