A Pleiotropy-Informed Bayesian False Discovery Rate Adapted to a Shared Control Design Finds New Disease Associations From GWAS Summary Statistics

PLoS Genetics

Volumn 11, Issue 2, 2015, Pages 1-26

  Liley, James ^a   Wallace, Chris ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTOIMMUNE THYROIDITIS; BAYESIAN CONDITIONAL FALSE DISCOVERY RATE; CELIAC DISEASE; CONTROLLED STUDY; CROHN DISEASE; GENE CONTROL; GENE IDENTIFICATION; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MATHEMATICAL PARAMETERS; MULTIPLE SCLEROSIS; NARCOLEPSY; PLEIOTROPY; PRIMARY BILIARY CIRRHOSIS; PSORIASIS; REGULATORY MECHANISM; RHEUMATOID ARTHRITIS; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS; VALIDATION STUDY; AUTOIMMUNE DISEASE; BAYES THEOREM; BILIARY CIRRHOSIS; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN GENOME; PATHOLOGY; PHENOTYPE;

AUTOIMMUNE DISEASES; BAYES THEOREM; DIABETES MELLITUS, TYPE 1; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LIVER CIRRHOSIS, BILIARY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84924364251     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004926     Document Type: Article

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