Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhancement of adiponectin production

Biochemical and Biophysical Research Communications

Volumn 431, Issue 2, 2013, Pages 258-263

  Kim, Sun Woo ^a   Park, Kun Young ^a   Kim, Bobae ^a   Kim, Eunha ^a   Hyun, Chang Kee ^a  

^a Handong University   (South Korea)

Author keywords

Adiponectin; Adiposity; AMPK; Insulin sensitivity; Lactobacillus rhamnosus GG

Indexed keywords

ADIPONECTIN; FATTY ACID; GLUCOSE TRANSPORTER 4; PROBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; GENE EXPRESSION; GLUCOSE METABOLISM; INSULIN SENSITIVITY; LACTOBACILLUS RHAMNOSUS; LIPID DIET; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SKELETAL MUSCLE; WEIGHT GAIN;

ADIPONECTIN; ADIPOSITY; ANIMALS; DIET, HIGH-FAT; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORTER TYPE 4; INSULIN RESISTANCE; LACTOBACILLUS RHAMNOSUS; MALE; METABOLIC SYNDROME X; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROBIOTICS; PROTEIN KINASES; RNA, MESSENGER;

LACTOBACILLUS RHAMNOSUS; MUS;

EID: 84873478465     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.12.121     Document Type: Article

References (31)

1. Moller D.E. New drug targets for type 2 diabetes and the metabolic syndrome. Nature 2001, 414:821-827.
2. Witters L.A. The blooming of French lilac. J. Clin. Invest. 2001, 108:1105-1107.
3. Alberti K.G., Eckel R.H., Grundy S.M., Zimmet P.Z., Cleeman J.I., Donato K.A., Fruchart J.C., James W.P., Loria C.M., Smith S.C. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009, 120:1640-1645.
4. Ley R.E., Turnbaugh P.J., Klein S., Gordon J.I. Microbial ecology: human gut microbes associated with obesity. Nature 2006, 444:1022-1023.
5. Turnbaugh P.J., Ley R.E., Mahowald M.A., Magrini V., Mardis E.R., Gordon J.I. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444:1027-1031.
6. Vijay-Kumar M., Aitken J.D., Carvalho F.A., Cullender T.C., Mwangi S., Srinivasan S., Sitaraman S.V., Knight R., Ley R.E., Gewirtz A.T. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010, 328:228-231.
7. Cani P.D., Bibiloni R., Knauf C., Waget A., Neyrinck A.M., Delzenne N.M., Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008, 57:1470-1481.
8. Kadooka Y., Sato M., Imaizumi K., Ogawa A., Ikuyama K., Akai Y., Okano M., Kagoshima M., Tsuchida T. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. Eur. J. Clin. Nutr. 2010, 64:636-643.
9. Uronis J.M., Arthur J.C., Keku T., Fodor A., Carroll I.M., Cruz M.L., Appleyard C.B., Jobin C. Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis. Inflamm. Bowel Dis. 2011, 17:289-297.
10. Xu R.Y., Wan Y.P., Fang Q.Y., Lu W., Cai W. Supplementation with probiotics modifies gut flora and attenuates liver fat accumulation in rat nonalcoholic fatty liver disease model. J. Clin. Biochem. Nutr. 2012, 60:72-77.
11. Canani R.B., Cirillo P., Terrin G., Cesarano L., Spagnuolo M.I., De Vincenzo A., Albano F., Passariello A., De Marco G., Manguso F., Guarino A. Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations. BMJ 2007, 335:340-345.
12. Kalliomaki M., Salminen S., Arvilommi H., Kero P., Koskinen P., Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001, 357:1076-1079.
13. Lin P.W., Myers L.E., Ray L., Song S.C., Nasr T.R., Berardinelli A.J., Kundu K., Murthy N., Hansen J.M., Neish A.S. Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation. Free Radical Biol. Med. 2009, 47:1205-1211.
14. Tabuchi M., Ozaki M., Tamura A., Yamada N., Ishida T., Hosoda M., Hosono A. Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats. Biosci., Biotechnol., Biochem. 2003, 67:1421-1424.
15. Honda K., Moto M., Uchida N., He F., Hashizume N. Anti-diabetic effects of lactic acid bacteria in normal and type 2 diabetic mice. J. Clin. Biochem. Nutr. 2012, 51:96-101.
16. Kim E., Lee J.H., Ntambi J.M., Hyun C.K. Inhibition of stearoyl-CoA desaturase1 activates AMPK and exhibits beneficial lipid metabolic effects in vitro. Eur. J. Pharmacol. 2011, 672:38-44.
17. Kadooka Y., Ogawa A., Ikuyama K., Sato M. The probiotic Lactobacillus gasseri SBT2055 inhibits enlargement of visceral adipocytes and upregulation of serum soluble adhesion molecule (sICAM-1) in rats. Int. Dairy J. 2011, 21:623-627.
18. Ma X., Hua J., Li Z. Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. J. Hepatol. 2008, 49:821-830.
19. Amar J., Chabo C., Waget A., Klopp P., Vachoux C., Bermudez-Humaran L.G., Smirnova N., Berge M., Sulpice T., Lahtinen S., Ouwehand A., Langella P., Rautonen N., Sansonetti P.J., Burcelin R. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol. Med. 2011, 3:559-572.
20. Boden G., Chen X., Stein T.P. Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus. Am. J. Physiol. Endocrinol. Metab. 2001, 280:E23-30.
21. Herman M.A., Kahn B.B. Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J. Clin. Invest. 2006, 116:1767-1775.
22. DeFronzo R.A., Gunnarsson R., Björkman O., Olsson M., Wahren J. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J. Clin. Invest. 1985, 76:149-155.
23. Rasouli N., Kern P.A. Adipocytokines and the metabolic complications of obesity. J. Clin. Endocrinol. Metab. 2008, 93:S64-S73.
24. Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., Yamashita S., Noda M., Kita S., Ueki K., Eto K., Akanuma Y., Froguel P., Foufelle F., Ferre P., Carling D., Kimura S., Nagai R., Kahn B.B., Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 2002, 8:1288-1295.
25. Zhang B.B., Zhou G., Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 2009, 9:407-416.
26. Fujii N., Jessen N., Goodyear L.J. AMP-activated protein kinase and the regulation of glucose transport. Am. J. Physiol. Endocrinol. Metab. 2006, 291:867-877.
27. Satoh H., Nguyen M.T., Trujillo M., Imamura T., Usui I., Scherer P.E., Olefsky J.M. Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats. Diabetes 2005, 54:1304-1313.
28. Kadowaki T., Yamauchi T., Kubota N. The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS. FEBS Lett. 2008, 582:74-80.
29. He L., Sabet A., Djedjos S., Miller R., Sun X., Hussain M.A., Radovick S., Wondisford F.E. Metformin and insulin suppress hepatic gluconeogenesis by inhibiting cAMP signaling through phosphorylation of CREB binding protein (CBP). Cell 2009, 137:635-646.
30. Horike N., Sakoda H., Kushiyama A., Ono H., Fujishiro M., Kamata H., Nishiyama K., Uchijima Y., Kurihara Y., Kurihara H., Asano T. AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver. J. Biol. Chem. 2008, 283:33902-33910.
31. Miller R.A., Chu Q., Lay J.L., Scherer P.E., Ahima R.S., Kaestner K.H., Foretz M., Viollet B., Birnbaum M.J. Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. J. Clin. Invest. 2011, 121:2518-2528.