Increased risk of respiratory tract infections in children with Down syndrome: The consequence of an altered immune system

Microbes and Infection

Volumn 12, Issue 11, 2010, Pages 799-808

  Bloemers, Beatrijs L P ^a   Broers, Chantal J M ^b   Bont, Louis ^a   Weijerman, Michel E ^b   Gemke, Reinoud J B J ^b   van Furth, A Marceline ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adaptive immunity; Down syndrome; Immunology; Innate immunity; Respiratory tract infections

Indexed keywords

IMMUNOGLOBULIN M; PHYTOHEMAGGLUTININ; SELENIUM; THYMUS HORMONE;

ADAPTIVE IMMUNITY; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTIFICIAL VENTILATION; B LYMPHOCYTE; CELL COUNT; CELL FUNCTION; CHILDHOOD DISEASE; DISEASE ASSOCIATION; DOWN SYNDROME; HUMAN; IMMUNE DYSREGULATION; IMMUNOCOMPETENT CELL; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INFECTION RISK; INFECTION SENSITIVITY; INNATE IMMUNITY; LOWER RESPIRATORY TRACT INFECTION; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MORBIDITY; NATURAL KILLER CELL; NEUTROPHIL; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY TRACT INTUBATION; SENESCENCE; SHORT SURVEY; T LYMPHOCYTE; THYMUS; UPPER RESPIRATORY TRACT INFECTION;

DOWN SYNDROME; HUMANS; IMMUNE SYSTEM; INFANT, NEWBORN; RESPIRATORY TRACT INFECTIONS; RISK ASSESSMENT;

EID: 77957749242     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2010.05.007     Document Type: Short Survey

References (87)

1. Weijerman M.E., van Furth A.M., Vonk N.A., van Wouwe J.P., Broers C.J., Gemke R.J. Prevalence, neonatal characteristics, and first-year mortality of Down syndrome: a national study. J. Pediatr. 2008, 152:15-19.
2. Goldacre M.J., Wotton C.J., Seagroatt V., Yeates D. Cancers and immune related diseases associated with Down's syndrome: a record linkage study 2. Arch. Dis. Child. 2004, 89:1014-1017.
3. Bloemers B.L., van Furth A.M., Weijerman M.E., Gemke R.J., Broers C.J., van den Ende K., Kimpen J.L., Strengers J.L., Bont L.J. Down syndrome: a novel risk factor for respiratory syncytial virus bronchiolitis-a prospective birth-cohort study. Pediatrics 2007, 120:e1076-e1081.
4. Hilton J.M., Fitzgerald D.A., Cooper D.M. Respiratory morbidity of hospitalized children with trisomy 21. J. Paediatr. Child. Health 1999, 35:383-386.
5. Selikowitz M. Health problems and health checks in school-aged children with Down syndrome. J. Paediatr. Child. Health 1992, 28:383-386.
6. Turner S., Sloper P., Cunningham C., Knussen C. Health problems in children with Down's syndrome. Child. Care Health Dev. 1990, 16:83-97.
7. Chaney R.H., Eyman R.K., Miller C.R. The relationship of congenital heart disease and respiratory infection mortality in patients with Down's syndrome. J. Ment. Defic. Res. 1985, 29:23-27.
8. Scholl T., Stein Z., Hansen H. Leukemia and other cancers, anomalies and infections as causes of death in Down's syndrome in the United States during 1976. Dev. Med. Child. Neurol. 1982, 24:817-829.
9. Thase M.E. Longevity and mortality in Down's syndrome. J. Ment. Defic. Res. 1982, 26:177-192.
10. Yang Q., Rasmussen S.A., Friedman J.M. Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet 2002, 359:1019-1025.
11. Garrison M.M., Jeffries H., Christakis D.A. Risk of death for children with down syndrome and sepsis. J. Pediatr. 2005, 147:748-752.
12. Shott S.R. Down syndrome: common otolaryngologic manifestations. Am. J. Med. Genet. C. Semin. Med. Genet. 2006, 142:131-140.
13. Piatti G., Allegra L., Ambrosetti U., De Santi M.M. Nasal ciliary function and ultrastructure in Down syndrome. Laryngoscope 2001, 111:1227-1230.
14. Bruijn M., van der Aa L.B., van Rijn R.R., Bos A.P., van Woensel J.B. High incidence of acute lung injury in children with Down syndrome. Intensive Care Med. 2007, 33:2179-2182.
15. Martin T.R., Nakamura M., Matute-Bello G. The role of apoptosis in acute lung injury. Crit. Care Med. 2003, 31:S184-S188.
16. Yasui K., Shinozaki K., Nakazawa T., Agematsu K., Komiyama A. Presenility of granulocytes in Down syndrome individuals. Am. J. Med. Genet. 1999, 84:406-412.
17. Cant A.J., Gibson P.J., West R.J. Bacterial tracheitis in Down's syndrome. Arch. Dis. Child. 1987, 62:962-963.
18. Winters J.L., O'Connor W.N., Broughton R.A., Noonan J.A. Bordetella bronchiseptica pneumonia in a patient with Down syndrome: a case report and review. Pediatrics 1992, 89:1262-1265.
19. Orlicek S.L., Walker M.S., Kuhls T.L. Severe mycoplasma pneumonia in young children with Down syndrome. Clin. Pediatr. (Phila) 1992, 31:409-412.
20. Fjaerli H.O., Farstad T., Bratlid D. Hospitalisations for respiratory syncytial virus bronchiolitis in Akershus, Norway, 1993-2000: a population-based retrospective study. BMC. Pediatr. 2004, 4:25.
21. Medrano C., Garcia-Guereta L., Grueso J., Insa B., Ballesteros F., Casaldaliga J., Cuenca V., Escudero F., de la Calzada L.G., Luis M., Luque M., Mendoza A., Prada F., del Mar R.M., Suarez P., Quero C., Guilera M. Respiratory infection in congenital cardiac disease. Hospitalizations in young children in Spain during 2004 and 2005: the CIVIC Epidemiologic Study. Cardiol. Young 2007, 17:360-371.
22. Bertrand P., Navarro H., Caussade S., Holmgren N., Sanchez I. Airway anomalies in children with Down syndrome: endoscopic findings. Pediatr. Pulmonol. 2003, 36:137-141.
23. Cooney T.P., Thurlbeck W.M. Pulmonary hypoplasia in Down's syndrome. N. Engl. J. Med. 1982, 307:1170-1173.
24. Cooney T.P., Wentworth P.J., Thurlbeck W.M. Diminished radial count is found only postnatally in Down's syndrome. Pediatr. Pulmonol. 1988, 5:204-209.
25. Schloo B.L., Vawter G.F., Reid L.M. Down syndrome: patterns of disturbed lung growth. Hum. Pathol. 1991, 22:919-923.
26. Brumbaugh D.E., Accurso F.J. Persistent silent aspiration in a child with Trisomy 21. Curr. Opin. Pediatr. 2002, 14:231-233.
27. Weir K., McMahon S., Barry L., Ware R., Masters I.B., Chang A.B. Oropharyngeal aspiration and pneumonia in children. Pediatr. Pulmonol. 2007, 42:1024-1031.
28. Cossarizza A., Ortolani C., Forti E., Montagnani G., Paganelli R., Zannotti M., Marini M., Monti D., Franceschi C. Age-related expansion of functionally inefficient cells with markers of natural killer activity in Down's syndrome. Blood 1991, 77:1263-1270.
29. de Hingh Y.C., van der Vossen P.W., Gemen E.F., Mulder A.B., Hop W.C., Brus F., de Vries E. Intrinsic abnormalities of lymphocyte counts in children with down syndrome. J. Pediatr. 2005, 147:744-747.
30. Novo E., Garcia M.I., Lavergne J. Nonspecific immunity in Down syndrome: a study of chemotaxis, phagocytosis, oxidative metabolism, and cell surface marker expression of polymorphonuclear cells. Am. J. Med. Genet. 1993, 46:384-391.
31. Barroeta O., Nungaray L., Lopez-Osuna M., Armendares S., Salamanca F., Kretschmer R.R. Defective monocyte chemotaxis in children with Down's syndrome. Pediatr. Res. 1983, 17:292-295.
32. Khan A.J., Evans H.E., Glass L., Skin Y.H., Almonte D. Defective neutrophil chemotaxis in patients with Down syndrome. J. Pediatr. 1975, 87:87-89.
33. Forslid J., Bjorksten B., Hagersten K., Hed J. Erythrocyte-mediated scavenging of reactive oxygen metabolites generated by human polymorphonuclear leukocytes during phagocytosis: comparison between normal and Down's syndrome blood cells. Inflammation 1989, 13:543-551.
34. Rosner F., Kozinn P.J. Leucocyte function in Down's syndrome. Lancet 1972, 2:283-284.
35. Nurmi T., Huttunen K., Lassila O., Henttonen M., Sakkinen A., Linna S.L., Tiilikainen A. Natural killer cell function in trisomy-21 (Down's syndrome). Clin. Exp. Immunol. 1982, 47:735-741.
36. Montagna D., Maccario R., Ugazio A.G., Nespoli L., Pedroni E., Faggiano P., Burgio G.R. Cell-mediated cytotoxicity in Down syndrome: impairment of allogeneic mixed lymphocyte reaction, NK and NK-like activities. Eur. J. Pediatr. 1988, 148:53-57.
37. Nair M.P., Schwartz S.A. Association of decreased T-cell-mediated natural cytotoxicity and interferon production in Down's syndrome. Clin. Immunol. Immunopathol. 1984, 33:412-424.
38. Epstein L.B., Epstein C.J. Localization of the gene AVG for the antiviral expression of immune and classical interferon to the distal portion of the long arm of chromosome 21. J. Infect. Dis. 1976, 133(Suppl.):A56-A62.
39. Lutfalla G., Gardiner K., Proudhon D., Vielh E., Uze G. The structure of the human interferon alpha/beta receptor gene. J. Biol. Chem. 1992, 267:2802-2809.
40. Epstein L.B., Lee S.H., Epstein C.J. Enhanced sensitivity of trisomy 21 monocytes to the maturation-inhibiting effect of interferon. Cell Immunol. 1980, 50:191-194.
41. Levin S., Schlesinger M., Handzel Z., Hahn T., Altman Y., Czernobilsky B., Boss J. Thymic deficiency in Down's syndrome. Pediatrics 1979, 63:80-87.
42. Schlesinger M., Levin S., Handzel Z., Hahn T., Altman Y., Chernobilski B., Bos J. Clinical, immunological and histopathological evidence for thymic deficiency in Down's syndrome (mongolism). Adv. Exp. Med. Biol. 1976, 66:665-671.
43. Larocca L.M., Piantelli M., Valitutti S., Castellino F., Maggiano N., Musiani P. Alterations in thymocyte subpopulations in Down's syndrome (trisomy 21). Clin. Immunol. Immunopathol. 1988, 49:175-186.
44. Musiani P., Valitutti S., Castellino F., Larocca L.M., Maggiano N., Piantelli M. Intrathymic deficient expansion of T cell precursors in Down syndrome. Am. J. Med. Genet. Suppl. 1990, 7:219-224.
45. Larocca L.M., Lauriola L., Ranelletti F.O., Piantelli M., Maggiano N., Ricci R., Capelli A. Morphological and immunohistochemical study of Down syndrome thymus. Am. J. Med. Genet. Suppl. 1990, 7:225-230.
46. Duse M., Brugo M.A., Martini A., Tassi C., Ferrario C., Ugazio A.G. Immunodeficiency in Down's syndrome: low levels of serum thymic factor in trisomic children. Thymus 1980, 2:127-131.
47. Franceschi C., Licastro F., Chiricolo M., Bonetti F., Zannotti M., Fabris N., Mocchegiani E., Fantini M.P., Paolucci P., Masi M. Deficiency of autologous mixed lymphocyte reactions and serum thymic factor level in Down's syndrome. J. Immunol. 1981, 126:2161-2164.
48. Fabris N., Mocchegiani E., Amadio L., Zannotti M., Licastro F., Franceschi C. Thymic hormone deficiency in normal ageing and Down's syndrome: is there a primary failure of the thymus?. Lancet 1984, 1:983-986.
49. Murphy M., Lempert M.J., Epstein L.B. Decreased level of T cell receptor expression by Down syndrome (trisomy 21) thymocytes. Am. J. Med. Genet. Suppl. 1990, 7:234-237.
50. Murphy M., Epstein L.B. Down syndrome (trisomy 21) thymuses have a decreased proportion of cells expressing high levels of TCR alpha, beta and CD3. A possible mechanism for diminished T cell function in Down syndrome. Clin. Immunol. Immunopathol. 1990, 55:453-467.
51. Murphy M., Hyun W., Hunte B., Levine A.D., Epstein L.B. A role for tumor necrosis factor-alpha and interferon-gamma in the regulation of interleukin-4-induced human thymocyte proliferation in vitro. Heightened sensitivity in the Down syndrome (trisomy 21) thymus. Pediatr. Res. 1992, 32:269-276.
52. Murphy M., Friend D.S., Pike-Nobile L., Epstein L.B. Tumor necrosis factor-alpha and IFN-gamma expression in human thymus. Localization and overexpression in Down syndrome (trisomy 21). J. Immunol. 1992, 149:2506-2512.
53. Murphy M., Epstein L.B. Down syndrome (DS) peripheral blood contains phenotypically mature CD3+TCR alpha, beta+ cells but abnormal proportions of TCR alpha, beta+, TCR gamma, delta+, and CD4+ CD45RA+ cells: evidence for an inefficient release of mature T cells by the DS thymus. Clin. Immunol. Immunopathol. 1992, 62:245-251.
54. Prada N., Nasi M., Troiano L., Roat E., Pinti M., Nemes E., Lugli E., Ferraresi R., Ciacci L., Bertoni D., Biagioni O., Gibertoni M., Cornia C., Meschiari L., Gramazio E., Mariotti M., Consolo U., Balli F., Cossarizza A. Direct analysis of thymic function in children with Down's syndrome. Immun. Ageing 2005, 2.
55. Roat E., Prada N., Lugli E., Nasi M., Ferraresi R., Troiano L., Giovenzana C., Pinti M., Biagioni O., Mariotti M., Di I.A., Consolo U., Balli F., Cossarizza A. Homeostatic cytokines and expansion of regulatory T cells accompany thymic impairment in children with Down syndrome. Rejuvenation. Res. 2008, 11:573-583.
56. Cocchi G., Mastrocola M., Capelli M., Bastelli A., Vitali F., Corvaglia L. Immunological patterns in young children with Down syndrome: is there a temporal trend?. Acta Paediatr. 2007, 96:1479-1482.
57. Cossarizza A., Monti D., Montagnani G., Ortolani C., Masi M., Zannotti M., Franceschi C. Precocious aging of the immune system in Down syndrome: alteration of B lymphocytes, T-lymphocyte subsets, and cells with natural killer markers. Am. J. Med. Genet. Suppl. 1990, 7:213-218.
58. Lockitch G., Singh V.K., Puterman M.L., Godolphin W.J., Sheps S., Tingle A.J., Wong F., Quigley G. Age-related changes in humoral and cell-mediated immunity in Down syndrome children living at home. Pediatr. Res. 1987, 22:536-540.
59. Rabinowe S.L., Rubin I.L., George K.L., Adri M.N., Eisenbarth G.S. Trisomy 21 (Down's syndrome): autoimmunity, aging and monoclonal antibody-defined T-cell abnormalities. J. Autoimmun. 1989, 2:25-30.
60. Bertotto A., Arcangeli C., Crupi S., Marinelli I., Gerli R., Vaccaro R. T cell response to anti-CD3 antibody in Down's syndrome. Arch. Dis. Child. 1987, 62:1148-1151.
61. Scotese I., Gaetaniello L., Matarese G., Lecora M., Racioppi L., Pignata C. T cell activation deficiency associated with an aberrant pattern of protein tyrosine phosphorylation after CD3 perturbation in Down's syndrome. Pediatr. Res. 1998, 44:252-258.
62. Bertotto A., Crupi S., Arcangeli C., Gerli R., Marinelli I., Velardi A., Vaccaro R. T-cell response to anti-CD2 monoclonal antibodies in Down's syndrome. Scand. J. Immunol. 1989, 30:39-43.
63. Burgio G.R., Ugazio A.G., Nespoli L., Marcioni A.F., Bottelli A.M., Pasquali F. Derangements of immunoglobulin levels, phytohemagglutinin responsiveness and T and B cell markers in Down's syndrome at different ages. Eur. J. Immunol. 1975, 5:600-603.
64. Epstein L.B., Epstein C.J. T-lymphocyte function and sensitivity to interferon in trisomy 21. Cell Immunol. 1980, 51:303-318.
65. Karttunen R., Nurmi T., Ilonen J., Surcel H.M. Cell-mediated immunodeficiency in Down's syndrome: normal IL-2 production but inverted ratio of T cell subsets. Clin. Exp. Immunol. 1984, 55:257-263.
66. Licastro F., Chiricolo M., Tabacchi P., Barboni F., Zannotti M., Franceschi C. Enhancing effect of lithium and potassium ions on lectin-induced lymphocyte proliferation in aging and Down's syndrome subjects. Cell Immunol. 1983, 75:111-121.
67. Warren R.P., Healey M.C., Johnston A.V., Sidwell R.W., Radov L.A., Murray R.J., Kinsolving C.R. PR 879-317A enhances in vitro immune activity of peripheral blood mononuclear cells from patients with Down syndrome. Int. J. Immunopharmacol. 1987, 9:919-926.
68. Wisniewski K., Cobill J.M., Wilcox C.B., Caspary E.A., Williams D.G., Wisniewski H.M. T lymphocytes in patients with Down's syndrome. Biol. Psychiatry 1979, 14:463-471.
69. Philip R., Berger A.C., McManus N.H., Warner N.H., Peacock M.A., Epstein L.B. Abnormalities of the in vitro cellular and humoral responses to tetanus and influenza antigens with concomitant numerical alterations in lymphocyte subsets in Down syndrome (trisomy 21). J. Immunol. 1986, 136:1661-1667.
70. Epstein L.B., Philip R. Abnormalities of the immune response to influenza antigen in Down syndrome (trisomy 21). Prog. Clin. Biol. Res. 1987, 246:163-182.
71. Gerez L., Madar L., Arad G., Sharav T., Reshef A., Ketzinel M., Sayar D., Silberberg C., Kaempfer R. Aberrant regulation of interleukin-2 but not of interferon-gamma gene expression in Down syndrome (trisomy 21). Clin. Immunol. Immunopathol. 1991, 58:251-266.
72. Torre D., Broggini M., Zeroli C., Agrifoglio L., Botta V., Casalone R., Ferrario G. Serum levels of gamma interferon in patients with Down's syndrome. Infection 1995, 23:66-67.
73. Levin S., Nir E., Mogilner B.M. T system immune-deficiency in Down's syndrome. Pediatrics 1975, 56:123-126.
74. Gupta S., Fikrig S.M., Mariano E., Quazi Q. Monoclonal antibody defined T cell subsets and autologous mixed lymphocyte reaction in Down's syndrome. Clin. Exp. Immunol. 1983, 53:25-30.
75. Barrena M.J., Echaniz P., Garcia-Serrano C., Zubillaga P., Cuadrado E. Differential expression of lymphocyte function-associated antigen (LFA-1) on peripheral blood leucocytes from individuals with Down's syndrome. Clin. Exp. Immunol. 1992, 88:41-44.
76. Taylor G.M., Williams A., D'Souza S.W. Increased expression of lymphocyte functional antigen in Down syndrome. Lancet 1986, 2:740.
77. Lin S.J., Wang J.Y., Klickstein L.B., Chuang K.P., Chen J.Y., Lee J.F., Shieh C.C. Lack of age-associated LFA-1 up-regulation and impaired ICAM-1 binding in lymphocytes from patients with Down syndrome. Clin. Exp. Immunol. 2001, 126:54-63.
78. Taylor G.M., Haigh H., Williams A., D'Souza S.W., Harris R. Down's syndrome lymphoid cell lines exhibit increased adhesion due to the over-expression of lymphocyte function-associated antigen (LFA-1). Immunology 1988, 64:451-456.
79. Anneren G., Magnusson C.G., Lilja G., Nordvall S.L. Abnormal serum IgG subclass pattern in children with Down's syndrome. Arch. Dis. Child. 1992, 67:628-631.
80. Costa-Carvalho B.T., Martinez R.M., Dias A.T., Kubo C.A., Barros-Nunes P., Leiva L., Sole D., Carneiro-Sampaio M.M., Naspitz C.K., Sorensen R.U. Antibody response to pneumococcal capsular polysaccharide vaccine in Down syndrome patients. Braz. J. Med. Biol. Res. 2006, 39:1587-1592.
81. Loh R.K., Harth S.C., Thong Y.H., Ferrante A. Immunoglobulin G subclass deficiency and predisposition to infection in Down's syndrome. Pediatr. Infect. Dis. J. 1990, 9:547-551.
82. Seger R., Buchinger G., Stroder J. On the influence of age on immunity in Down's syndrome. Eur. J. Pediatr. 1977, 124:77-87.
83. Anneren G., Magnusson C.G., Nordvall S.L. Increase in serum concentrations of IgG2 and IgG4 by selenium supplementation in children with Down's syndrome. Arch. Dis. Child. 1990, 65:1353-1355.
84. Vaziri H., Schachter F., Uchida I., Wei L., Zhu X., Effros R., Cohen D., Harley C.B. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am. J. Hum. Genet. 1993, 52:661-667.
85. Holmes D.K., Bates N., Murray M., Ladusans E.J., Morabito A., Bolton-Maggs P.H., Johnston T.A., Walkenshaw S., Wynn R.F., Bellantuono I. Hematopoietic progenitor cell deficiency in fetuses and children affected by Down's syndrome. Exp. Hematol. 2006, 34:1611-1615.
86. Corsi M.M., Ponti W., Venditti A., Ferrara F., Baldo C., Chiappelli M., Licastro F. Proapoptotic activated T-cells in the blood of children with Down's syndrome: relationship with dietary antigens and intestinal alterations. Int. J. Tissue React. 2003, 25:117-125.
87. Roat E., Prada N., Ferraresi R., Giovenzana C., Nasi M., Troiano L., Pinti M., Nemes E., Lugli E., Biagioni O., Mariotti M., Ciacci L., Consolo U., Balli F., Cossarizza A. Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome. FEBS Lett. 2007, 581:521-525.