The role of ubiquitin-proteasome system in ageing

General and Comparative Endocrinology

Volumn 172, Issue 1, 2011, Pages 39-43

  Löw, Peter ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Ageing; Insulin; Insulin like growth factor; Proteasome; Ubiquitin

Indexed keywords

DEUBIQUITYLATING ENZYME; INSULIN; INSULIN RECEPTOR KINASE; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PROTEASOME; SOMATOMEDIN C RECEPTOR; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR FOXO; UBIQUITIN; UNCLASSIFIED DRUG;

AGING; ANTIGEN PRESENTATION; AUTOPHAGY; BRAIN; CELL CYCLE; ENZYME ACTIVITY; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; LONGEVITY; MUSCLE TISSUE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; STRESS; UBIQUITINATION; UPREGULATION;

EID: 79955737369     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2011.02.005     Document Type: Review

References (29)

1. Balasubramanyam M., Sampathkumar R., Mohan V. Is insulin signaling molecules misguided in diabetes for ubiquitin-proteasome mediated degradation?. Mol. Cell. Biochem. 2005, 275:117-125.
2. Bednarski E., Ribak C.E., Lynch G. Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus. J. Neurosci. 1997, 17:4006-4021.
3. Borissenko L., Groll M. Diversity of proteasomal missions: fine tuning of the immune response. Biol. Chem. 2007, 388:947-955.
4. Capel F., Prod'homme M., Bechet D., Taillandier D., Balage M., Attaix D., Combaret L. Lysosomal and proteasome-dependent proteolysis are differentially regulated by insulin and/or amino acids following feeding in young mature and old rats. J. Nutr. Biochem. 2009, 20:570-576.
5. Chondrogianni N., Stratford F.L., Trougakos I.P., Friguet B., Rivett A.J., Gonos E.S. Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation. J. Biol. Chem. 2003, 278:28026-28037.
6. Coux O., Tanaka K., Goldberg A.L. Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem. 1996, 65:801-847.
7. Crowe E., Sell C., Thomas J.D., Johannes G.J., Torres C. Activation of proteasome by insulin-like growth factor-I may enhance clearance of oxidized proteins in the brain. Mech. Ageing Dev. 2009, 130:793-800.
8. Dahlmann B. Role of proteasomes in disease. BMC Biochem. 2007, 8(suppl. 1):S3.
9. Dahlmann B., Rutschmann M., Kuehn L., Reinauer H. Activation of the multicatalytic proteinase from rat skeletal muscle by fatty acids or sodium dodecyl sulphate. Biochem. J. 1985, 228:171-177.
10. Fernandez S., Fernandez A.M., Lopez-Lopez C., Torres-Aleman I. Emerging roles of insulin-like growth factor-I in the adult brain. Growth Horm. IGF Res. 2007, 17:89-95.
11. Hershko A., Ciechanover A. The ubiquitin system. Annu. Rev. Biochem. 1998, 67:425-479.
12. Kamura T., Sato S., Haque D., Liu L., Kaelin W.G., Conaway R.C., Conaway J.W. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat and ankyrin repeat families. Genes Dev. 1998, 12:3872-3881.
13. Katsiki M., Chondrogianni N., Chinou I., Rivett A.J., Gonos E.S. The olive constituent oleuropein exhibits proteasome stimulatory properties in vitro and confers life span extension of human embryonic fibroblasts. Rejuvenation Res. 2007, 10:157-172.
14. Keller J.N., Gee J., Ding Q. The proteasome in brain aging. Ageing Res. Rev. 2002, 1:279-293.
15. Keller J.N., Hanni K.B., Markesbery W.R. Possible involvement of proteasome inhibition in aging: implications for oxidative stress. Mech. Ageing Dev. 2000, 113:61-70.
16. Kisselev A.F., Kaganovich D., Goldberg A.L. Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes. Evidence for peptide-induced channel opening in the alpha-rings. J. Biol. Chem. 2002, 277:22260-22270.
17. Köhler A., Cascio P., Leggett D.S., Woo K.M., Goldberg A.L., Finley D. The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release. Mol. Cell 2001, 7:1143-1152.
18. Lam Y.A., Pickart C.M., Alban A., Landon M., Jamieson C., Ramage R., Mayer R.J., Layfield R. Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 2000, 97:9902-9906.
19. Martinez-Vicente M., Cuervo A.M. Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol. 2007, 6:352-361.
20. McNaught K.S., Olanow C.W., Halliwell B., Isacson O., Jenner P. Failure of the ubiquitin-proteasome system in Parkinson's disease. Nat. Rev. Neurosci. 2001, 2:589-594.
21. Nixon R.A. The calpains in aging and aging-related diseases. Ageing Res. Rev. 2003, 2:407-418.
22. Nixon R.A., Wegiel J., Kumar A., Yu W.H., Peterhoff C., Cataldo A., Cuervo A.M. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J. Neuropathol. Exp. Neurol. 2005, 64:113-122.
23. Rui L., Fisher T.L., Thomas J., White M.F. Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2. J. Biol. Chem. 2001, 276:40362-40367.
24. Rui L., Yuan M., Frantz D., Shoelson S., White M.F. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS-1 and IRS-2. J. Biol. Chem. 2002, 277:42394-42398.
25. Sullivan P.G., Dragicevic N.B., Deng J.H., Bai Y.D., Dimayuga E., Ding Q.X., Chen Q.H., Bruce-Keller A.J., Keller J.N. Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnover. J. Biol. Chem. 2004, 279:20699-20707.
26. Sun X.J., Goldberg J.L., Qiao L.Y., Mitchell J.J. Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway. Diabetes 1999, 48:1359-1364.
27. Vellai T., Takacs-Vellai K., Sass M., Klionsky D.J. The regulation of aging: does autophagy underlie longevity?. Trends Cell Biol. 2009, 19:487-494.
28. Voges D., Zwickl P., Baumeister W. The 26S proteasome: A molecular machine designed for controlled proteolysis. Ann. Rev. Biochem. 1999, 68:1015-1068.
29. Wilkinson K.D. Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome. Semin. Cell Dev. Biol. 2000, 11:141-148.