Repeated inhalation exposure of rats to an anionic high molecular weight polymer aerosol: Application of prediction models to better understand pulmonary effects and modes of action

Experimental and Toxicologic Pathology

Volumn 66, Issue 5-6, 2014, Pages 243-256

  Pauluhn, Jürgen ^a  

^a Institute of Toxicology   (Germany)

Author keywords

Anionic polyurethane resins; Disposition; Modeling; Organic polymer aerosol; Pulmonary phospholipidosis; Volume displacement overload

Indexed keywords

ANIONIC HIGH MOLECULAR WEIGHT ANIONIC POLYURETHANE POLYMER; GAMMA GLUTAMYLTRANSFERASE; LUNG SURFACTANT; PHOSPHOLIPID; POLYMER; UNCLASSIFIED DRUG; AEROSOL; ANION; POLYETHERURETHANE UREA; POLYURETHAN;

ADULT; AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BIODEGRADABILITY; BODY WEIGHT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOLOGY; DISPERSION; ELIMINATION KINETICS; EXPOSURE; FEMALE; HISTOPATHOLOGY; KINETIC OVERLOAD; LIPIDOSIS; LIPOPHAGOCYTOSIS; LUNG ALVEOLUS MACROPHAGE; LUNG BURDEN; LUNG LAVAGE; LUNG TOXICITY; MALE; NEUTROPHIL; NONHUMAN; ORGAN WEIGHT; PNEUMONIA; PREDICTION; RAT; TOXICITY TESTING; TOXICOKINETICS; YOUNG ADULT; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; LUNG; METABOLISM; MOLECULAR WEIGHT; ORGAN SIZE; PATHOLOGY; PILOT STUDY; TIME; TOXICITY; WISTAR RAT;

AEROSOLS; ANIMALS; ANIONS; BODY WEIGHT; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INHALATION EXPOSURE; LUNG; MALE; MOLECULAR WEIGHT; ORGAN SIZE; PILOT PROJECTS; PNEUMONIA; POLYURETHANES; RATS, WISTAR; TIME FACTORS;

EID: 84901033662     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2014.03.001     Document Type: Article

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