Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins

Journal of Molecular Biology

Volumn 427, Issue 6, 2015, Pages 1224-1238

  Ernst, Katharina ^a   Langer, Simon ^a   Kaiser, Eva ^a   Osseforth, Christian ^b   Michaelis, Jens ^b   Popoff, Michel R ^c   Schwan, Carsten ^d   Aktories, Klaus ^d   Kahlert, Viktoria ^e   Malesevic, Miroslav ^f   Schiene Fischer, Cordelia ^f   Barth, Holger ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c INSTITUT PASTEUR   (France)

^d UNIVERSITY OF FREIBURG   (Germany)

^e MAX PLANCK RESEARCH UNIT FOR ENZYMOLOGY OF PROTEIN FOLDING   (Germany)

^f MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

bacterial protein toxin; cellular uptake; cyclophilin 40; membrane transport; PPIase

Indexed keywords

ACTIN; ADENOSINE DIPHOSPHATE; BACTERIAL TOXIN; CLOSTRIDIUM BOTULINUM C2 TOXIN; CLOSTRIDIUM DIFFICILE TOXIN; CLOSTRIDIUM PERFRINGENS IOTA TOXIN; CYCLOPHILIN; CYCLOPHILIN 40; CYCLOPHILIN A; CYCLOSPORIN A; PEPTIDYLPROLYL ISOMERASE; UNCLASSIFIED DRUG; ACTIN-SPECIFIC ADP-RIBOSYLTRANSFERASE, CLOSTRIDIUM; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BOTULINUM TOXIN; BOTULINUM TOXIN TYPE C; CYCLOSPORIN; IOTA TOXIN, CLOSTRIDIUM PERFRINGENS; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PPID PROTEIN, HUMAN;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ARTICLE; BINDING AFFINITY; CELL ASSAY; CELL LYSATE; CELL MEMBRANE; CELL PROTECTION; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; ENDOSOME; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN UNFOLDING; PULL DOWN ASSAY; QUANTITATIVE ANALYSIS; VERO CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; HELA CELL LINE; METABOLISM; PROTEIN TRANSPORT;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM BOTULINUM; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM PERFRINGENS; MAMMALIA;

ACTINS; ADENOSINE DIPHOSPHATE; ADP RIBOSE TRANSFERASES; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BACTERIAL TOXINS; BOTULINUM TOXINS; CERCOPITHECUS AETHIOPS; CYCLOPHILINS; CYCLOSPORINE; HELA CELLS; HUMANS; PROTEIN TRANSPORT; VERO CELLS;

EID: 84924239313     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2014.07.013     Document Type: Article

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