Reduced numbers of switched memory B cells with high terminal differentiation potential in Down syndrome

European Journal of Immunology

Volumn 45, Issue 3, 2015, Pages 903-914

  Carsetti, Rita ^a   Valentini, Diletta ^a   Marcellini, Valentina ^a   Scarsella, Marco ^a   Marasco, Emiliano ^a   Giustini, Ferruccio ^a   Bartuli, Andrea ^a   Villani, Alberto ^a   Ugazio, Alberto G ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

B cells; Down syndrome; IgM memory; Switched memory; TLR9; Vaccine

Indexed keywords

IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN M; TOLL LIKE RECEPTOR 9; TLR9 PROTEIN, HUMAN; VACCINE;

ARTICLE; CELL DIFFERENTIATION; CELL POPULATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DOWN SYNDROME; FEMALE; HUMAN; IMMUNE DEFICIENCY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCING CELL; IMMUNOGLOBULIN PRODUCTION; IMMUNOLOGICAL PARAMETERS; INFECTION RISK; MALE; MEMORY CELL; PRIORITY JOURNAL; RECURRENT INFECTION; VACCINATION; B LYMPHOCYTE; BLOOD; CLINICAL TRIAL; DRUG EFFECTS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

B-LYMPHOCYTES; CELL DIFFERENTIATION; CHILD; DOWN SYNDROME; FEMALE; HUMANS; IMMUNOGLOBULIN M; IMMUNOLOGIC MEMORY; MALE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 9; VACCINATION; VACCINES;

EID: 84924530904     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201445049     Document Type: Article

References (45)

1. Ram, G. and Chinen, J., Infections and immunodeficiency in Down syndrome. Clin. Experim. Immunol. 2011. 164: 9-16.
2. Bloemers, B. L. P., Broers, C. J. M., Bont, L., Weijerman, M. E., Gemke, R. J. B. J. and Marceline van Furth, A., Increased risk of respiratory tract infections in children with Down syndrome: the consequence of an altered immune system. Microb. Infection. 2010. 12: 799-808.
3. Hasle, H., Clemmensen, I. H. and Mikkelsen, M., Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet 2000. 355: 165-169.
4. Hasle, H., Pattern of malignant disorders in individuals with Down's Syndrome. Lancet Oncol. 2001. 2: 429-436.
5. Bonamico, M., Mariani, P., Danesi, H. M., Crisogianni, M., Failla, P., Gemme, G., Quartino, A. R., et al., Prevalence and clinical picture of celiac disease in Italian Down syndrome patients: a multicenter study. J. Pediatr. Gastroenterol. Nutr. 2001. 33: 139-143.
6. Sánchez-Albisua, I., Storm, W., Wäscher, I. and Stern, M., How frequent is coeliac disease in Down syndrome? Eur. J. Pediatr. 2002. 161: 683-684.
7. Book, L., Hart, A., Black, J., Feolo, M., Zone, J. J. and Neuhausen, S. L., Prevalence and clinical characteristics of celiac disease in Down's syndrome in a U.S. study. Am. J. Med. Gen. 2001. 98: 70-74.
8. Van Goor, J. C., Massa, G. G. and Hirasing, R., Increased incidence and prevalence of diabetes mellitus in Down's syndrome. Arch. Dis. Child. 1997. 77: 186.
9. Anwar, A. J., Walker, J. D. and Frier, B. M., Type 1 diabetes mellitus and Down's Syndrome: prevalence, management and diabetic complications. Diabet. Med. 1998. 15: 160-163.
10. Goldacre, M. J., Wotton, C. J., Seagroatt, V. and Yeates, D., Cancers and immune related diseases associated with Down's syndrome: a record linkage study. Arch. Dis. Child. 2004. 89: 1014-1017.
11. King, K., O'Gorman, C. and Gallagher, S., Thyroid dysfunction in children with Down syndrome: a literature review. Ir. J. Med. Sci. 2014. 183: 1-6.
12. Irving, C., Basu, A., Richmond, S., Burn, J. and Wren, C., Twenty-year trends in prevalence and survival of Down syndrome. Eur. J. Hum. Genet. 2008. 16: 1336-1340.
13. Yang, Q., Rasmussen, S. A. and Friedman, J. M., Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet 2002. 359: 1019-1025.
14. Burgio, G. R., Ugazio, A. G., Nespoli, L., Marcioni, A. F., Bottelli, A. M. and Pasquali, F., Derangements of immunoglobulin levels, phytohemagglutinin responsiveness and T and B cell markers in Down's syndrome at different ages. Eur. J. Immunol. 1975. 5: 600-603.
15. Burgio, G. R., Lanzavecchia, A., Maccario, R., Vitiello, A., Plebani, A. and Ugazio, A. G., Immunodeficiency in Down's syndrome: T-lymphocyte subset imbalance in trisomic children. Clin. Exp. Immunol. 1978. 33: 298-301.
16. Levin, S., Nir, E. and Mogilner, B. M., T system immune-deficiency in Down's syndrome. Pediatrics 1975. 56: 123-126.
17. Levin, S., Schlesinger, M., Handzel, Z., Hahn, T., Altmam, Y., Czernobilsky, B. and Boss, J., Thymic deficiency in Down's syndrome. Pediatrics 1979. 63: 80-87.
18. Ugazio, A. G., Maccario, R., Notarangelo, L. D. and Burgio, G. R., Immunology of Down syndrome: a review. Am. J. Med. Genet. Suppl. 1990. 7: 204-212.
19. Avanzini, M. A., Monafo, V., De Amici, M., Maccario, R., Burgio, G. R., Plebani, A., Ugazio, A. G. et al., Humoral immunodeficiencies in Down Syndrome; serum IgG subclass and antibody response to hepatitis B vaccine. Am. J. Med. Genet. Suppl. 1990. 7: 231-233.
20. Costa-Carvalho, B. T., Martinez, R. M., Dias, A. T., Kubo, C. A., Barros-Nunes, P., Leiva, L., Solé, D. et al., Antibody response to pneumococcal capsular polysaccharide vaccine in Down syndrome patients. Braz. J. Med. Biol. Res. 2006. 39: 1587-1592.
21. Kusters, M. A., Bok, V. L., Bolz, W. E., Huijskens, E. G., Peeters, M. F. and de Vries, E., Influenza A/H1N1 vaccination response is inadequate in Down Syndrome children when the latest cut-off values are used. Pediatr. Infect. Dis. J. 2012. 31: 1284-1285.
22. Guazzarotti, L., Trabattoni, D., Castelletti, E., Boldrighini, B., Piacentini, L., Duca, P., Beretta, S. et al., T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome). Am. J. Intellect. Dev. Disabil. 2009. 114: 100-109.
23. Kusters, M. A., Gemen, E. F., Verstegen, R. H., Wever, P. C. and de Vries, E., Both normal memory counts and decreased naïve cells favor intrinsic defect over early senescence of Down Syndrome T lymphocites. Pediatr. Res. 2010. 67: 557-562.
24. Cetiner, S., Demirhan, O., Inal, T. C., Tastemir, D. and Sertdemir, Y., Analysis of peripheral blood T-cell subsets, natural killer cells and serum levels of cytokines in children with Down syndrome. Int. J. Immunogenet. 2010. 37: 233-237.
25. Broers, C. J., Gemke, R. J., Weijerman, M. E., van derSluijs, K. F. and van Furth, A. M., Increased pro-inflammatory cytokine production in Down syndrome children upon stimulation with live influenza A virus. J. Clin. Immunol. 2012. 32: 323-329.
26. Verstegen, R. H., Kusters, M. A., Gemen, E. F. and de Vries, E., Down Syndrome B-lymphocyte subpopulations, intrinsic defect or decresead T-lymphocyte help. Pediatr. Res. 2010. 67: 563-569.
27. +peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 1998. 188: 1679-1689.
28. Capolunghi, F., Rosado, M. M., Sinibaldi, M., Aranburu, A. and Carsetti, R., Why do we need IgM memory B cells? Immunol. Lett. 2013. 152: 114-120.
29. Kusters, M. A., Verstegen, R. H., Gemen, E. F. and de Vries, E., Intrinsic defect of the immune system in children with Down syndrome: a review. Clin. Exp. Immunol. 2009. 156: 189-193.
30. De Hingh, Y. C., van der Vossen, P. W., Gemen, E. F., Mulder, A. B., Hop, W. C., Brus, F. and de Vries, E., Intrinsic abnormalities of lymphocyte counts in children with Down syndrome. J. Pediatr. 2005. 147: 744-747.
31. Verstegen, R. H., Borte, S., Bok, L. A., Van Zwieten, P. H., Von Döbeln, U., Hammarström, L. and de Vries, E., Impact of Down syndrome on the performance of neonatal screening assays for severe primary immunodeficiency diseases. J. Allergy Clin. Immunol. 2014. 133: 1208-1211.
32. Garrison, M. M., Jeffries, H. and Christakis, D.A., Risk of death for children with Down syndrome and sepsis. J. Pediatr. 2005. 147: 748-752.
33. Joshi, A. Y., Abraham, R. S., Snyder, M. R. and Boyce, T. G., Immune evaluation and vaccine responses in Down Syndrome: evidence of immunodeficiency? Vaccine 2001. 29: 5040-5046.
34. Carsetti, R., Rosado, M. M. and Wardmann, H., Peripheral development of B cells in mouse and man. Immunol. Rev. 2004. 197: 179-191.
35. Freitas, A. A. and Rocha, B. Population biology of lymphocytes: the flight for survival. Annu. Rev. Immunol. 2000. 18: 83-111.
36. Baumjohann, D., Preite, S., Reboldi, A., Ronchi, F., Ansel, K. M., Lanzavecchia, A. and Sallusto, F., Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity 2013. 38: 596-605.
37. Xu, Y., Li, W., Liu, X., Chen, H., Tan, K., Chen, Y., Tu, Z. et al., Identification of dysregulated microRNAs in lymphocytes from children with Down syndrome. Gene 2013. 530: 278-286.
38. Gururajan, M., Haga, C. L., Das, S., Leu, C. M., Hodson, D., Josson, S., Turner, M. et al., MicroRNA 125b inhibition of B cell differentiation in germinal centers. Int. Immunol. 2010. 22: 583-592.
39. Willimott, S. and Wagner, S. D., miR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells. J. Biol. Chem. 2012. 287: 2608-2617.
40. De Martino, M. and Ballotti, S., The child with recurrent respiratory infections: normal or not? Pediatr. Allergy Immunol. 2007. 18: 13-18.
41. Principi, N. and Esposito, S., New insights into pediatric rhinosinusitis. Pediatr. Allergy Immunol. 2007. 18: 7-9.
42. Revai, K., Dobbs, L. A., Nair, S., Patel, J. A., Grady, J. J. and Chonmaitree, T., Incidence of acute otitis media and sinusitis complicating upper respiratory tract infection: the effect of age. Pediatrics 2007. 119: 1408-1412.
43. Kruetzmann, S., Rosado, M. M., Weber, H., Germing, U., Tournilhac, O., Peter, H. H., Berner, R. et al., Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. J. Exp. Med. 2003. 197: 939-945.
44. Rosado, M. M., Gesualdo, F., Marcellini, V., Di Sabatino, A., Corazza, G. R., Smacchia, M. P., Nobili, B. et al., Preserved antibody levels and loss of memory B cells against pneumococcus and tetanus after splenectomy: tailoring better vaccination strategies. Eur. J. Immunol. 2013. 43: 2659-2670.
45. Rosado, M. M., Scarsella, M., Cascioli, S., Giorda, E. and Carsetti, R., Evaluating B-cells: from bone marrow precursors to antibody-producing cells. Methods Mol. Biol. 2013. 1032: 45-57.