Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness

Nature Medicine

Volumn 10, Issue 8, 2004, Pages 865-869

  Miyahara, Nobuaki ^a   Swanson, Bradley J ^a   Takeda, Katsuyuki ^a   Taube, Christian ^a   Miyahara, Satoko ^a   Kodama, Taku ^a   Dakhama, Azzeddine ^a   Ott, Vanessa L ^a   Gelfand, Erwin W ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CD8 ANTIGEN; INTERLEUKIN 13;

ADOPTIVE TRANSFER; ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; FLOW CYTOMETRY; GOBLET CELL; LYMPHOCYTE MIGRATION; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; WILD TYPE;

ADOPTIVE TRANSFER; ALLERGENS; ALUM COMPOUNDS; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD8; BRONCHIAL HYPERREACTIVITY; BRONCHITIS; BRONCHOALVEOLAR LAVAGE FLUID; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; INTERLEUKIN-13; LUNG; METHACHOLINE CHLORIDE; MICE; MICE, MUTANT STRAINS; OVALBUMIN; T-LYMPHOCYTE SUBSETS;

ANIMALIA; BRONCHUS; ERAGROSTIS TEF;

EID: 4043073456     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1081     Document Type: Article

References (25)

1. Miyahara, N. et al. Contribution of antigen-primed CD8+ T cells in the development of airway hyperresponsiveness and airway inflammation is associated with IL-13. J. Immunol. 172, 2549-2558 (2004).
2. Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712 (1999).
3. Masopust, D., Vezys, V., Marzo, A.L. & Lefrancois, L. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291, 2413-2417 (2001).
4. Weninger, W., Crowley, M.A., Manjunath, N. & von Andrian, U.H. Migratory properties of naive, effector, and memory CD8+ T cells. J. Exp. Med. 194, 953-966 (2001).
5. Manjunath, N. et al. Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J. Clin. Invest. 108, 871-878 (2001).
6. Busse, W.W. & Lemanske Jr., R.F. Asthma. N. Engl. J. Med. 344, 350-362 (2001).
7. Oshiba, A. et al. Modulation of antigen-induced B and T cell responses by antigen-specific IgE antibodies. J. Immunol. 159, 4056-4063 (1997).
8. De Sanctis, G.T. et al. T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice. Nat. Med. 3, 460-462 (1997).
9. Robinson, D.S. et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326, 298-304 (1992).
10. Gonzalez, M.C. et al. Allergen-induced recruitment of bronchoalveolar helper (OKT4) and suppressor (OKT8) T-cells in asthma. Relative increases in OKT8 cells in single early responders compared with those in late-phase responders. Am. Rev. Resp. Dis. 136, 600-604 (1987).
11. O'Sullivan, S. et al. Activated, cytotoxic CD8(+) T lymphocytes contribute to the pathology of asthma death. Am. J. Resp. Crit. Care Med. 164, 560-564 (2001).
12. Hamelmann, E. et al. Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a murine model of airway sensitization. J. Exp. Med. 183, 1719-1729 (1996).
13. Swanson, B.J., Murakami, M., Mitchell, T.C., Kappler, J. & Marrack, P. RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR-dependent process. Immunity 17, 605-615 (2002).
14. Ott, V.L., Cambier, J.C., Kappler, J., Marrack, P. & Swanson, B.J. Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4. Nat. Immunol. 4, 974-981 (2003).
15. Takeda, K. et al. Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J. Exp. Med. 186, 449-454 (1997).
16. Tomkinson, A. et al. Temporal association between airway hyperresponsiveness and airway eosinophilia in ovalbumin-sensitized mice. Am. J. Respir. Crit. Care Med. 163, 721-730 (2001).
17. Wills-Karp, M. et al. Interleukin-13: central mediator of allergic asthma. Science 282, 2258-2261 (1998).
18. Hoshino, T., Winkler-Pickett, R.T., Mason, A.T., Ortaldo, J.R. & Young, H.A. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-γ. J. Immunol. 162, 51-59 (1999).
19. Akbari, O. et al. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat. Med. 9, 582-588 (2003).
20. Burd, P.R., Thompson W.C., Max, E.E. & Mills, F.C. Activated mast cells produce interleukin 13. J. Exp. Med. 181, 1373-1380 (1995).
21. Grunstein, M.M. et al. IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol. 282, L520-L528 (2002).
22. Watanabe, A. et al. Transfer of allergic airway responses with antigen-primed CD4+ but not CD8+ T cells in brown Norway rats. J. Clin. Invest. 96, 1303-1310 (1995).
23. Fung-Leung, W.P., Schilham, M.W. & Rahemtulla, A. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65, 443-449 (1991).
24. Fabien, N., Bergerot, I., Maguer-Satta, V., Orgiazzi, J. & Thivolet, C. Pancreatic lymph nodes are early targets of T cells during adoptive transfer of diabetes in NOD mice. J. Autoimmun. 8, 323-334 (1995).
25. Oshiba, A. et al. Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice. J. Clin. Invest. 97, 1398-1408 (1996).