메뉴 건너뛰기




Volumn 185, Issue 8, 2010, Pages 4602-4608

The capacity to induce cross-presentation dictates the success of a TLR7 agonist-conjugate vaccine for eliciting cellular immunity

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOLOGICAL ADJUVANT; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR AGONIST; ANTIGEN; MEMBRANE PROTEIN; OVALBUMIN; TLR7 PROTEIN, MOUSE; VACCINE;

EID: 78049511069     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1001892     Document Type: Article
Times cited : (55)

References (29)
  • 1
    • 1542317550 scopus 로고    scopus 로고
    • Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
    • DOI 10.1126/science.1093616
    • Diebold, S. S., T. Kaisho, H. Hemmi, S. Akira, and C. Reise Sousa. 2004. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303:1529-1531. (Pubitemid 38314425)
    • (2004) Science , vol.303 , Issue.5663 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis E Sousa, C.5
  • 3
    • 0037013830 scopus 로고    scopus 로고
    • Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets
    • Ito, T., R. Amakawa, T. Kaisho, H. Hemmi, K. Tajima, K. Uehira, Y. Ozaki, H. Tomizawa, S. Akira, and S. Fukuhara. 2002. Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J. Exp. Med. 195:1507-1512.
    • (2002) J. Exp. Med. , vol.195 , pp. 1507-1512
    • Ito, T.1    Amakawa, R.2    Kaisho, T.3    Hemmi, H.4    Tajima, K.5    Uehira, K.6    Ozaki, Y.7    Tomizawa, H.8    Akira, S.9    Fukuhara, S.10
  • 4
    • 0037738569 scopus 로고    scopus 로고
    • Toll-like receptor expression in murine DC subsets: Lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines
    • Edwards, A. D., S. S. Diebold, E. M. Slack, H. Tomizawa, H. Hemmi, T. Kaisho, S. Akira, and C. Reis e Sousa. 2003. Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines. Eur. J. Immunol. 33:827-833.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 827-833
    • Edwards, A.D.1    Diebold, S.S.2    Slack, E.M.3    Tomizawa, H.4    Hemmi, H.5    Kaisho, T.6    Akira, S.7    Reis E Sousa, C.8
  • 5
    • 0041845186 scopus 로고    scopus 로고
    • The immune response modifier and Toll-like receptor 7 agonist S-27609 selectively induces IL-12 and TNF-a production in CD11c+ CD11b+CD82 dendritic cells
    • Doxsee, C. L., T. R. Riter, M. J. Reiter, S. J. Gibson, J. P. Vasilakos, and R. M. Kedl. 2003. The immune response modifier and Toll-like receptor 7 agonist S-27609 selectively induces IL-12 and TNF-a production in CD11c+ CD11b+CD82 dendritic cells. J. Immunol. 171:1156-1163.
    • (2003) J. Immunol. , vol.171 , pp. 1156-1163
    • Doxsee, C.L.1    Riter, T.R.2    Reiter, M.J.3    Gibson, S.J.4    Vasilakos, J.P.5    Kedl, R.M.6
  • 6
    • 20444430129 scopus 로고    scopus 로고
    • Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses
    • Wille-Reece, U., C. Y. Wu, B. J. Flynn, R. M. Kedl, and R. A. Seder. 2005. Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses. J. Immunol. 174:7676-7683.
    • (2005) J. Immunol. , vol.174 , pp. 7676-7683
    • Wille-Reece, U.1    Wu, C.Y.2    Flynn, B.J.3    Kedl, R.M.4    Seder, R.A.5
  • 8
    • 27244443079 scopus 로고    scopus 로고
    • HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates
    • Wille-Reece, U., B. J. Flynn, K. Loré, R. A. Koup, R. M. Kedl, J. J. Mattapallil, W. R. Weiss, M. Roederer, and R. A. Seder. 2005. HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates. Proc. Natl. Acad. Sci. USA 102:15190-15194.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15190-15194
    • Wille-Reece, U.1    Flynn, B.J.2    Loré, K.3    Koup, R.A.4    Kedl, R.M.5    Mattapallil, J.J.6    Weiss, W.R.7    Roederer, M.8    Seder, R.A.9
  • 10
    • 0035399836 scopus 로고    scopus 로고
    • Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG-tagged antigen by dendritic cells
    • Shirota, H., K. Sano, N. Hirasawa, T. Terui, K. Ohuchi, T. Hattori, K. Shirato, and G. Tamura. 2001. Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG-tagged antigen by dendritic cells. J. Immunol. 167:66-74.
    • (2001) J. Immunol. , vol.167 , pp. 66-74
    • Shirota, H.1    Sano, K.2    Hirasawa, N.3    Terui, T.4    Ohuchi, K.5    Hattori, T.6    Shirato, K.7    Tamura, G.8
  • 11
    • 7444271904 scopus 로고    scopus 로고
    • A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses
    • Jackson, D. C., Y. F. Lau, T. Le, A. Suhrbier, G. Deliyannis, C. Cheers, C. Smith, W. Zeng, and L. E. Brown. 2004. A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses. Proc. Natl. Acad. Sci. USA 101:15440-15445.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 15440-15445
    • Jackson, D.C.1    Lau, Y.F.2    Le, T.3    Suhrbier, A.4    Deliyannis, G.5    Cheers, C.6    Smith, C.7    Zeng, W.8    Brown, L.E.9
  • 15
    • 15444378922 scopus 로고    scopus 로고
    • Protective CD8 T cell immunity triggered by CpG-protein conjugates competes withthe efficacyoflive vaccines. J
    • Heit, A., F. Schmitz, M. O'Keeffe, C. Staib, D. H. Busch, H. Wagner, and K. M. Huster. 2005. Protective CD8 T cell immunity triggered by CpG-protein conjugates competes withthe efficacyoflive vaccines. J. Immunol. 174:4373-4380.
    • (2005) Immunol. , vol.174 , pp. 4373-4380
    • Heit, A.1    Schmitz, F.2    O'Keeffe, M.3    Staib, C.4    Busch, D.H.5    Wagner, H.6    Huster, K.M.7
  • 16
    • 33645734929 scopus 로고    scopus 로고
    • Toll-dependent selection of microbial antigens for presentation by dendritic cells
    • Blander, J. M., and R. Medzhitov. 2006. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440:808-812.
    • (2006) Nature , vol.440 , pp. 808-812
    • Blander, J.M.1    Medzhitov, R.2
  • 17
    • 0037443413 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells
    • Heit, A., T. Maurer, H. Hochrein, S. Bauer, K. M. Huster, D. H. Busch, and H. Wagner. 2003. Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells. J. Immunol. 170:2802-2805.
    • (2003) J. Immunol. , vol.170 , pp. 2802-2805
    • Heit, A.1    Maurer, T.2    Hochrein, H.3    Bauer, S.4    Huster, K.M.5    Busch, D.H.6    Wagner, H.7
  • 18
    • 42449157557 scopus 로고    scopus 로고
    • Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation
    • Burgdorf, S., C. Schölz, A. Kautz, R. Tampé, and C. Kurts. 2008. Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nat. Immunol. 9:558-566.
    • (2008) Nat. Immunol. , vol.9 , pp. 558-566
    • Burgdorf, S.1    Schölz, C.2    Kautz, A.3    Tampé, R.4    Kurts, C.5
  • 19
    • 0024997246 scopus 로고
    • Removal of endotoxin from protein solutions by phase separation using Triton X-114
    • Aida, Y., and M. J. Pabst. 1990. Removal of endotoxin from protein solutions by phase separation using Triton X-114. J. Immunol. Methods 132:191-195.
    • (1990) J. Immunol. Methods , vol.132 , pp. 191-195
    • Aida, Y.1    Pabst, M.J.2
  • 20
    • 0032007065 scopus 로고    scopus 로고
    • Massive expansion of antigen-specific CD8+ T cells during an acute virus infection
    • Butz, E. A., and M. J. Bevan. 1998. Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. Immunity 8:167-175.
    • (1998) Immunity , vol.8 , pp. 167-175
    • Butz, E.A.1    Bevan, M.J.2
  • 21
    • 0036118394 scopus 로고    scopus 로고
    • Recombinant vaccinia virus-induced T-cell immunity: Quantitation of the response to the virus vector and the foreign epitope
    • Harrington, L. E., R. Most Rv, J. L. Whitton, and R. Ahmed. 2002. Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope. J. Virol. 76:3329-3337.
    • (2002) J. Virol. , vol.76 , pp. 3329-3337
    • Harrington, L.E.1    Rv, R.M.2    Whitton, J.L.3    Ahmed, R.4
  • 22
    • 33747092627 scopus 로고    scopus 로고
    • T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity
    • Zehn, D., and M. J. Bevan. 2006. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity 25:261-270.
    • (2006) Immunity , vol.25 , pp. 261-270
    • Zehn, D.1    Bevan, M.J.2
  • 23
    • 62249131518 scopus 로고    scopus 로고
    • Complete but curtailed T-cell response to very low-affinity antigen
    • Zehn, D., S. Y. Lee, and M. J. Bevan. 2009. Complete but curtailed T-cell response to very low-affinity antigen. Nature 458:211-214.
    • (2009) Nature , vol.458 , pp. 211-214
    • Zehn, D.1    Lee, S.Y.2    Bevan, M.J.3
  • 24
    • 0035940426 scopus 로고    scopus 로고
    • Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells
    • Potter, T. A., K. Grebe, B. Freiberg, and A. Kupfer. 2001. Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells. Proc. Natl. Acad. Sci. USA 98:12624-12629.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12624-12629
    • Potter, T.A.1    Grebe, K.2    Freiberg, B.3    Kupfer, A.4
  • 25
    • 33846540410 scopus 로고    scopus 로고
    • Combined TLR/CD40 stimulation mediates potent cellular immunity by regulating dendritic cell expression of CD70 in vivo
    • Sanchez, P. J., J. A. McWilliams, C. Haluszczak, H. Yagita, and R. M. Kedl. 2007. Combined TLR/CD40 stimulation mediates potent cellular immunity by regulating dendritic cell expression of CD70 in vivo. J. Immunol. 178:1564-1572.
    • (2007) J. Immunol. , vol.178 , pp. 1564-1572
    • Sanchez, P.J.1    McWilliams, J.A.2    Haluszczak, C.3    Yagita, H.4    Kedl, R.M.5
  • 26
    • 22844438014 scopus 로고    scopus 로고
    • Vaccine adjuvant technology: From theoretical mechanisms to practical approaches
    • Schijns, V. E., and A. Tangerås. 2005. Vaccine adjuvant technology: from theoretical mechanisms to practical approaches. Dev. Biol. 121:127-134.
    • (2005) Dev. Biol. , vol.121 , pp. 127-134
    • Schijns, V.E.1    Tangerås, A.2
  • 27
    • 30044434147 scopus 로고    scopus 로고
    • Priming of T cells by exogenous antigen crosspresented on MHC class I molecules
    • Shen, L., and K. L. Rock. 2006. Priming of T cells by exogenous antigen crosspresented on MHC class I molecules. Curr. Opin. Immunol. 18:85-91.
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 85-91
    • Shen, L.1    Rock, K.L.2
  • 28
    • 33749512465 scopus 로고    scopus 로고
    • Exiting the outside world for cross-presentation
    • Rock, K. L. 2006. Exiting the outside world for cross-presentation. Immunity 25:523-525.
    • (2006) Immunity , vol.25 , pp. 523-525
    • Rock, K.L.1
  • 29
    • 21044455622 scopus 로고    scopus 로고
    • Adjuvants and antibody production: Dispelling the myths associated with Freund's complete and other adjuvants
    • Stills, H. F., Jr. 2005. Adjuvants and antibody production: dispelling the myths associated with Freund's complete and other adjuvants. ILAR J. 46:280-293.
    • (2005) ILAR J. , vol.46 , pp. 280-293
    • Stills Jr., H.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.