Subchronic inhalation toxicity of iron oxide (magnetite, Fe3O4) in rats: Pulmonary toxicity is determined by the particle kinetics typical of poorly soluble particles

Journal of Applied Toxicology

Volumn 32, Issue 7, 2012, Pages 488-504

  Pauluhn, Jürgen ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Disposition; Iron oxide; Lung overload; Magnetite; Particle clearance; Poorly soluble particles; Pulmonary and extrapulmonary toxicity; Repeated inhalation exposure

Indexed keywords

COLLAGEN FIBER; FERRIC HYDROXIDE; FERRIC OXIDE; MAGNETITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; IRON OVERLOAD; KINETICS; LUNG LAVAGE; LUNG TOXICITY; LYMPH NODE; MALE; METAPLASIA; NEUTROPHIL COUNT; NONHUMAN; OCCUPATIONAL EXPOSURE; PILOT STUDY; PNEUMONIA; PRIORITY JOURNAL; RAT; TOXIC INHALATION;

ANIMALS; BRONCHOALVEOLAR LAVAGE; FEMALE; FERUMOXYTOL; INHALATION EXPOSURE; KINETICS; LUNG; LYMPH NODES; MALE; NEUTROPHILS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; OCCUPATIONAL EXPOSURE; PARTICLE SIZE; PILOT PROJECTS; PNEUMONIA; RATS; RATS, WISTAR; TOXICITY TESTS, SUBCHRONIC;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84857691610     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1668     Document Type: Article

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