Inhalation toxicity of propineb. Part I: Results of subacute inhalation exposure studies in rats

Inhalation Toxicology

Volumn 15, Issue 5, 2003, Pages 411-434

  Pauluhn, Jürgen ^a   Rosenbruch, Martin ^a  

^a Institute of Toxicology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 THIAZOLIDINETHIONE 4 CARBOXYLIC ACID; AGRICULTURAL CHEMICAL; BIOLOGICAL MARKER; CARBON DISULFIDE; CARBOXYLIC ACID DERIVATIVE; POLYMER; PROPINEB; UNCLASSIFIED DRUG; ZIRAM;

AGRICULTURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEGENERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENVIRONMENTAL EXPOSURE; FEMALE; FLACCID PARALYSIS; GENDER; HINDLIMB; IMMOBILIZATION STRESS; INHALATION; LONG TERM EXPOSURE; LUNG ALVEOLUS MACROPHAGE; LUNG WEIGHT; MALE; MAXIMUM ALLOWABLE CONCENTRATION; MICROSCOPIC ANATOMY; MORTALITY; MUSCLE ATROPHY; MUSCLE FUNCTION; MUSCLE STRENGTH; MUSCLE WEAKNESS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; THYROID FUNCTION; TOXICITY TESTING; URINE LEVEL; WEIGHT REDUCTION;

ADMINISTRATION, INHALATION; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LUNG; MALE; MUSCLE, SKELETAL; RATS; RATS, WISTAR; ZINEB;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0038292125     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370304465     Document Type: Article

References (47)

1. Amarnath, V., Anthony, D. C., Valentine, W. M., and Graham, D. G. 1991. The molecular mechanism of the carbon disulfide mediated cross-linking of proteins. Chem. Res. Toxicol. 4:148-150.
2. Anonymous. 2000. Dithiocarbamate pesticides. Toxicology 143:47-51.
3. Anthony, D. C., Montine, T. J., and Graham, D. G. 1996. Toxic responses of the nervous system. In Casarett and Doull's toxicology. The basic science of poisons, ed. C. D. Klaasen, 5th ed., pp. 463-486. New York: McGraw-Hill.
4. Ascher, M. 1996. The functional significance of brain metallothioneins. FASEB J. 10:1129-1136.
5. ASTM. 1984. Standard test method for estimating sensory irritancy of airborne chemicals. ASTM Targetation, E 981-84. Philadelphia: American Society for Testing and Materials.
6. Baars, A. J., Mukhtar, H., Zoetemelk, C. E. M., Jansen, M., and Breimer, D. 1981. Glutathione S-transferase activity in rat and human tissues and organs. Comp. Biochem. Physiol. 70C:285-288.
7. Bliss, C. I. 1938. The determination of the dosage-mortality curve from small numbers. Q. J. Pharm. Pharmacol. 11:192-216.
8. Bus, J. S. 1985. The relationship of carbon disulfide metabolism to development of toxicity. Neurotoxicology 6:73-80.
9. Clerici, W. J., and Fechter, L. D. 1991. Effects of chronic carbon disulfide inhalation on sensory and motor function in the rat. Neurotoxicol. Teratol. 13:249-255.
10. Colombi, A., Maroni, M., Picchi, O., Rota, E., Castano, P., and Foa, V. 1981. Carbon disulfide neuropathy in rats. A morphological and ultrastructural study of degeneration and regeneration. Clin. Toxicol. 18:1463-1474.
11. Cousins, R. J. 1985. Absorption, transport and hepatic matabolism of copper and Zn, special reference to metallothionein and caeruloplasmin. Physiol. Rev. 65:238-309.
12. Coyle, P., Philcox, J. C., Carey, L. C., and Rofe, A. M. 2002. Review - Metallothionein, The multipurpose protein. Cell. Mol. Life Sci. 56:627-647.
13. Deutsche Forschungsgemeinschaft. 1994. TTCA. In Analyses of hazardous substances in biological material, eds. J. Angerer and K. H. Schaller, vol. 4, pp. 207-222. Weinheim: Wiley-VCH Verlag.
14. Directive 86/609/EEC. 1986. Guideline of the Council dated November 24, 1986, on the Reconciliation of Legal and Administrative Regulations of the Member Countries for the Protection of Animals used for Studies and other Scientific Purposes. Journal of the European Community, Legal Specifications L358, 29.
15. Directive 92/69/EEC. 1992. Acute toxicity - Inhalation. Journal of the European Community, Legal Specifications L383A, 35, p. 121.
16. Frederickson, C. J., Suh, S. W., Silva, D., Frederickson, C. J., and Thompson, R. B. 2000. Importance of zinc in the central nervous system, the zinc-containing neuron. J. Nutr. 130(5S suppl.):1471S-1483S.
17. Gad, S. C., and Weil, C. S. 1982. Statistics for toxicologists. In Principles and methods of toxicology, ed. A. W. Hayes, 2nd ed., pp. 435-483. New York: Raven Press.
18. Graham, D. G., Amarnath, V., Valentine, W. M., Pyle, S. J., and Anthony, D. C. 1995. Pathogenetic studies of hexane and carbon disulfide neurotoxicity. Crit. Rev. Toxicol. 25:91-112.
19. Harry, G. J., Graham, D. G., Valentine, W. M., Morgan, D. L., and Sills, R. C. 1998. Carbon disulfide in rats, VIII. Summary. NeuroToxicology 19:159-162.
20. Hayes, W. J. 1982. Pesticides studied in man. Baltimore: Williams & Wilkins.
21. International Programme on Chemical Safety. 1999. Propineb. In Pesticide residues in food-1999. Geneva: WHO/PCS, World Health Organization. Draft, www.inchem.org/jmpr
22. Irwin, S. 1968. Comprehensive observational assessment, la, a systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmalogica 13:222-257.
23. 2 by dithiocarbamates. Chem. Res. Toxicol. 9:910-916.
24. Johnson, D. J., Graham, D. G., Amarnath, V., Amarmath, K., and Valentine, W. M. 1998. Release of carbon disulfide is a contributing mechanism in the axonopathy produced by N,N-diethyldithiocarbamate. Toxicol. Appl. Pharmacol. 148:288-296.
25. 2 to TTCA in rats. Arch. Toxicol. 69:185-190.
26. Kress, Y., Gaskin, F., Brosman, C. F., and Levine, S. 1981. Effects of zinc on the cytoskeletal proteins in the central nervous system of the rat. Brain Res. 220:139-149.
27. Lam, C.-W., and DiStefano, V. 1986. Characterization of carbon disulfide binding in blood and to other biological substances. Toxicol. Appl. Pharmacol. 86:235-242.
28. Leeuwenburgh, C., and Ji, L. L. 1995. Glutathione depletion in rested and exercised mice: Biochemical consequence and adaptation. Arch. Biochem. Biophys. 316:941-949.
29. Marinovich, M., Viviani, B., Capra, V., Corsini, E., Anselmi, L., D'Agostino, G., DiNucci, A., Binaglia, M., Tonini, M., and Galli, C. L. 2002. Facilitation of acetylcholine signaling by the dithiocarbamate fungicide propineb. Chem. Res. Toxicol. 15:26-32.
30. Organization for Economic Cooperation and Development. 1981a. Acute inhalation toxicity. OECD Guideline for Testing of Chemicals No. 403. Adopted 12 May.
31. Organization for Economic Cooperation and Development. 1981 b. Repeated dose inhalation toxicity, 28-day or 14-day study. OECD Guideline for Testing of Chemicals No. 412. Adopted 12 May.
32. Organization for Economic Cooperation and Development. 1983. Publication of the German version of the OECD Principles of Good Laboratory Practice (GLP). Bundesanzeiger 35(42a).
33. OPPTS 870.1300. 1998a. U.S. EPA Health Effects Test Guidelines 870.1300 - Acute Inhalation Toxicity. U.S. Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances, EPA 712C-98-193.
34. OPPTS 870.3465. 1998b. U.S. EPA Health Effects Test Guidelines 870.3465 - 90-Day Inhalation Toxicity. United States Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances, EPA 712C-98-193.
35. Pauluhn, J. 1994. Validation of an improved nose-only exposure system for rodents. J. Appl. Toxicol. 14:55-62.
36. Pauluhn, J., and Mohr, U. 2000. Review - Inhalation studies in laboratory animals - Current concepts and alternatives. Toxicol. Pathol. 28:734-753.
37. Pauluhn, J., Emura, M., Mohr, U., and Rosenbruch, M. 2003. Inhalation toxicity of propineb. Part II, results of mechanistic studies in rats. Inhal. Toxicol., in press.
38. Rosiello, A. P., Essigmann, J. M., and Wogan, G. N. 1977. Rapid and accurate determination of the median lethal dose (LD50) and its error with small computer. J. Toxicol. Environ. Health 3:797-809.
39. Schaumburg, H. H., and Berger, A. R. 1992. Human toxic neuropathy due to industrial agents. In Peripheral neuropathy, eds. P. J. Dyck and P. K. Thomas, 3rd ed., vol. 2, pp. 1533-1548. Philadelphia: W. B. Saunders.
40. Schmuck, G., Ahr, H. J., Mihail, F., Stahl, B., and Kayser, M. 2002. Effects of the dithiocarbamate fungicide propineb in primary neuronal cell cultures and thigh muscle cells of the rat. Arch. Toxicol. 76:414-422.
41. Sills, R. C., Harry, G. J., Morgan, D. L., Valentine, W. M., and Graham, D. G. 1998. Carbon disulfide neurotoxicity in rats: V. Morphology of axonal swelling in the muscular branch of the posterior tibial nerve and spinal cord. Neurotoxicology 19:117-127.
42. Tátrai, E., Kováciková, Z., Karácsony, G., Hudák, A., Adamis, Z., and Ungváry, G. 2001. Effects of sodium diethyldithiocarbamate on Type II pulmonary epithelial cells in vitro. J. Toxicol. Environ. Health A 62:207-216.
43. 2-mediated cross-linking of erythrocyte spectrin and neurofilament protein, dose response and temporal relationship to the formation of axonal swellings. Toxicol. Appl. Pharmacol. 142:95-105.
44. Vettorazzi, G., Almeida, W. F., Burin, G. J., Jaeger, R. B., Puga, F. R., Rahde, A. F., Reyes, F. G., and Schvartsman, S. 1995-1996. International safety assessment of pesticides, dithiocarbamate pesticides, ETU, and PTU - A review and update. Teratogen. Carcinogen. Mutagen. 15:313-337.
45. Weiss, T., Hardt, J., and Angerer, J. 1999. Determination of urinary 2-thiazolidinethione-4-carboxylic acid after exposure to alkylene bisdithiocarbamate using gas chromatography-mass spectrometry. J. Chromatogr. B 726:85-94.
46. WHO. 1988. Dithiocarbamate pesticides, ethylenethiourea, and propylenethiourea, a general introduction. Geneva: World Health Organization.
47. Young, J. T. 1981. Histopathologic examination of the rat nasal cavity. Fundam. Appl. Toxicol. 1:309-312.