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Volumn 10, Issue 11, 2014, Pages 943-949

A self-adjuvanting vaccine induces cytotoxic Tlymphocytes that suppress allergy

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; GAMMA INTERFERON; INTERLEUKIN 4; PEPTIDE VACCINE; TUMOR NECROSIS FACTOR ALPHA; ALLERGEN; ALPHA-GALACTOSYLCERAMIDE; ANTIINFLAMMATORY AGENT; GALACTOSYLCERAMIDE; IMMUNOGLOBULIN E; IMMUNOLOGICAL ADJUVANT; PEPTIDE; PRODRUG; VACCINE;

EID: 84924336773     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1640     Document Type: Article
Times cited : (65)

References (57)
  • 2
    • 34848837386 scopus 로고    scopus 로고
    • Taking dendritic cells into medicine
    • Steinman, R.M. & Banchereau, J. Taking dendritic cells into medicine. Nature 449, 419-426 (2007).
    • (2007) Nature , vol.449 , pp. 419-426
    • Steinman, R.M.1    Banchereau, J.2
  • 3
    • 7444271904 scopus 로고    scopus 로고
    • A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses
    • Jackson, D.C. et al. A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses. Proc. Natl. Acad. Sci. USA 101, 15440-15445 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 15440-15445
    • Jackson, D.C.1
  • 4
    • 34547094098 scopus 로고    scopus 로고
    • Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells
    • Khan, S. et al. Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells. J. Biol. Chem. 282, 21145-21159 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 21145-21159
    • Khan, S.1
  • 5
    • 78049511069 scopus 로고    scopus 로고
    • The capacity to induce cross-presentation dictates the success of a TLR7 agonist-conjugate vaccine for eliciting cellular immunity
    • Oh, J.Z. & Kedl, R.M. The capacity to induce cross-presentation dictates the success of a TLR7 agonist-conjugate vaccine for eliciting cellular immunity. J. Immunol. 185, 4602-4608 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 4602-4608
    • Oh, J.Z.1    Kedl, R.M.2
  • 6
    • 34548660856 scopus 로고    scopus 로고
    • Robust immune responses elicited by a fully synthetic three-component vaccine
    • Ingale, S., Wolfert, M.A., Gaekwad, J., Buskas, T. & Boons, G.J. Robust immune responses elicited by a fully synthetic three-component vaccine. Nat. Chem. Biol. 3, 663-667 (2007).
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 663-667
    • Ingale, S.1    Wolfert, M.A.2    Gaekwad, J.3    Buskas, T.4    Boons, G.J.5
  • 7
    • 0033923205 scopus 로고    scopus 로고
    • Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity
    • Tighe, H. et al. Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity. Eur. J. Immunol. 30, 1939-1947 (2000).
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1939-1947
    • Tighe, H.1
  • 8
    • 84902358526 scopus 로고    scopus 로고
    • Conjugation of a TLR7 agonist and antigen enhances protection in the S. Pneumoniae murine infection model
    • Vecchi, S. et al. Conjugation of a TLR7 agonist and antigen enhances protection in the S. pneumoniae murine infection model. Eur. J. Pharm. Biopharm. 87, 310-317 (2014).
    • (2014) Eur. J. Pharm. Biopharm. , vol.87 , pp. 310-317
    • Vecchi, S.1
  • 9
    • 0032482356 scopus 로고    scopus 로고
    • Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    • Bennett, S.R. et al. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393, 478-480 (1998).
    • (1998) Nature , vol.393 , pp. 478-480
    • Bennett, S.R.1
  • 10
    • 0032482337 scopus 로고    scopus 로고
    • A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    • Ridge, J.P., Di Rosa, F. & Matzinger, P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393, 474-478 (1998).
    • (1998) Nature , vol.393 , pp. 474-478
    • Ridge, J.P.1    Di Rosa, F.2    Matzinger, P.3
  • 11
    • 0032482474 scopus 로고    scopus 로고
    • T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    • Schoenberger, S.P., Toes, R.E., van der Voort, E.I., Offringa, R. & Melief, C.J. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393, 480-483 (1998).
    • (1998) Nature , vol.393 , pp. 480-483
    • Schoenberger, S.P.1    Toes, R.E.2    Van Der Voort, E.I.3    Offringa, R.4    Melief, C.J.5
  • 12
    • 84886943851 scopus 로고    scopus 로고
    • Exploiting invariant NKT cells to promote T-cell responses to cancer vaccines
    • Hunn, M.K. & Hermans, I.F. Exploiting invariant NKT cells to promote T-cell responses to cancer vaccines. Oncoimmunology 2, e23789 (2013).
    • (2013) Oncoimmunology , vol.2
    • Hunn, M.K.1    Hermans, I.F.2
  • 13
    • 0026645233 scopus 로고
    • An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor v β family
    • Arase, H., Arase, N., Ogasawara, K., Good, R.A. & Onoé, K. An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor V β family. Proc. Natl. Acad. Sci. USA 89, 6506-6510 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6506-6510
    • Arase, H.1    Arase, N.2    Ogasawara, K.3    Good, R.A.4    Onoé, K.5
  • 14
    • 0028025074 scopus 로고
    • An invariant T cell receptor α chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans
    • Lantz, O. & Bendelac, A. An invariant T cell receptor α chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. J. Exp. Med. 180, 1097-1106 (1994).
    • (1994) J. Exp. Med. , vol.180 , pp. 1097-1106
    • Lantz, O.1    Bendelac, A.2
  • 15
    • 0037787982 scopus 로고    scopus 로고
    • Activation of natural killer T cells by α-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein
    • Fujii, S., Shimizu, K., Smith, C., Bonifaz, L. & Steinman, R.M. Activation of natural killer T cells by α-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein. J. Exp. Med. 198, 267-279 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 267-279
    • Fujii, S.1    Shimizu, K.2    Smith, C.3    Bonifaz, L.4    Steinman, R.M.5
  • 16
    • 0037018103 scopus 로고    scopus 로고
    • Natural killer T cell ligand α-galactosylceramide enhances protective immunity induced by malaria vaccines
    • Gonzalez-Aseguinolaza, G. et al. Natural killer T cell ligand α-galactosylceramide enhances protective immunity induced by malaria vaccines. J. Exp. Med. 195, 617-624 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 617-624
    • Gonzalez-Aseguinolaza, G.1
  • 17
    • 10744230210 scopus 로고    scopus 로고
    • NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells
    • Hermans, I.F. et al. NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J. Immunol. 171, 5140-5147 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 5140-5147
    • Hermans, I.F.1
  • 18
    • 0037371115 scopus 로고    scopus 로고
    • NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8+ T cells in vivo
    • Stober, D., Jomantaite, I., Schirmbeck, R. & Reimann, J. NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8+ T cells in vivo. J. Immunol. 170, 2540-2548 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 2540-2548
    • Stober, D.1    Jomantaite, I.2    Schirmbeck, R.3    Reimann, J.4
  • 19
    • 77949830320 scopus 로고    scopus 로고
    • Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs
    • Semmling, V. et al. Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat. Immunol. 11, 313-320 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 313-320
    • Semmling, V.1
  • 20
    • 0032968706 scopus 로고    scopus 로고
    • Immunologic basis of antigen-induced airway hyperresponsiveness
    • Wills-Karp, M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17, 255-281 (1999).
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 255-281
    • Wills-Karp, M.1
  • 21
    • 17144367365 scopus 로고    scopus 로고
    • In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma
    • van Rijt, L.S. et al. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J. Exp. Med. 201, 981-991 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 981-991
    • Van Rijt, L.S.1
  • 22
    • 84863116777 scopus 로고    scopus 로고
    • Allergen-specific CTL require perforin expression to suppress allergic airway inflammation
    • Enomoto, N. et al. Allergen-specific CTL require perforin expression to suppress allergic airway inflammation. J. Immunol. 188, 1734-1741 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 1734-1741
    • Enomoto, N.1
  • 23
    • 73849149166 scopus 로고    scopus 로고
    • Specific CD8 T cells in IgE-mediated allergy correlate with allergen dose and allergic phenotype
    • Aguilar-Pimentel, J.A. et al. Specific CD8 T cells in IgE-mediated allergy correlate with allergen dose and allergic phenotype. Am. J. Respir. Crit. Care Med. 181, 7-16 (2010).
    • (2010) Am. J. Respir. Crit. Care Med. , vol.181 , pp. 7-16
    • Aguilar-Pimentel, J.A.1
  • 24
    • 33845930300 scopus 로고    scopus 로고
    • Regulation of allergic airway inflammation by class I-restricted allergen presentation and CD8 T-cell infiltration
    • Wells, J.W., Cowled, C.J., Giorgini, A., Kemeny, D.M. & Noble, A. Regulation of allergic airway inflammation by class I-restricted allergen presentation and CD8 T-cell infiltration. J. Allergy Clin. Immunol. 119, 226-234 (2007).
    • (2007) J. Allergy Clin. Immunol. , vol.119 , pp. 226-234
    • Wells, J.W.1    Cowled, C.J.2    Giorgini, A.3    Kemeny, D.M.4    Noble, A.5
  • 25
    • 0030696696 scopus 로고    scopus 로고
    • CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides
    • Kawano, T. et al. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science 278, 1626-1629 (1997).
    • (1997) Science , vol.278 , pp. 1626-1629
    • Kawano, T.1
  • 26
    • 68249151165 scopus 로고    scopus 로고
    • Differential recognition of CD1d-α-galactosylceramide by the Vβ8.2 and Vβ7 semi-invariant NKT T cell receptors
    • Pellicci, D.G. et al. Differential recognition of CD1d-α-galactosylceramide by the Vβ8.2 and Vβ7 semi-invariant NKT T cell receptors. Immunity 31, 47-59 (2009).
    • (2009) Immunity , vol.31 , pp. 47-59
    • Pellicci, D.G.1
  • 27
    • 0000658454 scopus 로고
    • (Acyloxy)alkyl carbamates as novel bioreversible prodrugs for amines: Increased permeation through biological membranes
    • Alexander, J., Cargill, R., Michelson, S.R. & Schwam, H. (Acyloxy)alkyl carbamates as novel bioreversible prodrugs for amines: increased permeation through biological membranes. J. Med. Chem. 31, 318-322 (1988).
    • (1988) J. Med. Chem. , vol.31 , pp. 318-322
    • Alexander, J.1    Cargill, R.2    Michelson, S.R.3    Schwam, H.4
  • 28
    • 33745831228 scopus 로고    scopus 로고
    • High-affinity interactions between peptides and heat shock protein 70 augment CD8+ T lymphocyte immune responses
    • Flechtner, J.B. et al. High-affinity interactions between peptides and heat shock protein 70 augment CD8+ T lymphocyte immune responses. J. Immunol. 177, 1017-1027 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 1017-1027
    • Flechtner, J.B.1
  • 30
    • 76249106206 scopus 로고    scopus 로고
    • Langerin+ CD8α+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens
    • Farrand, K.J. et al. Langerin+ CD8α+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens. J. Immunol. 183, 7732-7742 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 7732-7742
    • Farrand, K.J.1
  • 31
    • 63749130382 scopus 로고    scopus 로고
    • Stabilized integrin-targeting ternary LPD (lipopolyplex) vectors for gene delivery designed to disassemble within the target cell
    • Mustapa, M.F.M. et al. Stabilized integrin-targeting ternary LPD (lipopolyplex) vectors for gene delivery designed to disassemble within the target cell. Bioconjug. Chem. 20, 518-532 (2009).
    • (2009) Bioconjug. Chem. , vol.20 , pp. 518-532
    • Mustapa, M.F.M.1
  • 32
    • 0142157012 scopus 로고    scopus 로고
    • The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Vα14i NKT cells
    • Elewaut, D. et al. The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Vα14i NKT cells. J. Exp. Med. 198, 1133-1146 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1133-1146
    • Elewaut, D.1
  • 33
    • 27144481169 scopus 로고    scopus 로고
    • Apolipoprotein-mediated pathways of lipid antigen presentation
    • van den Elzen, P. et al. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature 437, 906-910 (2005).
    • (2005) Nature , vol.437 , pp. 906-910
    • Van Den Elzen, P.1
  • 34
    • 84868628556 scopus 로고    scopus 로고
    • Scavenger receptors target glycolipids for natural killer T cell activation
    • Freigang, S. et al. Scavenger receptors target glycolipids for natural killer T cell activation. J. Clin. Invest. 122, 3943-3954 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 3943-3954
    • Freigang, S.1
  • 35
    • 0034627985 scopus 로고    scopus 로고
    • α-Galactosylceramide induces early B-cell activation through IL-4 production by NKT cells
    • Kitamura, H. et al. α-Galactosylceramide induces early B-cell activation through IL-4 production by NKT cells. Cell. Immunol. 199, 37-42 (2000).
    • (2000) Cell. Immunol. , vol.199 , pp. 37-42
    • Kitamura, H.1
  • 36
    • 0037460057 scopus 로고    scopus 로고
    • CD1d-restricted help to B cells by human invariant natural killer T lymphocytes
    • Galli, G. et al. CD1d-restricted help to B cells by human invariant natural killer T lymphocytes. J. Exp. Med. 197, 1051-1057 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 1051-1057
    • Galli, G.1
  • 37
    • 33746927114 scopus 로고    scopus 로고
    • The CD1d-binding glycolipid α-galactosylceramide enhances humoral immunity to T-dependent and T-independent antigen in a CD1d-dependent manner
    • Lang, G.A., Exley, M.A. & Lang, M.L. The CD1d-binding glycolipid α-galactosylceramide enhances humoral immunity to T-dependent and T-independent antigen in a CD1d-dependent manner. Immunology 119, 116-125 (2006).
    • (2006) Immunology , vol.119 , pp. 116-125
    • Lang, G.A.1    Exley, M.A.2    Lang, M.L.3
  • 38
    • 4043073456 scopus 로고    scopus 로고
    • Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness
    • Miyahara, N. et al. Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. Nat. Med. 10, 865-869 (2004).
    • (2004) Nat. Med. , vol.10 , pp. 865-869
    • Miyahara, N.1
  • 39
    • 0027164561 scopus 로고
    • Switch of CD8 T cells to noncytolytic CD8- CD4- cells that make TH2 cytokines and help B cells
    • Erard, F., Wild, M.T., Garcia-Sanz, J.A. & Le Gros, G. Switch of CD8 T cells to noncytolytic CD8- CD4- cells that make TH2 cytokines and help B cells. Science 260, 1802-1805 (1993).
    • (1993) Science , vol.260 , pp. 1802-1805
    • Erard, F.1    Wild, M.T.2    Garcia-Sanz, J.A.3    Le Gros, G.4
  • 40
    • 0033588821 scopus 로고    scopus 로고
    • Inhibition of T helper cell type 2 cell differentiation and immunoglobulin e response by ligand-activated Vα14 natural killer T cells
    • Cui, J. et al. Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Vα14 natural killer T cells. J. Exp. Med. 190, 783-792 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 783-792
    • Cui, J.1
  • 41
    • 27644586260 scopus 로고    scopus 로고
    • α-Galactosylceramide-induced iNKT cells suppress experimental allergic asthma in sensitized mice: Role of IFN-γ
    • Hachem, P. et al. α-Galactosylceramide-induced iNKT cells suppress experimental allergic asthma in sensitized mice: role of IFN-γ. Eur. J. Immunol. 35, 2793-2802 (2005).
    • (2005) Eur. J. Immunol. , vol.35 , pp. 2793-2802
    • Hachem, P.1
  • 42
    • 21844476225 scopus 로고    scopus 로고
    • α-Galactosylceramide, a ligand of natural killer T cells, inhibits allergic airway inflammation
    • Matsuda, H. et al. α-Galactosylceramide, a ligand of natural killer T cells, inhibits allergic airway inflammation. Am. J. Respir. Cell Mol. Biol. 33, 22-31 (2005).
    • (2005) Am. J. Respir. Cell Mol. Biol. , vol.33 , pp. 22-31
    • Matsuda, H.1
  • 43
    • 27644504027 scopus 로고    scopus 로고
    • Suppression of eosinophilic airway inflammation by treatment with α-galactosylceramide
    • Morishima, Y. et al. Suppression of eosinophilic airway inflammation by treatment with α-galactosylceramide. Eur. J. Immunol. 35, 2803-2814 (2005).
    • (2005) Eur. J. Immunol. , vol.35 , pp. 2803-2814
    • Morishima, Y.1
  • 44
    • 9644279528 scopus 로고    scopus 로고
    • Asthma is induced by intranasal coadministration of allergen and natural killer T-cell ligand in a mouse model
    • Kim, J.-O. et al. Asthma is induced by intranasal coadministration of allergen and natural killer T-cell ligand in a mouse model. J. Allergy Clin. Immunol. 114, 1332-1338 (2004).
    • (2004) J. Allergy Clin. Immunol. , vol.114 , pp. 1332-1338
    • Kim, J.-O.1
  • 45
    • 33644504477 scopus 로고    scopus 로고
    • Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells
    • Meyer, E.H. et al. Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proc. Natl. Acad. Sci. USA 103, 2782-2787 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 2782-2787
    • Meyer, E.H.1
  • 46
    • 24644433401 scopus 로고    scopus 로고
    • Glycolipid antigen induces long-term natural killer T cell anergy in mice
    • Parekh, V.V. et al. Glycolipid antigen induces long-term natural killer T cell anergy in mice. J. Clin. Invest. 115, 2572-2583 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 2572-2583
    • Parekh, V.V.1
  • 47
    • 33750628134 scopus 로고    scopus 로고
    • Novel synthesis of α-galactosylceramides and confirmation of their powerful NKT cell agonist activity
    • Lee, A. et al. Novel synthesis of α-galactosylceramides and confirmation of their powerful NKT cell agonist activity. Carbohydr. Res. 341, 2785-2798 (2006).
    • (2006) Carbohydr. Res. , vol.341 , pp. 2785-2798
    • Lee, A.1
  • 48
    • 0028178784 scopus 로고
    • T cell receptor antagonist peptides induce positive selection
    • Hogquist, K.A. et al. T cell receptor antagonist peptides induce positive selection. Cell 76, 17-27 (1994).
    • (1994) Cell , vol.76 , pp. 17-27
    • Hogquist, K.A.1
  • 49
    • 0024307348 scopus 로고
    • Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
    • Pircher, H., Bürki, K., Lang, R., Hengartner, H. & Zinkernagel, R.M. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342, 559-561 (1989).
    • (1989) Nature , vol.342 , pp. 559-561
    • Pircher, H.1    Bürki, K.2    Lang, R.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 51
    • 0030959640 scopus 로고    scopus 로고
    • Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice
    • Chen, Y.H., Chiu, N.M., Mandal, M., Wang, N. & Wang, C.R. Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice. Immunity 6, 459-467 (1997).
    • (1997) Immunity , vol.6 , pp. 459-467
    • Chen, Y.H.1    Chiu, N.M.2    Mandal, M.3    Wang, N.4    Wang, C.R.5
  • 52
    • 21144444056 scopus 로고    scopus 로고
    • Dynamics and function of Langerhans cells in vivo: Dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    • Kissenpfennig, A. et al. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22, 643-654 (2005).
    • (2005) Immunity , vol.22 , pp. 643-654
    • Kissenpfennig, A.1
  • 53
    • 0036896332 scopus 로고    scopus 로고
    • A phase i study of the natural killer T-cell ligand α-galactosylceramide (KRN7000) in patients with solid tumors
    • Giaccone, G. et al. A phase I study of the natural killer T-cell ligand α-galactosylceramide (KRN7000) in patients with solid tumors. Clin. Cancer Res. 8, 3702-3709 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3702-3709
    • Giaccone, G.1
  • 54
    • 23944448650 scopus 로고    scopus 로고
    • Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor
    • Zajonc, D.M. et al. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat. Immunol. 6, 810-818 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 810-818
    • Zajonc, D.M.1
  • 55
    • 0029029565 scopus 로고
    • CD1 recognition by mouse NK1+ T lymphocytes
    • Bendelac, A. et al. CD1 recognition by mouse NK1+ T lymphocytes. Science 268, 863-865 (1995).
    • (1995) Science , vol.268 , pp. 863-865
    • Bendelac, A.1
  • 56
    • 0018567556 scopus 로고
    • Continuous proliferation of murine antigen-specific helper T lymphocytes in culture
    • Watson, J. Continuous proliferation of murine antigen-specific helper T lymphocytes in culture. J. Exp. Med. 150, 1510-1519 (1979).
    • (1979) J. Exp. Med. , vol.150 , pp. 1510-1519
    • Watson, J.1
  • 57
    • 84878257969 scopus 로고    scopus 로고
    • Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells
    • Roediger, B. et al. Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nat. Immunol. 14, 564-573 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 564-573
    • Roediger, B.1


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