-
1
-
-
0030752709
-
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
-
DiFiglia, M., Sapp, E., Chase, K.O., Davies, S.W., Bates, G.P., Vonsattel, J.P. and Aronin, N. (1997) Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science, 277, 1990-1993.
-
(1997)
Science
, vol.277
, pp. 1990-1993
-
-
DiFiglia, M.1
Sapp, E.2
Chase, K.O.3
Davies, S.W.4
Bates, G.P.5
Vonsattel, J.P.6
Aronin, N.7
-
2
-
-
1242338856
-
Huntingtin-protein interactions and the pathogenesis of Huntington's disease
-
Li, S.H. and Li, X.J. (2004) Huntingtin-protein interactions and the pathogenesis of Huntington's disease. Trends Genet., 20, 146-154.
-
(2004)
Trends Genet.
, vol.20
, pp. 146-154
-
-
Li, S.H.1
Li, X.J.2
-
3
-
-
0027261537
-
Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease
-
Snell, R.G., MacMillan, J.C., Cheadle, J.P., Fenton, I., Lazarou, L. P., Davies, P., MacDonald, M.E., Gusella, J.F., Harper, P.S. and Shaw, D.J. (1993) Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease. Nat. Genet., 4, 393-397.
-
(1993)
Nat. Genet.
, vol.4
, pp. 393-397
-
-
Snell, R.G.1
MacMillan, J.C.2
Cheadle, J.P.3
Fenton, I.4
Lazarou, L.P.5
Davies, P.6
MacDonald, M.E.7
Gusella, J.F.8
Harper, P.S.9
Shaw, D.J.10
-
4
-
-
0042921188
-
Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release
-
Li, H., Wyman, T., Yu, Z.X., Li, S.H. and Li, X.J. (2003) Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release. Hum. Mol. Genet., 12, 2021-2030.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 2021-2030
-
-
Li, H.1
Wyman, T.2
Yu, Z.X.3
Li, S.H.4
Li, X.J.5
-
5
-
-
34248166420
-
Multiple pathways contribute to the pathogenesis of Huntington disease
-
Li, S. and Li, X.J. (2006) Multiple pathways contribute to the pathogenesis of Huntington disease. Mol. Neurodegener., 1, 19.
-
(2006)
Mol. Neurodegener.
, vol.1
, pp. 19
-
-
Li, S.1
Li, X.J.2
-
6
-
-
78650031174
-
Huntington's disease: from molecular pathogenesis to clinical treatment
-
Ross, C.A. and Tabrizi, S.J. (2011) Huntington's disease: from molecular pathogenesis to clinical treatment. Lancet Neurol., 10, 83-98.
-
(2011)
Lancet Neurol.
, vol.10
, pp. 83-98
-
-
Ross, C.A.1
Tabrizi, S.J.2
-
7
-
-
41549129945
-
Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice
-
Wang, J., Wang, C.E., Orr, A., Tydlacka, S., Li, S.H. and Li, X.J. (2008) Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice. J. Cell. Biol., 180, 1177-1189.
-
(2008)
J. Cell. Biol.
, vol.180
, pp. 1177-1189
-
-
Wang, J.1
Wang, C.E.2
Orr, A.3
Tydlacka, S.4
Li, S.H.5
Li, X.J.6
-
8
-
-
84886931430
-
Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms
-
Xu, Q., Huang, S., Song, M.,Wang, C.E., Yan, S., Liu, X., Gaertig, M.A., Yu, S.P., Li, H., Li, S. et al.(2013) Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms. J. Cell. Biol., 202, 1123-1138.
-
(2013)
J. Cell. Biol.
, vol.202
, pp. 1123-1138
-
-
Xu, Q.1
Huang, S.2
Song, M.3
Wang, C.E.4
Yan, S.5
Liu, X.6
Gaertig, M.A.7
Yu, S.P.8
Li, H.9
Li, S.10
-
9
-
-
77951290337
-
Alpha-synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: implications in Parkinson's disease
-
Banerjee, K., Sinha, M., Pham Cle, L., Jana, S., Chanda, D., Cappai, R. and Chakrabarti, S. (2010) Alpha-synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: implications in Parkinson's disease. FEBS Lett., 584, 1571-1576.
-
(2010)
FEBS Lett.
, vol.584
, pp. 1571-1576
-
-
Banerjee, K.1
Sinha, M.2
Pham Cle, L.3
Jana, S.4
Chanda, D.5
Cappai, R.6
Chakrabarti, S.7
-
10
-
-
33748283747
-
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
-
Devi, L., Prabhu, B.M., Galati, D.F., Avadhani, N.G. and Anandatheerthavarada, H.K. (2006) Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J. Neurosci., 26, 9057-9068.
-
(2006)
J. Neurosci.
, vol.26
, pp. 9057-9068
-
-
Devi, L.1
Prabhu, B.M.2
Galati, D.F.3
Avadhani, N.G.4
Anandatheerthavarada, H.K.5
-
11
-
-
44049099669
-
Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
-
Devi, L., Raghavendran, V., Prabhu, B.M., Avadhani, N.G. and Anandatheerthavarada, H.K. (2008) Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J. Biol. Chem., 283, 9089-9100.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 9089-9100
-
-
Devi, L.1
Raghavendran, V.2
Prabhu, B.M.3
Avadhani, N.G.4
Anandatheerthavarada, H.K.5
-
12
-
-
0039251419
-
Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase
-
Estevez, A.G., Crow, J.P., Sampson, J.B., Reiter, C., Zhuang, Y., Richardson, G.J., Tarpey, M.M., Barbeito, L. and Beckman, J.S. (1999) Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science, 286, 2498-2500.
-
(1999)
Science
, vol.286
, pp. 2498-2500
-
-
Estevez, A.G.1
Crow, J.P.2
Sampson, J.B.3
Reiter, C.4
Zhuang, Y.5
Richardson, G.J.6
Tarpey, M.M.7
Barbeito, L.8
Beckman, J.S.9
-
13
-
-
77956362155
-
Protein homeostasis and aging in neurodegeneration
-
Douglas, P.M. and Dillin, A. (2010) Protein homeostasis and aging in neurodegeneration. J. Cell. Biol., 190, 719-729.
-
(2010)
J. Cell. Biol.
, vol.190
, pp. 719-729
-
-
Douglas, P.M.1
Dillin, A.2
-
14
-
-
33750363298
-
The roles of intracellular proteindegradation pathways in neurodegeneration
-
Rubinsztein, D.C. (2006) The roles of intracellular proteindegradation pathways in neurodegeneration. Nature, 443, 780-786.
-
(2006)
Nature
, vol.443
, pp. 780-786
-
-
Rubinsztein, D.C.1
-
15
-
-
54249158324
-
Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction
-
Tai, H.C. and Schuman, E.M. (2008) Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction. Nat. Rev. Neurosci., 9, 826-838.
-
(2008)
Nat. Rev. Neurosci.
, vol.9
, pp. 826-838
-
-
Tai, H.C.1
Schuman, E.M.2
-
16
-
-
44649113841
-
Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin
-
Wang, C.E., Zhou, H., McGuire, J.R., Cerullo, V., Lee, B., Li, S.H. and Li, X.J. (2008) Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin. J. Cell. Biol., 181, 803-816.
-
(2008)
J. Cell. Biol.
, vol.181
, pp. 803-816
-
-
Wang, C.E.1
Zhou, H.2
McGuire, J.R.3
Cerullo, V.4
Lee, B.5
Li, S.H.6
Li, X.J.7
-
17
-
-
33750720268
-
Protein oxidation and degradation during aging: role in skin aging and neurodegeneration
-
Widmer, R., Ziaja, I. and Grune, T. (2006) Protein oxidation and degradation during aging: role in skin aging and neurodegeneration. Free Radic. Res., 40, 1259-1268.
-
(2006)
Free Radic. Res.
, vol.40
, pp. 1259-1268
-
-
Widmer, R.1
Ziaja, I.2
Grune, T.3
-
18
-
-
31544454404
-
Rapamycin alleviates toxicity of different aggregate-prone proteins
-
Berger, Z., Ravikumar, B., Menzies, F.M., Oroz, L.G., Underwood, B.R., Pangalos, M.N., Schmitt, I., Wullner, U., Evert, B. O.,O'Kane, C.J. et al.(2006) Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum. Mol. Genet., 15, 433-442.
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 433-442
-
-
Berger, Z.1
Ravikumar, B.2
Menzies, F.M.3
Oroz, L.G.4
Underwood, B.R.5
Pangalos, M.N.6
Schmitt, I.7
Wullner, U.8
Evert, B.O.9
O'Kane, C.J.10
-
19
-
-
0141987860
-
The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg
-
Ciechanover, A. and Brundin, P. (2003) The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron, 40, 427-446.
-
(2003)
Neuron
, vol.40
, pp. 427-446
-
-
Ciechanover, A.1
Brundin, P.2
-
20
-
-
78149475088
-
Regulation of mammalian autophagy in physiology and pathophysiology
-
Ravikumar, B., Sarkar, S., Davies, J.E., Futter, M., Garcia-Arencibia, M., Green-Thompson, Z.W., Jimenez-Sanchez, M., Korolchuk, V.I., Lichtenberg, M., Luo, S. et al.(2010) Regulation of mammalian autophagy in physiology and pathophysiology. Physiol. Rev., 90, 1383-1435.
-
(2010)
Physiol. Rev.
, vol.90
, pp. 1383-1435
-
-
Ravikumar, B.1
Sarkar, S.2
Davies, J.E.3
Futter, M.4
Garcia-Arencibia, M.5
Green-Thompson, Z.W.6
Jimenez-Sanchez, M.7
Korolchuk, V.I.8
Lichtenberg, M.9
Luo, S.10
-
21
-
-
80052303130
-
Autophagy and aging
-
Rubinsztein, D.C., Marino, G. and Kroemer, G. (2011) Autophagy and aging. Cell, 146, 682-695.
-
(2011)
Cell
, vol.146
, pp. 682-695
-
-
Rubinsztein, D.C.1
Marino, G.2
Kroemer, G.3
-
22
-
-
0026663539
-
The ubiquitin system for protein degradation
-
Hershko, A. and Ciechanover, A. (1992) The ubiquitin system for protein degradation. Annu. Rev. Biochem., 61, 761-807.
-
(1992)
Annu. Rev. Biochem.
, vol.61
, pp. 761-807
-
-
Hershko, A.1
Ciechanover, A.2
-
23
-
-
70350461507
-
Building ubiquitin chains: E2 enzymes at work
-
Ye, Y. and Rape, M. (2009) Building ubiquitin chains: E2 enzymes at work. Nat. Rev. Mol. Cell. Biol., 10, 755-764.
-
(2009)
Nat. Rev. Mol. Cell. Biol.
, vol.10
, pp. 755-764
-
-
Ye, Y.1
Rape, M.2
-
24
-
-
33947110425
-
Agedependent inhibition of proteasome chymotrypsin-like activity in the retina
-
Kapphahn, R.J., Bigelow, E.J. and Ferrington, D.A. (2007) Agedependent inhibition of proteasome chymotrypsin-like activity in the retina. Exp. Eye. Res., 84, 646-654.
-
(2007)
Exp. Eye. Res.
, vol.84
, pp. 646-654
-
-
Kapphahn, R.J.1
Bigelow, E.J.2
Ferrington, D.A.3
-
25
-
-
0033972037
-
Possible involvement of proteasome inhibition in aging: implications for oxidative stress
-
Keller, J.N., Hanni, K.B. and Markesbery, W.R. (2000) Possible involvement of proteasome inhibition in aging: implications for oxidative stress. Mech. Ageing. Dev., 113, 61-70.
-
(2000)
Mech. Ageing. Dev.
, vol.113
, pp. 61-70
-
-
Keller, J.N.1
Hanni, K.B.2
Markesbery, W.R.3
-
26
-
-
0034087369
-
Decreased levels of proteasome activity and proteasome expression in aging spinal cord
-
Keller, J.N., Huang, F.F. and Markesbery, W.R. (2000) Decreased levels of proteasome activity and proteasome expression in aging spinal cord. Neuroscience, 98, 149-156.
-
(2000)
Neuroscience
, vol.98
, pp. 149-156
-
-
Keller, J.N.1
Huang, F.F.2
Markesbery, W.R.3
-
27
-
-
79955737369
-
The role of ubiquitin-proteasome system in ageing
-
Low, P. (2011) The role of ubiquitin-proteasome system in ageing. Gen. Comp. Endocrinol., 172, 39-43.
-
(2011)
Gen. Comp. Endocrinol.
, vol.172
, pp. 39-43
-
-
Low, P.1
-
28
-
-
58149380769
-
Differential activities of the ubiquitin-proteasome system in neurons versus gliamay account for the preferential accumulation of misfolded proteins in neurons
-
Tydlacka, S.,Wang, C.E.,Wang, X., Li, S. and Li, X.J. (2008) Differential activities of the ubiquitin-proteasome system in neurons versus gliamay account for the preferential accumulation of misfolded proteins in neurons. J. Neurosci., 28, 13285-13295.
-
(2008)
J. Neurosci.
, vol.28
, pp. 13285-13295
-
-
Tydlacka, S.1
Wang, C.E.2
Wang, X.3
Li, S.4
Li, X.J.5
-
29
-
-
18544410106
-
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
-
Davies, S.W., Turmaine, M., Cozens, B.A., DiFiglia, M., Sharp, A.H., Ross, C.A., Scherzinger, E., Wanker, E.E., Mangiarini, L. and Bates, G.P. (1997) Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell, 90, 537-548.
-
(1997)
Cell
, vol.90
, pp. 537-548
-
-
Davies, S.W.1
Turmaine, M.2
Cozens, B.A.3
DiFiglia, M.4
Sharp, A.H.5
Ross, C.A.6
Scherzinger, E.7
Wanker, E.E.8
Mangiarini, L.9
Bates, G.P.10
-
30
-
-
0037444445
-
Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease
-
Yu, Z.X., Li, S.H., Evans, J., Pillarisetti, A., Li, H. and Li, X.J. (2003) Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease. J. Neurosci., 23, 2193-2202.
-
(2003)
J. Neurosci.
, vol.23
, pp. 2193-2202
-
-
Yu, Z.X.1
Li, S.H.2
Evans, J.3
Pillarisetti, A.4
Li, H.5
Li, X.J.6
-
31
-
-
49649117786
-
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease
-
Wang, C.E., Tydlacka, S., Orr, A.L., Yang, S.H., Graham, R.K., Hayden, M.R., Li, S., Chan, A.W. and Li, X.J. (2008) Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Hum. Mol. Genet., 17, 2738-2751.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 2738-2751
-
-
Wang, C.E.1
Tydlacka, S.2
Orr, A.L.3
Yang, S.H.4
Graham, R.K.5
Hayden, M.R.6
Li, S.7
Chan, A.W.8
Li, X.J.9
-
32
-
-
45149105779
-
Towards a transgenic model of Huntington's disease in a non-human primate
-
Yang, S.H., Cheng, P.H., Banta, H., Piotrowska-Nitsche, K., Yang, J.J., Cheng, E.C., Snyder, B., Larkin, K., Liu, J., Orkin, J. et al.(2008) Towards a transgenic model of Huntington's disease in a non-human primate. Nature, 453, 921-924.
-
(2008)
Nature
, vol.453
, pp. 921-924
-
-
Yang, S.H.1
Cheng, P.H.2
Banta, H.3
Piotrowska-Nitsche, K.4
Yang, J.J.5
Cheng, E.C.6
Snyder, B.7
Larkin, K.8
Liu, J.9
Orkin, J.10
-
33
-
-
84863100006
-
Influence of species differences on the neuropathology of transgenic Huntington's disease animal models
-
Li, X.J. and Li, S. (2012) Influence of species differences on the neuropathology of transgenic Huntington's disease animal models. J. Genet. Genomics, 39, 239-245.
-
(2012)
J. Genet. Genomics
, vol.39
, pp. 239-245
-
-
Li, X.J.1
Li, S.2
-
34
-
-
84902449003
-
Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues
-
Wade, B.E.,Wang, C.E., Yan, S., Bhat, K.,Huang, B., Li, S. and Li, X.J. (2014) Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues. J. Neurosci., 34, 8411-8422.
-
(2014)
J. Neurosci.
, vol.34
, pp. 8411-8422
-
-
Wade, B.E.1
Wang, C.E.2
Yan, S.3
Bhat, K.4
Huang, B.5
Li, S.6
Li, X.J.7
-
35
-
-
84860176236
-
Synaptic mitochondrial pathology in Alzheimer's disease
-
Du, H., Guo, L. and Yan, S.S. (2012) Synaptic mitochondrial pathology in Alzheimer's disease. Antioxid. Redox Signal., 16, 1467-1475.
-
(2012)
Antioxid. Redox Signal.
, vol.16
, pp. 1467-1475
-
-
Du, H.1
Guo, L.2
Yan, S.S.3
-
36
-
-
84866540615
-
Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases
-
Nakamura, T., Cho, D.H. and Lipton, S.A. (2012) Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases. Exp. Neurol., 238, 12-21.
-
(2012)
Exp. Neurol.
, vol.238
, pp. 12-21
-
-
Nakamura, T.1
Cho, D.H.2
Lipton, S.A.3
-
37
-
-
84870231777
-
Accumulation of alpha-synuclein triggered by presynaptic dysfunction
-
Nakata, Y., Yasuda, T., Fukaya, M., Yamamori, S., Itakura, M., Nihira, T., Hayakawa, H., Kawanami, A., Kataoka, M., Nagai, M. et al.(2012) Accumulation of alpha-synuclein triggered by presynaptic dysfunction. J. Neurosci., 32, 17186-17196.
-
(2012)
J. Neurosci.
, vol.32
, pp. 17186-17196
-
-
Nakata, Y.1
Yasuda, T.2
Fukaya, M.3
Yamamori, S.4
Itakura, M.5
Nihira, T.6
Hayakawa, H.7
Kawanami, A.8
Kataoka, M.9
Nagai, M.10
-
38
-
-
24144485928
-
Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A
-
Andersen, P.L., Zhou, H., Pastushok, L., Moraes, T., McKenna, S., Ziola, B., Ellison, M.J., Dixit, V.M. and Xiao, W. (2005) Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. J. Cell. Biol., 170, 745-755.
-
(2005)
J. Cell. Biol.
, vol.170
, pp. 745-755
-
-
Andersen, P.L.1
Zhou, H.2
Pastushok, L.3
Moraes, T.4
McKenna, S.5
Ziola, B.6
Ellison, M.J.7
Dixit, V.M.8
Xiao, W.9
-
39
-
-
84897921811
-
Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination
-
Lim, G.G., Chew, K.C., Ng, X.H., Henry-Basil, A., Sim, R.W., Tan, J.M., Chai, C. and Lim, K.L. (2013) Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination. PLoS One., 8, e73235.
-
(2013)
PLoS One.
, vol.8
, pp. e73235
-
-
Lim, G.G.1
Chew, K.C.2
Ng, X.H.3
Henry-Basil, A.4
Sim, R.W.5
Tan, J.M.6
Chai, C.7
Lim, K.L.8
-
40
-
-
35649021330
-
Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme
-
Petroski, M.D., Zhou, X., Dong, G., Daniel-Issakani, S., Payan, D.G. and Huang, J. (2007) Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme. J. Biol. Chem., 282, 29936-29945.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 29936-29945
-
-
Petroski, M.D.1
Zhou, X.2
Dong, G.3
Daniel-Issakani, S.4
Payan, D.G.5
Huang, J.6
-
41
-
-
84898814706
-
Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A
-
Bhat, K.P., Yan, S.,Wang, C.E., Li, S. and Li, X.J. (2014) Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A. Proc. Natl. Acad. Sci. U. S. A., 111, 5706-5711.
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. 5706-5711
-
-
Bhat, K.P.1
Yan, S.2
Wang, C.E.3
Li, S.4
Li, X.J.5
-
42
-
-
0141891952
-
Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity
-
Zhou, H., Cao, F.,Wang, Z., Yu, Z.X., Nguyen, H.P., Evans, J., Li, S.H. and Li, X.J. (2003) Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity. J. Cell. Biol., 163, 109-118.
-
(2003)
J. Cell. Biol.
, vol.163
, pp. 109-118
-
-
Zhou, H.1
Cao, F.2
Wang, Z.3
Yu, Z.X.4
Nguyen, H.P.5
Evans, J.6
Li, S.H.7
Li, X.J.8
-
43
-
-
84857642949
-
The toxic Abeta oligomer and Alzheimer's disease: an emperor in need of clothes
-
Benilova, I., Karran, E. and De Strooper, B. (2012) The toxic Abeta oligomer and Alzheimer's disease: an emperor in need of clothes. Nat. Neurosci., 15, 349-357.
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 349-357
-
-
Benilova, I.1
Karran, E.2
De Strooper, B.3
-
44
-
-
0033119123
-
Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology
-
Gutekunst, C.A., Li, S.H., Yi, H., Mulroy, J.S., Kuemmerle, S., Jones, R., Rye, D., Ferrante, R.J., Hersch, S.M. and Li, X.J. (1999) Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology. J. Neurosci., 19, 2522-2534.
-
(1999)
J. Neurosci.
, vol.19
, pp. 2522-2534
-
-
Gutekunst, C.A.1
Li, S.H.2
Yi, H.3
Mulroy, J.S.4
Kuemmerle, S.5
Jones, R.6
Rye, D.7
Ferrante, R.J.8
Hersch, S.M.9
Li, X.J.10
-
45
-
-
84883174947
-
Parkinson's disease dementia: convergence of alpha-synuclein, tau and amyloid-beta pathologies
-
Irwin, D.J., Lee, V.M. and Trojanowski, J.Q. (2013) Parkinson's disease dementia: convergence of alpha-synuclein, tau and amyloid-beta pathologies. Nat. Rev. Neurosci., 14, 626-636.
-
(2013)
Nat. Rev. Neurosci.
, vol.14
, pp. 626-636
-
-
Irwin, D.J.1
Lee, V.M.2
Trojanowski, J.Q.3
-
46
-
-
79955955066
-
Proteasomal dysfunction in aging and Huntington disease
-
Li, X.J. and Li, S. (2011) Proteasomal dysfunction in aging and Huntington disease. Neurobiol. Dis., 43, 4-8.
-
(2011)
Neurobiol. Dis.
, vol.43
, pp. 4-8
-
-
Li, X.J.1
Li, S.2
-
47
-
-
33749346301
-
Modification of proteins by ubiquitin and ubiquitin-like proteins
-
Kerscher, O., Felberbaum, R. and Hochstrasser, M. (2006) Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu. Rev. Cell. Dev. Biol., 22, 159-180.
-
(2006)
Annu. Rev. Cell. Dev. Biol.
, vol.22
, pp. 159-180
-
-
Kerscher, O.1
Felberbaum, R.2
Hochstrasser, M.3
-
48
-
-
84859900589
-
Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells
-
Chang, J.H., Xiao, Y., Hu, H., Jin, J., Yu, J., Zhou, X.,Wu, X., Johnson, H.M., Akira, S., Pasparakis, M. et al.(2012) Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat. Immunol., 13, 481-490.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 481-490
-
-
Chang, J.H.1
Xiao, Y.2
Hu, H.3
Jin, J.4
Yu, J.5
Zhou, X.6
Wu, X.7
Johnson, H.M.8
Akira, S.9
Pasparakis, M.10
-
49
-
-
84896850176
-
Fertilization-induced K63-linked ubiquitylation mediates clearance of maternal membrane proteins
-
Sato, M., Konuma, R., Sato, K. and Tomura, K. (2014) Fertilization-induced K63-linked ubiquitylation mediates clearance of maternal membrane proteins. Development, 141, 1324-1331.
-
(2014)
Development
, vol.141
, pp. 1324-1331
-
-
Sato, M.1
Konuma, R.2
Sato, K.3
Tomura, K.4
-
50
-
-
73949149563
-
Regulation of hematopoiesis by the K63-specific ubiquitinconjugating enzyme Ubc13
-
Wu, X., Yamamoto, M., Akira, S. and Sun, S.C. (2009) Regulation of hematopoiesis by the K63-specific ubiquitinconjugating enzyme Ubc13. Proc. Natl. Acad. Sci. U. S. A., 106, 20836-20841.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 20836-20841
-
-
Wu, X.1
Yamamoto, M.2
Akira, S.3
Sun, S.C.4
-
51
-
-
33845202484
-
Regulation of p53 localization and activity by Ubc13
-
Laine, A., Topisirovic, I., Zhai, D., Reed, J.C., Borden, K.L. and Ronai, Z. (2006) Regulation of p53 localization and activity by Ubc13. Mol. Cell. Biol., 26, 8901-8913.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 8901-8913
-
-
Laine, A.1
Topisirovic, I.2
Zhai, D.3
Reed, J.C.4
Borden, K.L.5
Ronai, Z.6
-
52
-
-
69149097080
-
Control of p53multimerization byUbc13 is JNK-regulated
-
Topisirovic, I., Gutierrez, G.J., Chen, M., Appella, E., Borden, K.L. and Ronai, Z.A. (2009) Control of p53multimerization byUbc13 is JNK-regulated. Proc. Natl. Acad. Sci. U. S. A., 106, 12676-12681.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 12676-12681
-
-
Topisirovic, I.1
Gutierrez, G.J.2
Chen, M.3
Appella, E.4
Borden, K.L.5
Ronai, Z.A.6
-
53
-
-
0034644474
-
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
-
Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C. and Chen, Z.J. (2000) Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell, 103, 351-361.
-
(2000)
Cell
, vol.103
, pp. 351-361
-
-
Deng, L.1
Wang, C.2
Spencer, E.3
Yang, L.4
Braun, A.5
You, J.6
Slaughter, C.7
Pickart, C.8
Chen, Z.J.9
-
54
-
-
0035913278
-
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
-
Wang, C., Deng, L., Hong, M., Akkaraju, G.R., Inoue, J. and Chen, Z.J. (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature, 412, 346-351.
-
(2001)
Nature
, vol.412
, pp. 346-351
-
-
Wang, C.1
Deng, L.2
Hong, M.3
Akkaraju, G.R.4
Inoue, J.5
Chen, Z.J.6
-
55
-
-
36749025467
-
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
-
Wang, B. and Elledge, S.J. (2007) Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc. Natl. Acad. Sci. U. S. A., 104, 20759-20763.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 20759-20763
-
-
Wang, B.1
Elledge, S.J.2
-
56
-
-
0035947372
-
Impairment of the ubiquitin-proteasome system by protein aggregation
-
Bence, N.F., Sampat, R.M. and Kopito, R.R. (2001) Impairment of the ubiquitin-proteasome system by protein aggregation. Science, 292, 1552-1555.
-
(2001)
Science
, vol.292
, pp. 1552-1555
-
-
Bence, N.F.1
Sampat, R.M.2
Kopito, R.R.3
-
57
-
-
0035958926
-
In vitro assembly and recognition of Lys-63 polyubiquitin chains
-
Hofmann, R.M. and Pickart, C.M. (2001) In vitro assembly and recognition of Lys-63 polyubiquitin chains. J. Biol. Chem., 276, 27936-27943.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 27936-27943
-
-
Hofmann, R.M.1
Pickart, C.M.2
-
58
-
-
34547130325
-
Certain pairs of ubiquitin-conjugating enzymes (E2 s) and ubiquitin-protein ligases (E3 s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages
-
Kim, H.T., Kim, K.P., Lledias, F., Kisselev, A.F., Scaglione, K.M., Skowyra, D., Gygi, S.P. and Goldberg, A.L. (2007) Certain pairs of ubiquitin-conjugating enzymes (E2 s) and ubiquitin-protein ligases (E3 s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. J. Biol. Chem., 282, 17375-17386.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 17375-17386
-
-
Kim, H.T.1
Kim, K.P.2
Lledias, F.3
Kisselev, A.F.4
Scaglione, K.M.5
Skowyra, D.6
Gygi, S.P.7
Goldberg, A.L.8
-
59
-
-
33745742269
-
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology
-
Kirkpatrick, D.S., Hathaway, N.A., Hanna, J., Elsasser, S., Rush, J., Finley, D., King, R.W. and Gygi, S.P. (2006) Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat. Cell. Biol., 8, 700-710.
-
(2006)
Nat. Cell. Biol.
, vol.8
, pp. 700-710
-
-
Kirkpatrick, D.S.1
Hathaway, N.A.2
Hanna, J.3
Elsasser, S.4
Rush, J.5
Finley, D.6
King, R.W.7
Gygi, S.P.8
-
60
-
-
60549107173
-
Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome
-
Saeki, Y., Kudo, T., Sone, T., Kikuchi, Y., Yokosawa, H., Toh-e, A. and Tanaka, K. (2009) Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome. EMBO J., 28, 359-371.
-
(2009)
EMBO J
, vol.28
, pp. 359-371
-
-
Saeki, Y.1
Kudo, T.2
Sone, T.3
Kikuchi, Y.4
Yokosawa, H.5
Toh-e, A.6
Tanaka, K.7
-
61
-
-
79251470118
-
Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysis
-
Conti, A., Rodriguez, G.C., Chiechi, A., Blazquez, R.M., Barbado, V., Krenacs, T., Novello, C., Pazzaglia, L., Quattrini, I., Zanella, L. et al.(2011) Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysis. Am. J. Pathol., 178, 88-97.
-
(2011)
Am. J. Pathol.
, vol.178
, pp. 88-97
-
-
Conti, A.1
Rodriguez, G.C.2
Chiechi, A.3
Blazquez, R.M.4
Barbado, V.5
Krenacs, T.6
Novello, C.7
Pazzaglia, L.8
Quattrini, I.9
Zanella, L.10
-
62
-
-
36848999334
-
Proteomic profiling of proteins associated with methamphetamine-induced neurotoxicity in different regions of rat brain
-
Li, X.,Wang, H., Qiu, P. and Luo, H. (2008) Proteomic profiling of proteins associated with methamphetamine-induced neurotoxicity in different regions of rat brain. Neurochem. Int., 52, 256-264.
-
(2008)
Neurochem. Int.
, vol.52
, pp. 256-264
-
-
Li, X.1
Wang, H.2
Qiu, P.3
Luo, H.4
-
63
-
-
84905482172
-
UBE2N, UBE2L3 and UBE2D2/3 ubiquitin-conjugating enzymes are essential for parkin-dependent mitophagy
-
Geisler, S., Vollmer, S., Golombek, S. and Kahle, P.J. (2014) UBE2N, UBE2L3 and UBE2D2/3 ubiquitin-conjugating enzymes are essential for parkin-dependent mitophagy. J. Cell. Sci., 127, 3280-3293.
-
(2014)
J. Cell. Sci.
, vol.127
, pp. 3280-3293
-
-
Geisler, S.1
Vollmer, S.2
Golombek, S.3
Kahle, P.J.4
-
64
-
-
33746065340
-
Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity
-
Leng, Y. and Chuang, D.M. (2006) Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. J. Neurosci., 26, 7502-7512.
-
(2006)
J. Neurosci.
, vol.26
, pp. 7502-7512
-
-
Leng, Y.1
Chuang, D.M.2
|