메뉴 건너뛰기




Volumn 8, Issue 1, 2015, Pages 21-29

Human Connexin43E42K mutation from a sudden infant death victim leads to impaired ventricular activation and neonatal death in mice

Author keywords

Connexin 43; Gap junctions; Sudden infant death

Indexed keywords

CONNEXIN 43; DESMOPLAKIN; NERVE CELL ADHESION MOLECULE; PLAKOPHILIN; PROTEIN ZO1;

EID: 84924528915     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.114.000793     Document Type: Article
Times cited : (13)

References (48)
  • 1
    • 0025996125 scopus 로고
    • Defining the sudden infant death syndrome (SIDS): Deliberations of an expert panel convened by the National Institute of Child Health and Human Development
    • Willinger M, James LS, Catz C. Defining the sudden infant death syndrome (SIDS): deliberations of an expert panel convened by the National Institute of Child Health and Human Development. Pediatr Pathol. 1991;11:677-684. doi:10.3109/15513819109065465.
    • (1991) Pediatr Pathol , vol.11 , pp. 677-684
    • Willinger, M.1    James, L.S.2    Catz, C.3
  • 2
    • 0026871136 scopus 로고
    • American Academy of Pediatrics AAP Task Force on Infant Positioning and SIDS: Positioning and SIDS
    • Kattwinkel J, Brooks J, Myerberg D. American Academy of Pediatrics AAP Task Force on Infant Positioning and SIDS: positioning and SIDS. Pediatrics. 1992;89:1120-1126.
    • (1992) Pediatrics , vol.89 , pp. 1120-1126
    • Kattwinkel, J.1    Brooks, J.2    Myerberg, D.3
  • 4
    • 84989030987 scopus 로고
    • The Sudden infant death syndrome: Cardio-respiratory mechanisms and interventions
    • Schwartz P, Southall D, Valdes-Dapena M, eds. The Sudden infant death syndrome: cardio-respiratory mechanisms and interventions. New York Acad Sci. 1988;533:1-472.
    • (1988) New York Acad Sci , vol.533 , pp. 1-472
    • Schwartz, P.1    Southall, D.2    Valdes-Dapena, M.3
  • 5
    • 44349181395 scopus 로고    scopus 로고
    • Infection and sudden unexpected death in infancy: A systematic retrospective case review
    • Weber MA, Klein NJ, Hartley JC, Lock PE, Malone M, Sebire NJ. Infection and sudden unexpected death in infancy: a systematic retrospective case review. Lancet. 2008;371:1848-1853. doi:10.1016/S0140-6736(08)60798-9.
    • (2008) Lancet , vol.371 , pp. 1848-1853
    • Weber, M.A.1    Klein, N.J.2    Hartley, J.C.3    Lock, P.E.4    Malone, M.5    Sebire, N.J.6
  • 6
    • 22544474319 scopus 로고    scopus 로고
    • Sudden infant death syndrome: How significant are the cardiac channelopathies?
    • Tester DJ, Ackerman MJ. Sudden infant death syndrome: how significant are the cardiac channelopathies? Cardiovasc Res. 2005;67:388-396. doi:10.1016/j.cardiores.2005.02.013.
    • (2005) Cardiovasc Res , vol.67 , pp. 388-396
    • Tester, D.J.1    Ackerman, M.J.2
  • 9
    • 0346727397 scopus 로고    scopus 로고
    • Sudden death associated with short-QT syndrome linked to mutations in HERG
    • Brugada R, Hong K, Dumaine R, Cordeiro J, Gaita F, Borggrefe M, et al. Sudden death associated with short-QT syndrome linked to mutations in HERG. Circulation. 2004;109:30-35. doi:10.1161/01.CIR.0000109482.92774.3A.
    • (2004) Circulation , vol.109 , pp. 30-35
    • Brugada, R.1    Hong, K.2    Dumaine, R.3    Cordeiro, J.4    Gaita, F.5    Borggrefe, M.6
  • 10
    • 33846046495 scopus 로고    scopus 로고
    • Prevalence of long-QT syndrome gene variants in sudden infant death syndrome
    • Arnestad M, Crotti L, Rognum TO, Insolia R, Pedrazzini M, Ferrandi C, et al. Prevalence of long-QT syndrome gene variants in sudden infant death syndrome. Circulation. 2007;115:361-367. doi:10.1161/CIRCULATIONAHA.106.658021.
    • (2007) Circulation , vol.115 , pp. 361-367
    • Arnestad, M.1    Crotti, L.2    Rognum, T.O.3    Insolia, R.4    Pedrazzini, M.5    Ferrandi, C.6
  • 11
    • 79960529413 scopus 로고    scopus 로고
    • Cardiac channelopathies and sudden infant death syndrome
    • Tfelt-Hansen J, Winkel BG, Grunnet M, Jespersen T. Cardiac channelopathies and sudden infant death syndrome. Cardiology. 2011;119:21-33. doi:10.1159/000329047.
    • (2011) Cardiology , vol.119 , pp. 21-33
    • Tfelt-Hansen, J.1    Winkel, B.G.2    Grunnet, M.3    Jespersen, T.4
  • 12
    • 0030248881 scopus 로고    scopus 로고
    • Connexins in mammalian heart function
    • Gros DB, Jongsma HJ. Connexins in mammalian heart function. Bioessays. 1996;18:719-730. doi:10.1002/bies.950180907.
    • (1996) Bioessays , vol.18 , pp. 719-730
    • Gros, D.B.1    Jongsma, H.J.2
  • 13
    • 0347126503 scopus 로고    scopus 로고
    • An update on connexin genes and their nomenclature in mouse and man
    • Söhl G, Willecke K. An update on connexin genes and their nomenclature in mouse and man. Cell Commun Adhes. 2003;10:173-180.
    • (2003) Cell Commun Adhes , vol.10 , pp. 173-180
    • Söhl, G.1    Willecke, K.2
  • 14
    • 84881646732 scopus 로고    scopus 로고
    • Connexin diversity in the heart: Insights from transgenic mouse models
    • Verheule S, Kaese S. Connexin diversity in the heart: insights from transgenic mouse models. Front Pharmacol. 2013;4:81. doi:10.3389/fphar.2013.00081.
    • (2013) Front Pharmacol , vol.4 , pp. 81
    • Verheule, S.1    Kaese, S.2
  • 16
    • 0347635339 scopus 로고    scopus 로고
    • Functional role of connexin43 gap junction channels in adult mouse heart assessed by inducible gene deletion
    • Eckardt D, Theis M, Degen J, Ott T, van Rijen HV, Kirchhoff S, et al. Functional role of connexin43 gap junction channels in adult mouse heart assessed by inducible gene deletion. J Mol Cell Cardiol. 2004;36:101-110.
    • (2004) J Mol Cell Cardiol , vol.36 , pp. 101-110
    • Eckardt, D.1    Theis, M.2    Degen, J.3    Ott, T.4    Van Rijen, H.V.5    Kirchhoff, S.6
  • 17
    • 33751202968 scopus 로고    scopus 로고
    • Cardio-myocyte-restricted deletion of connexin43 during mouse development
    • Eckardt D, Kirchhoff S, Kim JS, Degen J, Theis M, Ott T, et al. Cardio-myocyte-restricted deletion of connexin43 during mouse development. J Mol Cell Cardiol. 2006;41:963-971. doi:10.1016/j.yjmcc.2006.07.017.
    • (2006) J Mol Cell Cardiol , vol.41 , pp. 963-971
    • Eckardt, D.1    Kirchhoff, S.2    Kim, J.S.3    Degen, J.4    Theis, M.5    Ott, T.6
  • 18
    • 0035895649 scopus 로고    scopus 로고
    • Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43
    • Gutstein DE, Morley GE, Tamaddon H, Vaidya D, Schneider MD, Chen J, et al. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res. 2001;88:333-339.
    • (2001) Circ Res , vol.88 , pp. 333-339
    • Gutstein, D.E.1    Morley, G.E.2    Tamaddon, H.3    Vaidya, D.4    Schneider, M.D.5    Chen, J.6
  • 19
    • 58149092631 scopus 로고    scopus 로고
    • Connexin-caused genetic diseases and corresponding mouse models
    • Dobrowolski R, Willecke K. Connexin-caused genetic diseases and corresponding mouse models. Antioxid Redox Signal. 2009;11:283-295. doi:10.1089/ars.2008.2128.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 283-295
    • Dobrowolski, R.1    Willecke, K.2
  • 20
    • 85027941134 scopus 로고    scopus 로고
    • Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death
    • Van Norstrand DW, Asimaki A, Rubinos C, Dolmatova E, Srinivas M, Tester DJ, et al. Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death. Circulation. 2012;125:474-481. doi:10.1161/CIRCULATIONAHA.111.057224.
    • (2012) Circulation , vol.125 , pp. 474-481
    • Van Norstrand, D.W.1    Asimaki, A.2    Rubinos, C.3    Dolmatova, E.4    Srinivas, M.5    Tester, D.J.6
  • 21
    • 38849142479 scopus 로고    scopus 로고
    • The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans
    • Dobrowolski R, Sasse P, Schrickel JW, Watkins M, Kim JS, Rackauskas M, et al. The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans. Hum Mol Genet. 2008;17:539-554. doi:10.1093/hmg/ddm329.
    • (2008) Hum Mol Genet , vol.17 , pp. 539-554
    • Dobrowolski, R.1    Sasse, P.2    Schrickel, J.W.3    Watkins, M.4    Kim, J.S.5    Rackauskas, M.6
  • 22
    • 0026635749 scopus 로고
    • A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency
    • Magin TM, McWhir J, Melton DW. A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency. Nucleic Acids Res. 1992;20:3795-3796.
    • (1992) Nucleic Acids Res , vol.20 , pp. 3795-3796
    • Magin, T.M.1    McWhir, J.2    Melton, D.W.3
  • 23
    • 0035135651 scopus 로고    scopus 로고
    • Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene
    • Theis M, de Wit C, Schlaeger TM, Eckardt D, Krüger O, Döring B, et al. Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene. Genesis. 2001;29:1-13.
    • (2001) Genesis , vol.29 , pp. 1-13
    • Theis, M.1    De Wit, C.2    Schlaeger, T.M.3    Eckardt, D.4    Krüger, O.5    Döring, B.6
  • 24
  • 25
    • 0030878260 scopus 로고    scopus 로고
    • Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo
    • Agah R, Frenkel PA, French BA, Michael LH, Overbeek PA, Schneider MD. Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J Clin Invest. 1997;100:169-179. doi:10.1172/JCI119509.
    • (1997) J Clin Invest , vol.100 , pp. 169-179
    • Agah, R.1    Frenkel, P.A.2    French, B.A.3    Michael, L.H.4    Overbeek, P.A.5    Schneider, M.D.6
  • 26
    • 0026575430 scopus 로고
    • Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: Molecular cloning of mouse connexin31 and -45 cDNAs
    • Hennemann H, Schwarz HJ, Willecke K. Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin31 and -45 cDNAs. Eur J Cell Biol. 1992;57:51-58.
    • (1992) Eur J Cell Biol , vol.57 , pp. 51-58
    • Hennemann, H.1    Schwarz, H.J.2    Willecke, K.3
  • 27
    • 0031944052 scopus 로고    scopus 로고
    • Measurement of heart rate and Q-T interval in the conscious mouse
    • Mitchell GF, Jeron A, Koren G. Measurement of heart rate and Q-T interval in the conscious mouse. Am J Physiol. 1998;274(3 Pt 2): H747-H751.
    • (1998) Am J Physiol , vol.274 , Issue.3 , pp. H747-H751
    • Mitchell, G.F.1    Jeron, A.2    Koren, G.3
  • 28
    • 0026694158 scopus 로고
    • Expression of Cx26, Cx32 and Cx43 gap junction proteins in normal and neoplastic human tissues
    • Wilgenbus KK, Kirkpatrick CJ, Knuechel R, Willecke K, Traub O. Expression of Cx26, Cx32 and Cx43 gap junction proteins in normal and neoplastic human tissues. Int J Cancer. 1992;51:522-529.
    • (1992) Int J Cancer , vol.51 , pp. 522-529
    • Wilgenbus, K.K.1    Kirkpatrick, C.J.2    Knuechel, R.3    Willecke, K.4    Traub, O.5
  • 29
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 30
    • 84875663184 scopus 로고    scopus 로고
    • Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels
    • Lübkemeier I, Requardt RP, Lin X, Sasse P, Andrié R, Schrickel JW, et al. Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels. Basic Res Cardiol. 2013;108:348. doi:10.1007/s00395-013-0348-y.
    • (2013) Basic Res Cardiol , vol.108 , pp. 348
    • Lübkemeier, I.1    Requardt, R.P.2    Lin, X.3    Sasse, P.4    Andrié, R.5    Schrickel, J.W.6
  • 31
    • 33745094980 scopus 로고    scopus 로고
    • Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube
    • Liu S, Liu F, Schneider AE, St Amand T, Epstein JA, Gutstein DE. Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube. Development. 2006;133:2063-2073. doi:10.1242/dev.02374.
    • (2006) Development , vol.133 , pp. 2063-2073
    • Liu, S.1    Liu, F.2    Schneider, A.E.3    St Amand, T.4    Epstein, J.A.5    Gutstein, D.E.6
  • 32
    • 0032100436 scopus 로고    scopus 로고
    • Alteration in connexin 43 gap junction gene dosage impairs conotruncal heart development
    • Huang GY, Wessels A, Smith BR, Linask KK, Ewart JL, Lo CW. Alteration in connexin 43 gap junction gene dosage impairs conotruncal heart development. Dev Biol. 1998;198:32-44.
    • (1998) Dev Biol , vol.198 , pp. 32-44
    • Huang, G.Y.1    Wessels, A.2    Smith, B.R.3    Linask, K.K.4    Ewart, J.L.5    Lo, C.W.6
  • 33
    • 0032373862 scopus 로고    scopus 로고
    • Heart malformations in transgenic mice exhibiting dominant negative inhibition of gap junctional communication in neural crest cells
    • Sullivan R, Huang GY, Meyer RA, Wessels A, Linask KK, Lo CW. Heart malformations in transgenic mice exhibiting dominant negative inhibition of gap junctional communication in neural crest cells. Dev Biol. 1998;204:224-234. doi:10.1006/dbio.1998.9089.
    • (1998) Dev Biol , vol.204 , pp. 224-234
    • Sullivan, R.1    Huang, G.Y.2    Meyer, R.A.3    Wessels, A.4    Linask, K.K.5    Lo, C.W.6
  • 34
    • 0035827720 scopus 로고    scopus 로고
    • Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development
    • Vaidya D, Tamaddon HS, Lo CW, Taffet SM, Delmar M, Morley GE, et al. Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development. Circ Res. 2001;88:1196-1202.
    • (2001) Circ Res , vol.88 , pp. 1196-1202
    • Vaidya, D.1    Tamaddon, H.S.2    Lo, C.W.3    Taffet, S.M.4    Delmar, M.5    Morley, G.E.6
  • 35
    • 0027218911 scopus 로고
    • The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system
    • Gourdie RG, Severs NJ, Green CR, Rothery S, Germroth P, Thompson RP. The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system. J Cell Sci. 1993;105 (Pt 4):985-991.
    • (1993) J Cell Sci , vol.105 , pp. 985-991
    • Gourdie, R.G.1    Severs, N.J.2    Green, C.R.3    Rothery, S.4    Germroth, P.5    Thompson, R.P.6
  • 36
    • 33846816953 scopus 로고    scopus 로고
    • The area composita of adhering junctions connecting heart muscle cells of vertebrates - III: Assembly and disintegration of intercalated disks in rat cardiomyocytes growing in culture
    • Franke WW, Schumacher H, Borrmann CM, Grund C, Winter-Simanowski S, Schlechter T, et al. The area composita of adhering junctions connecting heart muscle cells of vertebrates - III: assembly and disintegration of intercalated disks in rat cardiomyocytes growing in culture. Eur J Cell Biol. 2007;86:127-142. doi:10.1016/j.ejcb.2006.11.003.
    • (2007) Eur J Cell Biol , vol.86 , pp. 127-142
    • Franke, W.W.1    Schumacher, H.2    Borrmann, C.M.3    Grund, C.4    Winter-Simanowski, S.5    Schlechter, T.6
  • 37
    • 84859340997 scopus 로고    scopus 로고
    • Connexin43 and the regulation of intercalated disc function
    • Delmar M, Liang FX. Connexin43 and the regulation of intercalated disc function. Heart Rhythm. 2012;9:835-838. doi:10.1016/j.hrthm.2011.10.028.
    • (2012) Heart Rhythm , vol.9 , pp. 835-838
    • Delmar, M.1    Liang, F.X.2
  • 38
    • 0031024666 scopus 로고    scopus 로고
    • Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium
    • Angst BD, Khan LU, Severs NJ, Whitely K, Rothery S, Thompson RP, et al. Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium. Circ Res. 1997;80:88-94.
    • (1997) Circ Res , vol.80 , pp. 88-94
    • Angst, B.D.1    Khan, L.U.2    Severs, N.J.3    Whitely, K.4    Rothery, S.5    Thompson, R.P.6
  • 39
    • 0028093157 scopus 로고
    • Spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium
    • Peters NS, Severs NJ, Rothery SM, Lincoln C, Yacoub MH, Green CR. Spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium. Circulation. 1994;90:713-725.
    • (1994) Circulation , vol.90 , pp. 713-725
    • Peters, N.S.1    Severs, N.J.2    Rothery, S.M.3    Lincoln, C.4    Yacoub, M.H.5    Green, C.R.6
  • 40
    • 84899620475 scopus 로고    scopus 로고
    • Assembly of the cardiac intercalated disk during pre- and postnatal development of the human heart
    • Vreeker A, van Stuijvenberg L, Hund TJ, Mohler PJ, Nikkels PG, van Veen TA. Assembly of the cardiac intercalated disk during pre- and postnatal development of the human heart. PLoS One. 2014;9:e94722. doi:10.1371/journal.pone.0094722.
    • (2014) PLoS One , vol.9 , pp. e94722
    • Vreeker, A.1    Van Stuijvenberg, L.2    Hund, T.J.3    Mohler, P.J.4    Nikkels, P.G.5    Van Veen, T.A.6
  • 41
    • 84859312522 scopus 로고    scopus 로고
    • Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice
    • Jansen JA, Noorman M, Musa H, Stein M, de Jong S, van der Nagel R, et al. Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice. Heart Rhythm. 2012;9:600-607. doi:10.1016/j.hrthm.2011.11.025.
    • (2012) Heart Rhythm , vol.9 , pp. 600-607
    • Jansen, J.A.1    Noorman, M.2    Musa, H.3    Stein, M.4    De Jong, S.5    Van Der Nagel, R.6
  • 42
    • 0035806899 scopus 로고    scopus 로고
    • Heterogeneous expression of Gap junction channels in the heart leads to conduction defects and ventricular dysfunction
    • Gutstein DE, Morley GE, Vaidya D, Liu F, Chen FL, Stuhlmann H, et al. Heterogeneous expression of Gap junction channels in the heart leads to conduction defects and ventricular dysfunction. Circulation. 2001;104:1194-1199.
    • (2001) Circulation , vol.104 , pp. 1194-1199
    • Gutstein, D.E.1    Morley, G.E.2    Vaidya, D.3    Liu, F.4    Chen, F.L.5    Stuhlmann, H.6
  • 44
    • 0037089088 scopus 로고    scopus 로고
    • Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart
    • Ferreira-Cornwell MC, Luo Y, Narula N, Lenox JM, Lieberman M, Radice GL. Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart. J Cell Sci. 2002;115(Pt 8):1623-1634.
    • (2002) J Cell Sci , vol.115 , pp. 1623-1634
    • Ferreira-Cornwell, M.C.1    Luo, Y.2    Narula, N.3    Lenox, J.M.4    Lieberman, M.5    Radice, G.L.6
  • 45
    • 33750539318 scopus 로고    scopus 로고
    • Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice
    • Kirchhof P, Fabritz L, Zwiener M, Witt H, Schäfers M, Zellerhoff S, et al. Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice. Circulation. 2006;114:1799-1806. doi:10.1161/CIRCULATIONAHA.106.624502.
    • (2006) Circulation , vol.114 , pp. 1799-1806
    • Kirchhof, P.1    Fabritz, L.2    Zwiener, M.3    Witt, H.4    Schäfers, M.5    Zellerhoff, S.6
  • 46
    • 33748741625 scopus 로고    scopus 로고
    • Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy
    • Yang Z, Bowles NE, Scherer SE, Taylor MD, Kearney DL, Ge S, et al. Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res. 2006;99:646-655. doi:10.1161/01.RES.0000241482.19382.c6.
    • (2006) Circ Res , vol.99 , pp. 646-655
    • Yang, Z.1    Bowles, N.E.2    Scherer, S.E.3    Taylor, M.D.4    Kearney, D.L.5    Ge, S.6
  • 47
    • 62349094053 scopus 로고    scopus 로고
    • A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy
    • Asimaki A, Tandri H, Huang H, Halushka MK, Gautam S, Basso C, et al. A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy. N Engl J Med. 2009;360:1075-1084. doi:10.1056/NEJMoa0808138.
    • (2009) N Engl J Med , vol.360 , pp. 1075-1084
    • Asimaki, A.1    Tandri, H.2    Huang, H.3    Halushka, M.K.4    Gautam, S.5    Basso, C.6
  • 48
    • 70349242035 scopus 로고    scopus 로고
    • Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes
    • Sato PY, Musa H, Coombs W, Guerrero-Serna G, Patiño GA, Taffet SM, et al. Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. Circ Res. 2009;105:523-526. doi:10.1161/CIRCRESAHA.109.201418.
    • (2009) Circ Res , vol.105 , pp. 523-526
    • Sato, P.Y.1    Musa, H.2    Coombs, W.3    Guerrero-Serna, G.4    Patiño, G.A.5    Taffet, S.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.